Updates in Surgery最新文献_第6页

Risk factors for postoperative anastomotic leakage in obstructive left colonic carcinoma. 梗阻性左结肠癌术后吻合口瘘的危险因素分析。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-13 DOI: 10.1007/s13304-025-02231-z

Zhenzhen Liu, Chaowei Zhang, Binliang Zhao, Zhicheng Zhang, Yunjie Huang, Zhaohui Lin, Jie Qin, Lijun Huang

{"title":"Risk factors for postoperative anastomotic leakage in obstructive left colonic carcinoma.","authors":"Zhenzhen Liu, Chaowei Zhang, Binliang Zhao, Zhicheng Zhang, Yunjie Huang, Zhaohui Lin, Jie Qin, Lijun Huang","doi":"10.1007/s13304-025-02231-z","DOIUrl":"https://doi.org/10.1007/s13304-025-02231-z","url":null,"abstract":"Anastomotic leakage (AL) is one of the most severe complications of colon carcinoma surgery. This study aims to investigate the related factors of AL and evaluate the independent risk factors in predicting AL after one-stage resection and primary anastomosis (RPA) for obstructive left colonic carcinoma (OLCC) patients. The demographic and clinical data, intra-operative indexes, pathologic characteristics, and ileocecal valve status shown on CT of the patients with OLCC who submitted to one-stage RPA were retrospectively analyzed. They were divided into AL group and no AL group. All indexes of the two groups were compared and the independent risk factors for AL were investigated. Receiver operating characteristic (ROC) curve analysis was used to explore the ability of the statistically significant parameters to predict AL. A total of 141 patients (AL group, 15; no AL group, 126) were enrolled. There were no statistical differences in these indexes between the two groups except for BMI (P = 0.001), ALB (P = 0.020), lymphatic metastasis (P = 0.027), and ileocecal valve status (P < 0.001). BMI, ALB, and ileocecal valve status shown on CT were the independent risk factors for AL. A BMI and ALB cutoff value of 22.2 kg/m2 and 27.9 g/L showed the area under the curve (AUC 0.765; 95% CI 0.686-0.832 and 0.684; 95% CI 0.601-0.760) in predicting AL, separately. Higher BMI, lower ALB, and incontinent ileocecal valve shown on preoperative CT may indicate an increased risk of postoperative AL after one-stage RPA for OLCC patients.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does preservation of the ileocecal valve make a difference? A propensity score matched comparison of Deloyers procedure versus extended right hemicolectomy. 保留回盲瓣会有影响吗？倾向评分与Deloyers手术与扩展右半结肠切除术的比较相匹配。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-13 DOI: 10.1007/s13304-025-02159-4

Lukas Schabl, Philipp Schredl, Florentina Dermuth, Ruth Bogusch, Hermann Kessler, Jan Philipp Ramspott, Klaus Emmanuel, Tarkan Jäger, Jaroslav Presl

{"title":"Does preservation of the ileocecal valve make a difference? A propensity score matched comparison of Deloyers procedure versus extended right hemicolectomy.","authors":"Lukas Schabl, Philipp Schredl, Florentina Dermuth, Ruth Bogusch, Hermann Kessler, Jan Philipp Ramspott, Klaus Emmanuel, Tarkan Jäger, Jaroslav Presl","doi":"10.1007/s13304-025-02159-4","DOIUrl":"https://doi.org/10.1007/s13304-025-02159-4","url":null,"abstract":"Background: When performing left hemicolectomies, surgeons might encounter difficulties when restoring bowel continuity. Ileocecal valve resection and performing an ileosigmoid anastomosis is one possible solution. An alternative is preserving the ileocecal valve by counterclockwise rotation of the remaining colon, ensuring a tension-free anastomosis. This study compares functional outcomes after Deloyers procedure and extended right colectomy with an ileosigmoid anastomosis.Methods: Between 2008 and 2021, we included patients who underwent Deloyers procedure. Using propensity score matching, controls who underwent extended right hemicolectomy were identified. Perioperative outcomes were compared and patients were questioned using the St. Marks-score and the EORTC-29CR.Results: We identified 19 patients who underwent the Deloyers procedure and 28 controls. Both groups had comparable mean age (61.4 years, p = 0.3), gender distribution (women: 40%, p = 0.19), ASA classification (p = 0.89) and BMI (26.8 kg/m2, p = 74). Deloyers patients were less often treated for oncologic indications (53% vs. 86%, p = 0.02). Postoperative morbidity (37% vs. 36%, p = 0.99) and mortality (0 vs. 4%, p = 0.99) were similar. Deloyers patients reported worse body perception (83.3 vs. 100, p = 0.02), but frequency of bowel movements (2 vs. 3, p = 0.09) and use of antimotility agents (8% vs. 0%, p = 0.22) were comparable. The overall and individual results of the St. Marks and EORTC QLQ-CR29 questionnaires showed no significant differences (p > 0.05).Conclusion: In our study, patients who underwent Deloyers procedure showed no mortality and comparable morbidity, functional and quality of life outcomes to patients who underwent extended right hemicolectomy.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of anatomic landmarks during laparoscopic cholecystectomy with the use of artificial intelligence-a systematic review of the literature. 在腹腔镜胆囊切除术中使用人工智能检测解剖标志-对文献的系统回顾。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-12 DOI: 10.1007/s13304-025-02227-9

