Veterinary and human toxicology最新文献_第4页

The pathogenesis of reproductive failure induced in sheep by the ingestion of Ateleia glazioviana. 羊食入青苔草导致生殖衰竭的发病机制。

Veterinary and human toxicology Pub Date : 2004-10-01

Margarida B Raffi, Ricardo R Barros, José F M Bragança, Raquel R Rech, Fabiano N Oliveira, Claudio S L Barros

{"title":"The pathogenesis of reproductive failure induced in sheep by the ingestion of Ateleia glazioviana.","authors":"Margarida B Raffi, Ricardo R Barros, José F M Bragança, Raquel R Rech, Fabiano N Oliveira, Claudio S L Barros","doi":"","DOIUrl":"","url":null,"abstract":"Seventeen pregnant ewes were orally fed variable amounts of either green or dried leaves of Ateleia glazioviana in 1 through 24 daily doses. All 17 ewes manifested some form of reproductive failure. Nine (52.9%) aborted their fetuses at 4 through 36 d after starting being fed the leaves of the plant; 1 had a stillbirth and in another 1 intrauterine fetal death was diagnosed. The other 6 ewes delivered 8 weak lambs, 7 of which died from few min to 48 h after birth. Three ewes had neurologic disturbances and loss of weight. Thirteen ewes were euthanatized 1-48 h after lambing or pregnancy loss; 2 of them had gross and histopathological changes related to the A glazioviana. Gross and histopathological changes observed in 7 lambs and in a stillborn, and histopathological changes found in 4 aborted fetuses from A glazioviana-fed ewes, were similar to those found in spontaneous poisoning by A glazioviana in adult cattle. It is concluded that A glazioviana has a powerful abortifacient activity whether ingested green or dried. The abortions caused by A glazioviana were not due to placental damage, but rather to transplacental induced fetal lesions consisting of toxic cardiomyopathy and spongy degeneration of the white matter of the brain. Fetuses succumbing to these lesions were expelled from the uterus; those not lethally affected are born weak with meager chances to survive.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 5","pages":"233-8"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40922361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Life-threatening isopropyl alcohol intoxication: is hemodialysis really necessary? 危及生命的异丙醇中毒:血液透析真的有必要吗?

Veterinary and human toxicology Pub Date : 2004-10-01

J C Trullas, S Aguilo, P Castro, S Nogue

引用次数: 0

Fires and toxicology. 火灾和毒理学。

Veterinary and human toxicology Pub Date : 2004-10-01

William O Robertson

引用次数: 0

Polymer fume fever-like syndrome due to hairspray inhalation. 因吸入发胶引起的聚合物烟雾热样综合征。

Veterinary and human toxicology Pub Date : 2004-10-01

Joao H Delgado, Javier C Waksman

引用次数: 0

Interaction between enrofloxacin and monensin in broiler chickens. 恩诺沙星与莫能菌素在肉鸡体内的相互作用。

Veterinary and human toxicology Pub Date : 2004-10-01

V Sureshkumar, K V Venkateswaran, S Jayasundar

{"title":"Interaction between enrofloxacin and monensin in broiler chickens.","authors":"V Sureshkumar, K V Venkateswaran, S Jayasundar","doi":"","DOIUrl":"","url":null,"abstract":"Enrofloxacin, a fluoroquinolone, and its interaction with monensin, an ionophore drug, was studied to explore the influence of enrofloxacin on drug metabolizing enzymes that can lead to physiological and toxicological consequences upon coadministration with monensin in broiler chickens. Group I, treated with 100 mg monesin/kg feed from 1 d old to 41st d of age, did not show any influence on aniline hydroxylase and cytochrome b5 levels. Group II, treated with 10 mg enrofloxacin/kg body weight per os for three consecutive days on 33rd, 34th, 35th d of age, had a highly significant decrease in aniline hydroxylase on 38th d (ie on 3rd d post-treatment with enrofloxacin); a reversal effect was noticed on the 41st day (ie on 6th d post-treatment with enrofloxacin). There was no alteration in cytochrome b5 level. Group III with monensin and enrofloxacin coadministration 100 mg monensin/kg feed from 1 d old to the 41st day + 10 mg enrofloxacin/kg body weight, per os for 3 consecutive days on the 33rd, 34th, 35th d of age) had a significant decrease in aniline hydroxylase level on the 3rd d post-treatment with enrofloxacin, but an elevation tending to reach normal on the 6th d post-treatment with enrofloxacin. Monensin + enrofloxacin coadministration did not produce any alteration in cytochrome b5 level. Creatine kinase (CK) and alanine amino transferase (ALT) levels significantly increased on the 3rd d post-treatment with enrofloxacin, but on the 6th d post-treatment with enrofloxacin the increase declined. Aspartate amino transferase (AST) significantly increased on the 6th d post enrofloxacin treatment. This study demonstrated the reversible competitive type of inhibition of enrofloxacin on CYP450 enzymes, and with coadministration with monensin produced increased CK, AST and ALT serum enzymes suggesting heart and liver injury. Simultaneous administration of enrofloxacin and monensin even at recommended levels could result in adverse interactions.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 5","pages":"242-5"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40922308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum luteinizing hormone response to administration of gonadotropin-releasing hormone to atrazine-treated gilts. 血清促性腺激素释放激素对阿特拉津处理的后备母猪的反应。

