Ukrainian Journal of Dermatology, Venerology, Cosmetology最新文献

{"title":"Psorias: current status of incidence and organizational measures","authors":"V. Kravchenko, Ya.A. Emchenko, A. Kravchenko, A. Dashchuk","doi":"10.30978/ujdvk2022-3-4-42","DOIUrl":"https://doi.org/10.30978/ujdvk2022-3-4-42","url":null,"abstract":"Objective — to conduct an epidemiological analysis of the incidence of psoriasis in the world and in Ukraine and to determine the reasons for its permanent spread, as well as to outline the main tasks of the dermatovenerological field to improve the situation in our country. \u0000Materials and methods. In order to conduct a comparative analysis, available data from epidemiological studies and our own long-term dermatological practice were used. \u0000Results and discussion. Quite high prevalence rates of psoriasis in economically developed countries can be considered as a reflection of the existing organizational health care system and high level of medical care. Analytical data on the incidence of psoriasis in certain regions of Ukraine indicate a significant prevalence of this dermatosis, even in the absence of strict registration of diseases in the regions. The therapy of psoriatic disease, especially its complicated forms, is currently accompanied by significant difficulties and does not provide long-term remission. Therefore, the treatment of such patients must be carried out in specialized dermatovenerological institutions, in which the necessary personnel and material resources and special medical equipment should be concentrated. \u0000Conclusions. In order to carry out effective measures in the fight against psoriatic disease and its consequences, dermatological units of municipal and private property should establish accounting and reporting on the morbidity. The presidium of the UALDVK should create a clear plan of measures for the earliest possible detection, treatment and prevention of complications of dermatosis, as well as, develop algorithms and protocols for the treatment of patients with various clinical types and forms of psoriasis on the basis of the latest national and international scientific achievements. Only the joint efforts of the association of dermatologists and a significant part of the medical community (pediatricians, cardiologists, endocrinologists, immunologists) under the leadership of the National Health Service of Ukraine and the Ministry of Health of Ukraine can defeat this disease, since the epidemiological and therapeutic aspects of psoriasis are not purely dermatological problems.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83524182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined treatment of actinic keratosis with carbon dioxide laser and imiquimod","authors":"M. Zapolsky, M. Lebediuk, Yu.V. Tepliuk, L. Tymofieieva","doi":"10.30978/ujdvk2022-3-4-36","DOIUrl":"https://doi.org/10.30978/ujdvk2022-3-4-36","url":null,"abstract":"Objective — to increase the effectiveness of treatment of various forms of actinic keratosis (AK) with application of topical immunoregulator imiquimod in combination with carbon dioxide (СО2) laser in the form of dermal optical thermolysis (DOT). \u0000Materials and methods. 95 patients with various forms of AK were under observation. They were divided into two groups: the main group (50 persons) and the control group (45 persons). Patients of both groups used imiquimod as the main method of treatment for AK. In the main group, before applying imiquimod, additional treatment of AK zone was carried out 1 cm along the peripheral area with a СО2-laser in the form of DOT. \u0000Results and discussion. The results of treatment of patients of both groups were evaluated 10, 20 and 60 days after the last application of imiquimod. The following characteristics were analyzed: soreness during and after the procedure, speed of epidermis recovery, presence or absence of dermatoscopic signs of AK, formation of complications (scarring or dyschromic), absence or presence of disease recurrences within 2 months. It was noted that combined treatment with imiquimod and СО2-laser slowed down the epithelialization of the affected areas (up to 20 days in 37 (39.5 %) patients of the main group and only in 19 (20 %) patients of the control group), by increasing the depth and intensity of the intervention, but it slightly increased the effect of post-traumatic hyperpigmentation (after 60 days) in 5 (5.2 %) patients of the main group and in 3 (3.1 %) patients of the control group. This therapy reduced the number of AK recurrences (especially in the hyperkeratotic form) by 3.2 % compared to the imiquimod monotherapy and had a positive effect on the rate of disappearance of dermatoscopic signs of AK (20 days after the end of treatment, they were observed only in 2 (2.1 %) patients of the main group and in 7 (7.5 %) patients of the control group). \u0000Conclusions. The combined treatment of AK that includes the application of imiquimod and the use of СО2-laser is promising, etiopathogenetically justified and well tolerated.