Vestnik of Vitebsk State Medical University最新文献

{"title":"SELECTION AND DETERMINATION OF THE OPTIMAL CONCENTRATION OF THE PLATELET AGGREGATION INDUCER IN INTENSIVE THERAPY OF PATIENTS WITH COVID-19 INFECTION","authors":"A. Marochkov, A. Lipnitski, A.G. Starovoitov, V. Dazortsava, V. Livinskaya","doi":"10.22263/2312-4156.2021.3.16","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.16","url":null,"abstract":"The change in platelet function that occurs in patients during treatment for a new coronavirus infection can be determined using the platelet aggregation method. Objectives. To determine optimal inducer of platelet aggregation and to assess its prognostic significance in intensive therapy of patients with COVID-19 infection. Material and methods. 34 patients with new coronavirus infection were included in group 1, and 30 healthy women were included in group 2. The study of platelet aggregation was carried out by the turbidimetric method with AP2110 analyzer (SOLAR, Results. The area under the aggregation curve was statistically significantly greater in patients in group 1 when using an ADP inducer at a dose of 0.3 μg/ml (69.1 (27.3; 164.4) unit in comparison with 55.3 (31.5; 68.2) units in group 2, p<0.001). When using an ADP inducer in high concentrations of 1.25 and 2.5 μg/ml and an adrenaline inducer in concentrations of 2.5 and 5 μM, the area under the curve in patients with COVID-19 infection was statistically significantly lower compared to group 2. The area under the aggregation curve according to the Hosmer-Lemeshov criterion has been found to be an independent predictor of death in the intensive care unit (Chi-square=5.074, p=0.06 for ADP 0.3 μg/ml and Chi square=15.121, p=0.057 for ADP 0.6 μg/ml). Conclusions. A comparative analysis of platelet aggregation using inducers of ADP, adrenaline and collagen has shown that in patients with new coronavirus infection, the degree of coagulation imbalance should be determined according to the indications obtained with an ADP inducer at a dose of 0.3 and 0.6 μg/ml.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80500213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPIDEMIOLOGICAL CHARACTERISTICS OF HIV-INFECTED DRUG USERS AT THE STAGE OF BECOMING A MEMBER OF THE OPIOID SUBSTITUTION THERAPY PROGRAM IN THE CITY OF MINSK","authors":"M. Shylava, A. V. Abramovich","doi":"10.22263/2312-4156.2021.3.63","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.63","url":null,"abstract":"Objectives. To identify the medico-social and epidemiological peculiarities of HIV-infected people injecting drugs (PWID) at the stage of joining the opioid substitution therapy (OST) program, who adopted it in 2019 in the city of Minsk. Material and methods. The data of the primary accounting documentation of the Health Care Institution «City Clinical Narcological Dispensary» and the Health Care Institution «City Clinical Infectious Diseases Hospital» of PWID HIV-infected patients were analyzed on joining the opioid substitution therapy program who adopted it in 2019 in the city of Minsk (n=91). Results. It has been found that the largest proportion of the OST program participants constituted males (73.63%) aged 36 years and older (73.62%); 64.84% of them were convicted more than 3 times, 83.52% were not officially married, 64.84% were officially unemployed. The median experience of using opioid drugs made up 21 (19-24) years. Almost ½ (46.15%) of HIV-infected drug users were members of OST program for 3 (1-5) years in 2019. Most of the OST program participants (83.52%) had up to 3 periods without drug use, while in 54.95% of them these breaks were due to serving a sentence, and in 21.98% because of undergoing rehabilitation. Lifestyle changes and socialization in society were authentically the most significant reasons and motives for the participation of PWID HIV-infected persons in the OST program in Minsk (p<0.05). The analysis of the comorbidity rate showed that all the participants in the studied group were infected with viral hepatitis C, 6.59% - with hepatitis B against the background of hepatitis C virus (HCV), and 1.01% - with hepatitis D. Conclusions. The revealed medical, social and epidemiological features of HIV-infected PWID persons at the stage of joining the opioid substitution therapy program will make it possible to increase the efficiency of providing medical care to opioid drug users with HIV infection and parenteral viral hepatites and extend the coverage of the studied contingent by this program.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88649152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE PECULIARITIES OF DETECTION AND DIAGNOSIS OF TUBERCULOSIS IN CHILDREN AND ADOLESCENTS","authors":"N. Pravada, A.M. Budritskiy, V.A. Seryogina","doi":"10.22263/2312-4156.2021.3.40","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.40","url":null,"abstract":"Objectives. To assess the peculiarities of diagnosis and clinical course of tuberculosis in children and adolescents. Material and methods. Retrospective analysis of outpatient records of children and adolescents with tuberculosis in Vitebsk region during the period from 2016 to 2020 was made. Results. In the tuberculous disease structure in children and adolescents, pulmonary tuberculosis (infiltrative pulmonary tuberculosis) prevails. In the majority of cases, tuberculosis was diagnosed during adolescence. Almost all of the sick had close family contact with tuberculosis patients. The medical risk group included 25% of patients. In patients with infiltrative pulmonary tuberculosis, symptoms and changes in the total blood count were observed only in the phase of disintegration and seeding. Bacteriological excreters made up 75% of cases. More than half of children and adolescents with tuberculosis had multidrug resistance of mycobacterium tuberculosis. Immunodiagnosing plays an important role in the detection of tuberculosis in children and adolescents. Among the sick children, only extrapulmonary forms of tuberculosis were recorded. Conclusions. Most often, tuberculosis in children and adolescents affects the respiratory organs and is asymptomatic or oligosymptomatic. 