Transfusion Clinique et Biologique最新文献_第2页

Current challenges of blood transfusions in patients with thalassemia in India and future perspectives 当前印度地中海贫血患者输血面临的挑战及未来展望。

IF 1.4 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-03-20 DOI: 10.1016/j.tracli.2024.03.004

{"title":"Current challenges of blood transfusions in patients with thalassemia in India and future perspectives","authors":"","doi":"10.1016/j.tracli.2024.03.004","DOIUrl":"10.1016/j.tracli.2024.03.004","url":null,"abstract":"<div><p>The introduction of regular red blood cell transfusions transformed thalassemia major from a fatal childhood disease into a chronic disorder. Thalassemia is highly prevalent in South Asia, including the Indian subcontinent, and blood transfusion remains the cornerstone of management for these patients. But safe blood transfusions still remain a major problem in India. Difficulties in maintaining adequate blood inventory, a lack of a national blood act, and fragmented blood transfusion services are some of the major contributing factors for the delay in blood supply. In most of the blood centers, alloantibody detection facilities and extended red cell antigen typing are unavailable. Awareness is the key to reducing alloimmunization, which limits the effectiveness of transfusions and the potential availability of blood. Patients with thalassemia are also at high risk of transfusion-transmitted infections unless appropriate blood screening is in place. Hence, many patients remain under-transfused, resulting in decreased health and quality-of-life outcomes. Facilities such as leucoreduction and immunohematological monitoring following a blood transfusion are often lacking in India, especially at the sub-district level. Continuous efforts to raise community awareness, regular training of health-care workers, and proper utilization of available resources are essential to ensuring safe blood transfusions for patients with thalassemia. Access to the new treatments at an affordable cost may reduce the blood transfusion burden for thalassemia patients in India.</p></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140186800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units 研究红细胞单位及其镰状细胞病受体的抗原特征以及输血红细胞单位的 G6PD 活性。

IF 1.4 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-03-09 DOI: 10.1016/j.tracli.2024.03.002

{"title":"Study of the antigenic characteristics of red blood cells units and their sickle cell disease recipients and the G6PD activity of transfused red blood cells units","authors":"","doi":"10.1016/j.tracli.2024.03.002","DOIUrl":"10.1016/j.tracli.2024.03.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Transfusion has a central place in the treatment of patients with sickle cell disease (SCD). Matching blood groups of red blood cell (RBC) units with the blood groups of the patient is essential to prevent alloimmunization and delayed hemolytic transfusion reaction. African ancestry donors have the best phenocompatibility with patients of the same origin, however their RBCs may present characteristic that can alter quality of the unit such as glucose-6-phosphate dehydrogenase (G6PD) deficiency. The objective is to analyze transfusion protocol, immunization rate and mismatch situations of SCD recipients and to evaluate the frequency of G6PD deficiency in RBCs units from African ancestry donors.</p></div><div><h3>Methods</h3><p>Samples of units transfused to SCD patients were analyzed. Transfusion data were collected from institutional databases. The activity of G6PD was measured in the segment of the RBC units.</p></div><div><h3>Results</h3><p>A total of 98 segments of units transfused to 37 SCD recipients in 41 transfusions episodes was collected. Among patients, 35.1% (<em>n</em> = 13) had no antibodies; 10.8% (<em>n</em> = 4) had antibodies against Fy<sup>a</sup>/Fy<sup>b</sup>, Jk<sup>a</sup>/Jk<sup>b</sup>, M/N, S/s; 21.6% (<em>n</em> = 8) against RH/K antigens. In all cases, the protocols were in line with the recommendations. G6PD deficiency was observed in 9 units, that were all collected from Afro-Caribbean donors.</p></div><div><h3>Conclusion</h3><p>The transfusion protocol is established to prevent immunological reactions due to disparities in blood group antigens between donors and SCD recipients. However, the units of African ancestry donors, which allowed the best compatibility, displayed a high rate of G6PD deficiency. The storage and recovery impact of this deficiency must be evaluated.</p></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative and immediate postoperative transfusion: Clinical-hematological profile of transfunded patients in a university hospital 术中和术后即刻输血：一家大学医院输血患者的临床血液学特征

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-03-09 DOI: 10.1016/j.tracli.2024.03.003

Lorena dos Santos Goiabeira , Sara Silva Meireles , Allan Santos Silva Leocadio , Heitor J S Medeiros , Fernanda Cunha Soares , Wallace Andrino da Silva

