{"title":"Equidistant and Plebeian- Basal Cell Carcinoma","authors":"Anu Bajaj","doi":"10.31579/2834-8508/007","DOIUrl":"https://doi.org/10.31579/2834-8508/007","url":null,"abstract":"Basal cell carcinoma is a frequently discerned, malignant, cutaneous neoplasm arising from inter-follicular or follicular epithelium. The locally aggressive neoplasm is associated with minimal mortality wherein distant metastasis to pulmonary parenchyma or bones is exceptional. Tumefaction is comprised of nests and aggregates of basaloid cells with peripheral nuclear palisading circumscribed with fibromyxoid stroma. Additionally designated as basal cell epithelioma, basalioma or fibroepithelioma of Pinkus, ulcerated nodular basal cell carcinoma was initially scripted as ‘rodent ulcer’. Moh’s micrographic surgical technique is frequently adopted for evaluation of surgical perimeter of tissue samples and is accompanied by superior proportionate 5-year tumour alleviation and decimated reoccurrence. Basal cell carcinoma is commonly discerned within Caucasian population demonstrating Fitzpatrick type I and type II cutaneous subtypes. Middle aged adults are frequently incriminated wherein proportionate tumour emergence enhances with increasing age. A male predominance is observed with male to female proportion of 1.5:1. Incriminated younger subjects demonstrate a female predisposition. Tumefaction arising within younger individuals is associated with aggressive biological behaviour.","PeriodicalId":234436,"journal":{"name":"Archives of Clinical and Experimental Pathology","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115205653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of dibenzoylmethane-flavonoid hybrids as potential uv filters. Hybrids of chalcones","authors":"F. Svarc","doi":"10.31579/2834-8508/002","DOIUrl":"https://doi.org/10.31579/2834-8508/002","url":null,"abstract":"Background: It has been reported that chalcones (a family of flavonoids) have activity as UV rays absorbers. Previously we have reported that the compounds2´-hydroxy-4- methoxychalcone and 2´-hydroxy-4-methoxy dibenzoylmethane have the basic properties of UVA filters (both show their maximum absorption in the range 350-370 nm with good photostability) Objective: in this work, we describea new series of chalcone-dibenzoylmethane hybrid candidates as synthetic UV filtersand flavonoids Method: The compounds resultedfrom multi step synthesisstarting from 4-formylbenzoic acid and 2´- hydroxy acetophenone. Purification was done by recrystallization or column chromatography. Results: The compounds were obtained with good yields and characterized by spectroscopy. Conclusion: They are good candidates for UVA filters in cosmetics. Drs. Svarc and Minaberry will performthe corresponding photostability studies.","PeriodicalId":234436,"journal":{"name":"Archives of Clinical and Experimental Pathology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117282509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neutrophil‐to‐Lymphocyte and Platelet‐to-Lymphocyte Ratio in Children with Multiple Sclerosis","authors":"F. Incecik","doi":"10.31579/2834-8508/003","DOIUrl":"https://doi.org/10.31579/2834-8508/003","url":null,"abstract":"Introduction: Multiple sclerosis (MS) is a chronic, inflammatory condition that affects the central nervous system. MS in children often manifests with a relapsing-remitting disease course. Recently, blood neutrophil-to-lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have proposed as a potentially useful markers of clinical outcome in autoimmune/inflamatory diseases. The aim of this study was to clarify the association of NLR and PLR in children with MS. Materials and Methods: Ten patients with MS and 11 healthy controls were enrolled in the study. NLR and PLR were calculated using complete blood count data. Results: The serum NLR and PLR level in relaps period with MS patients were significantly higher than those of remission period with MS patients and controls (P < 0.001). Conclusions: To our knowledge, this is the first study which investigated the role of NLR and PLR as inflammatory biomarkers in patients with MS. Our results demonstrate that NLR and PLR levels are higher in patients with relaps period compared with controls and remission period. NLR and PLR, a simple and easily obtainable parameters, can be used to identify relaps period in MS.","PeriodicalId":234436,"journal":{"name":"Archives of Clinical and Experimental Pathology","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126372361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Malnutrition in Surgery","authors":"Siniša