Vietnam Journal of Chemistry最新文献

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Pancreatic lipase inhibitory and anti‐acne activity of Piper betle: Kinetic studies, in silico docking, and chemical characterization of bioactive compounds 胡椒槟榔的胰脂肪酶抑制和抗痤疮活性:动力学研究、硅学对接和生物活性化合物的化学特征描述
IF 1.3
Vietnam Journal of Chemistry Pub Date : 2024-07-22 DOI: 10.1002/vjch.202400030
Rani A. Shinde, Mohini R. Patil, R. Patil, K. S. Vishwakarma, Vijay L. Maheshwari
{"title":"Pancreatic lipase inhibitory and anti‐acne activity of Piper betle: Kinetic studies, in silico docking, and chemical characterization of bioactive compounds","authors":"Rani A. Shinde, Mohini R. Patil, R. Patil, K. S. Vishwakarma, Vijay L. Maheshwari","doi":"10.1002/vjch.202400030","DOIUrl":"https://doi.org/10.1002/vjch.202400030","url":null,"abstract":"Lipases play important roles in obesity and skin infections. Piper betle (Piperaceae) is widely cultivated and used in daily life. It is a rich source of lead compounds used in skin infections. This study reveals anti‐acne and pancreatic lipase inhibitory potential of leaf extract of Piper betle using in‐vitro and in‐silico molecular docking. The inhibitory potential of 13 selected plant extracts was evaluated at various concentrations (5–25 µg/mL). Ethyl‐acetate extract of Piper betle with strong pancreatic lipase inhibitory activity was further fractionated by preparative thin layer chromatography and eluted bands showing strong inhibitory activity were characterized by high performance liquid chromatography and gas chromatography. The purified compounds, namely, anodendroside E,2‐monoacetate, and 5H‐cyclopropa (3, 4) benz (1, 2‐ejazulen‐5‐one), were identified and showed over 90% pancreatic lipase inhibition. The isolated compounds showed strong dose‐dependent inhibitory effects on Propionibacterium acnes. These observations were consistent with molecular docking studies, which showed that anodendroside E,2‐monoacetate binds to the allosteric site with a binding energy of –7.0 kcal/mol, and this binding site is stabilized by hydrogen and carbon hydrogen bonds contributed by Phe 354 and Asp130, ser103. These findings suggest that the pancreatic lipase inhibitory and anti‐acne effects of Piper betle are attributed to anodendroside E,2‐monoacetate.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new cytotoxic saponin from the ethyl acetate extract of Myrsine semiserrata wall Myrsine semiserrata 壁乙酸乙酯提取物中的一种新细胞毒性皂甙
IF 1.3
Vietnam Journal of Chemistry Pub Date : 2024-07-10 DOI: 10.1002/vjch.202400143
Thi Binh Yen Nguyen, Thuy Linh Nguyen, V. Vu, Quy Hung Trieu, Thi Mai Huong Doan, Van Cuong Pham
{"title":"A new cytotoxic saponin from the ethyl acetate extract of Myrsine semiserrata wall","authors":"Thi Binh Yen Nguyen, Thuy Linh Nguyen, V. Vu, Quy Hung Trieu, Thi Mai Huong Doan, Van Cuong Pham","doi":"10.1002/vjch.202400143","DOIUrl":"https://doi.org/10.1002/vjch.202400143","url":null,"abstract":"Myrsine semiserrata Wall. (Primulaceae) is an evergreen shrub found in some Asian regions including Northern Vietnam, Southern China, India, Nepal, and Myanmar. Its bark and leaves are utilized in leather tanning while the fruit serves as a commonly used antiseptic agent. Phytochemical study on the ethyl acetate extract from the aerial parts of this plant led to the isolation of a new saponin 3‐O‐α‐L‐arabinopyranosyl juglangenin A (1) and four known triterpenes, lupeol acetate (2), taraxerone (3), cucurbitacin D (4), and cucurbitacin H (5). Their structures were proven by analyzing 1D, 2D NMR, and HR‐ESI‐MS spectroscopic techniques. All isolated compounds were tested for their cytotoxicity on human cancer cell lines: HepG2, KB, MCF7, and A549. Compounds 4 and 5 exhibited potent activity against HepG2 and KB cell lines with IC50 values ranging from 1.06 to 5.99 µm. Saponin substance 1 demonstrated action against all cancer cell lines with IC50 values of 74.26, 42.83, 40.65, and 70.82 µm, respectively.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contents: Vietnam Journal of Chemistry 3/2024 目录越南化学杂志》3/2024
