Transfusion Clinique et Biologique最新文献

{"title":"Designing and assessing the impact of a competency-based training program in transfusion medicine among MBBS interns","authors":"Manish Raturi ,&nbsp;Yashaswi Dhiman ,&nbsp;Naveen Bansal ,&nbsp;Basanta Khatiwada ,&nbsp;Dushyant Singh Gaur ,&nbsp;Poonam Rawat","doi":"10.1016/j.tracli.2025.06.003","DOIUrl":"10.1016/j.tracli.2025.06.003","url":null,"abstract":"<div><h3>Introduction</h3><div>It has been widely recognized that there is a pressing need to strengthen transfusion medicine education for both undergraduate and postgraduate medical trainees across various clinical specialties to enhance patient safety. In response to this, the National Medical Commission (NMC) of India implemented a competency-based medical education (CBME) framework in 2019 for undergraduate MBBS students across all medical colleges in the country. The present study aimed to assess the impact of a training program designed for medical interns, developed in alignment with the CBME curriculum prescribed by the NMC.</div></div><div><h3>Materials and methods</h3><div>This was a questionnaire-based cross-sectional study conducted among MBBS interns undergoing rotatory training in different departments of a tertiary care teaching hospital. A structured two-day educational program was organized, comprising six modules—three focusing on bedside transfusion practices and three addressing blood donation and laboratory-based transfusion medicine. Each module was designed to reflect the competencies outlined in the CBME curriculum and included pre- and post-training assessments to evaluate knowledge improvement. A pre-test was conducted to assess the knowledge of transfusion medicine among the participants and the post-test was conducted to assess the impact of the training program.</div></div><div><h3>Results</h3><div>Overall, the pre-test score in the present study was 14.1 (47%) which increased to 22.3 (77.6%) in the post-test. Analysis of the pre-test scores showed that 80% of the interns had weak knowledge of blood transfusion reactions and its management. 55.6% of the interns had weak knowledge of indications of blood component therapy whereas 32.2% of the interns had weak knowledge of bedside transfusion medicine practices. 73.3% of the interns had weak knowledge of blood donor selection and counselling. 62.3% of the interns and 73.3% of the interns had weak knowledge of transfusion transmitted infections and basic blood banking including compatibility testing and storage conditions for various blood components, respectively. Post-training results showed a significant improvement across all domains. Effect size analysis using Cohen’s <em>d</em> indicated that the training program was highly effective in five out of six domains, with moderate effectiveness observed in the domain of immunohematology.</div></div><div><h3>Conclusion</h3><div>Although transfusion medicine knowledge is essential for routine practice in core medical and surgical specialties, a substantial knowledge gap exists among medical interns. This study demonstrates that a structured, CBME program is an effective strategy to improve transfusion medicine knowledge among MBBS interns.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 305-308"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the therapeutic efficacy of platelet-rich plasma intestinal spray in patients with ulcerative colitis","authors":"Liyun Zheng,&nbsp;Yiming Ma,&nbsp;Hailong Zhuo,&nbsp;Mengyun Deng,&nbsp;Qun Luo,&nbsp;Xiaofei Li","doi":"10.1016/j.tracli.2025.06.005","DOIUrl":"10.1016/j.tracli.2025.06.005","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 338-340"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfusion medicine beyond earth: preparing for human blood management in space missions","authors":"Yamac Akgun","doi":"10.1016/j.tracli.2025.05.002","DOIUrl":"10.1016/j.tracli.2025.05.002","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 259-260"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation challenges and opportunities of platelet inventory models in oncology setting based blood banks","authors":"Naveen Bansal,&nbsp;Rajbir Kaur Cheema","doi":"10.1016/j.tracli.2025.04.001","DOIUrl":"10.1016/j.tracli.2025.04.001","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Page 333"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using SARS-CoV-2 red cell kodecytes to assess vaccine-induced immune response to the conserved 1147-58 region of the spike protein in Indian blood donors: exploring the potential role of blood transfusion services in population surveillance","authors":"Suvro