{"title":"Intraoperative and immediate postoperative transfusion: Clinical-hematological profile of transfunded patients in a university hospital","authors":"Lorena dos Santos Goiabeira , Sara Silva Meireles , Allan Santos Silva Leocadio , Heitor J S Medeiros , Fernanda Cunha Soares , Wallace Andrino da Silva","doi":"10.1016/j.tracli.2024.03.003","DOIUrl":"10.1016/j.tracli.2024.03.003","url":null,"abstract":"<div><h3>Introduction</h3><p>The transfusion practice by surgery blood reserve, varied among services, must be performed through the rational and restrictive use of blood components because it is a scarce and expensive resource for health care services.</p></div><div><h3>Objective</h3><p>Analyze the use of blood products for surgery blood reserve by means of the study of the clinical-hematological profile of patients submitted to intraoperative and immediate postoperative transfusions.</p></div><div><h3>Methods</h3><p>This was an observational, cross-sectional, and retrospective study, conducted by collecting biological, operational, and laboratory variables, involving 680 patients at a university hospital who had elective surgery with surgery blood reserve request sent during the period from October 2021 to October 2022.</p></div><div><h3>Results</h3><p>The overall transfusion rate was 25.44%, and the mean preoperative hemoglobin level of transfused patients was 9.74 ± 2.50 g/dL, with the mean number of transfusions packed red blood cell units was 1.58 ± 0.77. Patients with higher preoperative hemoglobin levels were less likely to have transfusion (<em>p</em> < 0.001) and patients who had surgical oncologic were more likely to require transfusion (<em>p</em> = 0.048). The transfusion rate of packed red blood cells and platelets concentrates, compared to what was requested, was 15.86% and 5.82%.</p></div><div><h3>Conclusion</h3><p>There is a tendency of transfusions to follow restrictive models, with higher transfusion probability in surgical oncologic. Furthermore, there should be more a conscise use of the surgery blood reserves request.</p></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140095475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How we forecast tomorrow’s haemovigilance 我们如何预测未来的血液监测？

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-03-07 DOI: 10.1016/j.tracli.2024.03.001

Erica M Wood , Barbee I Whitaker , Mary Townsend , Shruthi Narayan

引用次数: 0

In memoriam 悼念

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-02-28 DOI: 10.1016/j.tracli.2024.02.002

Olivier Garraud (Editor in Chief) , Pierre Tiberghien , Jacques Chiaroni , France Pirenne

引用次数: 0

Expression of microRNAs during apheresis platelet storage up to day 14 in a blood bank in China 中国一家血库在无创血小板储存至第 14 天期间的 microRNA 表达。

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-02-07 DOI: 10.1016/j.tracli.2024.02.001

Jie Shi , Anqi Xu , Jun Ai , Jin Chen , Ying Luo

{"title":"Expression of microRNAs during apheresis platelet storage up to day 14 in a blood bank in China","authors":"Jie Shi , Anqi Xu , Jun Ai , Jin Chen , Ying Luo","doi":"10.1016/j.tracli.2024.02.001","DOIUrl":"10.1016/j.tracli.2024.02.001","url":null,"abstract":"<div><h3>Background</h3><p>Storage affects platelet microRNAs (miRNAs); discussing miRNA expression differences in apheresis platelets after varied storage periods is important for developing platelet quality measurement tools and identifying platelet storage lesion biomarkers. To our knowledge, the difference of MicroRNA expression profile in up to 14-day storage apheresis platelets has less relevant reports.</p></div><div><h3>Study design and methods</h3><p>Apheresis platelet bags from three donors were collected, divided into six groups, and stored for 1, 3, 5, 7, 9, and 14 days. miRNA expression was determined using quantitative reverse transcription polymerase chain reaction. Differentially expressed miRNAs were screened using RNA sequencing.</p></div><div><h3>Results</h3><p>MiRNA expression profiles showed that the six treatment groups generally highly expressed hsa-let-7 family, hsa-miR-26a-5p, hsa-miR-92a-3p, hsa-miR-199, and hsa-miR-103a-3p. A total of 15 miRNAs in the top 10 known miRNAs of the six groups were highly expressed. Time series analyses for the trend classification of 944 differentially expressed miRNAs indicated 43 genes with 14 trend changes. Hsa-miR-223-3p, hsa-miR-181a-5p, hsa-miR-4433b-5p, hsa-miR-22-3p, and hsa-miR-30c-5p were selected, and the qRT-PCR results also showed that they were significantly reduced under standard blood bank condition.</p></div><div><h3>Discussion</h3><p>Expression of microRNAs lays the foundation for further research on apheresis platelet storage lesions. Based on our results from information analysis and miRNA target gene prediction, we suggest hsa-miR-30c-5p as a biomarker of the quality and viability of apheresis platelets during storage in blood banks.</p></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1246782024000375/pdfft?md5=6f6e4564ad5f819680c6ee387c9aa813&pid=1-s2.0-S1246782024000375-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledging our reviewers 2023 感谢审查员 2023