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-06-01 DOI: 10.1002/vjch.202390023
{"title":"Contents: Vietnam Journal of Chemistry 3/2024","authors":"","doi":"10.1002/vjch.202390023","DOIUrl":"https://doi.org/10.1002/vjch.202390023","url":null,"abstract":"","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141401540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover 封面
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-06-01 DOI: 10.1002/vjch.202390024
{"title":"Cover","authors":"","doi":"10.1002/vjch.202390024","DOIUrl":"https://doi.org/10.1002/vjch.202390024","url":null,"abstract":"","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141396174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced solubility and in vitro drug release of diosmetin from soy lecithin based‐diosmetin phytosome 基于大豆卵磷脂的双香叶酮植物胶囊提高了双香叶酮的溶解度和体外药物释放率
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-05-14 DOI: 10.1002/vjch.202300326
T. Huynh, Bich‐Ngoc Duong, Bao‐Tram Ho, Hoang‐Phuc Nguyen, Anh‐Khoa Ton, Thi‐Cam‐Thu Nguyen, Thi‐Hong‐An Nguyen, Kim‐Khanh‐Huy Ngo, Ngoc‐Kim‐Ngan Phan, Quoc‐Tuan Le, Van‐Thanh Nguyen, Thi‐Kim‐Dung Hoang
{"title":"Enhanced solubility and in vitro drug release of diosmetin from soy lecithin based‐diosmetin phytosome","authors":"T. Huynh, Bich‐Ngoc Duong, Bao‐Tram Ho, Hoang‐Phuc Nguyen, Anh‐Khoa Ton, Thi‐Cam‐Thu Nguyen, Thi‐Hong‐An Nguyen, Kim‐Khanh‐Huy Ngo, Ngoc‐Kim‐Ngan Phan, Quoc‐Tuan Le, Van‐Thanh Nguyen, Thi‐Kim‐Dung Hoang","doi":"10.1002/vjch.202300326","DOIUrl":"https://doi.org/10.1002/vjch.202300326","url":null,"abstract":"The Diosmetin Phytosome (Dt‐Ph) was developed to enhance the complex's aqueous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants’ molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis. The resulting Dt‐Ph possessed a particle size of 213.9 nm, a zeta potential of −115.1 mV, and a 95.6% encapsulation effectiveness, indicating the successful formation of the phytosome. Scanning electron microscopy (SEM) was used to analyze the morphology of the surface of Dt and Dt‐Ph. The in vitro dissolution in 24 h and normal cell cytotoxic activities of the selected formulation were evaluated. The solubility of Dt‐Ph in buffered media was four times higher than Dt, indicating greater hydrophilicity of Dt‐Ph in comparison to the more lipophilic‐free drug. Additionally, the formulation showed a noticeably increased rate and extent of dissolution studies on drug release, which was two times better than Dt. Cytotoxicity results on HEK‐293A cells showed that Dt‐Ph had less impact on normal cells compared to Dt.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140980991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of sodium hydroxide treatment on the fracture toughness of luffa natural fiber reinforced epoxy epikote 828 氢氧化钠处理对丝瓜天然纤维增强环氧树脂 epikote 828 断裂韧度的影响
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-05-10 DOI: 10.1002/vjch.202400010
D. Trung, Doan Thi Yen Oanh
{"title":"Effect of sodium hydroxide treatment on the fracture toughness of luffa natural fiber reinforced epoxy epikote 828","authors":"D. Trung, Doan Thi Yen Oanh","doi":"10.1002/vjch.202400010","DOIUrl":"https://doi.org/10.1002/vjch.202400010","url":null,"abstract":"Micro‐sized luffa natural fibers (MLNFs) were derived from raw luffa natural fibers from Vietnam by undergoing treatment with sodium hydroxide. This study examined the impact of sodium hydroxide concentration, temperature, and treatment duration on the fracture toughness of epoxy resin 828 reinforced with MLNFs. The results showed that the fracture toughness of the composite, as measured by the critical‐stress‐intensity factor (KIC) and Izod impact strength, was improved after the treatment of the MLNFs with sodium hydroxide. Specifically, with the optimal sodium hydroxide treatment parameters of 6% NaOH at 70 °C for 6 h, the critical‐stress‐intensity factor increased by 93% (from 2.0 to 3.86 MPa m1/2) and the Izod impact strength rose by 44.6% (from 3.81 to 5.51 kJ/m2). The thermal properties and surface structure of MLNFs treated with NaOH were analyzed using thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) images.