75% of patients were bacteria discharging persons, more than half of them having multidrug resistance. Family contact is of great importance in tuberculosis in children and adolescents. Doctors of all specialties need to have phthisiatric alertness in relation to patients with diseases of various localization resistant to nonspecific therapy, especially to persons with chronic diseases and to those who contact with patients suffering from tuberculosis. In case of ineffective antibiotic therapy, it is necessary to take the material for the study and verification of tuberculous infection and to carry out immunodiagnosing of tuberculosis.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"423 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76744531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMMUNITY AND BACTERIAL BIOFILMS: CURRENT STATUS OF THE MATTER (LITERATURE REVIEW)","authors":"P. Plotnikov, N.A. Movsesyan, T. Lepteeva, T. Torosyan, V. Ziamko, E. Ilyin","doi":"10.22263/2312-4156.2021.3.7","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.7","url":null,"abstract":"The problem of prevention and treatment of infectious diseases in practical health care is one of the most difficult, unsolved and priority ones. At the same time, the fact of biofilm formation by microorganisms-causative agents of infectious diseases has already been proved, which leads to an increase in the resistance of pathogens of infectious-inflammatory diseases to antibacterial drugs, chronization of the infectious process, and an atypical course of the disease. The results of numerous studies have shown the relationship between the immune system and bacterial biofilms. The effect of the links of humoral and cellular immunity on the matrix of biofilms or some of its components has been described. Neutrophils, that play a key role in phagocytosis rank first in antibiofilm immunity. However, it has been shown that the polysaccharide matrix of biofilms reduces phagocytosis by inhibiting the phagocytic clearance of biofilm bacteria. Bacteria of biofilms have become able to use many protective reactions of the immune system, designed to fight with microorganisms for their own purposes for development, growth, nutrition. For example, lysozyme enhanced the adhesion of S. aureus to the surface, triggering biofilm formation. Several studies have shown the destruction of biofilms when exposed to blood serum. Other studies have demonstrated the activation of the complement system in the presence of biofilm.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82004050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN INNOVATIVE APPROACH TO THE TREATMENT OF TRANSVERSE FRACTURES OF MOLAR ROOTS","authors":"N. Baitus, Y.P. Chernyavski","doi":"10.22263/2312-4156.2021.3.90","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.90","url":null,"abstract":"A tooth fracture is a traumatic injury to a tooth with the disturbance of its crown or root part integrity. A root fracture is a fracture that involves cementum, dentin, periodontium and, in some cases, dental pulp. Root fractures occur in 0.2-7% of all cases of permanent teeth injuries. The aim of the study was to investigate clinical effectiveness of using a material based on hydroxyapatite «Bioplast-Dent» paste and a material based on mineral trioxide aggregate - «Rutsil» in the treatment of a transverse fracture of the medial tooth root 4.6 (clinical case). The object of the study was a patient with a fracture of the medial tooth root 4.6 and destructive processes in the tissues of the apical periodontium of tooth 4.6, who applied to the Chair of Restorative Dentistry with the course of the Faculty for Advanced Training & Retraining of «VSMU» in 2019. Temporary obturation of the root canals of the root of tooth 4.6 was performed using the material based on hydroxyapatite «Bioplast-Dent» in the form of a paste. Permanent obturation of the root canals of the root of tooth 4.6 was carried out using domestic material based on mineral trioxide aggregate (MTA) - «Rutsil». The final restoration of the tooth crown was carried out after X-ray control from the moment of permanent obturation of the root canals in 3 months. Additionally, dynamic R-control was performed in 12 months. The results of the treatment have shown that the use of hydroxyapatite-containing paste and domestic material based on mineral trioxide aggregate - «Rutsil» brings about activation of osteogenesis in periodontal tissues and stops the process of resorption in the fracture line, shortening the time of bone tissue recovery and contributing to a greater success of treatment.