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81706020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of specific autoimmune disorders in the pathogenesis of psoriasis and the prospects of immunobiological therapy of dermatosis","authors":"K. S. Tkachyshyna","doi":"10.30978/ujdvk2022-3-4-12","DOIUrl":"https://doi.org/10.30978/ujdvk2022-3-4-12","url":null,"abstract":"Objective — to analyze the features of specific autoimmune disorders in patients with psoriasis, determine their importance in the pathogenesis of this dermatosis, and assess the prospects of immunobiological therapy for dermatosis. \u0000Materials and methods. Based on an in-depth analysis of the results of modern special studies, the leading role of specific autoantigens and autoantibodies in the body of patients with this dermatosis has been confirmed in the pathogenesis of psoriasis. \u0000Results and discussion. The article analyzes the importance of specific autoantigens, including keratin-17, LL-37, ADAMTSL5, and lipid antigens generated by PLA2G4D, which are essential in the pathogenesis of psoriasis. Emphasis is placed on the potential importance of immunobiological therapy, which significantly decrease levels of autoantigens LL-37 and ADAMTSL5 in areas of skin affected by psoriatic rash. The prospects of therapeutic approaches to the inhibition of cytokines derived from T cells and innate cells, such as IL-17, as well as to the inhibition of PLA2G4D or CD1a are also considered. Further study of specific autoimmune disorders in patients with psoriasis is important to improve therapeutic approaches to the treatment of psoriasis. \u0000Conclusions. Autoimmune disorders, combined with genetic and a number of other factors, are one of the important of the development of psoriasis. Analysis of the results of current special studies has promising therapeutic value because, in addition to supporting approaches to inhibiting cytokines derived from T cells and dendritic cells, they support the development of approaches to inhibiting autoantigens directly.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91525993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical case of Kavasaki syndrome","authors":"V. Tkach, M. Voloshynovych, B. Zubyk, L.A. Vitovska, Yu.V. Tsipochka, N. Kozak","doi":"10.30978/ujdvk2022-3-4-24","DOIUrl":"https://doi.org/10.30978/ujdvk2022-3-4-24","url":null,"abstract":"Kawasaki syndrome is rare in Europe. This relatively «young» disease was first described by Japanese pediatrician Tomisaku Kawasaki in 1967. The causes of the disease are not clear. Most scientists tend to believe that the disease is triggered by existing foci of infection of viral or bacterial origin in the body, causing inflammation and damage to blood and lymphatic vessels. Kawasaki syndrome is a non­contagious disease, but cases of recurrence have been described.Patients with a high temperature, in the range of 38—40 °C, develop polymorphic rashes: roseola, erythema, urticaria, papules that can mimic measles or scarlet fever. Children are tearful, irritable, often wake up, suffer from diarrhea, abdominal pain. The rash affects the extremities and torso. The lower and upper extremities are swollen; especially pronounced swelling is on the palms, soles and fingers. After 1,5—2 weeks there is a lamellar peeling of the fingertips and toes. The interphalangeal joints are swollen, active movements in children’s joints cause pain and crying as a result. The mucous membranes of the oral cavity are hyperemic, the tongue is deep red (crimson), cheilitis is also diagnosed. There are three phases of the disease: acute — within 2 weeks since the onset, subacute — from 2 to 4 weeks, the recovery phase — from 1 to 3 months. In most patients, the cervical lymph nodes are affected, often one node is palpated ranging in size from 1 to 1.5 cm in diameter. There are no specific laboratory tests to diagnose the syndrome.Considering the sporadic nature and complexity of the diagnosis, we present a clinical case of Kawasaki syndrome in a 3.5­year­old boy. The probable cause of the disease was a combination of chickenpox virus and COVID­19. The variety of symptoms of the syndrome led to diagnostic errors and, accordingly, influenced the tactics of treatment of the primary care physician. Clinical manifestations, complications, route of the patient, complex treatment and rehabilitation are described.In our report, we have focused the attention of pediatricians, family physicians and dermatologists on the fact that Kawasaki syndrome is not a rare disease during the pandemic, and the combination of COVID­19 with other viral and microbial infections led to a multifold increase in the likelihood of serious complications. Timely diagnosis and rational therapy are the prevention of diagnostic errors and complications.