Sankha Datta ,&nbsp;Aniruddha Hazra ,&nbsp;Najla Haneefa Basheela ,&nbsp;Kaushik Gupta ,&nbsp;Pradip Kumar Mondal ,&nbsp;Elena Aliper ,&nbsp;Nicolai V. Bovin ,&nbsp;Stephen M. Henry","doi":"10.1016/j.tracli.2025.05.001","DOIUrl":"10.1016/j.tracli.2025.05.001","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Blood transfusion services are uniquely poised to take part in the population surveillance study by providing snapshots of the SARS-CoV-2 immunity status among vaccinated blood donors. The immunogenic 1147-58 region of the intact SARS-CoV-2 spike protein is partly spatially hidden. These 1147-58-region-specific antibodies have previously been observed in COVID-19 infected patients but have not been documented in vaccinated individuals. In this study, we aimed to determine the immune response to this conserved region of the spike protein using SARS-CoV-2 red cell kodecytes among vaccinated blood donors.</div></div><div><h3>Material and methods</h3><div><span>Three hundred fifteen voluntary blood donors of Indian ethnicity vaccinated twice against SARS-CoV-2 who, to their knowledge, had not had COVID-19 infection, were screened using quantitative chemiluminescent (CLIA) SARS-CoV-2 immunoassay (detecting total S1 IgG antibodies<span> by measuring the binding antibody units [BAU]), as well as a SARS-CoV-2 red cell kodecytes assay detecting IgG antibodies specific to the 1147-58 region by column </span></span>agglutination technique.</div></div><div><h3>Results</h3><div>The CLIA assay was antibody-reactive with 100% of the 315 samples from vaccinated individuals (BAU/mL &gt; 20), of which 311 (98.7%) were considered immune (BAU/mL &gt; 58). Of the 315 CLIA-reactive samples, moderate to strong kodecyte serologic grades were observed for 63.2% (<em>n</em> = 199) of the samples, while 24.8% (<em>n</em> = 78) yielded weak serologic responses, and 12.1% (<em>n</em> = 38) were unreactive against kodecytes.</div></div><div><h3>Conclusions</h3><div>These results show that about 12% of vaccinated individuals do not have detectable antibodies to the conserved 1147-58 region of the SARS-CoV-2 spike protein and suggest that future studies should clarify whether this has biological implications regarding long-term immune protection.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 286-291"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell exchange in Hemoglobin Evans: A novel therapeutic avenue for a rare hemoglobinopathy","authors":"Radheshyam Meher","doi":"10.1016/j.tracli.2025.05.005","DOIUrl":"10.1016/j.tracli.2025.05.005","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 328-329"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What recent progress and proposals have been made and are to be made in blood transfusion?","authors":"Olivier Garraud (Emeritus Professor of Immunology, Editor in Chief)","doi":"10.1016/j.tracli.2025.06.006","DOIUrl":"10.1016/j.tracli.2025.06.006","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 263-264"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trend of blood donation including coronavirus pandemic: A nationwide cross-sectional study during 2017–2022 in Iran","authors":"Fahimeh Ranjbar Kermani ,&nbsp;Sedigheh Amini Kafi-Abad","doi":"10.1016/j.tracli.2025.04.007","DOIUrl":"10.1016/j.tracli.2025.04.007","url":null,"abstract":"<div><h3>Objectives</h3><div>Blood transfusion is vital in modern medicine, saving lives in cases of hemoglobin disorders, transplants, major surgeries, trauma, and cancer treatments. This study primarily aimed to evaluate blood donation trends in Iran.</div></div><div><h3>Materials and methods</h3><div>A time trend ecological study with a nationwide cross-sectional design was conducted over a six-year period, from 2017 to 2022. The analysis focused on aggregate data obtained from the Iranian Blood Transfusion Organization (IBTO) database. We used trend analysis for proportions to examine the trend in blood donation and the chi-squared test to compare the characteristics of blood donations.</div></div><div><h3>Results</h3><div>A total of 12,352,275 blood donations were collected during the six- years study. The donation rate changed dramatically in 2020. Trend analysis revealed a significant decrease in donation rate (number of donations per 1000 population) from 25.78 in 2017 to 22.67 in 2020 (Slope = -0.001, p_trend &lt; 0.000), followed by a significant increase to 26.25 in 2022 (Slope = 0.002, p_trend &lt; 0.0001). There was a significant difference in gender, age groups, blood groups, and donation statuses (p &lt; 0.0001) during the years. Age groups younger than 36 years showed a decrease from 46.35% in 2017 to 35.47% in 2022 (p &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>Although a decrease in blood donations was observed due to factors such as the COVID-19 pandemic, donation rates have since returned to and even exceeded previous levels, confirming the success of the measures taken by IBTO. However, a decline in donations among individuals younger than 36 years old remains one of IBTO’s major concerns.