Transplantation最新文献

{"title":"Common Immunosuppressants Impair Recipient Immunity but do not Safeguard Donor Tissue-resident Immunity in Kidney Transplantation.","authors":"Sarah J Dart, Amy C Prosser, Liu Liu, Jaskirat Kaur, Xiao Zhang, Sean J O'Halloran, Rui Zhang, Bernadette K Williams, Ella L Trolio, Jason Madore, Wen Hua Huang, Priyanka K Pindoria, Francina Thomas, Andrew D Lucas, Gary P Jeffrey, David A Joyce, Michaela Lucas","doi":"10.1097/TP.0000000000005840","DOIUrl":"10.1097/TP.0000000000005840","url":null,"abstract":"<p><strong>Background: </strong>Immunosuppressive drugs have been used in transplantation for decades; however, their impact on donor and recipient leukocyte dynamics after transplantation have not been well defined.</p><p><strong>Methods: </strong>Murine mismatched kidney transplants were exposed to tacrolimus, mycophenolate, methylprednisolone, abatacept, and T-cell depletion therapy. Drug dosing was determined by pharmacokinetic analysis to mimic therapeutic levels of human kidney recipients. Donor and recipient leukocytes of 19 subsets, isolated from the graft and periphery after kidney transplantation in the presence of monotherapy or combination immunosuppression, were examined.</p><p><strong>Results: </strong>Immunosuppression significantly reduced recipient leukocyte infiltration into the graft. Additionally, methylprednisolone reduced peripheral leukocyte counts, while mycophenolate had a moderate effect. Tacrolimus was most immunosuppressive, reducing day 7 graft histological rejection scores, inducing changes in graft donor and recipient macrophage phenotypes, reducing T-cell co-inhibitory receptor and granzyme B expression, and peripheral leukocyte counts. Combination therapy with tacrolimus, mycophenolate, and methylprednisolone displayed an additive immunosuppressive effect. Despite these significant changes to recipient leukocyte immunity, the impact of conventional immunosuppressive agents on donor leukocyte retention was modest.</p><p><strong>Conclusions: </strong>These data confirm the critical importance of tacrolimus in preventing acute graft rejection. We demonstrate that conventional immunosuppressive strategies do not contribute to substantial donor leukocyte maintenance in grafted kidneys despite impairing recipient immunity, highlighting the need for alternative approaches to preserve beneficial donor immunity after kidney transplantation.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e2057-e2071"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148537009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Biology of Organ Preservation Extends Beyond the Liver.","authors":"Valeria R Mas, Bing Ma, Jonathan Bromberg","doi":"10.1097/TP.0000000000005887","DOIUrl":"10.1097/TP.0000000000005887","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":"110 10","pages":"e1981-e1982"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade of Progress in Uterus Transplantation in the United States: Results From the World Transplant Congress 2025.","authors":"Paige M Porrett, Liza Johannesson","doi":"10.1097/TP.0000000000005746","DOIUrl":"10.1097/TP.0000000000005746","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e1962-e1964"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of mTOR Inhibitors in CMV Prevention: An Overlooked Aspect of the Fourth International CMV Consensus Guidelines.","authors":"Björn Nashan","doi":"10.1097/TP.0000000000005852","DOIUrl":"10.1097/TP.0000000000005852","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e2144-e2145"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Donor Functional Warm Ischemic Time in Donation After Circulatory Death Organ Transplantation: Moving Beyond Arbitrary Thresholds.","authors":"Sophie P Ciere, Jeroen de Jonge, Frank J M F Dor","doi":"10.1097/TP.0000000000005871","DOIUrl":"10.1097/TP.0000000000005871","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e1992-e1993"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary Report of the Fifth International Pancreas and Islet Transplant Association Summit on Stem Cell-derived Islets.","authors":"Jon S Odorico, Antonio Citro, Eelco J P de Koning, Thomas H Kay, Esther Latres, Jeffrey R Millman, Maria Cristina Nostro, Lorenzo Piemonti, Michael R Rickels, Holger A Russ, Kevin Alessandri, Joana Almaça, Juan R Alvarez-Dominguez, Diego Balboa, Jessie M Barra, Thomas Bollenbach, Michael