Translational gastroenterology and hepatology最新文献_第8页

Advances in endoscopic resection: a review of endoscopic submucosal dissection (ESD), endoscopic full thickness resection (EFTR) and submucosal tunneling endoscopic resection (STER). 内镜下切除术的研究进展:综述了内镜下粘膜剥离术(ESD)、内镜下全层切除术(EFTR)和粘膜下隧道切除术(STER)。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-08-06 DOI: 10.21037/TGH-2019-IE-07

I. Dalal, Iman Andalib

{"title":"Advances in endoscopic resection: a review of endoscopic submucosal dissection (ESD), endoscopic full thickness resection (EFTR) and submucosal tunneling endoscopic resection (STER).","authors":"I. Dalal, Iman Andalib","doi":"10.21037/TGH-2019-IE-07","DOIUrl":"https://doi.org/10.21037/TGH-2019-IE-07","url":null,"abstract":"Subepithelial lesions are often detected incidentally in patients undergoing an endoscopy. They are common tumors of the gastrointestinal (GI) tract which can originate from different layers of the GI tract wall. These lesions can be further classified based on GI layer of origin and unique histochemical staining. While most are benign and asymptomatic, some of these lesions have malignant potential with distant metastases. However, current diagnostic modalities including endoscopy with biopsy or endoscopic ultrasound with fine needle aspiration are not always reliable. In addition, management of these lesions has historically involved surgical resection via open or laparoscopic approaches. In recent years, with advancement in endoscopic techniques and improvement in endoscopists' skills, less invasive procedures such as endoscopic submucosal dissection (ESD), endoscopic full thickness resection (EFTR) and submucosal tunneling endoscopic resection (STER) have been developed and now are being used by endoscopists worldwide. Upon reviewing the literature, multiple studies have shown the advantages of these endoscopic techniques when compared with surgical treatment. As a result, there has been a dramatic shift towards minimally invasive endoscopic procedures for the management of these subepithelial lesions. In this review article, we will discuss these endoscopic resection techniques in detail, their safety and efficacy, as well as comparison studies to other therapeutic modalities.","PeriodicalId":23267,"journal":{"name":"Translational gastroenterology and hepatology","volume":"21 1","pages":"19"},"PeriodicalIF":3.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83267388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Endoscopic bariatrics: current therapies and future directions. 内窥镜减肥:目前的治疗方法和未来的方向。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-08-05 DOI: 10.21037/TGH.2020.03.09

D. Reja, Clark Zhang, A. Sarkar

引用次数: 1

A primer to image enhanced endoscopy. 图像增强内窥镜的入门。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-13 DOI: 10.21037/TGH-2019-AESI-13

K. Ragunath, P. Chiu

{"title":"A primer to image enhanced endoscopy.","authors":"K. Ragunath, P. Chiu","doi":"10.21037/TGH-2019-AESI-13","DOIUrl":"https://doi.org/10.21037/TGH-2019-AESI-13","url":null,"abstract":"of endoscopic Imaging it also allows detailed understanding of the pathophysiology of various disease states. Probe based confocal endomicroscopy system (Mauna Kea) utilises low power laser light source for tissue illumination with the resultant reflected fluorescence light captured via a pin hole with focal plane being the same for illumination and reflectance thus increasing the spatial resolution. It has been extensively studied in the GI tract as well as biliopancreatic applications. The advantage of pCLE lies in its ability to be used with any endoscopy system and visualise at cellular level thus lending to molecular imaging. On the other hand, it is also a limitation since it cannot be used widely in community setting outside of Academic centres. The combination of widefield scanning and detailed imaging of surface and subsurface epithelium is now achieved in the oesophagus with volumetric laser endomicroscopy (VLE) which is a new endoscopic imaging technology (NvisionVLE Imaging System, NinePoint Medical) utilizing advanced optical coherence tomography with near infrared light and balloon - centered imaging probes that produce scans of 6 - cm segments of the oesophagus useful in Barrett’s surveillance endoscopy . Endocytoscopy is a variation from pCLE wherein higher magnification is achieved with a single integrated zoom lens providing continuous zoom-focus magnification up to 500× and observation range of 570 μm × 500 μm incorporated in a standard gastroscope colonoscope. This allows real time viewing at cellular level during routine upper or lower GI endoscopy field imaging Capsule finally series imaging st","PeriodicalId":23267,"journal":{"name":"Translational gastroenterology and hepatology","volume":"17 1","pages":"1"},"PeriodicalIF":3.0,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85780372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation. 非酒精性脂肪性肝病的发病机制及其对肝移植心血管预后的影响

