Van Medical Journal最新文献

Epiretinal Membrane Surgery on Youtube Youtube上的视网膜外膜手术

Van Medical Journal Pub Date : 2023-10-13 DOI: 10.5505/vtd.2022.67503

M. Songur, M. Çıtırık

引用次数: 1

IL-6, IL-8, TNF-α and C-Reactive Protein Levels in the Diagnosis and Prognosis of Neonatal Sepsis IL-6、IL-8、TNF-α和c反应蛋白水平对新生儿脓毒症的诊断和预后的影响

Van Medical Journal Pub Date : 2023-10-13 DOI: 10.5505/vtd.2022.89166

Ruken Yıldırım, Mehmet Celal Devecioğlu

{"title":"IL-6, IL-8, TNF-α and C-Reactive Protein Levels in the Diagnosis and Prognosis of Neonatal Sepsis","authors":"Ruken Yıldırım, Mehmet Celal Devecioğlu","doi":"10.5505/vtd.2022.89166","DOIUrl":"https://doi.org/10.5505/vtd.2022.89166","url":null,"abstract":"Objective: This study aimed to determine the importance and reliability of interleukin-6 (IL-6), IL8, tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels in terms of diagnosis and prognosis in neonatal sepsis. Methods: Thirty newborns who were followed up and treated in the neonatal intensive care unit with a pre-diagnosis of neonatal sepsis and 20 healthy newborns who were born without any problem from mothers without any disease were included in the study.Gender, gestational age, postnatal age, place and mode of delivery, birth weight, IL-6, IL-8, TNF-α, and CRP levels were recorded. Results: Of the 30 cases diagnosed with sepsis, 16 (53.3%) were male and 14 (46.7%) were female. In the control group of 20 cases, 11 (55%) were male, and 9 (45%) were female. Of the cases diagnosed with sepsis, 8 were considered early-onset (26.6%) and 22 were considered late-onset (73.4%) neonatal sepsis. The mortality rate in early-onset sepsis was 25%, while this rate was 36.3% in late-onset sepsis cases. The levels of CRP, IL-6, and IL-8 were significantly higher in the sepsis group than in the control group. The difference between the groups in terms of TNF-α levels was not statistically significant. IL-6 (P = 0.001) and IL-8 (P = 0.007) levels were found to be statistically significantly higher in the deceased cases than in the healing cases. Conclusion: CRP, IL-6,and IL-8 levels were found to be useful parameters in the diagnosis of neonatal sepsis, while TNF-α was not found to have diagnostic value.IL-6 and IL-8 levels were found to be significant in the prognosis of neonatal sepsis.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79772442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells 辛酸对HT-22细胞的顺铂毒性有神经保护作用吗

Van Medical Journal Pub Date : 2023-05-24 DOI: 10.5505/vtd.2023.98411

B. Çiçek, Sidika Genc

{"title":"Does Sinapic Acid Provide Neuroprotection Against Cisplatin-Induced Toxicity in HT-22 Cells","authors":"B. Çiçek, Sidika Genc","doi":"10.5505/vtd.2023.98411","DOIUrl":"https://doi.org/10.5505/vtd.2023.98411","url":null,"abstract":"Objective: The aim of this study was to explain the benefits and possible protective mechanisms of sinapic acid (SA) against cisplatin-induced oxido-inflammatory damage in HT-22 rat hippocampal cells by biochemical and molecular methods. Materials and methods: Sinapic acid (SA) was applied at different concentrations (100, 400, and 800 μM) before cisplatin treatment on HT-22 cells under in vitro conditions to elicit neuroprotective activity. Half an hour after SA treatment, 5.5 μM cisplatin was added to all wells except the control group and incubated for 24 hours. Cell viability was determined by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and cytotoxicity was determined by lactate dehydrogenase (LDH) assays. Oxidative stress was evaluated by total antioxidant capacity (TAC), catalase (CAT), glutathione reductase (GSH), malondialdehyde (MDA), and superoxide dismutase (SOD) assays. In addition, the effect of SA on Caspase-3 gene regulation in HT-22 cells was investigated by real-time PCR. Results: Cisplatin decreased cell viability by approximately 40% and increased LDH level in HT-22 cells. In SA-treated groups, cell viability increased and LDH level decreased dose-independently. SA showed neuroprotective activity by inhibiting the cytotoxic activity of cisplatin and increasing the antioxidant activity in cells. Similarly, Caspase-3, which was up-regulated by cisplatin, approached the control value upon SA administration. SA eliminated the neurotoxicity of cisplatin and significantly reduced cell death and oxidative stress. Conclusion: The results of this study indicate that SA protects HT-22 cells against cisplatin by inhibiting both the formation of oxidative stress and induction of cell apoptosis.","PeriodicalId":23509,"journal":{"name":"Van Medical Journal","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83574344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femoral Pseudoaneurysm Compression Theraphy With Usg Guidance Usg引导下的股假性动脉瘤压迫治疗

Van Medical Journal Pub Date : 2023-01-01 DOI: 10.5505/vtd.2023.76094

Ensar Türko, Muhammed Bilal Akıncı

引用次数: 0

Correlation Between the Modified and the Classical Methods in Carpal Tunnel Syndrome Diagnosis 修正方法与经典方法在腕管综合征诊断中的相关性分析

Van Medical Journal Pub Date : 2023-01-01 DOI: 10.5505/vtd.2023.29863

H. Şahin

引用次数: 0

Earthquake: What is Post Traumatic Normal? Where Does the Psychopathology Begin? 地震:什么是创伤后正常?精神病理学从何开始?

Van Medical Journal Pub Date : 2023-01-01 DOI: 10.5505/vtd.2023.30075

Yavuz Selim Atan, Pınar Guzel Ozdemir