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82133809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cold urticaria in the doctor’s practice","authors":"A. Bogomolov","doi":"10.30978/ujdvk2022-1-2-55","DOIUrl":"https://doi.org/10.30978/ujdvk2022-1-2-55","url":null,"abstract":"Objective — to improve the methods of differential diagnosis and management of patients with cold urticaria. \u0000Materials and methods. A review of the literature is presented and diagnostic approaches and principles of management of patients with cold urticaria are analyzed. \u0000Results and discussion. Cold urticaria is characterized by itching, angioneurotic edema, or both, with or without anaphylaxis which occurs in response to cooling of the skin and/or mucous membranes. The incidence of cold urticaria is estimated at 0.05 %, with higher rates in cold climates. It is believed that the symptoms of urticaria are primarily related to the activation of mast cells in the skin. However, in recent years, data have emerged highlighting the possible role of blood coagulation in the pathophysiology of the disease. In some patients, in parallel with the development of cold urticaria in response to cold factors, especially cold air, there may be reactions that are clinically similar to sinusitis, conjunctivitis and bronchial asthma, although it may coexist with other types of urticaria. The main principles of treatment of patients with urticaria are: identification of causative factors, education of patients and prevention of contact with causative factors, and stepwise pharmacotherapy. \u0000Conclusions. Cold urticaria is a subtype of chronic induced urticaria that has all the features of this heterogeneous group of diseases, but is still poorly understood in terms of both pathogenesis and real epidemiology. Elimination measures, patient education and treatment according to existing algorithms can significantly improve the quality of life of patients, which is a priority for the treatment of any chronic disease.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81918918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of self­esteem quality of life by health workers during the Coronavirus pandemic in 2020—2021","authors":"O. Fedorenko, K. Kolyadenko, L.V. Sologyb","doi":"10.30978/ujdvk2022-1-2-11","DOIUrl":"https://doi.org/10.30978/ujdvk2022-1-2-11","url":null,"abstract":"A relatively new term, VUCA, has emerged in the modern information field. It clearly reflects 4 essential features of modern life: Volatility — due to the need to study many factors that change in the decision-making process; Uncertainty — the inability to see and predict the future prospects; Complexity — lack of clarity of understanding of many events; Ambiguity — uncertainty of interpretation of the situation. This could not but affect the self-esteem of young health professionals of their quality of life (QOL) during 2020 and 2021. \u0000Objective — to remotely monitor the dynamics of changes in self-esteem of certain indicators of quality of life (QOL) in young health professionals depending on their professional background against the negative impact of chronic stress (infodemia), various administrative quarantine restrictions and forced professional communication with various patients with somatic diseases. during the COVID-19 pandemic during 2020—2021. \u0000Materials and methods. The study used: general clinical methods — for the overall assessment of somatic condition; psychodiagnostic survey – adapted SF-36 questionnaire to determine QOL; biostatistical methods — for the purpose of mathematical processing of the received data. \u0000Results and discussion. Interpersonal contacts with 4th year students of medical and dental faculties related to remote testing for the period from spring 2020 to December 2021 took place exclusively remotely due to quarantine restrictions and mainly at the initiative of health workers themselves, who learned about the possibility to effectively assess their psychological state and QOL.An objective analysis of the dynamics of self-assessment by young health workers of their own QOL over the past two years shows their successful psychosomatic adaptation to learning and clinical work in complex, unpredictable due to instability, ambiguity and some uncertainty in the 2020—2021 pandemic. Their average self-assessment of QOL should be considered as a kind of positive standard control when compared with data from similar tests conducted among other segments of the population. \u0000Conclusions. An objective analysis of the dynamics of self-esteem by young physicians of their own QOL over the past two years shows their successful psychosomatic adaptation in the pandemic of 2020—2021. They should be considered as a kind of positive standard when compared with data from similar testing of other segments of the population in these years.