Vietnam Journal of Chemistry最新文献_第2页

Evaluation of the effect of the chitosan/carrageenan ratio on lovastatin release from chitosan/carrageenan based biomaterials 壳聚糖/卡拉胶配比对壳聚糖/卡拉胶基生物材料洛伐他汀释放的影响

Vietnam Journal of Chemistry Pub Date : 2022-10-27 DOI: 10.1002/vjch.202200078

Hà Mạnh Hùng, Vu Quoc Manh, Vu Thi Thu Thao, Dao Thi Phuong Thuy, Phạm Tiến Dũng, Nguyen Thi Bich Viet, Đường Khánh Linh, Nguyễn Ngọc Linh, Đoàn Thị Yến Oanh, Nguyễn Thúy Chinh, Thái Hoàng, Vũ Quốc Trung

{"title":"Evaluation of the effect of the chitosan/carrageenan ratio on lovastatin release from chitosan/carrageenan based biomaterials","authors":"Hà Mạnh Hùng, Vu Quoc Manh, Vu Thi Thu Thao, Dao Thi Phuong Thuy, Phạm Tiến Dũng, Nguyen Thi Bich Viet, Đường Khánh Linh, Nguyễn Ngọc Linh, Đoàn Thị Yến Oanh, Nguyễn Thúy Chinh, Thái Hoàng, Vũ Quốc Trung","doi":"10.1002/vjch.202200078","DOIUrl":"https://doi.org/10.1002/vjch.202200078","url":null,"abstract":"Abstract The chitosan/carrageenan/lovastatin biomaterials were prepared using a solution technique with 5 % lovastatin and a variable chitosan/carrageenan mass ratio. Fourier transform infrared spectroscopy (FT‐IR) and field emission scanning electron microscopy (FESEM) images revealed that the complex's components were well dispersed into each other without changing the chemical structure, forming dipole interactions and hydrogen bonds among them. The abilities to release Lovastatin (Lov) in pH 2 and pH 7.4 solutions, corresponding to the environments in stomach and intestinal fluids, respectively, are both affected by the ratio of polymer components. The best results were obtained with the chitosan/carrageenan/lovastatin (w/w/%w = 10/90/5%) (CsCL195) biomaterial sample in which the particles are evenly dispersed. While the drug release process was poor in the pH 2 solution (gastric juice), a good release observed in the pH 7.4 solution (intestinal fluid) allows facilitating drug absorption through the intestinal mucosa cells into the blood, from which the effects of hypercholesterolemia treatment can be obtained.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"60 S1","pages":"72-78"},"PeriodicalIF":0.0,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/vjch.202200078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147916244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

PDMS – Coated pomelo peel carbon aerogel: Synthesis, characterization, and oil removal application PDMS -包覆柚子皮碳气凝胶：合成、表征和除油应用

Vietnam Journal of Chemistry Pub Date : 2022-10-25 DOI: 10.1002/vjch.202200040

La Nam Phat, Phan Minh Tu, Tong Hoang Lin, Ton That Buu, Trinh Dinh Thao Tram, Tran Thanh Son, Dao Xuan Tien, Nguyen Ngoc Kim Tuyen, Nguyễn Trường Sơn, Đoàn Thị Yến Oanh, Mai Thanh Phong, Nguyễn Hữu Hiếu

