Van Medical Journal最新文献_第6页

Evaluating the Knowledge, Attitude and Experience of Anesthesiologist About Nasotracheal Intubation: A Questionnaire Study 评估麻醉医师对鼻气管插管的知识、态度和经验:一项问卷调查研究

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.32043

Sibel Çatalca, G. Kulturoglu, R. Polat

引用次数: 0

The Effect of GLP-1 Agonist Treatment On Subclinical Atherosclerosis GLP-1激动剂治疗亚临床动脉粥样硬化的作用

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.09815

D. Sakız, M. Çalapkulu, M. Sencar, Seyit Murat Bayram, I. Ozturk Unsal, M. Kizilgul, B. Uçan, M. Özbek, E. Çakal

{"title":"The Effect of GLP-1 Agonist Treatment On Subclinical Atherosclerosis","authors":"D. Sakız, M. Çalapkulu, M. Sencar, Seyit Murat Bayram, I. Ozturk Unsal, M. Kizilgul, B. Uçan, M. Özbek, E. Çakal","doi":"10.5505/vtd.2022.09815","DOIUrl":"https://doi.org/10.5505/vtd.2022.09815","url":null,"abstract":"Introduction: Although GLP-1 agonists have been shown to reduce cardiovascular events, their effect on the progression of subclinical atherosclerosis is not clear. In this respect, it was planned to evaluate cardiovascular risk markers in obese and diabetic patients receiving exenatide therapy. Materials and Methods: This retrospective study included 56 patients with Type 2 Diabetes Mellitus (DM) with a body mass index (BMI) >35. Demographic, anthropometric and clinic characteristics before and after six-month treatment with exenatide were screened. Cardiovascular risk marker Atherogenic Index of Plasma (AIP), uric acid, carotis intima media thickness (CIMT), HbA1c, fasting blood glucose (FBS) and postprandial blood glucose (TCG) levels were evaluated. Results: Eleven of the fifty-six patients had discontinued exenatide due to side effects, etc. 45 patients (35 females, 10 males; age 50 ± 9.5 years) completed the study. AIP, HbA1c, uric acid, fasting plasma glucose, postprandial glucose, waist circumference, hip circumference, body mass index (BMI), total cholesterol, and triglyceride levels were improved with exenatide treatment. However, no change was detected in CIMT, blood pressure, spot urine albumin/creatinine ratio, LDL, and HDL levels. Conclusion: Glycemic parameters, AIP and uric acid levels, which are biochemical predictors of subclinical atherosclerosis, were improved with GLP-1 agonist exetide treatment. However, no change was observed in CIMT measurements. These findings can be interpreted as exenatide therapy, can slow down the progression of subclinical atherosclerosis, but has no effect on existing atherosclerotic plaque.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81896980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Computed Tomography on Planning the Type of Operation in Hip Intertochanteric Fractures 计算机断层扫描对髋粗隆间骨折手术方式选择的影响

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.92331

Abbas Tokyay, S. Özkan, N. Güven, Tülin Türközü, Bayram Ersidar

引用次数: 0

G6PD Deficiency in Neonatal Jaundice 新生儿黄疸中G6PD缺乏

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.96237

Altay Babacan, F. F. Şenol, I. Bahceci

引用次数: 0

Explant Culture of Ovarian Tissue 卵巢组织的外植体培养

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.90947

Murat Serkant Ünal, Elif Önder, N. Çil, Hatice Çoban, Mücahit Seçme, Gül Yıldırım, Gülçin Abban Mete

引用次数: 0

Suberoylanilide Hydroxamic Acid (SAHA) Reduces Glutamate-Induced Oxidative Stress in Hippocampal Cells 亚甲基苯胺羟肟酸(SAHA)减少谷氨酸诱导的海马细胞氧化应激

