Vestnik dermatologii i venerologii最新文献_第6页

Efficacy and safety profile of Minolexin in patients with urogenital chlamydia infection: results of an open randomized comparative clinical trial 米诺列辛治疗泌尿生殖道衣原体感染的疗效和安全性:一项开放随机对照临床试验的结果

Vestnik dermatologii i venerologii Pub Date : 2023-09-13 DOI: 10.25208/vdv11877

Margarita Rakhmatulina

{"title":"Efficacy and safety profile of Minolexin in patients with urogenital chlamydia infection: results of an open randomized comparative clinical trial","authors":"Margarita Rakhmatulina","doi":"10.25208/vdv11877","DOIUrl":"https://doi.org/10.25208/vdv11877","url":null,"abstract":"Background. Urogenital chlamydia infections is a widespread STI: 131 million people are infected every year. Scientists are studying the issue of reducing the sensitivity of the pathogen to traditionally used drugs and are investigating the effectiveness of antibacterial drugs active against C. trachomatis. Aims: to study the efficacy and safety of the minocycline in the treatment of urogenital chlamydia infection in comparison with the doxycycline. Methods: an open randomized comparative clinical trial included 100 patients: group 1 50 patients who received minocycline 100 mg 2 times a day for 7 days, group 2 50 patients who received doxycycline 100 mg 2 times a day in within 7 days. The diagnosis was confirmed by the detection of C. trachomatis by PCR. The parameter of the effectiveness of therapy was the eradication of C. trachomatis and the absence of clinical symptoms 4 weeks after therapy. Results: 1 week after therapy, clinical symptoms were registered in 20;40.8% patients of group 1 and 28;57.1% patients of group 2 (p=0.106), 4 weeks later in 4;8.2% and 7;18.4% patients (p=0.524). In group 1, the absence of most subjective clinical symptoms was recorded in a shorter time than in the comparison group. 100% of patients had achieved eradication C. trachomatis, laboratory signs of an inflammatory reaction were recorded in 2;5.0% patients of group 1 and 3;7.3% patients of group 2 (p=1,000). According to the frequency of adverse drug events, there were also no significant differences between the groups, however, in group 2 patients, adverse drug events that had a high probability of being associated with taking the drug were recorded more often than in the group 1. Conclusions. The results of the study demonstrated the comparable effectiveness of minocycline and doxycycline in the treatment of urogenital chlamydia infection and a similar safety profile of these drugs.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"361 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135734781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current state of the etiopathogenesis and the treatment of recurrent vulvovaginitis candidiasis 念珠菌病复发性外阴阴道炎的发病及治疗现状

Vestnik dermatologii i venerologii Pub Date : 2023-09-06 DOI: 10.25208/vdv11879

Margarita Rakhmatulina

{"title":"Current state of the etiopathogenesis and the treatment of recurrent vulvovaginitis candidiasis","authors":"Margarita Rakhmatulina","doi":"10.25208/vdv11879","DOIUrl":"https://doi.org/10.25208/vdv11879","url":null,"abstract":"Vulvovaginal candidiasis is a widespread infection caused by Candida. The disease affects 75-80% of women of reproductive age at least once during their lifetime, and 9-20% of them indicate the presence of three or more episodes of the disease during the year, which is classified as recurrent vulvovaginal candidiasis (RVVC). To date, the question of the causes of the formation of recurrent forms of the disease has not been definitively resolved, since RVVC is also observed in women who do not have known risk factors. Due to the fact that about 20-30% of patients with RVVC are healthy women without factors predisposing to its development, interindividual differences such as genetic predisposition and ethnicity, immune disorders, as well as the species diversity of Candida fungi and their antimycotic resistance may play a key role in the pathogenesis of idiopathic RVVC. \u0000In the literature review, the main etiopathogenetic mechanisms of the disease development are presented, the role of immune and genetic factors of predisposition to the development of recurrent vulvovaginal candidiasis is evaluated, changes in the species structure of the pathogen in recent years are analyzed. Modern approaches to the treatment of the disease are described, taking into account the indicators of antimycotic resistance, and the analysis of RVVC therapy regimens according to domestic and foreign clinical recommendations is carried out. The possibilities of using sertaconazole in the treatment of the disease are considered, the results of studies of its efficacy and safety in patients with vulvovaginal candidiasis are presented.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42830075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indeterminate dendritic cell tumor (IDCT) 不确定的树突状细胞肿瘤（IDCT）