{"title":"<scp>PDMS</scp> – Coated pomelo peel carbon aerogel: Synthesis, characterization, and oil removal application","authors":"La Nam Phat, Phan Minh Tu, Tong Hoang Lin, Ton That Buu, Trinh Dinh Thao Tram, Tran Thanh Son, Dao Xuan Tien, Nguyen Ngoc Kim Tuyen, Nguyễn Trường Sơn, Đoàn Thị Yến Oanh, Mai Thanh Phong, Nguyễn Hữu Hiếu","doi":"10.1002/vjch.202200040","DOIUrl":"https://doi.org/10.1002/vjch.202200040","url":null,"abstract":"Abstract Raw pomelo peel (RPP) has been widely reported as a potential eco‐friendly adsorbent due to its porous structure. In this work, pomelo peel‐derived carbon aerogel (PCA) was synthesized by approaching simple methods: Hydrothermal treatment and freeze‐drying technique. The obtained PCA from RPP exhibits an abundance of honeycomb‐like open porous structure, ultralight density of 0.03 g/cm 3 , and porosity of 99.23 %. To enhance the hydrophobicity and selectivity for removal of oil in water, PCA was coated with Poly(dimethylsiloxane) (PDMS) by facile dip‐coating method. The as‐prepared hydrophobic PDMS‐coated pomelo peel carbon aerogel (PDMS/PCA) exhibits the water resistance ability via the water contact angle of 101.6 o and good adsorption capacity of 11.672 and 7.691 g/g for used cooking and lubricating oils, respectively. Furthermore, the pseudo‐first‐order and pseudo‐second‐order models were approached to predict the adsorption behavior of PDMS/PCA for both used cooking and lubricating oils. The obtained results illustrate the potential application of RPP for synthesizing eco‐friendly and low‐cost adsorbents for the removal of oil in water.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"60 S1","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/vjch.202200040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147910796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Flavonoids as potential agents for development of multi‐target drugs for covid‐19 treatment: An in silico study 黄酮类化合物作为开发治疗covid - 19多靶点药物的潜在药物:一项计算机研究

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2022-06-01 DOI: 10.1002/vjch.202100108

Nguyễn Thị Thu Hằng, N. Van Phuong

引用次数: 2

An in silico study on inhibitability of Baloxavir marboxil, Baricitinib, Galidesivir, Nitazoxanide, and Oseltamivir against SARS‐CoV‐2 Baloxavir marboxil、Baricitinib、Galidesivir、Nitazoxanide和Oseltamivir对SARS - CoV - 2的抑制作用的计算机实验研究

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2022-05-17 DOI: 10.1002/vjch.202100145

Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Thi Ai My, Nguyen Ho Vu Phong, N. Nhan, P. Quy, N. D. Nguyen, N. Nhung

{"title":"An in silico study on inhibitability of Baloxavir marboxil, Baricitinib, Galidesivir, Nitazoxanide, and Oseltamivir against SARS‐CoV‐2","authors":"Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Thi Ai My, Nguyen Ho Vu Phong, N. Nhan, P. Quy, N. D. Nguyen, N. Nhung","doi":"10.1002/vjch.202100145","DOIUrl":"https://doi.org/10.1002/vjch.202100145","url":null,"abstract":"Abstract Baloxavir marboxil (D1), Baricitinib (D2), Galidesivir (D3), Nitazoxanide (D4), and Oseltamivir (D5) are well‐known performing broad‐spectrum activity against a variety of viruses, thus holding high potentiality towards SARS‐CoV‐2. Quantum properties were examined using density functional theory (DFT). The inhibitability of the drugs towards Angiotensin‐converting enzyme 2 (ACE2) and SARS‐CoV‐2 main protease (6LU7) was evaluated by molecular docking simulation, while their bio‐compatibility was justified by physicochemical properties obtained from QSARIS‐based analysis in reference to Lipinski's rule of five. Quantum analysis suggests that the compounds are highly favourable for intermolecular interaction towards protein structures. Given ligand‐ACE2 systems, the inhibitory effectiveness follows the order D3‐ACE2 > D4‐ACE2 > D2‐ACE2 > D5‐ACE2 > D1‐ACE2; and the corresponding order for ligand‐6LU7 systems is D2‐6LU7 > D4‐6LU7 > D3‐6LU7 > D5‐6LU7 > D1‐6LU7. Galidesivir is predicted as the most effective inhibitor towards both targeted protein structures (DSaverage ‐13.1 kcal.mol‐1) and the most bio‐compatible molecule (Mass 264.9 amu; LogP ‐0.9; Polarisability 26.8 Å3). The theoretical screening suggests all drugs, especially Galidesivir (D3), promising for treatment of SARS‐CoV‐2 infection and encourages in‐related clinical trials.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"73 1","pages":"333 - 345"},"PeriodicalIF":0.9,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85817632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical study on inhibitability of some natural alkaloids against influenza virus hemagglutinin and SARS‐CoV‐2 main protease 几种天然生物碱对流感病毒血凝素和SARS - CoV - 2主要蛋白酶抑制作用的理论研究

