World Journal of Current Medical and Pharmaceutical Research最新文献

{"title":"Combinational Effect of Andrographis paniculata, Azadirachta indica and Carica papaya latex for Anthelmintic Potential on Pontoscolex corethrurus","authors":"Shilpashree V. K., Navdesh Velip, Deepraj Gaonkar, Grishm Kundaikar, Chandrakant Gaude, H. Poojari, R. Nayak","doi":"10.37022/wjcmpr.v4i5.238","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.238","url":null,"abstract":"The present study was done with the aim to screen the anthelmintic activity of decoction containing Andrographis paniculata (Kalmegh), Azadirachta indica (Neem), Carica papaya latex using Pontoscolex corethrurus. The different concentrations (40%, 60% and 80%) of decoction were evaluated for determining the time of paralysis and the time of death of earthworms. Albendazole (10mg/ml) used as standard reference and normal saline as control. The data of the study revealed that the decoction at 80% concentration showed better anthelmintic activity compared to standard drug Albendazole.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88694183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development, Standardization and Microbiological appraisal of Herbal Dentifrice prepared from Achyranthes aspera Linn. (Apamarga) leaves","authors":"Ganesh Asnotikar, Anusha Shetty, Dhananjaya Dhananjaya, Mithun C., R. Nayak, Shilpashree V. K.","doi":"10.37022/wjcmpr.v4i5.237","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.237","url":null,"abstract":"Dentifrices are the products which are important in our daily life and mainly used to maintain good oral hygiene. The oral hygiene can be maintained throughout the day by using a variety of dentifrices prepared by herbal and synthetic ingredients. Most of the synthetic preparation of dentifrices causes side effects. In this study an attempt is made to prepare a tooth powder which can be used as a tool for proper oral hygiene and to overcome the side effects of synthetic one. The tooth powder was developed using various herbal ingredients such as Apamarga, Clove, Triphala, Pacha karpoora, Ritha and Mulethi. Developed formulation was standardized by analysing necessary evaluation parameters such as organoleptic, microscopical, physicochemical, rheological, phytochemical characteristics. The formulation was screened for its antimicrobial activity by agar well diffusion method against Streptococcus aureus. The results showed that the developed dentifrice has promising antimicrobial effect to use against dental diseases.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86539044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of retinoblastoma in children in Madagascar","authors":"H. Randrianarisoa, R. Rakotoarisoa, LG Miray, ML Rakotomahefa Narison, L. Raobela","doi":"10.37022/wjcmpr.v4i5.230","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.230","url":null,"abstract":"Introduction: Retinoblastoma is the most common intraocular tumor in child. The treatment is well codified combining chemotherapy, surgery, radiotherapy and conservative treatment. It involves both the visual and vital prognosis. The aim of this study was to describe epidemiological aspect of retinoblastoma and evaluate therapeutic aspects and evolution of retinoblastoma in Madagascar. \u0000Method: We report in this retrospective study 52 cases found during 5 years, from January 2010 to December 2015. We have collected information about epidemiological and clinical aspect. Delay of diagnosis, treatment done in children and evolution. Data was collected with excel software and analysis was done with Epi info 7.0 software. The quantitative variables were expressed as an average and the qualitative variables as a proportion and percentage. \u0000Result: We had collected 52 cases. The incidence was 10.4 cases per year. Mean age was 3 years, with no gender predominance. More than half or 53.8% (n=28) of children presented minor signs: including leucocoria in 25 children and strabismus in 3 children. Exophthalmos was found in 46.5% (n=24) of cases. Exophthalmia and leukocoria were associated in 6 (10%) children. The delay time before diagnosis was 11 months and 2 days. 39 pieces were sent for examination. Result of Anatomo-pathological study was: 51% (n=20) was undifferentiated retinoblastoma, 36% (n=14) differentiated retinoblastoma, 13% diffused retinoblastoma (n=5) Optic nerve was affected in 7.69% of cases (n=3). Before diagnosis, 55.8% (n=29) of our patients received non-specialized medical treatment and 44.2% (n=23) used traditional treatment. Four patients had primitive enucleation without first chemotherapy. Nine children or 18.75% didn’t have surgical treatment. Neoadjuvant chemotherapy was done in 92.3% (n = 48). 39 patients had first chemotherapy before enucleation. Only 58% of children have received adjuvant chemotherapy. The evolution was marked by 27% (n = 14) of remission, 21% (n = 11) of death and 8% (n = 4) of recurrence. Twenty-three patients (44%) were lost to follow-up. \u0000Conclusion: Diagnosis of retinoblastoma was made in advanced stage. Number of lost to follow-up were high. Treatment consist in chemotherapy and enucleation. Prognosis was worse in Madagascar. Communication with parents, medical personal must recommended to reduce number of children lost to follow-up.