Vestnik dermatologii i venerologii Pub Date : 2023-09-06 DOI: 10.25208/vdv8137

Evgenia V. Okladnikova, Vladimir M. Merk, Yuriy А. Krivopalov, Vladimir A. Khorzhevskii, Tatiana Ruksha

引用次数: 0

Resources and performance rates of medical organizations providing medical care in the field of dermatovenereology in the Russian Federation in 2016-2022 2016-2022年俄罗斯联邦在皮肤性病学领域提供医疗服务的医疗组织的资源和绩效

Vestnik dermatologii i venerologii Pub Date : 2023-09-04 DOI: 10.25208/vdv12385

E. Bogdanova, A. Kubanov

引用次数: 0

Analysis of equipment for phototherapy in institutions of dermatovenerologic profile 皮肤性病专科机构的光疗设备分析

Vestnik dermatologii i venerologii Pub Date : 2023-09-04 DOI: 10.25208/vdv13730

Elena Yu. Novoselova, M. Rakhmatulina, A. Karamova

{"title":"Analysis of equipment for phototherapy in institutions of dermatovenerologic profile","authors":"Elena Yu. Novoselova, M. Rakhmatulina, A. Karamova","doi":"10.25208/vdv13730","DOIUrl":"https://doi.org/10.25208/vdv13730","url":null,"abstract":"Aims: to assess the current state of the technical support of medical organizations of the dermatovenerological profile with equipment for phototherapy of dermatoses. \u0000Materials and methods: information about the availability of equipment for phototherapy of dermatosis and/or the need to purchase it, the intensity of use of the available equipment for various nosologies, as well as problems related to its service, obtained from 64 medical organizations of the dermatovenerological profile in 62 constituent entities of the Russian Federation. \u0000Results: 8 (12%) specialized medical organizations are currently not equipped with phototherapy equipment. In 56 medical organizations using phototherapy equipment, the share of foreign-made medical equipment is 84%. Of the 22 models of medical equipment, only 12 (54%) are included in the State Register of Medical Devices and have a valid registration certificate. 192 (75%) pieces of equipment of medical organizations are intended for local phototherapy in the medium-wave (UVB) or long-wave (UFA) ultraviolet radiation mode, and only 63 (25%) units are represented by ultraviolet cabins (57 UVA (PUVA) and UVB-311 cabins). and 6 UVA and UVB (SFT) booths). Out of 57 UV cabins, only 18 (32%) are simultaneously equipped with UVA and UVB-311 radiation sources. Half of the medical organizations of the dermatovenerological profile (50%) experience difficulties with servicing the installed devices, 43 (67%) medical organizations reported the need for equipment for phototherapy of dermatosis. \u0000Conclusions. Due to the instability of logistics and sanctions for the supply of medical equipment to the country, the development and registration of a medical device for phototherapy of dermatosis and T-cell lymphomas of the skin, and its further production in Russia, is relevant.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45491639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anogenital herpesvirus infection: focus on HIV-positive patients 肛门生殖器疱疹病毒感染:重点关注艾滋病毒阳性患者