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82482928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of emergency remote dermatological care in wartime","authors":"K. Kolyadenko, O. Fedorenko","doi":"10.30978/ujdvk2022-1-2-26","DOIUrl":"https://doi.org/10.30978/ujdvk2022-1-2-26","url":null,"abstract":"On February 24, 2022, the sudden aggression of the Russian Federation against Ukraine began. The usual way of life has changed. Due to the real risks to life, the traditional majority of medical services and outpatient consultations have become impossible. The question arose as to how to provide dermatological care to patients in this situation. At this time, especially useful was the use of the Internet, namely Facebook and Telegram. \u0000Materials and methods. We created several posts on Facebook where announced free online medical consultation during the war. Moreover, a Telegram channel was created. Any doctor could register there at will, and with the help of a bot they received requests from patients in their specialty. \u0000Results and discussion. For the first 10 days of war, we received around 200 requests from patients with dermatological problems. Most (95 %) of these patients had allergic reaction or herpes, others had an exacerbation of psoriasis or pityriasis rosea.A comparative analysis of patients’ appeals showed a sharp increase in allergic skin diseases caused by the herpes virus. Moreover, such allergic reactions have been observed in people who have not previously had similar skin problems. In two cases of herpes simplex, the rash spread to the entire skin of the face, which could have been caused by sudden and significant stress due to information about bombings and rocket attacks. Only one patient who has approached us since the beginning of the war had hemorrhagic vasculitis due to severe comorbidity and not directly due to stress. Unfortunately, in the future we will probably only see a worsening of this situation. The consequences of prolonged stress due to forced stay in the war zone will have a negative impact on the health of our patients for a long time to come. \u0000Conclusions. The transition to remote medical counseling for dermatological patients, forced by wartime circumstances, proved to be quite successful in terms of its clinical results, although it significantly reduced the number of such appeals. At the same time, it allowed more extensive use of free remote assistance from foreign clinicians. Both in the initial unmotivated appearance of various skin rashes and in the exacerbation of chronic dermatoses, the objective stressful situation of the sudden Russian military aggression was dominant.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75568680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of non­hormonal cream Solivin™ in combination with selective phototherapy in treatment of chronic skin dermatoses","authors":"I.V. Kadyhrob, N.V. Khytryna, N.V. Gutsu, V.B. Chirva","doi":"10.30978/ujdvk2022-1-2-31","DOIUrl":"https://doi.org/10.30978/ujdvk2022-1-2-31","url":null,"abstract":"Objective — determining the therapeutic efficacy of a six-week use of Solivin™ cream among patients with plaque psoriasis and eczema. \u0000Materials and methods. 60 patients aged 18 to 60 years were monitored. There were 30 people with plaque psoriasis including 10 men and 20 women, and 30 people — with chronic eczema including 12 men and 18 women. \u0000Results and discussions. The PASI index decreased from moderate to mild severity in 100 % of patients with psoriasis when using Solivin™ cream (monotherapy), residual effects in the form of erythema were observed in 42 % of patients. The PASI index decreased to mild severity in 100% of patients when using Solivin™ cream in combination with selective phototherapy (SFT 311 nm), and residual erythema was observed in 28 % of patients. The eczema area and severity index (EASI) decreased to moderate severity in 62 % of patients with eczema after using Solivin™ cream (monotherapy) and in 5 % of patients decreased to mild. 33 % of patients had no clinical manifestations. Residual effects expressed as erythema were observed in 24% of patients. The EASI index significantly decreased to mild in 44 % of patients when using Solivin™ cream in combination with SFT (311 nm), and to moderate in 56 % of patients. No side effects were observed. All patients tolerated the treatment well. \u0000Conclusions. High efficiency of Solivin™ cream for problematic skin was observed. The balanced combination of organic active ingredients allows long-term use of the cream without restrictions on the size of the area and the amount of application of the product. When used both as monotherapy and in combination with SFT, a significant decrease in PASI and EASI indices as well as all indicators of clinical manifestations of chronic skin diseases were revealed.