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86925830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of plateletpheresis on hematological parameters","authors":"Dito Setiadarma, Angelastro Angela","doi":"10.37022/wjcmpr.v4i5.231","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.231","url":null,"abstract":"Apheresis for platelet concentrates has been used more frequently in recent years due to the rising demand for platelet transfusions for patients with various medical and surgical disorders. Studies on the effect of repeated or frequent plateletpheresis on the donor's hematological parameters are still limited. This article will review the effects of plateletpheresis on the donor's hematological parameters to define the proper deferral for repeat donation because this treatment is relatively new and requires early repeat donations. We systematically search the studies and review current evidence about the effects of plateletpheresis on blood parameters in healthy donors. Literature tracking was performed on PubMed, CENTRAL, EbscoHost, and ProQuest databases. There are different effects, and some studies reveal that plateletpheresis can decrease hematological parameters (HB, HCT, PLT, PDW). Some can cause an increase in hematological parameters (HB, HCT). These different effects can be caused by variable cell separator technologies, residual blood volume lost during apheresis, and mechanical hemolysis of blood in tubes by machine pumps.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81616538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF METHANOLIC EXTRACT OF AVERRHOA BILIMBI USING VARIOUS ANIMAL MODELS”","authors":"Sujana V Mestha, Sahana Nagesh, Preeti Shanbhag, Ramdas Bhat","doi":"10.37022/wjcmpr.v4i5.234","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.234","url":null,"abstract":"Aim of the study: Averrhoa bilimbi is used to treat a variety of illnesses, including those that affect the central nervous system. In this study, albino rats were given methanolic extract of Averrhoa bilimbi leaves (MEAB) to investigate its effects using behavioral assays that are sensitive to antidepressants with clinical efficacy. Methodology: When mice were subjected to the Tail suspension test (TST) and Forced swim test (FST), the extract (125,250, and 500mg/kg) was able to reduce the immobility duration of the mice dose-dependently; the effects are comparable to those of standard medicines, i.e., imipramine (10mg/kg). Results: Our research revealed that MEAB, when administered at greater concentrations, significantly (p<0.0001) reduced immobility in tail suspension and forced swim model of depression comparable to Imipramine. These findings showed that AB exhibited in vivo effects that were selectively antidepressant. Conclusion: The results of this study, in summary, revealed that AB extracts may have antidepressant properties that make them potentially useful for treating patients with depressive disorders. However, more research is required to comprehend the mechanism of action and to pinpoint the key ingredient that produces antidepressant-like activity. \u0000 ","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89321740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cutaneous manifestations of COVID-19, personal protective equipment and treatment","authors":"A. Haddad, I. Haddad","doi":"10.37022/wjcmpr.v4i5.226","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.226","url":null,"abstract":"Since the beginning of COVID-19 pandemic in late 2019, the symptoms and signs detailed in the medical literature and the media concentrated on the effect of causative virus SARS-COV-2 on the respiratory tract, the coagulopathy associated with severe forms of the disease and the febrile flu like illness in the mild cases. The widespread publicising of the symptoms has been one of the important public health measures in combatting the rapid spread of COVID-19. Less known is the direct or indirect effect of COVID-19 on the skin and underlying soft tissue. Recognising the various cutaneous manifestations may prove a useful tool in early detection and management of COVID-19.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82043384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A A review on role of neuromodulators in autism spectrum disorder","authors":"Sajid T. Hussain, F. Deeba","doi":"10.37022/wjcmpr.v4i5.228","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.228","url":null,"abstract":"Autism spectrum disorder (ASD) is a group of complex neurodevelopmental disorders whose diagnosis is exclusively made on a behavioral basis. According to the diagnostic and statistical manual of mental disorders, autism is defined by deficits in two main symptoms (social interaction & communication, and repetitive/restrictive behaviors), which emerge in premature phases of postnatal development. The authors review evidence that ASD is a neurobiological disorder influenced by both genetic and environmental factors affecting the developing brain, and enumerate factors that correlate with ASD risk. Finally, the article describes how clinical evaluation begins with developmental screening.