Vestnik dermatologii i venerologii Pub Date : 2023-09-04 DOI: 10.25208/vdv7753

S. Prozherin, A. Podymova

{"title":"Anogenital herpesvirus infection: focus on HIV-positive patients","authors":"S. Prozherin, A. Podymova","doi":"10.25208/vdv7753","DOIUrl":"https://doi.org/10.25208/vdv7753","url":null,"abstract":"The annual growth in the number of people living with HIV infection inevitably leads to an increase in the number of cases of any type of comorbidity. The article analyzes modern epidemiological, clinical, therapeutic aspects of anogenital herpes simplex virus infection (AHVI) in HIV-positive patients. Human immunodeficiency virus (HIV) and herpes simplex virus 2 (HSV-2) combine epidemiological and biological synergy. Concomitant anogenital herpes increases the risk of HIV infection by 2.7-4.7 times, and also contributes to its transmission through unprotected sexual intercourse. In HIV-infected patients with AHVI, the genital excretion of HSV-2 is increased. Among HIV-positive individuals, the seroprevalence of HSV-2 exceeds the population figures by 1.9-3.8 times. The incidence of AHVI in a cohort of Russians with a positive HIV status is 5-7.8 times higher than in the general population. The review demonstrates that both infections can have a negative mutual influence on the clinical course of each other. Particular emphasis is placed on the timely diagnosis of cases of coinfection. Based on the current regulatory documents, the authors developed and presented an algorithm for testing for HIV in patients with a newly diagnosed anogenital herpes.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syphilis and some other STIs in the Russian Federation: past, present and ways to control of the epidemiological situation in the future 俄罗斯联邦的梅毒和其他一些性传播感染:过去、现在和今后控制流行病学情况的方法

Vestnik dermatologii i venerologii Pub Date : 2023-09-04 DOI: 10.25208/vdv13726

T. Krasnoselskikh, E. Sokolovskiy, M. Rakhmatulina, Elena Yu. Novoselova, L. Melekhina

{"title":"Syphilis and some other STIs in the Russian Federation: past, present and ways to control of the epidemiological situation in the future","authors":"T. Krasnoselskikh, E. Sokolovskiy, M. Rakhmatulina, Elena Yu. Novoselova, L. Melekhina","doi":"10.25208/vdv13726","DOIUrl":"https://doi.org/10.25208/vdv13726","url":null,"abstract":"The article is devoted to assessing the situation with syphilis and other sexually transmitted infections in the USSR and Russia in the period after the Second World War. On the basis of long-term statistical data, the patterns of rises and decreases in syphilis, gonorrhoea, chlamydia infection are analyzed, possible factors influencing the epidemic process are discussed and a comparative assessment of the current situation in Russia and Western countries is carried out. Comparing to the previous year, there was an increase of the syphilis incidence by 39.4% in 2021, by 33.7% in 2022 and by 14.7% in the first 4 months of 2023. The incidence of gonococcal infection increased by 10.4%, 10.0% and 5.5%, respectively. The attention is drawn to the negative trend of an increase of latent and late syphilis among other forms, as well as rising number of late neurosyphilis and late cardiovascular syphilis cases. In view of the predicted increase in the incidence of syphilis and other STIs in the coming years, the authors emphasize the urgent need to develop and implement a state interdisciplinary program aimed to epidemiological monitoring, improvement of the diagnosis and treatment, prevention of the dissemination of syphilis and other STIs and controlling of factors that negatively affect the reproductive health of the nation.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44771870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Аlexey V. Samtsov is 70 years old Аlexey V. Samtsov今年70岁

Vestnik dermatologii i venerologii Pub Date : 2023-07-25 DOI: 10.25208/vdv14138

I. Belousova, A. Patrushev, Dmitry V. Chernyshov

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To the question of the effect of isotretinoin on the neuropsychic state of patients with acne 探讨异维甲酸对痤疮患者神经精神状态的影响

Vestnik dermatologii i venerologii Pub Date : 2023-07-04 DOI: 10.25208/vdv1414

A. Samtsov

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DEMONSTRATION OF A CLINICAL CASE BASED ON THE PHENOTYPIC APPROACH OF ROSACEA THERAPY 一个基于表型方法治疗酒渣鼻的临床病例的演示

Vestnik dermatologii i venerologii Pub Date : 2023-06-20 DOI: 10.25208/vdv1401

M. Drozhdina, V. Bobro

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