Veterinary and human toxicology Pub Date : 2004-10-01

Tihomira Gojmerac, Jelka Pleadin, Marijan Zuric, Ranka Rajkovic-Janje, Mirko Korsic

{"title":"Serum luteinizing hormone response to administration of gonadotropin-releasing hormone to atrazine-treated gilts.","authors":"Tihomira Gojmerac, Jelka Pleadin, Marijan Zuric, Ranka Rajkovic-Janje, Mirko Korsic","doi":"","DOIUrl":"","url":null,"abstract":"The aim of the study was to evaluate the response of porcine luteinizing hormone (pLH) in serum to a single iv administration of gonadotropin-releasing hormone (GnRH) in atrazine-treated pigs. Experiments were performed in 15 mature female pigs (10 atrazine-treated, 5 control). From the onset of estrous (day 0), the pigs were given 1 mg atrazine/kg body mass in feed for 20 d of the estrous cycle. On the last day, blood samples were collected at min 0 from control and atrazine-exposed, and 5 atrazine-exposed pigs were immediatey given 100 mg GnRH iv. Blood samples were collected from atrazine-exposed and the GnRH-injected atrazine-exposed groups at 20, 30, 40 and 90 min and serum pLH concentrations were determined by radioimmunoassay. The administration of atrazine led to significant (p< 0.001) suppression of serum pLH concentrations (0.57 +/- 0.05 ng/ml) compared to control animals (2.24 +/- 0.20 ng/ml). The single iv GnRH administration to the atrazine-exposed pigs provoked significant pLH release at 20 and 30 min after GnRH administration, indicating attenuation of GnRH release in the atrazine-exposed animals was responsible for the suppression of serum pLH.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 5","pages":"245-7"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40922309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dying to be thin: a dinitrophenol related fatality. 渴望变瘦:与二硝基苯酚有关的死亡。

Veterinary and human toxicology Pub Date : 2004-10-01

R B McFee, T R Caraccio, M A McGuigan, S A Reynolds, P Bellanger

引用次数: 0

Acute lead intoxication in cattle housed in an old battery factory. 旧电池厂饲养牛的急性铅中毒。

Veterinary and human toxicology Pub Date : 2004-10-01

Ozlem Ozmen, Firdevs Mor

引用次数: 0

Diagnosis and treatment of zinc poisoning in a dog. 犬锌中毒的诊断与治疗。

Veterinary and human toxicology Pub Date : 2004-10-01

Genevieve M Hammond, Matthew E Loewen, Barry R Blakley

引用次数: 0

Safety of Pochonia chlamydosporia var catenulata in acute oral and dermal toxicity/pathogenicity evaluations in rats and rabbits. 在大鼠和家兔急性口服和皮肤毒性/致病性评价中的安全性。

Veterinary and human toxicology Pub Date : 2004-10-01

Liseth García, Carlos Bulnes, Gleiby Melchor, Ernesto Vega, Miranda Ileana, Nivian Montes de Oca, Leopoldo Hidalgo, Eva Marrero

{"title":"Safety of Pochonia chlamydosporia var catenulata in acute oral and dermal toxicity/pathogenicity evaluations in rats and rabbits.","authors":"Liseth García, Carlos Bulnes, Gleiby Melchor, Ernesto Vega, Miranda Ileana, Nivian Montes de Oca, Leopoldo Hidalgo, Eva Marrero","doi":"","DOIUrl":"","url":null,"abstract":"The nematophagous fungus, Pochonia chlamydosporia var. catenulata (Kamyschlco ex Barron & Onions) Zare & W-Gams, was investigated as a potential biocontrol agent in integrated pest management strategy for Meloidogyne incognita (Kofoid and White) Chitwood in vegetable crops in Cuba. An acute oral and dermal toxicity/patogenicity study was performed to determine the safety of this fungus in non-target organisms. In the first study, a 1-dose level of 5 x 10(8) units of the microbial pest control agent/treated rat was used. Mortality or clinical signs were not evident and no adverse effects on body weight, hematology, microbiology and gross or microscopic pathology were observed. Food and water consumption was not significantly different between control and treated groups. In the acute dermal toxicity study, there was neither mortality nor clinical signs of toxicity, and no toxic effects in gross and microscopic pathology were detected. Thus, Pochonia chlamydosporia var. catenulate (Vcc-108, IMI SD 187), administered oral and dermally to rats and rabbits respectively, was safe in toxicity/pathogenicity studies.","PeriodicalId":23486,"journal":{"name":"Veterinary and human toxicology","volume":"46 5","pages":"248-50"},"PeriodicalIF":0.0,"publicationDate":"2004-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40922310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0