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Insulin—Five ‘M’s that Matter 胰岛素5个M很重要
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.01.14
S. Kalra
{"title":"Insulin—Five ‘M’s that Matter","authors":"S. Kalra","doi":"10.17925/USE.2017.13.01.14","DOIUrl":"https://doi.org/10.17925/USE.2017.13.01.14","url":null,"abstract":"T his editorial describes a simple and useful checklist that facilitates timely and appropriate insulin initiation and usage in type 2 diabetes. The ‘five Ms’ (5Ms) mnemonic list facilitates timely insulin use by breaking the process down into five ‘M’s: match, motivate, method, monitor, and modify. The 5Ms approach conveys the need to match the patient to the appropriate insulin regime, preparation, and delivery device; to motivate the patient to accept insulin through a process of informed, shared decision making; to ensure the correct method of insulin delivery by teaching injection technique; to monitor therapy by both biomedical (glycemic control, metabolic benefit) and patient reported outcomes (quality of life); and to modify therapeutic strategy, as and when needed. This concept can be used as a teaching tool, a clinical aid, and a practice audit.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Thyroidectomy—Preliminary Experience from a Tertiary Care Center in Delhi, India 内窥镜甲状腺切除术——印度德里一家三级医疗中心的初步经验
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.01.27
V. Aggarwal, Bhanu Kiran Raja, M. Garg, D. Khandelwal, B. Agarwal
{"title":"Endoscopic Thyroidectomy—Preliminary Experience from a Tertiary Care Center in Delhi, India","authors":"V. Aggarwal, Bhanu Kiran Raja, M. Garg, D. Khandelwal, B. Agarwal","doi":"10.17925/USE.2017.13.01.27","DOIUrl":"https://doi.org/10.17925/USE.2017.13.01.27","url":null,"abstract":"C osmesis after thyroid surgery has always been a concern for patients approaching thyroid surgery. To achieve a scarless surgery in the neck, endoscopic thyroidectomy using different techniques has been described in the literature. The aim of this article is to study the feasibility of endoscopic combined axillary breast approach for thyroid surgery. This is a retrospective study in the department of Endocrine Surgery from a tertiary care center in Delhi, India. Patients who underwent endoscopic thyroidectomy at our center during May 2010–November 2015 were included. The procedure was carried out in subjects who opted for the procedure with unilateral thyroid nodules of size less than 4 cm, with benign and indeterminate cytology, and with no previous neck surgery or radiation to the neck. The details of demographic profile, operative parameters, and postoperative management were collected for all the cases. All 12 subjects were females. The mean age of the subjects was 27.2 (range 14–45) years. Mean operative time was 187 (range 110–232) minutes. There was a temporary recurrent laryngeal nerve injury in one case, local wound infection in two cases, prolonged subcutaneous emphysema in five cases, and prolonged analgesic requirement (>5 days) in 10 cases. No life-threatening complications were seen in any of the subjects. Cosmetic results were excellent as there was no visible scar in the neck. The combined breast axillary approach using endoscopic technique for unilateral thyroid nodule is feasible with acceptable morbidity and can be offered to selected patients for cosmetic advantage.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
New Aspects of Cellular Cholesterol Regulation on Blood Glucose Control—Review and Perspective on the Impact of Statin Medications on Metabolic Health 细胞胆固醇调控对血糖控制的新进展——他汀类药物对代谢健康影响的综述与展望
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.02.63
Brian A. Grice, J. S. Elmendorf
{"title":"New Aspects of Cellular Cholesterol Regulation on Blood Glucose Control—Review and Perspective on the Impact of Statin Medications on Metabolic Health","authors":"Brian A. Grice, J. S. Elmendorf","doi":"10.17925/USE.2017.13.02.63","DOIUrl":"https://doi.org/10.17925/USE.2017.13.02.63","url":null,"abstract":"C holesterol is an essential component of cell membranes, and during the past several years, diabetes researchers have found that membrane cholesterol levels in adipocytes, skeletal muscle fibers and pancreatic beta cells influence insulin action and insulin secretion. Consequently, it is thought that dysregulated cell cholesterol homeostasis could represent a determinant of type 2 diabetes (T2D). Recent clinical findings compellingly