Transfusion Clinique et Biologique最新文献

{"title":"Donor vigilance – Current situation and future directions","authors":"Tomislav Vuk, Constantina Politis, Olivier Garraud","doi":"10.1016/j.tracli.2025.03.001","DOIUrl":"10.1016/j.tracli.2025.03.001","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 131-133"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet demand forecasting based on the SARIMA model: optimizing blood bank resource allocation and clinical supply","authors":"Wang Feng ,&nbsp;Xu Wen-long ,&nbsp;Xu Zhi-guo ,&nbsp;Wang Yun ,&nbsp;Yang Hai-ying ,&nbsp;Chen Yi-zhu ,&nbsp;Lv Ke ,&nbsp;Shi Lei","doi":"10.1016/j.tracli.2025.03.005","DOIUrl":"10.1016/j.tracli.2025.03.005","url":null,"abstract":"<div><h3>Background</h3><div>With advances in medical technology and an aging population, the demand for single-donor platelet transfusions is increasing because of their significant therapeutic effects. However, the short shelf-life of platelets and the lack of large-scale reserves make accurate demand forecasting crucial for blood bank inventory management, resource allocation and clinical supply.</div></div><div><h3>Objective</h3><div>This study aims to forecast platelet demand trends via time series analysis, specifically the SARIMA model, to provide scientific evidence for blood banks, optimize resource allocation and improve clinical supply efficiency.</div></div><div><h3>Methods</h3><div>Monthly aggregate data from type A BPC units supplied by Huzhou Central Blood Station from January 2015 to December 2023 were collected. By analyzing these data, a SARIMA model was constructed to predict platelet demand in the first half of 2024.</div></div><div><h3>Results</h3><div>The SARIMA(0,1,1)(0,1,1)₁₂ model performed best in terms of goodness of fit and Bayesian information criterion (BIC) tests and accurately predicted platelet demand. The predicted results revealed that the actual monthly supply in the first half of 2024 was within the 95% confidence interval of the forecast, with a mean relative error of 3.61%.</div></div><div><h3>Conclusion</h3><div>The SARIMA model effectively predicts platelet demand, providing a practical tool for blood banks to optimize inventory management and clinical supply. Future research should explore further optimizations and improvements to better serve clinical needs and resource management.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 185-194"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in medical information retrieval: A word of caution","authors":"Paramjit Kaur,&nbsp;Ravneet Kaur,&nbsp;Gagandeep Kaur,&nbsp;Kshitija Mittal","doi":"10.1016/j.tracli.2024.11.003","DOIUrl":"10.1016/j.tracli.2024.11.003","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 253-254"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which is the best storage temperature to preserve the haemostatic quality of non-leukoreduced whole blood units collected under a military emergency protocol − Cold or room temperature?","authors":"J. Degueldre ,&nbsp;E. Dessy ,&nbsp;F. T’Sas ,&nbsp;V. Deneys ,&nbsp;M-A. Van Dievoet","doi":"10.1016/j.tracli.2025.02.003","DOIUrl":"10.1016/j.tracli.2025.02.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Emergency collection may be the only way to access blood when an urgent need arises, such as in a military setting. However, it is important to preserve any excess whole blood donations for future transfusion needs. Cold or room temperature (RT) storage has been reported in the literature. This raises the question of which storage temperature best preserves haemostatic properties of whole blood (WB). Our study investigated this question for storage times up to 48 h.</div></div><div><h3>Methods</h3><div>This comparison study used 30 bags of WB collected from eligible military personnel. WB bags were randomly stored at either 22 °C or 4 °C. Samples from each bag were taken immediately after blood collection and analysed again after 48 h storage. Analyses included: metabolic and haematological parameters, coagulation factors, thrombin generation potential and platelet function (platelet activity, clotting capacity and aggregometry).</div></div><div><h3>Results</h3><div>The overall quality of both storage conditions at 48 h was adequate according to metabolic parameters. Aggregometry was significantly affected in both groups. Clot stiffness was better preserved in WB stored at RT, however coagulation time was extended compared to storage at 4 °C. The platelet count was reduced in 4 °C. The thrombin generation potential was maintained irrespective of storage conditions.</div></div><div><h3>Conclusion</h3><div>The storage at RT offers encouraging in vitro results to promote its use to recover haemostatic functions. As both conservation temperature is acceptable, this will offer greater flexibility to access blood in a resource-limited environment. The choice of either temperature should depend on the frequency of patient admissions.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 178-184"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of isotonic applied muscle tension in reducing the vasovagal event in first-time blood donors: A cohort study","authors":"Somnath Mukherjee,&nbsp;Ayan Bose,&nbsp;Ansuman Sahu,&nbsp;Debasish Mishra,&nbsp;Satya Prakash","doi":"10.1016/j.tracli.2025.02.006","DOIUrl":"10.1016/j.tracli.2025.02.006","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Prevention of vasovagal events has been a major concern for blood centres to reduce the negative impact of decreased donor return for whole blood donation. This study aims to find out the effectiveness of applied muscle tension in reducing vasovagal events in first-time blood donors.