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2022-05-17 DOI: 10.1002/vjch.202100175

Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Van Chen, P. Quy, Ly Nguyen Hai Du, T. Cuong, Nguyen Thanh Triet, Nguyen Thi Thu Thuy, N. Nhung

{"title":"Theoretical study on inhibitability of some natural alkaloids against influenza virus hemagglutinin and SARS‐CoV‐2 main protease","authors":"Thanh Q. Bui, Nguyen Thi Thanh Hai, Tran Van Chen, P. Quy, Ly Nguyen Hai Du, T. Cuong, Nguyen Thanh Triet, Nguyen Thi Thu Thuy, N. Nhung","doi":"10.1002/vjch.202100175","DOIUrl":"https://doi.org/10.1002/vjch.202100175","url":null,"abstract":"Abstract Berberine (V1), lycorine (V2), hemanthamine (V3), aloperin (V4), dendrobine (V5) possess structural frameworks resembling known anti‐influenza and anti‐SARS‐CoV‐2 drugs, thus subjected for a computational screening. Their quantum properties were examined using density functional theory (DFT); the ligand‐protein inhibitability was evaluated using molecular docking simulation; physicochemical properties were obtained from QSARIS‐based analysis in reference to Lipinski's rule of five; pharmacokinetic parameters were assessed by ADMET‐based analysis. DFT calculations indicate that there are no abnormal bonding constraints observed; NBO analysis suggests all possessing favorable electric configurations for intermolecular inhibition. Regarding ligand‐2VIU, the order for static inhibitability is V3‐2VIU > V2‐2VIU > V1‐2VIU > V5‐2VIU > V4‐2VIU; Regarding ligand‐6LU7, the corresponding order follows: V2‐6LU7 > V3‐6LU7 > V1‐6LU7 > V5‐6LU7 > V4‐6LU7. An exceptional hydrophilic bonding (π‐cation) with the associated Gibbs free energy of ‐10.9 kcal.mol‐1 is detected in inhibitory complex V1‐2VIU. QSARIS‐based analysis reveals that all the candidates are highly bio‐compatible. ADMET‐based analysis specifies V2 and V3 as being safe and suitable for the use as orally administrated drugs. The results encourage further investigations for more in‐depth mechanisms and experimental validations, such as molecular dynamics simulation and in vitro enzyme assays.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"9 1","pages":"502 - 517"},"PeriodicalIF":0.9,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90137613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In silico screening of natural antivirals as potential inhibitors of SARS‐CoV‐2 virus 天然抗病毒药物作为SARS - CoV - 2病毒潜在抑制剂的计算机筛选

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2022-04-01 DOI: 10.1002/vjch.202100187

T. Hằng, Do Thi Hong Khanh, B. Tùng

{"title":"In silico screening of natural antivirals as potential inhibitors of SARS‐CoV‐2 virus","authors":"T. Hằng, Do Thi Hong Khanh, B. Tùng","doi":"10.1002/vjch.202100187","DOIUrl":"https://doi.org/10.1002/vjch.202100187","url":null,"abstract":"Abstract Coronavirus infectious disease 2019 (COVID‐19) is an infectious disease of the human respiratory tract caused by the SARS‐CoV‐2 virus. Spike protein is a class I glycoprotein trimeric TM involved in viral entry and infection. Four major targets to inhibit the SARS‐CoV‐2 virus are spike protein, angiotensin‐converting enzyme 2 (ACE2), main protease and the enzyme RNA‐dependent RNA polymerase (RdRp). In this study, we evaluated the inhibitory potential of natural antiviral compounds against spike protein, ACE2, main protease, RdRp targets by molecular docking and molecular dynamics simulations. Lipinski Rule of Five was used to evaluate the drug‐like properties of these compounds. The pkCSM tool was used to assess the pharmacokinetic parameters of prospective substances. Based on the ChemFaces database, we have collected 273 natural antiviral compounds. The results showed that the 7/273 compounds with the most potential to inhibit SARS‐CoV‐2 were: hinokiflavone, sotetsuflavone, mulberroside C, daphnoretin, morellic acid, digitoxin, and hypericin. Among them, sotetsuflavone is the most potent compound that inhibits four targets, with drug‐like properties, good intestinal absorption, and low toxicity. The molecular dynamics simulation results of the complexes are also relatively stable. As a results, in vitro and in vivo test should be carried out to verify the potential for COVID‐19 treatment of this compound.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"6 1","pages":"211 - 222"},"PeriodicalIF":0.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84443870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Decomposition of glyphosate in water by peroxymonosulfate activated with CuCoFe‐LDH material CuCoFe - LDH材料活化过氧单硫酸盐分解水中草甘膦的研究