Dimitrios Kehagias, Charalampos Lampropoulos, Aggeliki Bellou, Ioannis Kehagias

{"title":"Detection of anatomic landmarks during laparoscopic cholecystectomy with the use of artificial intelligence-a systematic review of the literature.","authors":"Dimitrios Kehagias, Charalampos Lampropoulos, Aggeliki Bellou, Ioannis Kehagias","doi":"10.1007/s13304-025-02227-9","DOIUrl":"https://doi.org/10.1007/s13304-025-02227-9","url":null,"abstract":"Identifying the critical view of safety (CVS) and other safe anatomic landmarks during laparoscopic cholecystectomy (LC) is the cornerstone for avoiding bile duct injuries (BDI). Artificial intelligence (AI), which has infiltrated in the operating room, appears as a promising tool, enabling surgeons to safely dissect during LC. The aim of this study is to investigate the AI models and their performance for identifying these critical structures. A systematic literature review of the PubMed and Google Scholar databases was conducted using medical subject headings (MeSH). Studies presenting the application of AI models for identifying CVS and anatomic landmarks were included and analyzed in terms of performance and reliability. Clinical feasibility trials with preliminary data were separately analyzed. Seventeen studies were found eligible and analyzed for various parameters. Generating AI models for identifying CVS and anatomic landmarks during LC is feasible, while their performance in terms of accuracy, precision and recall has remarkably improved. Regarding their reliability, intersection over union (IoU) and F1/Dice scores have been improved, as well. AI models can be successfully deployed in the operating room, and could assist surgeons in decision-making. Implementation of AI during LC for identifying CVS and important anatomic landmarks appears as a feasible and promising option. Preliminary data are encouraging in terms of performance but still major obstacles and barriers need to be overcome. Whether this will lead to reduced BDIs and enhanced patient safety, requires more well-designed studies. PROSPERO database registration: (UIN: CRD42024557432).","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presidential address: current state and future prospects of the European Society of Endocrine Surgeons. 主席讲话：欧洲内分泌外科医师协会的现状和未来展望。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-08 DOI: 10.1007/s13304-025-02249-3

Marcin Barczyński, Thomas J Musholt, Marco Raffaelli

{"title":"Presidential address: current state and future prospects of the European Society of Endocrine Surgeons.","authors":"Marcin Barczyński, Thomas J Musholt, Marco Raffaelli","doi":"10.1007/s13304-025-02249-3","DOIUrl":"https://doi.org/10.1007/s13304-025-02249-3","url":null,"abstract":"The European Society of Endocrine Surgeons (ESES) was officially founded in Vienna in 2003, following discussions that began in the late 1990s. Its primary mission is to promote collaboration, research, and education in endocrine surgery across Europe. The society organizes biennial congresses and topic-specific conferences focused on guidelines and consensus statements. ESES has established partnerships with key organizations, including the Eurocrine Society, the Division of Endocrine Surgery (DES) of the European Union of Medical Specialists (UEMS), and the British Journal of Surgery Foundation, to enhance surgical standards, education, and research dissemination. In addition, ESES collaborates with various international endocrine surgery societies to further innovation and improve clinical outcomes. Recent initiatives include the accreditation of European surgical units as competence centers in endocrine surgery, ensuring high standards in training and practice. The field has seen transformative advancements, such as minimally invasive techniques, precision medicine, improved diagnostics, and multidisciplinary collaboration. These innovations were showcased at the 10th Biennial Congress of ESES in Rome in 2024, which marked the society's 20th anniversary and featured research presentations from international experts. This special issue of Updates in Surgery highlights key contributions from the congress, providing insight into the latest advancements shaping endocrine surgery.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: "An outcome analysis of utilizing contrast-free near-infrared autofluorescence imaging in thyroid cancer surgery: a retrospective study". 点评：“无对比近红外自体荧光成像在甲状腺癌手术中的疗效分析：一项回顾性研究”。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-07 DOI: 10.1007/s13304-025-02248-4