</div></div><div><h3>Materials and methods</h3><div>This cohort study involves the active application of applied muscle tension given by the donor with an inbuilt mechanism through an adjustable spring-fitted footrest in the blood donor couch (Remi India Pvt. Ltd). The outcome measure was encountering vasovagal events from the beginning of whole blood donation till at least 15 min of the observation period after blood donation in the blood donation complex. Vasovagal events were monitored objectively by measuring heart rate and blood pressure before, during whole blood donation, and after recovery from vasovagal events. Various signs of VVRs, such as dizziness, facial pallor, and sweating, were taken into consideration.</div></div><div><h3>Results</h3><div>This study includes the observation of adverse donor events among first-time blood donors in a total of 2192 whole blood donations. The vaso-vagal events were associated significantly with the muscle tension applied, education, and anxiety level of the blood donors. The regression analysis showed the muscle tension applied, education level, anxiety scale, hemoglobin percentage, volume of blood collected and BMI as an independent predictor of adverse vaso-vagal events in whole blood donation.</div></div><div><h3>Conclusion</h3><div>Applied muscle tension is an effective tool to reduce the incidence of VVRs in first-time blood donors. Pre-donation counseling of first-time donors may reduce the anxiety level and, in turn, the VVRs.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 153-158"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential mechanisms of extracellular vesicles in transfusion-related adverse reactions: Recent advances","authors":"Keyi Tao ,&nbsp;Keran Tao ,&nbsp;Jing Wang","doi":"10.1016/j.tracli.2025.03.006","DOIUrl":"10.1016/j.tracli.2025.03.006","url":null,"abstract":"<div><div>Blood transfusion is an irreplaceable clinical treatment. Blood components are differentiated and stored according to specific guidelines. Storage temperatures and times vary depending on the blood component, but they all release extracellular vesicles (EVs) during storage. Although blood transfusions can be life-saving, they can also cause many adverse transfusion reactions, among which the effects of EVs are of increasing interest to researchers. EVs are submicron particles that vary in size, composition, and surface biomarkers, are encapsulated by a lipid bilayer, and are not capable of self-replication. EVs released by blood cells are important contributors to pathophysiologic states through proinflammatory, coagulant, and immunosuppressive effects, which in turn promote or inhibit the associated disease phenotype. Therefore, this review explores the potential mechanisms of hematopoietic-derived EVs in transfusion-associated adverse reactions and discusses the potential of the latest proteomics tools to be applied to the analysis of EVs in the field of transfusion medicine with a view to reducing the risk of blood transfusion.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 205-227"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of quadruplet induction therapy on stem cell mobilization yields in newly diagnosed multiple myeloma","authors":"Ryan Beechinor ,&nbsp;Stepfanie Lam ,&nbsp;Aaron Steele ,&nbsp;Machelle Wilson ,&nbsp;Jeffrey Fine ,&nbsp;Ayman Ullah ,&nbsp;Aaron Rosenberg","doi":"10.1016/j.tracli.2025.02.001","DOIUrl":"10.1016/j.tracli.2025.02.001","url":null,"abstract":"<div><div>Daratumumab-containing quadruplet induction regimens have recently become the standard of care for patients with newly diagnosed multiple myeloma who are candidates for autologous hematopoietic stem cell transplantation. Daratumumab is a known immunosuppressant, and previous studies have shown that it may impair stem cell mobilization yields. We report a retrospective study of 104 newly diagnosed multiple myeloma patients comparing mobilization yields between those who received quadruplet daratumumab-containing induction and those who received traditional three-drug induction. Our results demonstrated that there were no statistically significant differences in achieving the patient-specific minimally required CD34+ cell yield after the first mobilization attempt between patients in the daratumumab-containing arm and those in the non-daratumumab-containing arm (<em>P</em> = 0.28).However, patients who received the quadruplet induction regimen with daratumumab experienced a statistically significant longer duration of apheresis collection (median of 2 days in the daratumumab-containing arm vs. 1 day in the non-daratumumab-containing arm, <em>P</em> = 0.011) than those who received traditional three-drug induction.Our findings reinforce the importance of incorporating both granulocyte-colony stimulating factors and plerixafor upfront into mobilization practices. Furthermore, the findings of this study may have implications for the judicious use of apheresis machines and further inform the optimal delivery of daratumumab-containing induction therapies for newly diagnosed multiple myeloma.