Vietnam Journal of Chemistry Pub Date : 2021-12-01 DOI: 10.1002/vjch.202100045

Nguyen Trung Dung, Vu Dinh Thao, Nguyễn Nhật Huy

{"title":"Decomposition of glyphosate in water by peroxymonosulfate activated with <scp>CuCoFe‐LDH</scp> material","authors":"Nguyen Trung Dung, Vu Dinh Thao, Nguyễn Nhật Huy","doi":"10.1002/vjch.202100045","DOIUrl":"https://doi.org/10.1002/vjch.202100045","url":null,"abstract":"Abstract In this study, the CuCoFe‐layered double hydroxide was employed for the degradation of glyphosate in water via peroxymonosulfate (PMS) activation. Scanning electron microscopy, X‐ray powder diffraction, energy‐dispersive X‐ray spectroscopy, Fourier‐transform infrared spectroscopy, and Brunauer‐Emmett‐Teller analyses were used to characterize the material. The effects of the catalytic system, initial solution pH, and catalyst and PMS dose on the degradation efficiency of glyphosate were investigated. The results indicated that after 6 min the CuCoFe‐LDH/PMS system can degrade 99.54 % of glyphosate (100 mg/L) using 100 mg/L of CuCoFe‐LDH, 200 mg/L of PMS, and pH 11. In addition, radical quenching experiments prove that the reactive oxygen species (e.g., SO 4 ●‐ , HO ● , O 2 ●– , and 1 O 2 ) are formed and SO 4 ●‐ plays a decisive role in glyphosate degradation. Moreover, the CuCoFe‐LDH catalyst is reusable and stable with a glyphosate removal efficiency of 90.34 % after five continuous degradation cycles.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":"59 6","pages":"813-822"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/vjch.202100045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cytotoxic and antimicrobial benzodiazepine and phenolic metabolites from Aspergillus ostianus IMBC-NMTP03 ostianus Aspergillus IMBC-NMTP03的细胞毒性和抗菌苯二氮卓和酚类代谢物

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2021-10-01 DOI: 10.1002/VJCH.202100032

T. Quang, Le Ngoc Anh, T. H. Hanh, N. X. Cuong, N. Ngan, N. Q. Trung, N. H. Nam

引用次数: 1

Mg2+ embedded MIL-101(Cr)-NH2 framework for improved CO2 adsorption and CO2/N2 selectivity Mg2+包埋MIL-101(Cr)-NH2框架改善CO2吸附和CO2/N2选择性

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2021-10-01 DOI: 10.1002/VJCH.202100035

Duong Tuan Quang

引用次数: 2

Spectroscopic (FTIR and UV), quantum Chemical, antifungal and antioxidant investigations of (E)-7-(4-(trifluoromethyl)benzylidene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one: A combined experimental and theoretical study (E)-7-(4-(三氟甲基)苄基)-1,2,6,7-四氢- 8h -吲哚[5,4-b]呋喃-8-酮的光谱(FTIR和UV)、量子化学、抗真菌和抗氧化研究:实验和理论相结合的研究

IF 0.9

Vietnam Journal of Chemistry Pub Date : 2021-10-01 DOI: 10.1002/VJCH.202100034

V. A. Adole, R. More, R. Shinde, Sunil L. Dhonnar, Bapusonu Jagdale, S. Shinde, A. V. Patil, T. B. Pawar

引用次数: 1