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84086718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An investigation of diuretic activity of aqueous extract of malus sulvestris (l) mil fruits in experimental animal models","authors":"Ramdas Bhat, Sahana Nagesh, Preeti Shanbhag, Sujana V Mestha, Shilpashree V K, R. Kumar","doi":"10.37022/wjcmpr.v4i5.229","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.229","url":null,"abstract":"Objective and background: Malus sylvestris Linn are a plant widely used as a traditional medicinal herb has a wide range of Pharmacotherapeutic activities. The current study was carried out to investigate the diuretic activity of Malus sylvestris Linn fruit aqueous extract (AEMS) in experimental animals. Methods: In the current study Wister rats were divided into 5 groups of n=6 each using Furosemide (100 mg/kg, p.o) as the standard drug and normal saline as the control. AEMS is given at the doses of 200 mg/kg, 400 mg/kg and 800 mg/kg p.o. in distilled water respectively. Lipchitz method was used for his study. Parameters such as volume of urine, concentration of sodium and concentration of potassium are noted. Results and discussion: The study revealed that extract of AEMS has considerably increased the urine volume with significant increase in cationic concentration at increased doses. The concentration of Na+/K+ indicates the dose dependent response with the comparable results at the doses of 200 mg/kg, 400 mg/kg and 800 mg/kg with reference with the standard administered. Oral administration of AEMS at the dose of 800 mg/kg shows high significance (P<0.001) with that of control and dose of AEMS of 400 mg/kg shows significance (P<0.05) shows and dose of AEMS of 200 mg/kg shows less significance (P<0.01) with decreased urine output with that of control.  Conclusion: As a result of foregoing study aqueous extract of Malus sylvestris Linn fruit has considerable diuretic activity at higher doses.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75343163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on looking at prescription quality in Ayurveda and principles of ethical Ayurvedic prescription","authors":"Sireesha Badri, Anjali Malapati, Bhavya sri Mullagura, S. K., Suvartha R, P. T.","doi":"10.37022/wjcmpr.v4i5.227","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.227","url":null,"abstract":"Medical prescriptions have few common generic features, usally containing the basic details of the patient and prescriber identification followed by the medications including its dose, intake schedules and total duration of drug consumption . The importance of prescription quality among every system of medicine an attempt was made to design a prescription quality index for ayurveda. Prescription quality index for ayurveda was found useful in between the ideal and generated prescriptions. Ayurvedic practice of medicine is largely criticized for not utilizing its own concepts of disease, diagnosis and management imposing the modern concepts of pathogenesis and treatments upon their own treatment principles. There is a poor quality of ayurvedic prescriptions is an undercurrent observations and brought into notice frequently. The pilot test was also able to reveal many underlying limitations in contemporary ayurvedic prescription writing. Great caution is warrented while prescribing medicines in children, elders and pregnant ladies and it has been suggested to prescribe disease- specific drugs in limited number of combinations in proper doses with proper adjuvants.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79669123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Covid-19 on Orthopaedic Surgery in Regional Covid-19 Referral Hospital: A Cross-Sectional Study","authors":"Shianita Limena, Anak Agung Ngurah Ronny Kesuma, I. K. A. K. Saputra","doi":"10.37022/wjcmpr.v4i5.225","DOIUrl":"https://doi.org/10.37022/wjcmpr.v4i5.225","url":null,"abstract":"Introduction: The Covid-19 pandemic has been a profound phenomenon affecting the entire world, primarily healthcare systems. Since the first Covid-19 case in Indonesia around March 2020, the healthcare systems and public regulations have been constantly readjusted. In our centre, the pandemic has also had major effects on the orthopaedic and trauma services. This study aims to evaluate the impact of Covid-19 on orthopaedic surgery in Wangaya General Hospital. \u0000Method: A cross-sectional study is done retrospectively through medical records among patients underwent orthopaedic surgery from March 2019 to 2021. Pre-Covid control group (March 2019-2020) is compared to Covid case group (March 2020-2021). The parameter of study includes: patient’s demographics, orthopaedic diagnosis, anatomical location, orthopaedic surgery, and type of surgery. T test and chi square test is used for data analysis. \u0000Result: Out of the total 916 cases, the number of orthopaedic surgeries is decreased by 42,61% (582 vs. 334 cases; 48,5±10,11 vs. 27,83±4,89 cases/month) on the first year of pandemic. The number of emergency surgeries has escalated significantly with inverted proportion to elective surgeries, such as arthroplasties, implant and benign tumor removal. Polytrauma, lacerations and tendon rupture case has been increased considerably requiring immediate surgical treatment. \u0000Conclusion: In response to the pandemic, the objective is to restore high quality healthcare systems by reconstructing newly updated strategies for patient management plan and public regulations during the ongoing Covid-19 pandemic.","PeriodicalId":23642,"journal":{"name":"World Journal of Current Medical and Pharmaceutical Research","volume":"215 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78125400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}