Brehm, Remi J Creusot, Jacques Galipeau, Alessandro Grattoni, Matthias Hebrok, Nathaniel Hogrebe, Christian Honore, Danwei Huangfu, Eddie A James, Norma S Kenyon, Minglin Ma, Marjana Marinac, Maki Nakayama, Audrey V Parent, Edward A Phelps, Alvin C Powers, Joseph Sushil Rao, Trevor Reichman, Bart O Roep, Sonja Schrepfer, Peter Stock, Piotr Witkowski, James F Markmann","doi":"10.1097/TP.0000000000005783","DOIUrl":"https://doi.org/10.1097/TP.0000000000005783","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149115381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying the Donation After Circulatory Death Process: Addressing Misunderstandings, Correcting Misinformation, and Building Trust Through Education.","authors":"Gabriel E Gondolesi, Marti Manyalich, Steven Potter, David Thomson, John Fung","doi":"10.1097/TP.0000000000005754","DOIUrl":"10.1097/TP.0000000000005754","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e1969-e1971"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147983413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Procurement Strategy and Ex Vivo Lung Perfusion in US Donation After Circulatory Death Lung Transplantation: Insights and Caveats From a United Network for Organ Sharing Cohort.","authors":"Kevin C McGann, Caitlin T Demarest","doi":"10.1097/TP.0000000000005875","DOIUrl":"10.1097/TP.0000000000005875","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e1990-e1991"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C5b-9 Deposition in Renal Transplant Biopsies Associates With Prolonged Delayed Graft Function in Kidneys Donated After Circulatory Death.","authors":"Laura W D Knijff, Mieke F van Essen, Daniëlle J van Gijlswijk-Janssen, Esther N M de Rooij, Jonna R Bank, Nicole Schlagwein, Jesper Kers, Johan W de Fijter, Rutger J Ploeg, Cees van Kooten","doi":"10.1097/TP.0000000000005815","DOIUrl":"10.1097/TP.0000000000005815","url":null,"abstract":"<p><strong>Background: </strong>Ischemia-reperfusion injury is a risk factor for delayed graft function (DGF). During reperfusion, the damaged tissues and cells are exposed to blood, thereby contributing to complement activation. The aim of this study was to investigate if complement activation correlates with the duration of DGF in donation after circulatory death (DCD) kidney transplants and whether it provides additional information beyond regular histology.</p><p><strong>Methods: </strong>In day-10 protocol, biopsies from 64 DCD recipients, complement deposition (C4d, C3d, C5b-9) was assessed by immunohistochemistry, quantified and correlated with fDGF duration (early graft function [≤7 d], intermediate [8-20 d], and prolonged duration [≥21 d]), as well as with Banff classification.</p><p><strong>Results: </strong>C4d and C3d deposition was not different between fDGF durations. In contrast, C5b-9 deposition was higher in recipients with prolonged DGF (median 8.1%) compared with those with early graft function (median 5.6%) and intermediate DGF (median 5.6%). Kidneys from expanded criteria donors exhibited significantly higher C5b-9 deposition compared with standard criteria donors ( P = 0.001), but no correlation with warm or cold ischemia times. Banff classification scores showed only significant associations of C4d with interstitial inflammation (i), total inflammation (ti), and arteriolar hyalinosis (ah). Similar results were found with semiquantitative complement scoring in specific kidney compartments. No significant associations were observed between C5b-9 deposition and any of the Banff scores.</p><p><strong>Conclusions: </strong>C5b-9 deposition is increased in DCD kidneys with prolonged fDGF, representing a marker not reflected by Banff scoring. Higher C5b-9 levels in expanded criteria donors kidneys suggest that intrinsic donor factors contributes to early complement activation after transplantation.</p>","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e2049-e2056"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Unmet Need: The Global Chasm Between Liver Disease Burden and Transplant Capacity.","authors":"Alissa M Cutrone, Heidi Yeh","doi":"10.1097/TP.0000000000005865","DOIUrl":"10.1097/TP.0000000000005865","url":null,"abstract":"","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":"e1988-e1989"},"PeriodicalIF":4.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148680137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}