Clarion and Protuberant-Papillary Thyroid Carcinoma

Abstract

Papillary thyroid carcinoma is a malignant thyroid neoplasm exhibiting histological subtypes as classic papillary carcinoma, tall cell, micro-carcinoma, follicular, oxyphilic, diffuse sclerosing, cribriform morular, solid or insular variant. Tumefaction enunciates distinctive nuclear features as altered nuclear magnitude and outline, nuclear enlargement or elongation, nuclear overlapping, and ground glass nuclei. Genomic fusions of BRAF, RET, PPARG, NTRK1, NTRK3, ALK, LTK, MET, FGFR2 or THADA genes may be observed. Initial disease representation emerges as 67% singular thyroid nodules, 13% thyroid nodules combined with cervical lymph node metastasis and 20% neoplasms confined singularly to lymph nodes