Franjić","doi":"10.31579/2834-8508/005","DOIUrl":"https://doi.org/10.31579/2834-8508/005","url":null,"abstract":"Malnutrition can occur due to insufficient nutrient intake, malabsorption, impaired metabolism, loss of nutrients or increased nutritional needs. Malnutrition progresses through stages, and each stage usually takes longer to develop. Nutrient levels in the blood and tissues change first, followed by intracellular changes in biochemical function and structure. Nutritional status has a major impact on the outcomes of surgical procedures. Nutritional status provides insight into the patient's condition, ie shows whether the patient is at risk of malnutrition or not. The most important thing is to assess the nutritional status immediately upon arrival at the hospital because it allows you to detect and recognize malnutrition in time and to assess the risk of malnutrition.Malnutrition of patients who are scheduled for surgery should be taken care of in time to avoid possible complications.","PeriodicalId":234436,"journal":{"name":"Archives of Clinical and Experimental Pathology","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127396412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"To The Question of Active Sports During the Period of Menstrual Bleeding","authors":"Konstantin Anatolyevich Bugaevsky","doi":"10.31579/2834-8508/001","DOIUrl":"https://doi.org/10.31579/2834-8508/001","url":null,"abstract":"The article presents the results of a study aimed at identifying the individual characteristics of the self-functioning and physical activity of athletes engaged in different sports, with their active sports, during menstrual bleeding. The results of anonymous questionnaire and additional interviews were studied and analyzed. The relationship between the timing of professional sports, the level of sports skills, durability and volume of physical exertion, is actively engaged in sports during menstrual bleeding. According to the results of the study, practical conclusions were made, and practical recommendations are given.","PeriodicalId":234436,"journal":{"name":"Archives of Clinical and Experimental Pathology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126514731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic Treatment Comparison of Humeral Cuff, Neuro Muscular Electrical Stimulation Versus Strapping in Reduction of Pain and Subluxation Gleno Humeral Stroke Survivors","authors":"T. Karthikeyan","doi":"10.31579/2834-8508/004","DOIUrl":"https://doi.org/10.31579/2834-8508/004","url":null,"abstract":"Background: Stroke is characterized by acute onset of neurological dysfunction due to abnormality in cerebral circulation with resultant signs and symptoms that correspond to involvement of the focal areas of brain. Aim: The aim of the study to identify the conventional physiotherapy, humeral cuff, neuro muscular electrical stimulation versus strapping in prevention of gleno humeral subluxation and pain in stroke survivors. Methods: This study includes 30 stroke survivors with gleno humeral subluxation and pain, who met the inclusion criteria, considered for this study. The duration of study conducted for a course of 6 weeks. The outcome used in this study pain measured by VAS and motor recovery measured through FMA. Group A undergone conventional physiotherapy, humeral cuff with strapping. Group B treatment applied conventional physiotherapy, humeral cuff with NMES. Results: The results of study shows that visual analogue scale between Group A pre mean score 7.47 and post mean score 5.20(P<0.5).Group B, pre mean score 7.60 and post mean score 3.20(P<0.5). The results of study shows that FMA between Group A pre mean score 39.33 and post mean score 46.00(P<0.5).Group B-FMA, pre mean score40.3 and post mean score 51.47 (P<0.5). Conclusion: The author concluded that both therapeutic treatment strategy of humeral cuff, neuro muscular electrical stimulation versus strapping which helps in prevention of gleno humeral subluxation and pain in stroke survivors. But statistical analysis which supports the Humeral Cuff, Neuro Muscular Electrical Stimulation is significantly better form treatment than Strapping for management of stroke survivors. This study also help to improve upper limb motor recovery, reduce pain, prevent gleno humeral subluxation, overall health, upper extremity muscular function, Gross motor and fine motor function, wellbeing, livelihood of stroke survivors.","PeriodicalId":234436,"journal":{"name":"Archives of Clinical and Experimental Pathology","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130693303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}