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stilbene derivatives from Gnetum montanum Markgr. with their xanthine oxidase inhibition activity Gnetum montanum Markgr.的二苯乙烯衍生物及其黄嘌呤氧化酶抑制活性
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-05-10 DOI: 10.1002/vjch.202400069
Nguyen Thi Viet Thanh, Ho Duc Cuong, B. H. Tai, Phan Van Kiem
{"title":"Stilbene derivatives from Gnetum montanum Markgr. with their xanthine oxidase inhibition activity","authors":"Nguyen Thi Viet Thanh, Ho Duc Cuong, B. H. Tai, Phan Van Kiem","doi":"10.1002/vjch.202400069","DOIUrl":"https://doi.org/10.1002/vjch.202400069","url":null,"abstract":"Phytochemical study on the methanol extract of the trunks of Gnetum montanum Markgr. led to the isolation of one new stilbene derivative, (E)‐2′‐methoxy‐3,5,5′‐trihydroxystilbene (1) and six known compounds, lehmbachol (2), gnetulin (3), trans‐shegansu B (4), cis‐shegansu B (5), (+)‐hannokinol (6), and gnetol (7). Their chemical structures were determined by spectroscopic analyses including HR‐ESI‐MS, 1D and 2D NMR, and circular dichroism methods in comparison with the reported data. In addition, compounds 1–5 showed xanthine oxidase inhibitory activity with IC50 values of 13.6, 35.2, 38.7, 43.4, and 47.7 µm, respectively, compared to the positive control, allopurinol, which showed IC50 value of 2.9 µm.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of n‐pentanol with novel water hyacinth biodiesel‐diesel ternary blends on diesel engine performance and emission characteristics 正戊醇与新型水葫芦生物柴油-柴油三元混合物对柴油发动机性能和排放特性的影响
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-05-10 DOI: 10.1002/vjch.202300383
Maneesh Singh, Prashant Saini, Divyanshi Srivastava, Srishti Mishra, Saif Nawaz Ahmad
{"title":"Effect of n‐pentanol with novel water hyacinth biodiesel‐diesel ternary blends on diesel engine performance and emission characteristics","authors":"Maneesh Singh, Prashant Saini, Divyanshi Srivastava, Srishti Mishra, Saif Nawaz Ahmad","doi":"10.1002/vjch.202300383","DOIUrl":"https://doi.org/10.1002/vjch.202300383","url":null,"abstract":"Present research deals with crude oil production from water hyacinth biomass and its biodiesel preparation. Alcohol additive n‐pentanol is mixed with biodiesel and diesel blends to identify their effects on diesel engine performance and emission parameters experimentally. Water hyacinth oil (WHO) is produced through Soxhlet extraction technique, and its biodiesel is prepared by transesterification. n‐pentanol is mixed through magnetic stirring in biodiesel‐diesel blends to improve their combustion quality and efficiency. Prepared fuel blends properties are examined as per ASTM standards. Experimental results reveal that, BSFC and BTE are evaluated as 0.26 kg/kW‐h and 29.5%, respectively, with HC emissions as 29 ppm, CO emissions as 0.28 vol%, NOx emissions as 330 ppm and CO2 emissions as 2.21 vol% for WHB20D75P5 fuel at maximum load. The comparison of D100 and WHB20D80 with respect to WHB20D75P5 reveals 3.27% reduction and 7.27% improvement in BTE, respectively. Both HC and CO are reduced by 14.70% and 22.22% for WHB20D75P5 fuel compared to diesel. NOx and CO2 emissions are increased by 6.79% and 12.75% for WHB20D75P5 fuel compared to diesel. Overall, WHB20D75P5 fuel is the best performer.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140991844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of vat blue removal by Aspergillus niger using scanning electron microscopy and glucose oxidase enzyme activity 利用扫描电子显微镜和葡萄糖氧化酶活性评估黑曲霉去除蝙蝠蓝的效果
