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The Oxford Handbook of Neuronal Protein Synthesis最新文献

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FMRP and MicroRNAs in Neuronal Protein Synthesis 神经元蛋白合成中的FMRP和microrna
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190686307.013.15
Monica C. Lannom, S. Ceman
{"title":"FMRP and MicroRNAs in Neuronal Protein Synthesis","authors":"Monica C. Lannom, S. Ceman","doi":"10.1093/oxfordhb/9780190686307.013.15","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190686307.013.15","url":null,"abstract":"New protein synthesis is critical for learning and memory. The discovery of ribosomes at synapses indicated the potential for local protein synthesis in response to stimulation. miRNAs play a key role in this process as evidenced by their role in normal neuronal development and function and in neurological disease. miRNA production is regulated and once bound by AGO2, the ensuing RISC complex is able to bind mRNAs and direct their translation suppression and degradation. However, other RNA binding proteins, including FMRP and MOV10, regulate AGO2 association with the miRNA recognition element (MRE) in target mRNAs. AGO2 itself is regulated by post-translational modifications, and neuronal activity controls post-translational modifications of FMRP and MOV10 that lead to their regulation and degradation. In addition, RNA localization at the synapse is a critical regulated event that depends on both cis sequences in the mRNA and the identity of the bound RNA binding proteins.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115173118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal mRNA Translation in Addiction 成瘾中的神经元mRNA翻译
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190686307.013.19
E. Puighermanal, E. Valjent
{"title":"Neuronal mRNA Translation in Addiction","authors":"E. Puighermanal, E. Valjent","doi":"10.1093/oxfordhb/9780190686307.013.19","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190686307.013.19","url":null,"abstract":"Addictive drugs trigger persistent synaptic and structural changes in the neuronal reward circuits that are thought to underlie the development of drug-adaptive behavior. While transcriptional and epigenetic modifications are known to contribute to these circuit changes, accumulating evidence indicates that altered mRNA translation is also a key molecular mechanism. This chapter reviews recent studies demonstrating how addictive drugs alter protein synthesis and/or the translational machinery and how this leads to neuronal circuit remodeling and behavioral changes. Future work will determine precisely which neuronal circuits and cell types participate in these changes. The chapter summarizes current methodologies for identifying cell type-specific mRNAs whose translation is affected by drugs of abuse and gives recent examples of the mechanistic insights into addiction they provide.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126933904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of Synaptic Homeostasis by Translational Mechanisms 翻译机制对突触稳态的调节
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190686307.013.14
M. Mori, Jay Penney, Pejmun Haghighi
{"title":"Regulation of Synaptic Homeostasis by Translational Mechanisms","authors":"M. Mori, Jay Penney, Pejmun Haghighi","doi":"10.1093/OXFORDHB/9780190686307.013.14","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190686307.013.14","url":null,"abstract":"The ability of synapses to modify their functional properties and adjust the amount of neurotransmitter release at their terminals is essential for formation of appropriate neural circuits during development and crucial for higher brain functions throughout life. Many forms of synaptic plasticity can adjust synaptic strength down (depression) or up (potentiation); however, depending on the cellular context as the forces of change act upon the synapse, other synaptic mechanisms are activated to resist change. This form of synaptic plasticity is generally referred to as homeostatic synaptic plasticity. Accumulating experimental evidence indicates that translational mechanisms play a critical role in the regulation of homeostatic synaptic plasticity. This chapter will review studies that contribute to this body of evidence, including a role for the target of rapamycin in the retrograde regulation of synaptic homeostasis.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122045140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Translational Controls in Pain 疼痛的转化控制
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190686307.013.22
S. Loerch, J. B. de la Peña, Jane Song, J. Pancrazio, Theodore John Price, Z. Campbell
