Veterinary and human toxicology最新文献_第9页

Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats. 妊娠期和哺乳期接触七氯胺不会改变大鼠的生殖系统发育。

Veterinary and human toxicology Pub Date : 2004-06-01

Gregory Lawson, Ulrike Luderer

{"title":"Gestational and lactational exposure to heptachlor does not alter reproductive system development in rats.","authors":"Gregory Lawson, Ulrike Luderer","doi":"","DOIUrl":"","url":null,"abstract":"Like other organochlorine insecticides, heptachlor is lipophilic and accumulates in fatty tissues. Earlier studies suggested that in utero exposure to heptachlor decreased fertility in the offspring; neonatal exposure to the closely related insecticide chlordane reportedly delayed puberty and disrupted estrous cycling in females. We hypothesized that in utero and lactational exposure to heptachlor would disrupt the development of the reproductive system in males and females, resulting in altered timing of puberty and abnormal gonadal histology and reproductive hormone levels. Timed pregnant Sprague-Dawley rats were treated by oral gavage with heptachlor in corn oil at doses of 0.5 and 5.0 mg/kg or an equivalent volume of corn oil alone daily from gestational day 8 through post-natal day (PND) 21, the day of weaning (n = 7-8/group). Litters were standardized to 4 males and 4 females on the day of birth. Two of the dams in the 5.0 mg/kg/d group died. Pups in the highest dose group weighed significantly less than those in the other 2 groups on PND 0. All but 1 litter of the 5.0 mg/kg/d group died within the first 4 post-natal days. Age at eye opening was delayed with increasing heptachlor dose. There was no effect of treatment on pup weight gain in the surviving litters, on anogenital distance, age at puberty, nipple retention past the infantile period in males, estrous cycling, serum sex steroid concentrations, reproductive organ weights, or testicular or ovarian histology. These results suggest that heptachlor exposure during gestation and lactation does not disrupt development of the reproductive system in rats.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 3","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24543456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Equine goiter associated with excess dietary iodine. 马甲状腺肿与过量饮食碘有关。

Veterinary and human toxicology Pub Date : 2004-06-01

H Eroksuz, Y Eroksuz, H Ozer, A O Ceribasi, I Yaman, N Ilhan

引用次数: 0

Is mass-mailing an effective form of passive poison center awareness enhancement? 群发邮件是一种有效的被动中毒中心意识增强形式吗?

Veterinary and human toxicology Pub Date : 2004-06-01

Edward P Krenzelok, Rita Mrvos

引用次数: 0

Life threatening tongue angioedema. 危及生命的舌血管性水肿。

Veterinary and human toxicology Pub Date : 2004-06-01

J W Billups

引用次数: 0

Acute iron intoxication. 急性铁中毒。

Veterinary and human toxicology Pub Date : 2004-06-01

Isao Sakaida, Fujio Murakami, Kiwama Okita

引用次数: 0

Trace metal profiles in hair samples from children in urban and rural regions of the United Arab Emirates. 阿拉伯联合酋长国城市和农村地区儿童头发样本中的痕量金属剖面。

Veterinary and human toxicology Pub Date : 2004-06-01

M Y Hasan, M Kosanovic, M A Fahim, A Adem, G Petroianu

{"title":"Trace metal profiles in hair samples from children in urban and rural regions of the United Arab Emirates.","authors":"M Y Hasan, M Kosanovic, M A Fahim, A Adem, G Petroianu","doi":"","DOIUrl":"","url":null,"abstract":"Pollution has increased with industrialization and humans are subjected to exposure to heavy metals from different environmental sources. In oil-producing countries heavy metals are considered a major threat to the population. Metals such as lead, aluminum, manganese, nickel and cadmium may impact various organs of the body, and controlling their toxicity is crucial for individuals at risk. Previous studies utilized blood levels for monitoring metal toxicity. The current study was designed to investigate exposure to lead, aluminum, manganese, nickel and cadmium using scalp hair. Hair samples were randomly collected from 42 children (aged 6-18 y) representing rural and urban areas of the United Arab Emirates. The rural regions were defined as at least 50 km away from factories or traffic sites. Immediately after cutting, hairs were stored in plastic bags and attached to a questionnaire with the relevant background information. Samples were dried, weighed and sealed with polyethylene envelopes. Following extraction procedures with nitric acid, ICP-MS was utilized for metals determination. The analytical instrument showed a high degree of sensitivity and revealed significant differences between levels of some metals in hairs from rural and urban areas. Children from rural areas had mean hair lead levels (microg/g) of 0.79 + 0.10 whereas children from urban area had higher hair lead levels (3.47 + 0.47). Measuring metals concentration in scalp hair could be a useful method for studying exposure and assessing environmental pollution. Although the technique has the potential of being an effective tool for evaluating extent of pollution and identifying potentially toxic elements, it cannot yet replace the standard procedures of measuring air, water and soil metal content.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 3","pages":"119-21"},"PeriodicalIF":0.0,"publicationDate":"2004-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24543458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Language preferences among callers to a regional Poison Center. 区域中毒中心呼叫者的语言偏好。