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-02-01 DOI: 10.1016/S1246-7820(24)00033-8

引用次数: 0

Corrigendum du résumé «P-119 Phénotypage étendu aux systèmes de groupes sanguins rhésus, KIDD, DUFFY, KELL, MNSS, LEWIS, LUTHERAN, P des donneurs de sang de groupe sanguin O rhésus positif au centre national de transfusion sanguine du Sénégal» [Transfusion Clinique et Biologique 30(Supplement 1) (2023) S106-S107] 对摘要 "P-119 表型分析扩展到恒河猴、KIDD、DUFFY、KELL、MNSS、LEWIS、LUTHERAN、塞内加尔国家输血中心的 P 血型 O 型恒河猴阳性献血者 "的更正[输血临床与生物 30(Supplement 1) (2023) S106-S107]。

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-02-01 DOI: 10.1016/j.tracli.2023.12.005

Harouna Ousmane Sow , Macoura Gadji , Oumar Atoumane Kane , Alioune Badara Senghor , Tandakha Ndiaye Dièye

引用次数: 0

Effect of vibration of the vortex mixer on the red blood cells 旋涡混合器振动对红细胞的影响。

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-02-01 DOI: 10.1016/j.tracli.2023.11.003

Chuang Xiang, Liang Wang

{"title":"Effect of vibration of the vortex mixer on the red blood cells","authors":"Chuang Xiang, Liang Wang","doi":"10.1016/j.tracli.2023.11.003","DOIUrl":"10.1016/j.tracli.2023.11.003","url":null,"abstract":"<div><h3>Purposes</h3><p>Red blood cells (RBCs) are often subject to vibration during processing, transfusion, and transport. Further research is necessary to understand the effects of vibration on human RBCs and to reduce experimental deviations caused by device vibration.</p></div><div><h3>Methods</h3><p>Flow cytometry was used in this study to observe the cytokine expression of IgG and IgA and deformation of human red blood cells affected by the vibration of a vortex mixer with varying frequency (750 rpm and 1500 rpm), duration (5 min and 10 min), and container volume (96 well plate and 48 well plate).</p></div><div><h3>Results</h3><p>The size of RBCs in duration of 10 min is obviously smaller than the duration of 5 min. The 10-minute duration led to visibly smaller RBC sizes compared to the 5-minute duration. There was little effect on the size of RBCs in the 10-minute groups from differences in frequency and container volume. However, decreased RBC size can be observed in the 5-minute groups, where frequency is increased or container volume is decreased. Echinocytes were present in photomicrographs of all 10-minute groups, but microstructure of the RBCs was not impacted by vortex mixer vibration. The elevated frequency or reduced container volume results in an increased cytokine expression of IgG within the 5-minute groupings.</p></div><div><h3>Conclusion</h3><p>It can be inferred that vibration must not be overlooked due to its potential impact on the shape and cytokine expression of RBCs. Hence, the inclusion of vibration must be taken into consideration in experiments and devices pertaining to RBCs.</p></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1246782023005463/pdfft?md5=934d074120c374e7f07d8ec0fb47b894&pid=1-s2.0-S1246782023005463-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138441880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum du résumé «P-061 Quantification des anticorps IgM et IgG anti SARS-COV-2 chez les étudiants de l’Université Cheikh Anta Diop de Dakar» [Transfusion Clinique et Biologique 30(Supplement 1) (2023) S84] 对摘要 "P-061 达喀尔谢赫-安塔-迪奥普大学学生 SARS-COV-2 IgM 和 IgG 抗体定量 "的更正 [Transfusion Clinique et Biologique 30(Supplement 1) (2023) S84]。

IF 1.7 4区医学

Transfusion Clinique et Biologique Pub Date : 2024-02-01 DOI: 10.1016/j.tracli.2023.12.004

Harouna Ousmane Sow , Macoura Gadji , Mamadou Woury Diallo , Oumar Atoumane Kane , Khadidiatou Kébé , Alioune Badara Senghor

引用次数: 0