Vestnik Farmacii最新文献_第2页

DEVELOPMENT AND EVALUATION OF LYOPHILIZED POWDER TO PREPARE SOLUTION FOR INJECTIONS BASED ON DOXYCYCLINE 以强力霉素为原料制备注射用冻干粉的研制与评价

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.53

E. A. Saliy, A. Y. Honcharuk, O. Getalo, H. Tarasenko

{"title":"DEVELOPMENT AND EVALUATION OF LYOPHILIZED POWDER TO PREPARE SOLUTION FOR INJECTIONS BASED ON DOXYCYCLINE","authors":"E. A. Saliy, A. Y. Honcharuk, O. Getalo, H. Tarasenko","doi":"10.52540/2074-9457.2021.3.53","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.3.53","url":null,"abstract":"The range of doxycycline drugs on the pharmaceutical market of the Ukraine is very limited and is represented by solid forms (capsules and tablets) while a rapid effect and maximum bioavailability of the drug can be provided by parenteral administration. The object of the study is the drug doxycycline hyclate in the form of lyophilisate to prepare solution for injections. During the development of the drug it was taken into account that aqueous doxycycline solution is pH dependent and tends to shift the solution pH during long-term storage. Therefore, excipients such as stabilizer and antioxidant providing buffering properties and stability of the solution were introduced into the composition. According to the research results an optimal composition of lyophilized powder was selected, the production technology with the stage of solution treatment with activated carbon was developed which allowed to obtain lyophilized powder with a well-formed porous mass without splits, cracks and fissures, resistant to shaking, and the prepared solution for parenteral administration is stable by the «Degree of coloration» quality indicator during accelerated storage regimen. It was found that doxycycline hyclate in the form of a lyophilisate shows a wide range of antibacterial activity. Comparative studies in vitro for two drugs, in the form of lyophilisate with doxycycline hyclate for injections and hard gelatin capsules with 100 mg of doxycycline hyclate, confirm equivalence of their bacteriostatic action against bacteria causing infectious diseases in humans.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89931956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

TO THE QUESTION ABOUT COMMUNICATIVE TOLERANCE OF THE PHARMACEUTICAL STUDENTS OF VSMU 关于中山医科大学药学专业学生交际耐受力问题的探讨

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.88

A. L. Tserkovskiy, O. I. Gapova, E. A. Skorikova, S. A. Petrovich, O. A. Kasyan, M. Deryabina

引用次数: 0

ANTI-INFLAMMATORY ACTIVITY OF THE SPRAY BASED ON IBUPROFEN AND LIQUID WORMWOOD EXTRACT 基于布洛芬和艾草液体提取物的喷雾抗炎活性

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.73

O. A. Sushinskaya, N. S. Golyak

引用次数: 0

PROBLEMS OF MAKING QUALITY ASSURANCE DOCUMENTATION 制作质量保证文件的问题

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.5

E. Alexandrova

{"title":"PROBLEMS OF MAKING QUALITY ASSURANCE DOCUMENTATION","authors":"E. Alexandrova","doi":"10.52540/2074-9457.2021.3.5","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.3.5","url":null,"abstract":"The article is devoted to the development of quality system documents for the pharmacy organization. The legislation of the Republic of Belarus, as well as the Eurasian Economic Union, requires the development and maintenance of the quality assurance system, the quality management system, the pharmaceutical quality system in a pharmacy organization, a distributor or manufacturer of medicinal products. The article presents the comparative analysis of regulatory requirements as well as approaches of the international standards ISO series to the construction of the quality systems and processes documentation. Such documents as the Quality Manual or its equivalent, Standard Operating Procedures (SOP) and Process Instructions are the most difficult to develop. The distribution of responsibility for processes within the organization is difficult to understand. On the example of RUE «BELPHARMATSIYA» it is shown how the processes in the pharmacy organization can be documented and responsibility for their implementation can be stated. The functioning of the quality system depends on the clarity of the documentation structure and its development and circulation organization. It is the responsibility of the organization authorities to maintain effective functioning of this system.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79356800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DETERMINATION OF SOIL TROPHICITY BY ELECTROPHYSICAL METHOD. MESSAGE 1. DEVICE AND LABORATORY TECHNIQUE 电物理法测定土壤营养性。消息1。设备和实验室技术

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.32

G. Buzuk

引用次数: 0

NOMENCLATURE ANALYSIS OF MEDICINES PREPARED BY PHARMACIES OF RUE «BELPHARMATSIYA» 真" belpharmatsiya "药房所制药品的命名分析