add to this notion by finding increased T2D susceptibility in individuals with alterations in a variety of cholesterol metabolism genes. While it remains imperfectly understood how statins influence glucose metabolism, the fact that they display an influence on blood glucose levels and diabetes susceptibility seems to intensify the emerging importance of understanding cellular cholesterol in glucose metabolism. Taking this into account, this review first presents cell system and animal model findings that demonstrate the negative impact of cellular cholesterol accumulation or diminution on insulin action and insulin secretion. With this framework, a description of how changes in cholesterol metabolism genes are associated with T2D susceptibility will be presented. In addition, the connection between statins and T2D risk will be reviewed with expanded information on pitavastatin, a newer statin medication that displays actions favoring metabolic health.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"63-68"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Introducing New Guidelines on Sudden Unexpected Death in Epilepsy 介绍癫痫猝死新指南
US endocrinology Pub Date : 2017-01-01 DOI: 10.17925/USE.2017.13.02.65
C. Harden
{"title":"Introducing New Guidelines on Sudden Unexpected Death in Epilepsy","authors":"C. Harden","doi":"10.17925/USE.2017.13.02.65","DOIUrl":"https://doi.org/10.17925/USE.2017.13.02.65","url":null,"abstract":"Received: June 12, 2017 Published Online: July 24, 2017 Citation: US Neurology, 2017;13(2):65–6 Corresponding Author: Cynthia L Harden, Mount Sinai Health System, Mount Sinai Beth Israel Phillips Ambulatory Care Center, 10 Union Square East, Suite 5D, New York, NY 10003, US. E: Cynthia.Harden@mountsinai.org N ew guidelines from the American Academy of Neurology (AAN) and the American Epilepsy Society on sudden unexpected death in epilepsy (SUDEP) were presented at the 69th Annual AAN Meeting held in Boston, MA, US, May 28–22, 2017 in parallel with their publication in Neurology. In an expert interview, Dr Cynthia L Harden of Mount Sinai discusses SUDEP, why the new guidelines were needed and the key recommendations.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"13 1","pages":"65"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67603541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional Recommendations—We Must Get Them Right at Last 营养建议——我们必须最终得到正确的建议
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.01.12
C. Lardinois
{"title":"Nutritional Recommendations—We Must Get Them Right at Last","authors":"C. Lardinois","doi":"10.17925/USE.2016.12.01.12","DOIUrl":"https://doi.org/10.17925/USE.2016.12.01.12","url":null,"abstract":"Almost four decades ago, the American medical establishment was bamboozled into believing that consumption of dietary fat and cholesterol were critical factors in cardiovascular disease. Many trace the confusion to Ancel Keys, who strongly believed that dietary fat and cholesterol were closely related to the development of heart disease. In 1970, Keys published the Seven Countries Study (which included Italy, Greece, Yugoslavia, Finland, the Netherlands, Japan, and the US), which showed that dietary saturated fat intake increased total cholesterol, and this was associated with an increase coronary mortality. However, data were actually available for 22, rather than seven, countries and, in the analysis of all the data, a poor relationship between total fat intake and heart disease can be seen. So why did Keys omit countries where the consumption of total and saturated fat were higher, yet the risk of heart disease was low? Many critics conclude that the study was biased in favor of his hypothesis.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concerns About the American Thyroid Association Guidelines on Pediatric Thyroid Cancer 对美国甲状腺协会儿童甲状腺癌指南的关注
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.01.24
M. Fridman, Y. Demidchik, V. Drozd, C. Reiners