Qi Xu, Xiaohui Chen

引用次数: 0

Ligation of the intersphincteric fistula fract (LIFT) in complex anorectal fistulas: retrospective analysis of the outcomes in a tertiary hospital. 结扎复杂肛肠瘘的括约肌间瘘（LIFT）：回顾性分析在三级医院的结果。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-07 DOI: 10.1007/s13304-025-02174-5

Dirk Van De Putte, Martijn Depuydt, Jan Colpaert, Gabrielle H Van Ramshorst

{"title":"Ligation of the intersphincteric fistula fract (LIFT) in complex anorectal fistulas: retrospective analysis of the outcomes in a tertiary hospital.","authors":"Dirk Van De Putte, Martijn Depuydt, Jan Colpaert, Gabrielle H Van Ramshorst","doi":"10.1007/s13304-025-02174-5","DOIUrl":"https://doi.org/10.1007/s13304-025-02174-5","url":null,"abstract":"Anal fistula treatment remains a surgical challenge. This study focuses on the efficiency and safety of the Ligation of Intersphincteric Fistula Tract (LIFT) procedure for high intersphincteric anorectal fistulas, aiming to identify prognostic factors for success and complications. A retrospective chart review was conducted on all patients who underwent LIFT procedure at a tertiary referral hospital between January 2013 and January 2021. The primary endpoint was the success rate of fistula closure, confirmed with clinical investigation. Secondary endpoints included postoperative complications, reintervention and self-reported incontinence. Logistic regression analyses were performed for assessing prognostic factors for fistula closure and postoperative complications. Ninety-two patients were included in the study; after a median follow-up of 19.3 months, fistula closure was achieved in 71% (n = 65) and in 89% (n = 82) after reinterventions. 46% (n = 42) reported persistent symptoms, although 83% of which (n = 32/42) had succesful fistula tract closure by clinical evaluation. One patient developed incontinency for gas. Smoking emerged as a significant risk factor for fistula closure failure, OR = 6.75, 95% CI = [1.65, 27.69], p = 0.030. Wound dehiscence was the most common complication, occuring in 25% (n = 23). Prolonged oral antibiotics demonstrated a significant protective effect against wound dehiscence, OR = 0.31, 95% CI = [0.10, 0.96], p = 0.036. The LIFT procedure is an efficient and safe treatment for complex perianal fistula. Patient satisfaction emerged as a crucial treatment goal, as patients can remain symptomatic after fistula closure. Emphasizing smoking cessation is integral to the treatment approach. The findings suggest prolonged antibiotic treatment as a potential preventive measure for wound dehiscence.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of predictive factors for lymph node metastasis in thyroid microcarcinoma: a two-year experience from two high-volume centers. 甲状腺微癌淋巴结转移的预测因素评估：来自两个高容量中心的两年经验。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-07 DOI: 10.1007/s13304-025-02211-3