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-05-10 DOI: 10.1002/vjch.202300374
Juana Lira Pérez, Juan Carlos Figueroa Estrada, Mayola García Rivero, Refugio Rodríguez Vázquez
{"title":"Evaluation of vat blue removal by Aspergillus niger using scanning electron microscopy and glucose oxidase enzyme activity","authors":"Juana Lira Pérez, Juan Carlos Figueroa Estrada, Mayola García Rivero, Refugio Rodríguez Vázquez","doi":"10.1002/vjch.202300374","DOIUrl":"https://doi.org/10.1002/vjch.202300374","url":null,"abstract":"The use of fungi to reduce dye removal in water from diverse industries can be an efficient option for solving environmental problems. However, the mycoremediation processes involved in color removal are unknown. In this article, Aspergillus niger CDBB‐H‐175 was applied for vat blue discoloration (DC). Hence, inactive biomass by two methods (metabolic inhibitor and heat) and active biomass were studied by scanning electron microscopy and enzyme activities to determine the vat blue DC. When using active biomass, 62% of DC, glucose oxidase (GOX) enzyme activity, 1.19 U/mL and 1.43 mg/L of H2O2 were obtained. It was observed that 68% of DC was due to the degradation process and 32% was due to biomass sorption. When the biomass was inactivated with sodium azide, DC increased by 90% (1.45‐fold), low GOX activity (0.138 U/mL), and H2O2 (0.25 mg/L) were detected. High DC might be due to a high dye sorption in hyphae, since an increase in the thickness and morphology of the hyphae were observed by SEM. Inactivated biomass through heating, showed a 69.5% of DC, where 0.01 U/mL GOX and 0.25 mg/L H2O2 were reached, demonstrating that inactivation of A. niger biomass by sodium azide can be considered as an alternative treatment for colored wastewater.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the potential of Satureja calamintha nepeta: A study on its phytochemical composition and antibacterial activity 揭示 Satureja calamintha nepeta 的潜力:关于其植物化学成分和抗菌活性的研究
IF 0.9
Vietnam Journal of Chemistry Pub Date : 2024-05-10 DOI: 10.1002/vjch.202300174
Mouhcine Hayani, Tariq Benabbouha, Wafaa Nachit, Said Byadi, Khalil Chefira, Aziz Aboulmouhajir, A. Tounsi, T. Zair
{"title":"Unveiling the potential of Satureja calamintha nepeta: A study on its phytochemical composition and antibacterial activity","authors":"Mouhcine Hayani, Tariq Benabbouha, Wafaa Nachit, Said Byadi, Khalil Chefira, Aziz Aboulmouhajir, A. Tounsi, T. Zair","doi":"10.1002/vjch.202300174","DOIUrl":"https://doi.org/10.1002/vjch.202300174","url":null,"abstract":"Satureja calamintha nepeta is a plant native to northwestern Morocco. The purpose of this investigation is to identify the chemical composition and evaluate the antibacterial of the essential oil extracted from this plant. Firstly, a quality inspection of the plant was carried out to quantify its level of metals, especially the heavier ones, using the ICP technique. Gas chromatography/mass spectrometry was used to characterize the chemical composition of essential oil. The chromatogram analysis shows the presence of 27 compounds, that is, 99.2% of the essential oil, with 1,8‐cineole (34.34%) and cis‐pinocamphone (11.87%) being the most significant. The antibacterial effectiveness of the essential oil was tested using the disc diffusion method against 6 gram‐positive and gram‐negative pathogens. The essential oil shows strong activity against Escherichia coli and Escherichia vekanda strains, with an MIC value of about 2.80 µg/mL. The authors were benefited from the modeling technique to better understand the antibacterial activity.","PeriodicalId":23525,"journal":{"name":"Vietnam Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.9,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140993157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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