{"title":"Concerns About the American Thyroid Association Guidelines on Pediatric Thyroid Cancer","authors":"M. Fridman, Y. Demidchik, V. Drozd, C. Reiners","doi":"10.17925/USE.2016.12.01.24","DOIUrl":"https://doi.org/10.17925/USE.2016.12.01.24","url":null,"abstract":"The Management Guidelines for Childhood Differentiated Thyroid Cancer by the American Thyroid Association (ATA) Pediatric Thyroid Cancer Task Force1 built up a system for evaluation, treatment, and follow-up of children with papillary carcinoma. For this approach, recommendations based on scientific evidence and expert opinion play a crucial role in identifying patients at risk of persistent cervical disease and/or distant metastases after initial total thyroidectomy with or without lymph node dissection. In our opinion, this issue needs further consideration because of several uncertainties that have to be addressed.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"24"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Key developments in pediatric endocrinology in 2015 2015年儿科内分泌学的主要进展
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.02.87
Nazaneen Eshragh, S. Lafranchi
{"title":"Key developments in pediatric endocrinology in 2015","authors":"Nazaneen Eshragh, S. Lafranchi","doi":"10.17925/USE.2016.12.02.87","DOIUrl":"https://doi.org/10.17925/USE.2016.12.02.87","url":null,"abstract":"","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"87-89"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 2 Diabetes in a Time of Change—A Tide of Good News 变革时代的2型糖尿病——好消息的浪潮
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.02.81
J. Gavin
{"title":"Type 2 Diabetes in a Time of Change—A Tide of Good News","authors":"J. Gavin","doi":"10.17925/USE.2016.12.02.81","DOIUrl":"https://doi.org/10.17925/USE.2016.12.02.81","url":null,"abstract":"T ype 2 diabetes has been definitively characterized as one of the most physiologically complex and heterogeneous metabolic known diseases. The extraordinary depth of knowledge that has been achieved regarding the pathophysiology has helped to stimulate an explosive array of therapeutic regimens and monitoring tools for improving outcomes in this disease. Indeed, the clinical narrative about ‘control’ of diabetes has shifted markedly in the last two years, away from a focus on glucose-mediated vascular complications to defining diabetes control as cardiovascular risk reduction and end organ protection. The new tools for management coupled with new pathophysiologic insights have brought a tide of good news for the millions of people living with type 2 diabetes.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"16 1","pages":"81"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Weight Loss in the Management of Type 2 Diabetes 减肥在2型糖尿病治疗中的作用
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.01.14
M. Franz
{"title":"The Role of Weight Loss in the Management of Type 2 Diabetes","authors":"M. Franz","doi":"10.17925/USE.2016.12.01.14","DOIUrl":"https://doi.org/10.17925/USE.2016.12.01.14","url":null,"abstract":"Weight loss is important for the prevention of prediabetes, for halting the progression of prediabetes to diabetes, and for improving metabolic outcomes early after the diagnosis of type 2 diabetes. However, as type 2 diabetes progresses from being primarily related to insulin resistance to insulin deficiency, weight loss that can be achieved by many individuals may or may not improve outcomes. A reduced energy intake continues to be essential. For some it may lead to weight loss, for some it may prevent weight regain after weight loss, and for some it may prevent weight gain, but even without weight loss, it can have beneficial effects on metabolic outcomes.","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"14"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67601923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Predictors of Scalp Hair Thinning in Women with Polycystic Ovary Syndrome 多囊卵巢综合征女性头皮头发稀疏的预测因素
US endocrinology Pub Date : 2016-01-01 DOI: 10.17925/USE.2016.12.01.26
D. E. Ikhena, Joanne Williams, N. Naqvi, L. Pal
{"title":"Predictors of Scalp Hair Thinning in Women with Polycystic Ovary Syndrome","authors":"D. E. Ikhena, Joanne Williams, N. Naqvi, L. Pal","doi":"10.17925/USE.2016.12.01.26","DOIUrl":"https://doi.org/10.17925/USE.2016.12.01.26","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women.1 According to National Institutes of Health (NIH) criteria (presence of ovulatory dysfunction and hyperandrogenism, after exclusion of related disorders), PCOS is estimated to affect 6–8% of women in the US, the prevalence is estimated to be almost doubled to 15% when on the Rotterdam criteria are utilized.2,3","PeriodicalId":23490,"journal":{"name":"US endocrinology","volume":"12 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67602071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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