Synthesis of dibenzoylmethane-flavonoid hybrids as potential uv filters. Hybrids of chalcones

Abstract

Background: It has been reported that chalcones (a family of flavonoids) have activity as UV rays absorbers. Previously we have reported that the compounds2´-hydroxy-4- methoxychalcone and 2´-hydroxy-4-methoxy dibenzoylmethane have the basic properties of UVA filters (both show their maximum absorption in the range 350-370 nm with good photostability) Objective: in this work, we describea new series of chalcone-dibenzoylmethane hybrid candidates as synthetic UV filtersand flavonoids Method: The compounds resultedfrom multi step synthesisstarting from 4-formylbenzoic acid and 2´- hydroxy acetophenone. Purification was done by recrystallization or column chromatography. Results: The compounds were obtained with good yields and characterized by spectroscopy. Conclusion: They are good candidates for UVA filters in cosmetics. Drs. Svarc and Minaberry will performthe corresponding photostability studies.