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73841628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EXPERIENCE OF NOSE TAMPONS APPLICATION WITH PRESERVATION OF THE NASAL RESPIRATION FUNCTION","authors":"V.A. Karnialiuk","doi":"10.22263/2312-4156.2021.3.34","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.34","url":null,"abstract":"Nasal tampons should provide effective hemostasis while maintaining the function of nasal breathing, and not produce a traumatic effect on the mucous membrane of the nasal cavity. Within the frames of the research work in the Republican Scientific and Practical Center of Otorhinolaryngology, together with LLC «Advantmed», nasal tampons with preservation of the nasal breathing function of several sizes (14×64×7 mm and 19×84×7 mm) have been developed and manufactured. A registration certificate for a medical device has been received. Objectives. To evaluate the effectiveness of the use of nasal tampons while maintaining the nasal breathing function. In the course of the work, the time of stopping bleeding has been measured, patients have been surveyed concerning preservation of their nasal breathing function during tamponade of the nasal cavity, comfort of the tamponade of the nasal cavity using a 10-point visual analogue scale has been assessed by the patients, the degree of edema and hyperemia of the nasal mucosa has been determined, the presence of scabs and fibrin plaque during endoscopic examination of the nasal cavity using a 3-point visual analogue scale has also been determined. Results. Nasal tampons with preservation of the nasal breathing function have good hemostatic quality: the speed of stopping bleeding was 5±1 seconds compared to 9±1 seconds in case of glove-gauze tamponade (p<0.05). When questionnairing all patients (100%) during the period of using the developed medical device, the function of nasal breathing was determined as sufficient. Conclusions. Tamponade of the nasal cavity using nasal tampons while maintaining the nasal breathing function is better tolerated by patients than the glove-gauze one (the comfort of tamponade of the nasal cavity according to the visual analogue scale varied from 4 to 6 points (with an average value of 4.9±0.6 points) in comparison with 5-8 points (on an average 6.8±0.3 points), respectively (p<0.05)). It has a less pronounced traumatic effect on the mucous membrane of the nasal cavity compared to that of the glove-gauze tamponade.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91078811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEED-MOTIVATIONAL COMPONENT OF COMMUNICATIVE ACTIVITIES OF MEDICAL STUDENTS OF VSMU","authors":"A.L. Tsercovsky, O. I. Gapova, E. A. Skorikova, S. A. Petrovich, O. A. Kasyan, V. Muzhichenko","doi":"10.22263/2312-4156.2021.3.104","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.104","url":null,"abstract":"Objectives. To study the need-motivational component of the communicative activities of medical students of VSMU and to analyze the dynamics and gender differences in the indices of levels of need and motivational orientation in communication. Material and methods.We examined 527 students of the medical faculty, there were 386 second-year students (117 boys and 269 girls); 141 sixth-year students (28 boys and 113 girls) from all of them. The study of the need for communication was carried out using the methodology of Yu.M. Orlov «The need for communication». To study motivational orientation in communication, we used the methodology «Diagnostics of motivational orientations in interpersonal communications» (I.D.Ladanov, V.A.Urazaeva). Results.The students demonstrated the dominance of the average level of the need for communication and motivational orientations in communication, which is considered to be optimal. The dynamics of the indices of the levels of the need for communication is considered as conditionally positive, and the levels of motivational orientation - as positive. The revealed patterns are most typical of young men. Conclusions.The patterns of the need for communication and communicative orientations (including their dynamics) identified by us can be explained by the quality of the humanities education of students, as well as the influence of the information and educational environment of VSMU on the personal growth of students of the medical faculty, on the formation of their communicative competence.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77898756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VALIDIZATION OF THE MOST INFORMATIVE TECHNIQUES FOR ULTRASOUND DIAGNOSTICS OF VISCERAL OBESITY","authors":"V. Bondarenko, S. Pimanov, E. Makarenko","doi":"10.22263/2312-4156.2021.3.46","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.46","url":null,"abstract":"Objectives. To validate the ultrasound method of diagnosing visceral obesity in patients with cardiovascular diseases and metabolic syndrome. Material and methods. The study involved 115 people aged from 19 to 60 years, who represented a continuous random sample (examination sample). The diagnostic efficacy of shear wave ultrasound elastography of the lower perirenal visceral adipose tissue (VAT) was evaluated in 59 patients. Ultrasound examination was performed on the Logiq E9 ultrasound machine (GE Healthcare, USA); convex 3.5 MHz and linear 10.0 MHz sensors were used. Results. To assess visceral obesity, the following measurements are recommended: the area of the lower perirenal adipose tissue (AT), the distance between the surface of the rectus abdominis muscle and the anterior wall of the aorta, the thickness of the epicardial and pericardial AT, as well as the elastography of the lower part of the perirenal AT. According to the results of the performed validation of ultrasound VAT measuring techniques, the