Giovanni Tacchi, Francesco Pedicini, Pierfilippo Crucitti, Massimo Carlini

{"title":"Evaluation of predictive factors for lymph node metastasis in thyroid microcarcinoma: a two-year experience from two high-volume centers.","authors":"Giovanni Tacchi, Francesco Pedicini, Pierfilippo Crucitti, Massimo Carlini","doi":"10.1007/s13304-025-02211-3","DOIUrl":"https://doi.org/10.1007/s13304-025-02211-3","url":null,"abstract":"Papillary thyroid carcinoma incidence has increased rapidly in recent decades with microcarcinoma (maximum diameter ≤ 10 mm) representing the majority of new diagnoses. Being its prognosis excellent and mortality steady after surgery, some authors suggested active surveillance for microcarcinoma. However, microcarcinomas with lymph node metastasis at diagnosis are not uncommon. We aimed to assess independent risk factors for lymph node metastasis in patients with microcarcinoma. From January 2022 to December 2023, 234 papillary thyroid carcinomas from Fondazione Policlinico Universitario Campus Bio-Medico of Rome and Sant'Eugenio Hospital in Rome were retrospectively analyzed. Age, sex, maximum diameter, lymph node metastasis, Hashimoto's Thyroiditis, multifocality, capsule invasion and histological subtype were considered. Papillary carcinomas were stratified according to size and lymph node metastasis. Microcarcinoma were 145 (62.5%) and lymph node metastasis occurred in 16.6% of them. Multivariate regression revealed that young age (OR 0.90; 95% CI 0.86-0.95; p < 0.001) and capsular invasion (OR \"presence\" = 3.36; 95% CI 1.16-9.76; p = 0.026) resulted as independent risk factors for lymph node metastasis in patients with microcarcinoma. Being younger than 40 years old emerged as a significant cutoff for risk stratification of lymph node metastasis. Lymph node metastasis rate in microcarcinoma is considerable. A more careful evaluation is required for young patients with peripheral microcarcinoma where a more aggressive surgical approach (e.g. prophylactic central lymph node dissection) may be theorized. New tools are essential for the pre-surgical detection of high risk papillary thyroid microcarcinoma.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intersegmental veins between segments 5 and 8 as a landmark along the intersegmental planes during laparoscopic anatomical segmentectomy for hepatocellular carcinoma. 在肝细胞癌腹腔镜解剖节段切除术中，5节段和8节段之间的节段间静脉作为沿节段间平面的标志。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-06 DOI: 10.1007/s13304-025-02080-w

Ke-Xi Liao, Li Cao, Rui Guo, Bao-Lin Wang, Jin-Ao Wang, Guang-Shen Zhang, Shu-Guo Zheng, Xiao-Jun Wang

{"title":"Intersegmental veins between segments 5 and 8 as a landmark along the intersegmental planes during laparoscopic anatomical segmentectomy for hepatocellular carcinoma.","authors":"Ke-Xi Liao, Li Cao, Rui Guo, Bao-Lin Wang, Jin-Ao Wang, Guang-Shen Zhang, Shu-Guo Zheng, Xiao-Jun Wang","doi":"10.1007/s13304-025-02080-w","DOIUrl":"https://doi.org/10.1007/s13304-025-02080-w","url":null,"abstract":"Laparoscopic anatomical hepatectomy (LAH) of segments 5 and 8 (LAHSg5/Sg8) for hepatocellular carcinoma (HCC) remains one of the most challenging procedures due to the difficulty in exposing the main vascular structure. The aim of our study was to investigate the anatomical characteristics of inter-SVs based on the three-dimensional (3D) visualization technology exploring its safety and feasibility during LAHSg5/Sg8. A total of 110 patients who underwent LAHSg5/Sg8 in our center between January 2019 and August 2022 were enrolled and analyzed retrospectively. During the operation, the inter-SVs of the first 10 patients were observed. Subsequently, 100 patients were included based on the previous intraoperative understanding. The anatomical parameters of inter-SVs and the perioperative outcomes were recorded and evaluated. The safety and short-term efficacy of LAHSg5/Sg8 were assessed. All the patients underwent preoperative 3D processing software analysis. Of the included patients, 74.6% had inter-SVs in Sg5/Sg8, which could be classified into three types: trunk type, double branch type and multi branch type, accounting for 35.4%, 22.2% and 17.0%, respectively. The concordance between pre-operation and intra-operation in terms of portal vein territory of Sg5/Sg8 was 82 ± 31%. The inlet point diameter was 3.3 ± 1.0 mm. The distance between the inter-SVs in Sg5/Sg8 and P8, point \"B\" were 17.7 ± 6.2 mm, 6.1 ± 17 mm, respectively. The confluence of inter-SVs in Sg5/Sg8 at \"point B\" and below accounted for 10.2%. Preoperative 3D reconstruction and personalized surgical planning based on individual anatomical variations are crucial for successful LAHSg5/Sg8. Inter-SVs between Sg5/Sg8 as a landmark along the ISP during LAHS for HCC may be safe and feasible.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline mutations of GCM2 cause a novel variant of hereditary primary hyperparathyroidism. GCM2的种系突变引起遗传性原发性甲状旁腺功能亢进的一种新变体。

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-06 DOI: 10.1007/s13304-025-02179-0

Maurizio Iacobone, Sara Watutantrige-Fernando, Stefania Zovato, Silvia Tognazzo, Silvia Dughiero, Veronica Augenti, Valentina Camozzi, Caterina Mian, Francesca Torresan, Claire Nomine-Criqui, Laurent Brunaud