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.41

A. Kirilyuk

{"title":"NOMENCLATURE ANALYSIS OF MEDICINES PREPARED BY PHARMACIES OF RUE «BELPHARMATSIYA»","authors":"A. Kirilyuk","doi":"10.52540/2074-9457.2021.3.41","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.3.41","url":null,"abstract":"The article is devoted to the nomenclature analysis of medicines prepared at 21 pharmacies of the 1st category of RUE «BELPHARMATSIYA», the largest state pharmacy network in Minsk. Medicines preparation at pharmacies is carried out according to the doctors’ prescriptions and the requirements (applications) of healthcare organizations as well as in the form of intra-pharmacy stocking and packing. The main tasks of pharmacy preparation are: providing the population and healthcare organizations with dosage forms not manufactured by industry, preparation of dosage forms mainly used in pediatric and geriatric practice, individual pharmacotherapy provision. Pharmacists make from 38 to 174 dosage forms in one day. The nomenclature of the medicines prepared numbers 392most common prescriptions of which 47,2% prescriptions are unique: they were prepared by one pharmacy only. The most prevalent (42,8%) is preparation of complex in composition dosage forms which contain at least 4 ingredients. Therefore, there is an urgent question about the stability of dosage forms and shelf life detection (currently, the legislation hasn’t established shelf life of medicines prepared at pharmacy). The assortment of active ingredients and excipients has been analyzed. There are cases of medicines preparation from industrial medicines. The need for almost 100 names of active ingredients has been established. Nomenclature analysis of the prescriptions has confirmed the importance of medicines preparation development at a pharmacy to provide the population with medicines.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77187978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSORTMENT ANALYSIS OF DRUGS FOR THE TREATMENT OF MILD AND MODERATE ULCERATIVE COLITIS 治疗轻、中度溃疡性结肠炎的药物分类分析

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.21

E. N. Tarasova, M. R. Konorev, K. V. Lapkouskaya

引用次数: 0

PROSPECTS FOR CREATING RADON CONTAINING AGENTS IN RADIONUCLIDE THERAPY 在放射性核素治疗中制造含氡剂的前景

Vestnik Farmacii Pub Date : 2021-09-30 DOI: 10.52540/2074-9457.2021.3.64

E. Dikusar, A. Pushkarchuk, T. V. Bezyazychnaya, E. A. Akishina, A. Soldatov, S. Kuten, S. Stepin, A. Nizovtsev, S. Kilin, L. F. Babichev, V. Potkin

引用次数: 2

PHARMACY MANUFACTURE AND QUALITY CONTROL OF MEDICINAL PREPARATIONS ABROAD 国外医药制剂生产与质量控制

Vestnik Farmacii Pub Date : 2021-06-30 DOI: 10.52540/2074-9457.2021.2.64

V. Kuhach

{"title":"PHARMACY MANUFACTURE AND QUALITY CONTROL OF MEDICINAL PREPARATIONS ABROAD","authors":"V. Kuhach","doi":"10.52540/2074-9457.2021.2.64","DOIUrl":"https://doi.org/10.52540/2074-9457.2021.2.64","url":null,"abstract":"The purpose of this work was to study foreign experience in pharmacy manufacture and quality control of medicinal preparations (MP). Scientific literature and internet sources analysis, the author's own observations from 2005 to 2020 were made. It has been established that pharmacy manufacture of MPs abroad is carried out for the special needs of patients when pharmaceutical industry cannot produce them for various reasons. There are various approaches to standardization of the number of manufacturing pharmacies abroad: from complete prohibition of pharmacy manufacture of medicinal preparations in Portugal to mandatory license requirement in Austria and Germany. To manufacture medicinal preparations at a pharmacy the laboratory is established where necessary equipment, inventory, pharmaceutical substances and excipients are placed and the technological process is carried out. Pharmacy manufacture of sterile medicinal preparations is conducted under aseptic conditions in a specially equipped room or in a laminar-airflow cabinet. MPs must not be registered in most countries of the world. In the US and the European Union (EU) medicinal preparations are classified into medicines for immediate use and for prolonged storage. Expiration date must be stated for prolonged storage medicinal preparations, a dossier is made for them in the EU pharmacies. Pharmacies in most countries of the world manufacture medicinal preparations from tablets and capsules. Much attention abroad is given to ensure the quality of pharmacy manufacture of medicinal preparations: in the US, pharmacy manufacture of medicinal preparations is carried out in accordance with the requirements of Pharmacopoeia, in the EU according to the EU Council Resolution. A number of countries have developed guidelines or standard operational procedures for pharmacy manufacture of medicinal preparations. Constant training and assessment of employees’ competencies engaged in pharmacy manufacture of medicinal preparations is performed.","PeriodicalId":23657,"journal":{"name":"Vestnik Farmacii","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85602974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

COMPARATIVE CHARACTERISTICS OF MEDICINAL PRODUCTS ASSORTMENT, MEDICAL DEVICES AND DIETARY SUPPLEMENTS BASED ON CHITOSAN DERIVATIVES REGISTERED IN THE REPUBLIC OF BELARUS, THE RUSSIAN FEDERATION, UKRAINE AND THE REPUBLIC OF KAZAHSTAN 在白俄罗斯共和国、俄罗斯联邦、乌克兰和哈萨克斯坦共和国注册的基于壳聚糖衍生物的医药产品分类、医疗装置和膳食补充剂的比较特征

Vestnik Farmacii Pub Date : 2021-06-30 DOI: 10.52540/2074-9457.2021.2.39

T. V. Shakolo, A. V. Kurliuk, A. Kalinova

引用次数: 0