accuracy of visceral obesity diagnosing in patients with arterial hypertension with the use of the boundary values of the lower part perirenal AT area made up 87.8%. The accuracy of visceral obesity diagnosing in patients with coronary heart disease, taking into account the boundary values of the epicardial AT thickness equalled 86.2%, and pericardial AT thickness amounted to 95.4%. Diagnosing of visceral obesity in patients with metabolic syndrome by measuring four ultrasound parameters (area of the lower part of perirenal AT, thickness of intraabdominal AT, epicardial and pericardial VAT) was carried out with an accuracy of 86.1%. Elastic modulus determination during elastography of the lower part of the perirenal AT using the boundary values, established for patients with metabolic syndrome, was performed with an accuracy of 91.5%.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91158167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF IMPLICIT ASSOCIATIONS TEST FOR DIAGNOSING ALCOHOL DEPENDENCE","authors":"G.O. Usialionak, A. A. Kirpichenka, A. F. Martsinkevich","doi":"10.22263/2312-4156.2021.3.55","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.55","url":null,"abstract":"Alcohol dependence syndrome is a severe disease that affects not only the health but also the social functioning of a person and leads to dangerous consequences. Early diagnosis of this disease will help to minimize the damage. Objectives. To develop a method for diagnosing alcohol dependence syndrome by means of implicit associations test. Material and methods. The indices of passing the implicit associations test by 152 patients with the diagnosis «Alcohol dependence syndrome», who made up the control group, and those of 189 practically healthy volunteers were investigated. The statistical analysis was made in R 4.0.3 format. To build the model, multiple logistic regression was used, the quality of which was assessed using ROC analysis. The differences were considered statistically significant at p-value <0.05. Results. These values were used to build a logistic regression model. The resulting model has a high predictive power - sensitivity and specificity made up 90.32% and 67.74%, respectively, AUC (area under the curve) and Fmes (general characteristics of predictive power) were 88.06% and 83.17%, correspondingly. Conclusions. As a result of the work carried out, a highly sensitive method for diagnosing alcohol dependence syndrome using an implicit associations test has been developed, which can be used for screening and diagnosing, as well as for dynamic observation of patients with alcohol dependence syndrome.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79386151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RISK ASSESSMENT FOR EMPLOYEES USING PICOLINAFEN-BASED HERBICIDE","authors":"S. I. Sychik, V. Hrynchak, L.G. Lappo, A.A. Shturych, G.V. Lisovskaya, T. P. Krymskaya","doi":"10.22263/2312-4156.2021.3.82","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.3.82","url":null,"abstract":"The aim of this work is to conduct a hygienic risk assessment for workers when using a herbicide based on picolinafen and to study its cumulative properties in a subacute experiment on male white rats. Material and methods. The object of the study was a herbicide based on picolinafen (CAS No. 37641-05-5). The content in the preparation is 21 g/l. The treatment was carried out by spraying wheat at a consumption rate of 3.5 l/ha and a working solution of 250 l/ha. The risk assessment for employees was carried out in accordance with the current technical regulatory legal acts. The toxic effect in a subacute experiment was studied with daily intragastric administration of picolinafen-based herbicide to male white rats for 28 days. At the end of the experiment the indices of the blood morphofunctional state, as well as those of hormonal and biochemical status were determined. Results. In the field, when carrying out mechanical treatments in compliance with the regulations for the use of the drug, there was no excess of the hygienic standards of the active substance in the air of the working area and there was no deterioration in working conditions. The total risk of dermal and inhalation exposure for the workers made up 0.015 and did not exceed the permissible level. The introduction of the herbicide based on picolinafen in a subacute experiment to rats at doses of 50.0, 300.0 and 900.0 mg/kg does not contribute to the development of lethal outcomes. According to the classification this preparation belongs to the substances with weakly expressed cumulation. However, the effect of a dose of 900.0 mg/kg of the drug initiated a statistically significant decrease in the relative coefficients of the liver mass by 12.5%, an increase in the content of leukocytes and platelets by 15.7% and 15.5%, respectively, against the background of a decreased average volume of platelets by 18,6%. Conclusions. The research results made it possible to evaluate the picolinafen-based herbicide as a drug with an acceptable risk for workers in the agro-industrial complex. Under the conditions of a subacute experiment, a dose of 300.0 mg/kg of the herbicide can be accepted as a threshold (inactive), however, additional experiments are required with the use of morphological research methods, as well as experiments with a longer exposure period and an increase in the levels of administered doses.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82507214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}