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.12.02

Benedict J Maliakkal

{"title":"Pathogenesis of non-alcoholic fatty liver disease and implications on cardiovascular outcomes in liver transplantation.","authors":"Benedict J Maliakkal","doi":"10.21037/tgh.2019.12.02","DOIUrl":"https://doi.org/10.21037/tgh.2019.12.02","url":null,"abstract":"Along with the obesity epidemic there has been a major increase in non-alcoholic fatty liver disease (NAFLD) prevalence, paralleling a steady increase in cirrhosis of the liver and hepatocellular cancer (HCC) related to NAFLD. Currently, NAFLD (related HCC and cirrhosis) is the second most common cause for liver transplantation (LT) and it is projected to take the top spot in the next 3-5 years. Patients with NAFLD cirrhosis and HCC have a unique set of comorbidities which potentially increases their risk for cardiovascular disease (CVD) and mortality. However, a review of the published data in NAFLD patients who undergo LT, does not paint a clear picture. While CVD is the most common cause of non-graft related mortality over the long-term, the short and intermediate-term survival post LT in NAFLD cirrhosis appears to be on par with other etiologies when age and comorbidities are factored. The cardiovascular complications are increased in the immediate post-transplant period but there is a shift from ischemic complications to arrhythmias and heart failure (HF). NAFLD recurs in 80-100% patients and occurs de novo in about 50% after LT, potentially impacting their long-term morbidity and mortality. This review summarizes the available data on CVD in NAFLD patients before and after LT, explains what is currently known about the epidemiology and pathogenesis of CVD in NAFLD and posits strategies to improve wait-list and post-transplant survival.","PeriodicalId":23267,"journal":{"name":"Translational gastroenterology and hepatology","volume":"5 ","pages":"36"},"PeriodicalIF":3.0,"publicationDate":"2020-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/tgh.2019.12.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38124770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Endocytoscopy: technology and clinical application in the lower GI tract. 下消化道内吞镜检查技术及临床应用。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.12.04

Hiroyuki Takamaru, Shih Yea Sylvia Wu, Yutaka Saito

引用次数: 11

Acute-on-chronic liver failure in liver transplant candidates with non-alcoholic steatohepatitis. 非酒精性脂肪性肝炎肝移植候选者的急性慢性肝衰竭

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.10.01

Iliana Doycheva, Paul J Thuluvath

{"title":"Acute-on-chronic liver failure in liver transplant candidates with non-alcoholic steatohepatitis.","authors":"Iliana Doycheva, Paul J Thuluvath","doi":"10.21037/tgh.2019.10.01","DOIUrl":"https://doi.org/10.21037/tgh.2019.10.01","url":null,"abstract":"Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. It is expected that non-alcoholic steatohepatitis (NASH), NASH-related cirrhosis and its decompensated forms will increase further in the next two decades. Acute-on-chronic liver failure (ACLF) is a distinct syndrome characterized by rapid deterioration of liver function in patients with chronic liver disease that is associated with development of one or more organ failures, and carries a very high short-term mortality. There is a paucity of data on ACLF in patients with NASH cirrhosis. Recent studies have shown that although ACLF incidence due to NASH is lower when compared to other etiologies, NASH is the fastest growing liver disease etiology among all ACLF hospitalizations. Higher rates of infections, as a precipitating factor, and circulatory failure were noted in this population. Metabolic derangements such as obesity and diabetes might also play a confounding role in the pathophysiology, clinical course, and prognosis of NASH patients with ACLF. Patients with ACLF due to NASH have shown a lower inpatient mortality despite a longer hospital length-of-stay and a higher 28- and 90-day mortality. Patients with ACLF should be promptly transferred to a transplant center and evaluated for liver transplantation (LT). Optimal prognostic scores, timing of LT, and the best bridge to LT therapy and treatment of post-LT complications need to be elucidated in prospective studies.","PeriodicalId":23267,"journal":{"name":"Translational gastroenterology and hepatology","volume":"5 ","pages":"38"},"PeriodicalIF":3.0,"publicationDate":"2020-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/tgh.2019.10.01","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38126153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Donor age predicts calcineurin inhibitor induced neurotoxicity after liver transplantation. 供体年龄预测肝移植后钙调磷酸酶抑制剂引起的神经毒性。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.12.08

Giovanni Battista Levi Sandri, Valerio Giannelli, Giuseppe Maria Ettorre

引用次数: 10

Pancreatic cancer. 胰腺癌。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.12.15

Helmut Friess, Florian Scheufele

引用次数: 0

Hepatoblastoma: current knowledge and promises from preclinical studies. 肝母细胞瘤:目前的知识和临床前研究的前景。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.12.03

Diego F Calvisi, Antonio Solinas

引用次数: 17

Does laparoscopy decrease incisional hernia and bowel obstruction rates after rectal cancer surgery?-results of 5 years follow-up in a randomized trial (COLOR II). 腹腔镜能降低直肠癌术后切口疝和肠梗阻的发生率吗?-随机试验5年随访结果(COLOR II)。

IF 3 4区医学

Translational gastroenterology and hepatology Pub Date : 2020-07-05 eCollection Date: 2020-01-01 DOI: 10.21037/tgh.2019.12.12

Cigdem Benlice, Bilgi Baca

引用次数: 0