{"title":"Germline mutations of GCM2 cause a novel variant of hereditary primary hyperparathyroidism.","authors":"Maurizio Iacobone, Sara Watutantrige-Fernando, Stefania Zovato, Silvia Tognazzo, Silvia Dughiero, Veronica Augenti, Valentina Camozzi, Caterina Mian, Francesca Torresan, Claire Nomine-Criqui, Laurent Brunaud","doi":"10.1007/s13304-025-02179-0","DOIUrl":"https://doi.org/10.1007/s13304-025-02179-0","url":null,"abstract":"Primary hyperparathyroidism (pHPT) occurs as hereditary disease in approximately 10% of cases. GCM2 germline mutations have been recently described as responsible for the development of a novel variant of hereditary pHPT. This study aimed to determine the features of GCM2-related pHPT. Demographics, laboratory, and surgical data were assessed in a series of 17 index cases carrying GCM2 mutations undergoing surgery for pHPT. The GCM2 germline pathogenic variant c.1181 A>C p.(Tyr394Ser) was detected in 59% of cases. GCM2-related pHPT was diagnosed at a median age of 57 years (range 32-82) with a Female/Male ratio 1.8. Preoperative median calcemia was 2.89 mmol/L (range 2.69-3.8). Family history of pHPT was absent in 65% of cases. Complete clinical, surgical and follow-up data were available for 13 patients. At initial surgery, bilateral neck exploration with subtotal parathyroidectomy was performed in 46% of patients; achieving cure in all cases at a median follow-up of 51 months (range 7-60). In the remaining cases undergoing selective parathyroidectomy, a persistent pHPT occurred in 3 cases; recurrent pHPT in 1 patient (after a disease-free interval of 4 years) while 3 are disease free at a mean follow-up of 21 months. Thus, at an overall prolonged follow-up (median 48 months, range 7-216), multiglandular involvement occurred in 77% of cases. GCM2 germline mutations may cause hereditary pHPT, even if it may mimic sporadic variant due to the absence of familial history and late onset. The main feature is multiglandular involvement, needing bilateral neck exploration and subtotal parathyroidectomy to achieve long-term cure.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between preoperative serum cystatin C levels and postoperative oncologic outcomes in patients with renal cell carcinoma: a systematic review and meta-analysis of 1641 patients. 肾细胞癌患者术前血清胱抑素C水平与术后肿瘤预后的关系：1641例患者的系统回顾和荟萃分析

IF 2.4 3区医学

Updates in Surgery Pub Date : 2025-05-06 DOI: 10.1007/s13304-025-02208-y

Shuai Lu, Yulin Wang, Zhongbao Zhou, Yong Zhang, Liqing Yang, Xudong Yang

{"title":"The relationship between preoperative serum cystatin C levels and postoperative oncologic outcomes in patients with renal cell carcinoma: a systematic review and meta-analysis of 1641 patients.","authors":"Shuai Lu, Yulin Wang, Zhongbao Zhou, Yong Zhang, Liqing Yang, Xudong Yang","doi":"10.1007/s13304-025-02208-y","DOIUrl":"https://doi.org/10.1007/s13304-025-02208-y","url":null,"abstract":"An increasing number of studies have indicated that cystatin C (CysC) may serve as an effective indicator for predicting the prognosis of renal cell carcinoma (RCC). However, there was currently a lack of meta-analysis examining the influence of serum CysC on the prognosis of RCC. From April 2016 to June 2024, we ultimately selected five retrospective studies including 1641 participants to evaluate the effect of serum CysC on patients with RCC. All data were analyzed using Review Manager version 5.3. The research findings primarily focused on overall survival (OS) and disease-free survival (DFS). Both univariate and multivariate analyses were conducted to evaluate the results. Five studies involving a total of 1641 patients were selected based on predefined eligibility criteria. Univariate analysis revealed that serum CysC levels were significantly correlated with OS (P < 0.00001) and DFS (P = 0.02) in postoperative patients with RCC. Elevated serum CysC levels were considered a reliable predictor of poor prognosis in patients with RCC. Multivariate analysis indicated that high serum CysC levels were an independent risk factor for OS (P < 0.00001) and DFS (P = 0.006) in postoperative patients with RCC, remaining unaffected by other factors. Our research results indicated that elevated serum CysC levels were associated with reduced OS and DFS in patients with RCC. However, caution must be exercised before making recommendations as this interpretation was based on very few clinical studies and small samples.","PeriodicalId":23391,"journal":{"name":"Updates in Surgery","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0