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 195-198"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Effect of platelet storage duration on platelet increment and clinical outcomes in critically ill patients – A randomised controlled trial”","authors":"Shunsuke Kondo","doi":"10.1016/j.tracli.2025.03.003","DOIUrl":"10.1016/j.tracli.2025.03.003","url":null,"abstract":"<div><div>The randomized trial by Muraleedharan et al. explored the optimal duration of platelet concentrate storage, concluding that storage duration has no clinical relevance. While the study provides novel insights, we identified two methodological concerns. First, the sample size estimation was based on local transfusion needs rather than a broader population, potentially affecting effect estimation and generalizability. Additionally, the study’s inclusion of intensive care unit (ICU) patients may introduce heterogeneity that is not accounted for in a small study population. Second, the absence of clear criteria for platelet transfusion, coupled with the non-blinded study design, raises concerns about potential bias in treatment decisions. Addressing these limitations in future research will improve the validity and applicability of findings.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 255-256"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143627291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of thrombophilia: pathophysiology, prevalence, risk factors, and molecular diagnosis","authors":"Reham Altwayan ,&nbsp;Huseyin Tombuloglu ,&nbsp;Galyah Alhamid ,&nbsp;Aysel Karagoz ,&nbsp;Thamer Alshammari ,&nbsp;Moneerah Alsaeed ,&nbsp;Mohammed Al-Hariri ,&nbsp;Ali Rabaan ,&nbsp;Turgay Unver","doi":"10.1016/j.tracli.2025.03.004","DOIUrl":"10.1016/j.tracli.2025.03.004","url":null,"abstract":"<div><div>Thrombophilia, characterized by an imbalance between fibrinolysis and coagulation leading to inappropriate blood clotting, is a significant medical condition. The CDC has designated it as an underdiagnosed, serious, and potentially preventable disorder, contributing to an estimated 600,000–900,000 cases and 100,000 deaths annually in the United States. These figures surpass the combined annual mortality of AIDS, breast cancer, and motor vehicle accidents. The pathogenesis of thrombophilia involves complex interactions between genetic predispositions, such as mutations in <em>Factor V Leiden</em>, <em>Factor II</em>, <em>MTHFR</em>, and <em>Serpine-1</em>, and environmental factors, including unhealthy lifestyles, prolonged hospitalization, obesity, and cancer. Prevalence of specific genetic mutations varies across populations. Additional risk factors include age, family history, and pregnancy, with recent attention to increased susceptibility in SARS-CoV-2 infection. While molecular diagnostic techniques are available, there remains a need for robust, cost-effective, and accurate screening methods for large populations. This systematic review provides an updated overview of thrombophilia, encompassing pathophysiology, epidemiology, genetic and environmental risk factors, coagulation cascade, population-specific mutation prevalence, and diagnostic approaches. By synthesizing clinical and molecular evidence, this review aims to guide researchers, hematologists, and clinicians in the diagnosis and management of thrombophilia.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 228-244"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbilirubinemia in neonates with blood group incompatibilities − A bane or a boon for the management","authors":"Smita Mahapatra ,&nbsp;Kaushik Patra ,&nbsp;Swarupa Panda ,&nbsp;Sasmita Behuria ,&nbsp;Pratima Kumari Sahu ,&nbsp;Madan Mohan Majhi","doi":"10.1016/j.tracli.2025.01.004","DOIUrl":"10.1016/j.tracli.2025.01.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Neonatal hyperbilirubinemia, or newborn jaundice, is a common condition caused by high bilirubin levels. Blood group incompatibility between mother and baby is a major cause. This study examined the link between different blood group incompatibilities and their management in newborns with jaundice.</div></div><div><h3>Material &amp; Methods</h3><div>This prospective observational study included 190 neonates with hyperbilirubinemia requiring phototherapy. They were divided into two groups: control (blood group compatible) and case (blood group incompatible). Data on demographics, investigations, and management were collected.</div></div><div><h3>Results</h3><div>Blood group incompatibility was present in 36.3% of cases, primarily ABO (28.9%). Rh incompatibility and ABO + Rh incompatibility accounted for 5.3% and 1.6%, respectively. DAT was positive in 32.7% of ABO incompatible cases, with anti-B more prevalent. Neonates with ABO incompatibility had the highest mean total serum bilirubin (TSB) level (13.04 mg/dL) and the largest overall decrease in TSB (–33.77%).The mean phototherapy duration was significantly longer in cases (44.1 h) compared to controls (35.5 h). ABO incompatible neonates had a longer average phototherapy duration (42.32 h) compared to controls. However, ABO+Rh and pure Rh incompatible cases had highest phototherapy duration among cases. Moreover, within ABO cases, the mean phototherapy duration was higher in DAT-positive cases (46 h) compared to DAT-negative cases (40.2 h). Delivery mode, parity, and gender did not significantly influence phototherapy duration, but gestational age might play a role.</div></div><div><h3>Conclusion</h3><div>Various blood group incompatibilities, beyond RhD, are significantly associated with hyperbilirubinemia requiring phototherapy. ABO incompatibility was the most common cause. Neonatal jaundice is linked to blood group mismatch, with ABO+Rh and pure Rh incompatibility requiring longer phototherapy. However, ABO incompatible cases had longer phototherapy in comparison to controls. Gestational age might influence phototherapy duration.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 82-86"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}