{"title":"Translational Controls in Pain","authors":"S. Loerch, J. B. de la Peña, Jane Song, J. Pancrazio, Theodore John Price, Z. Campbell","doi":"10.1093/oxfordhb/9780190686307.013.22","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190686307.013.22","url":null,"abstract":"Pain is an unpleasant but essential sensation. On a cellular level, pain typically originates in sensory neurons called nociceptors. They undergo rapid increases in cap-dependent translation in response to noxious stimuli. The specificity of translational controls in nociceptors is governed by regulatory factors and mRNAs that collaborate to ensure precise temporal and spatial regulation of protein synthesis. Multiple signaling pathways bridge extracellular cues to nascent translation, including the mammalian target of rapamycin (mTOR), AMP-activated protein kinase (AMPK), and the integrated stress response (ISR). The torrent of information on both mechanisms and targets of translational controls in nociceptive circuits supports an enticing corollary. Targeted inhibition of aberrant translation in the cells responsible for the genesis of pain signals in the periphery affords a new strategy to prevent or reverse chronic pain states. We describe the implications of emerging insights into translational controls predominantly in the peripheral nervous system on the search for safer and more specific pain therapeutics.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130232122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Protein Synthesis and Synapse Specificity in Functional Plasticity 功能可塑性中的蛋白质合成和突触特异性
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190686307.013.16
Radha Raghuraman, Amrita Benoy, Sajikumar Sreedharan
{"title":"Protein Synthesis and Synapse Specificity in Functional Plasticity","authors":"Radha Raghuraman, Amrita Benoy, Sajikumar Sreedharan","doi":"10.1093/OXFORDHB/9780190686307.013.16","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190686307.013.16","url":null,"abstract":"This chapter discusses the role of protein synthesis in the maintenance of long-term potentiation (LTP) and its associative properties, synaptic tagging and capture, which are cellular correlates of long-term memory. Starting from a brief overview of the early and late phases of LTP, the chapter discusses various existing models for synaptic activity-induced protein synthesis and its roles in late-LTP. The synaptic tagging and capture and cross-tagging theories are given emphasis, along with the elucidation of local dendritic protein synthesis and its significance in the maintenance of LTP. Inverse synaptic tagging, synaptic competition for plasticity-related proteins, and metaplasticity are also covered. The importance of the balance between proteasomal degradation and synthesis of plasticity-related proteins in persistent potentiation is briefly discussed. This chapter touches upon the physiological implications of epigenetic regulation in the control of neuronal functions and the molecular mechanisms within the neurons that translate epigenetic changes into long-lasting responses.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"147 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129908124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation 树突靶向和调控RNA调控局部神经元翻译
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190686307.013.8
T. Eom, I. Muslimov, A. Iacoangeli, H. Tiedge
{"title":"Dendritic Targeting and Regulatory RNA Control of Local Neuronal Translation","authors":"T. Eom, I. Muslimov, A. Iacoangeli, H. Tiedge","doi":"10.1093/OXFORDHB/9780190686307.013.8","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190686307.013.8","url":null,"abstract":"This chapter reviews current developments in the area of translational control in neurons. It focuses on the activity-dependent translational modulation by neuronal regulatory RNAs, including underlying interactions with eukaryotic initiation factors (eIFs), and on the role of such modulation in locally controlled protein synthesis in synapto-dendritic domains. It highlights the role of dendritic RNA targeting as a key prerequisite of local translation at the synapse and discusses the significance of these mechanisms in the expression of higher brain functions, including learning, memory, and cognition. The chapter concludes with discussion of anticipated future work to continue to elucidate these mechanisms and provide advances in the area of translational regulation in neurons and our understanding of how translational dysregulation contributes to neurological and cognitive disorders.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131001389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis 神经干细胞发育和神经发生中的蛋白质合成和翻译控制
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190686307.013.21
Lamees Mohammad, J. Wiseman, Sarah L. Erickson, Guang Yang
{"title":"Protein Synthesis and Translational Control in Neural Stem Cell Development and Neurogenesis","authors":"Lamees Mohammad, J. Wiseman, Sarah L. Erickson, Guang Yang","doi":"10.1093/oxfordhb/9780190686307.013.21","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190686307.013.21","url":null,"abstract":"Neural stem/progenitor cells (NSCs) are the origin of almost all neural cells in the mammalian brain and generate neurons throughout life. The balance of NSC maintenance and differentiation is thus critical for brain development and function. This balance is precisely controlled by sophisticated gene expression programs at multiple levels. While transcriptional regulation is vital for many aspects of neurogenesis from NSCs, recent studies highlight that protein synthesis controlled by spatiotemporal translational programs plays an equally important role in NSC lineage progression and fate decision. Alterations in coordinated translational programs underlie the pathogenesis of some human diseases. In this review, we discuss how protein synthesis changes in NSCs during neurogenesis, how it is regulated in a global or gene-specific manner by the orchestrated action of the translational machinery and RNA-binding proteins, and how deregulation of protein synthesis in NSCs contributes to neurodevelopmental disorders.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132685248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Translational Control Through the EIF4E Binding Proteins in the Brain 脑内EIF4E结合蛋白的翻译控制