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 272-279"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-year review of acute transfusion reactions and transfusion errors at a tertiary center","authors":"Tugcan Alp Kirkizlar","doi":"10.1016/j.tracli.2025.04.008","DOIUrl":"10.1016/j.tracli.2025.04.008","url":null,"abstract":"<div><h3>Aim</h3><div>Although blood transfusion is a life-saving procedure, it is associated with a number of preventable and unpreventable transfusion reactions. Transfusion errors account for the majority of preventable causes. The aim of our study was to determine the frequency and characteristics of acute transfusion reactions (ATR) and preventable transfusion errors in our center.</div></div><div><h3>Methods</h3><div>Data on transfusion reactions and transfusions administered between January 2019 and December 2023 were collected retrospectively from reported transfusion reaction forms and transfusion center records.</div></div><div><h3>Results</h3><div>Among 163.114 transfusion administered, 116 (0.071%) acute transfusion reactions were reported (71.1 reaction per 100.000 transfusion). The most common type of ATR was allergic reactions and the most common blood product associated with reaction was red blood cell (RBC). The ABO incompatible RBC transfusion due to human error rate is 1.22/100.000 per transfusion. None of the reactions resulted in death.</div></div><div><h3>Conclusion</h3><div>In our study, the incidence and type of transfusion reactions are similar to the literature. However, the incidence of transfusion of ABO incompatible RBC due to human error is slightly higher than the reported rates. In addition to raising awareness about reporting, immediate action should be taken by closely monitoring transfusion errors especially during pre-transfusion safety.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 280-285"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restrictive RBC transfusion in the ICU: Trends in clinical adherence","authors":"Merijn C. Reuland ,&nbsp;Senta J. Raasveld ,&nbsp;Alexander P.J. Vlaar ,&nbsp;Marcella C.A. Müller","doi":"10.1016/j.tracli.2025.04.003","DOIUrl":"10.1016/j.tracli.2025.04.003","url":null,"abstract":"<div><h3><em>Introduction:</em></h3><div>The balance between the risks and benefits of red blood cell (RBC) transfusions in critically ill patients is of ongoing debate. Clinical guidelines suggest a restrictive transfusion strategy with a transfusion hemoglobin trigger of 7 g/dL for most critically ill patients. However, recent literature shows many RBC transfusions are given with a prior hemoglobin above 7 g/dL. We aimed to evaluate adherence to our own transfusion protocol and changes in transfusion policy over time for the entire Intensive Care Unit (ICU) and in subgroups.</div></div><div><h3><em>Methods:</em></h3><div>Retrospective observational cohort study of patients admitted between 2017 and 2024 to the ICU of Amsterdam UMC. Data was extracted from the electronic health record and the Dutch national quality registry (NICE). Subgroup analysis was done based on referring specialty.</div></div><div><h3><em>Results:</em></h3><div>In total 24 761 ICU stays were analyzed with 12 064 RBC transfusions in 3444 ICU stays. Median hemoglobin value before RBC transfusion decreased from 7.7 g/dL (1st–3rd<!--> <!-->quartile 7.1–8.4) in 2017 to 6.8 g/dL ((1st–3rd<!--> <!-->quartile 6.4–7.3) in 2024 (p <span><math><mrow><mo>&lt;</mo></mrow></math></span> 0.001). This decrease was present in all subgroups. The percentage of RBC transfusions with a prior hemoglobin <span><math><mrow><mo>&lt;</mo></mrow></math></span>7 g/dL increased from 18.8% to 64.8% (p <span><math><mrow><mo>&lt;</mo></mrow></math></span> 0.001).</div></div><div><h3><em>Conclusion:</em></h3><div>We report the long term successful implementation of a comprehensive restrictive RBC transfusion protocol in a tertiary care ICU, independent of the patient’s referring specialty. A median hemoglobin level of 6.8 g/dL before RBC transfusion was reached in 2024.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 3","pages":"Pages 309-314"},"PeriodicalIF":1.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}