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.01979

Caner Günayd, Z. B. Çelik

{"title":"Suberoylanilide Hydroxamic Acid (SAHA) Reduces Glutamate-Induced Oxidative Stress in Hippocampal Cells","authors":"Caner Günayd, Z. B. Çelik","doi":"10.5505/vtd.2022.01979","DOIUrl":"https://doi.org/10.5505/vtd.2022.01979","url":null,"abstract":"Glutamate is an essential excitatory neurotransmitter in the brain, neuronal cell loss by overactivation in high concentrations. Epigenetic mechanisms, such as histone modifications, alter gene expression for maintaining cellular balance and are activated during sustained neuroinflammation and oxidative stress. Suberoylanilide hydroxamic acid (SAHA) is a well-known histone deacetylase inhibitor for its antitumor and anti-inflammatory properties. Therefore, in this study, we aimed to investigate the neuroprotective effect of SAHA against glutamate-induced oxidative stress in HT-22 hippocampal cells. Materials and Methods: The HT-22 hippocampal neuronal cells were cultured in DMEM medium with 10% FBS and 1% penicillin/streptomycin and incubated at 37°C in a humidified atmosphere containing 5% CO 2 . Cell viability was determined by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay after administration of glutamate and SAHA to HT-22 cells, and then the absorbance levels were measured at 550 nm using a microplate reader. The neuroprotective effect of SAHA was evaluated by measuring the oxidative stress parameters like reduced glutathione (GSH) level, and antioxidant enzyme activities of glutathione reductase (GR) and glutathione peroxide (GPx) by Enzyme-like immunosorbent assay (ELISA). Results: SAHA has reduced glutamate-induced neuron death in HT-22 cells. Moreover, SAHA alleviated glutamate-induced oxidative stress by increasing GSH levels, and the activities of the antioxidant enzymes GR and GPx. Conclusion: These results demonstrated that SAHA has antioxidant activity, reduces glutamate-induced oxidative stress, and confers protection against glutamate-induced neuronal death.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81997393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Covid-19 Course in Connective Tissue Disease-Related Interstitial Lung Disease Patients 结缔组织病相关间质性肺病患者的Covid-19病程

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.67790

H. Satış, Y. Ünsal, A. Tufan

{"title":"Covid-19 Course in Connective Tissue Disease-Related Interstitial Lung Disease Patients","authors":"H. Satış, Y. Ünsal, A. Tufan","doi":"10.5505/vtd.2022.67790","DOIUrl":"https://doi.org/10.5505/vtd.2022.67790","url":null,"abstract":"Introduction: Coronovirus 2019 (COVID-19) infection has spread rapidly, causing a worldwide pandemic. Although a good clinical course ranging from asymptomatic carriage to a simple flu infection is encountered in most patients, pneumonia and even multi-organ failure and mortality can be seen in some patients. In studies on which patients are more associated with a worse prognosis, it has been associated with increased mortality in patients with lung disease. In this study, it was aimed to show the mortality rate and possible prognostic factors associated with COVID-19 in patients with interstitial lung disease due to connective tissue disease (CTD-ILD). Materials and Methods: In a tertiary referral centre, patients with previously diagnosed CTD-ILD were retrospectively reviewed. Between 1st April 2020 to 1st April 2021 patient data related to ILD disease, COVID-19 infection and mortality were obtained from electronic records retrospectively. The primary outcome was death on day 30 of COVID-19 infection Results: There were 271patients diagnosed with CTD-ILD. 74 patients had COVID-19 infection, which was confirmed by polymerase chain reaction. 29 patients were dead during the followed-up period of whom 13 patients had COVID-19 infection-related mortality (17.5% vs 8.1%, p:0.045). COVID infection related to mortality was more frequently seen in patients with decreased forced vital capacity , smoking history, extended disease and rheumatoid arthritis. On multivariate regression analysis, only decreased forced vital capacity were related to poor outcomes. Conclusion : COVID-19 infection is related to increased risk of mortality in CTD-ILD patients. Decreased forced vital capacity is a poor prognostic risk factor","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"77 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89519431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence is Unavoidable in Hand and Wrist Ganglion Cyst Surgery 手腕神经节囊肿手术复发是不可避免的

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.54037

A. Oztermeli, B. Yılmaz, G. Ozdemir, E. Şirin, I. Arslan, B. Komur, A. I. Demir

引用次数: 1

Clinical Characteristics and Visual Outcomes of Pediatric Optic Neuritis: A Single Center Experience 儿童视神经炎的临床特征和视力结果:单中心经验

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.92604

Dilek Cebeci, E. Gurkas, Z. Öztürk, A. GÜven, Z. S. Karalok, A. Değerliyurt, Nefise Arıbaş Öz, İ. Öncel, Serkan Özmen, Ş. Yılmaz, Tulin Hakan Demirkan

引用次数: 0

Protective Effects of Berberis Vulgaris Plant Extract on Paracetamol-induced Liver Toxicity in Rats 小檗提取物对扑热息痛所致大鼠肝毒性的保护作用

Van Medical Journal Pub Date : 2022-01-01 DOI: 10.5505/vtd.2022.36675

S. Yi̇ği̇t, A. Gezer, M. Yayla, Erdem Toktay, Pinar Aksu Kilicle, S. Bingol, Çiğdem Eda BALKAN BOZLAK

引用次数: 0