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90966712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing of some cosmetic and hygiene products of the CHOICE campany in patients with chronic dermatoses using skin application tests","authors":"P. Fedorych, S. Ostapenko, N.E. Kovalevska, E. Zakharchuk, O. V. Demchenko, O.P. Novakovska","doi":"10.30978/ujdvk2022-1-2-36","DOIUrl":"https://doi.org/10.30978/ujdvk2022-1-2-36","url":null,"abstract":"Objective — using skin application samples to test for allergenicity of some cosmetic and hygienic environmentally friendly products of the CHOICE campany in patients with chronic recurrent dermatosis — eczema, atopic dermatitis and psoriasis. \u0000Materials and methods. With the help of skin application tests, some cosmetic and hygiene products of the CHOICE (Ukraine) company were tested in 36 patients with the most common chronic recurrent dermatosis — eczema, atopic dermatitis and psoriasis. The test products were applied to dry skin, free from rashes and topical medications, under a medical patch. Samples were counted on the 2nd, as well as on the 4th—5th and 7th—8th days after application. \u0000Results and discussion. No skin reactions were recorded in patients with psoriasis who participated in the study. The phenomena of contact dermatitis were observed in contact with only one type of tested product, namely, «Gentle Phytomousse» of the «Seaweed» line for washing all skin types. This type of product was allergenic for 1 out of 6 patients with true eczema and 4 out of 9 patients with atopic dermatitis. Other types of products did not cause any phenomena of contact dermatitis at all in the observed patients. \u0000Conclusions. Four of the five CHOICE (Ukraine) products tested by skin application trials, namely: ECO liquid soap, Green max.; egg shampoo for dry and damaged hair line Intensive Moisturizer, White mandarin; Soft and velvety skin hand and body milk, White mandarin; Soft and velvety skin shower gel, White mandarin can be used in patients with eczema, atopic dermatitis and psoriasis without prior allergy testing. Gentle Phytomousse for washing all skin types of the Seaweed line can cause contact dermatitis in patients with true eczema and atopic dermatitis.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82555793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithm of topical oxidant application in the treatment of seborrheic keratosіs based on ultrasound and pathomorphological features","authors":"G. Makurina, L. О. Cherneda","doi":"10.30978/ujdvk2022-1-2-41","DOIUrl":"https://doi.org/10.30978/ujdvk2022-1-2-41","url":null,"abstract":"Objective — to develop an algorithm for the use of a topical oxidizing agent (hydrogen peroxide) in the treatment of seborrheic keratosis (SK), taking into account the ultrasound (US) and pathomorphological data and using statistical models. \u0000Materials and methods. 35 patients aged 35 to 75 (32 (91.4 %) women and 3 (8.6 %) men) with seborrheic keratomas were examined on the basis of «University Clinic» Medical Educational and Scientific Center of Zaporizhzhia State Medi­cal University. Clinical, dermatoscopic and pathomorphological research methods were used for diagnostic purposes. To determine the thickness of keratosis, an ultrasound scan was performed. \u0000Results and discussion. Topical adapalene was applied locally to SK foci for 2 weeks, 2 times a day in 35 patients. After retinoid administration, the thickness of most foci decreased (n = 26; 74.3 %), but some of them did not change significantly (n = 9; 25.7 %). For the purpose of chemical destruction, it was recommended to use a topical oxidant — 30 % solution of hydrogen peroxide. Group 1 (application of topical oxidant in one cycle) included 20 patients who used the remedy for 5—6 days. The duration of treatment for ≥ 7—10 days was recommended for 15 patients of group 2. A comparison of keratoma thickness in patients of both groups with different duration of oxidant use revealed a statistically significant difference between subgroups (U = 88.500; p < 0.05). The greater the thickness of the keratoma was, the more it needed additional application of hydrogen peroxide. Taking into account the pathomorphological and ultrasound signs, a discriminant analysis was performed between groups of patients with 1 and 2 cycles of hydrogen peroxide application. In case of less than 0 index, longer therapy was recommended. \u0000Conclusions. The scheme using topical oxidant is a promising area of treatment for patients with SK and requires further study. The application of statistical methods made it possible to identify the main variable features (pathomorphological variant and keratoma thickness), which determine the choice of the duration of hydrogen peroxide application.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86189562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}