Veterinary and human toxicology Pub Date : 2004-04-01

Greene Shepherd, Gregory L Larkin, Larissa I Velez, Les Huddleston

{"title":"Language preferences among callers to a regional Poison Center.","authors":"Greene Shepherd, Gregory L Larkin, Larissa I Velez, Les Huddleston","doi":"","DOIUrl":"","url":null,"abstract":"Providing service to non-English speaking populations is a common challenge facing Poison Centers (PC). Previous studies have identified that people who do not speak functional English are unlikely to call a PC. We developed a survey to determine the language preferences of poison center callers and to identify if we were failing to offer services in languages other than English to callers who felt they needed them. We surveyed 322 parents during routine callbacks about language spoken at home, first and second languages, country of birth, and satisfaction with language used by the PC. We found that 93% primarily spoke English, 5% spoke English and Spanish, and 5% spoke other languages at home in a region where approximately 10% of the population speak English poorly. The majority of respondents were born in the US and were comfortable using English when using the PC. There were 6 cases where callers would have preferred using a different language. Our study supports data suggesting that poison centers are underutilized by people that are recent immigrants and speak English poorly. Awareness programs and educational efforts should be directed toward this sub-population.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 2","pages":"100-1"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24464704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood lead levels, clinico-pathological findings and erythrocyte metabolism in dogs from different habitats. 不同生境犬血铅水平、临床病理表现及红细胞代谢。

Veterinary and human toxicology Pub Date : 2004-04-01

Gabriele Ghisleni, Valentina Spagnolo, Paola Roccabianca, Eugenio Scanziani, Saverio Paltrinieri, Fabio Lupo, Enrica Ferretti, Fabio Nageli

引用次数: 0

Systemic granulomatous disease in Brazilian cattle grazing pasture containing vetch (Vicia spp). 巴西放牧含有紫薇属牧草的牛的系统性肉芽肿病。

Veterinary and human toxicology Pub Date : 2004-04-01

Rafael A Fighera, Claudio S L Barros

{"title":"Systemic granulomatous disease in Brazilian cattle grazing pasture containing vetch (Vicia spp).","authors":"Rafael A Fighera, Claudio S L Barros","doi":"","DOIUrl":"","url":null,"abstract":"Vetch associated disease (hairy vetch poisoning) was observed in 8 herds of dairy cows in the state of Rio Grande do Sul, southern Brazil. In the pasture where 4 of these 8 herds were, Vicia villosa was the only vetch species represented, while cattle in the remaining 4 herds had access to both V villosa and V sativa but with large predominance of the former. Observed clinical signs included fever, dramatic drop in milk yield, thickening and wrinkling of the skin with multifocal plaques of alopecia, pruritus, conjunctivitis, nasal and ocular serous discharge, loss of weight and diarrhea. The mean morbidity in the 8 affected herds, representing 219 cattle, was 11.1% and the mortality was 100%. The duration of the clinical disease varied from 10 to 30 d. Gross lesions consisted of multifocal to coalescing grey-white soft to moderately firm nodules which infiltrated several organs, but were particularly prominent in lymph nodes, adrenal, renal cortex, spleen, liver, and myocardium. Microscopically the lesions consisted of extensive cellular infiltration composed of variable proportions of epithelioid macrophages, lymphocytes, plasma cells, and multinucleated giant cells; variable numbers of eosinophils were present in the inflammatory foci of several organs, but they were more prominent in the myocardium.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 2","pages":"62-6"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24463629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lead contaminated moonshine: a report of Bureau of Alcohol, Tobacco and Firearms analyzed samples. 铅污染的私酒:酒精，烟草和火器局分析样本的报告。

Veterinary and human toxicology Pub Date : 2004-04-01

Brent W Morgan, Constance S Parramore, Michael Ethridge

{"title":"Lead contaminated moonshine: a report of Bureau of Alcohol, Tobacco and Firearms analyzed samples.","authors":"Brent W Morgan, Constance S Parramore, Michael Ethridge","doi":"","DOIUrl":"","url":null,"abstract":"The CDC's Healthy People 2010 has set a US population lead level goal of < 25 microg/dL. A recent study of Emergency Department patients in Atlanta, GA, revealed a significant association between reported moonshine consumption and elevated blood lead. However, beyond anecdotal reports and isolated case histories, laboratory analyses confirming the presence and extent of lead contamination among moonshine samples are absent from modern scientific literature. One hundred and fifteen suspected moonshine samples seized by local law enforcement between 1995 and 2001 were voluntarily submitted to the Bureau of Alcohol, Tobacco and Firearms' National Laboratory for lead analysis using flameless atomic absorption spectrophometry. Samples originated from 9 states: 5 southeastern states, Missouri, Ohio, Wisconsin and West Virginia. Lead levels ranged between 0.0 microg/dL and 53,200 microg/dL (median 44.0 microg/dL). Median percent alcohol by volume was 44.75% (range 3.85-65.80%). Thirty-three samples (28.7%) contained lead levels > 300 microg/dL, the limit designated potentially hazardous by the FDA. Percent alcohol by volume did not predict lead content. Consuming 1 L/d of moonshine contaminated with 400 microg/dL of lead would result in a blood lead level of approximately 25 microg/dL. At a high level of consumption, 25% of the samples could produce blood lead levels > or = 25 microg/dL. Moonshine production and consumption is an under-appreciated toxicologic and public health concern and is not restricted to the southeastern US.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 2","pages":"89-90"},"PeriodicalIF":0.0,"publicationDate":"2004-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24463638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0