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190686307.013.5
A. Aguilar-Valles, E. Matta-Camacho, N. Sonenberg
{"title":"Translational Control Through the EIF4E Binding Proteins in the Brain","authors":"A. Aguilar-Valles, E. Matta-Camacho, N. Sonenberg","doi":"10.1093/OXFORDHB/9780190686307.013.5","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190686307.013.5","url":null,"abstract":"Translation of messenger RNA (mRNA) into protein (protein synthesis) is a highly regulated process that controls gene expression. Various signaling pathways, including the mammalian target of rapamycin (mTOR), control mRNA translation at the initiation step. mTOR is part of a multi-subunit complex that regulates mRNA translation initiation by phosphorylating and inactivating the eukaryotic initiation factor 4E binding proteins (4E-BPs). 4E-BPs are a central mechanism in the control of cap-dependent translation in the brain. This chapter reviews the involvement of the 4E-BPs, particularly 4E-BP2, in brain development and synaptic transmission. Furthermore, it discusses the involvement of 4E-BP2 in autistic-like alterations, learning and memory, circadian rhythm regulation, and its roles in the pathophysiology and treatment of psychiatric (depressive disorders, schizophrenia) and neurodegenerative disorders (Parkinson’s).","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123869330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis 神经元蛋白合成中内部核糖体进入位点介导的翻译
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/OXFORDHB/9780190686307.013.9
M. Holcik
{"title":"Internal Ribosome Entry Site-Mediated Translation in Neuronal Protein Synthesis","authors":"M. Holcik","doi":"10.1093/OXFORDHB/9780190686307.013.9","DOIUrl":"https://doi.org/10.1093/OXFORDHB/9780190686307.013.9","url":null,"abstract":"While the majority of cellular mRNAs are translated by a cap-dependent mechanism, a subset of mRNAs can use an alternative mode of translation that, instead of cap, relies on discreet RNA elements that help to recruit the ribosome. This mode of translation, termed Internal Ribosome Entry Site (IRES)–dependent translation, is particularly important during conditions of compromised global protein synthesis or for a local, precisely timed translation of specific mRNAs. This latter purpose is of considerable importance in cells of the CNS for their normal function. Recently, the disruption of the IRES-mediated translation has also been linked to pathological processes, suggesting that full understanding and targeting of this peculiar mechanism could be used for therapeutic intervention.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128142122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dysregulated Protein Synthesis in Major Depressive Disorder 重度抑郁症中蛋白质合成失调
The Oxford Handbook of Neuronal Protein Synthesis Pub Date : 2018-03-07 DOI: 10.1093/oxfordhb/9780190686307.013.3
Chelcie F. Heaney, K. Raab-Graham
{"title":"Dysregulated Protein Synthesis in Major Depressive Disorder","authors":"Chelcie F. Heaney, K. Raab-Graham","doi":"10.1093/oxfordhb/9780190686307.013.3","DOIUrl":"https://doi.org/10.1093/oxfordhb/9780190686307.013.3","url":null,"abstract":"Major depressive disorder is a debilitating disorder with a lifetime prevalence of 17% in the adult population. By reverse engineering how antidepressants work at the cellular level, significant progress has been made within the last decade regarding the underlying etiology of depression. Unexpectedly, dysregulation of protein synthesis pathways is at the core of depression. Activation of one or more mRNA translation, initiation, or elongation pathways (including mammalian target of rapamycin [mTOR] kinase, extracellular regulated kinase, and eukaryotic elongation factor 2) is central to symptomatic relief. In preclinical models of stress and/or depression, co-administration of antidepressants and pharmacological inhibitors of these pathways block hallmark characteristics of antidepressant efficacy, including upregulation of key synaptic proteins, increased dendritic and spine complexity, and antidepressant-like behaviors. In this chapter, we review studies demonstrating altered translational pathways in animal models, treated and untreated patients, with a focus on mTOR-regulated protein synthesis.","PeriodicalId":234037,"journal":{"name":"The Oxford Handbook of Neuronal Protein Synthesis","volume":"52 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123211348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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