Transfusion Clinique et Biologique最新文献

{"title":"Hyperbilirubinemia in neonates with blood group incompatibilities − A bane or a boon for the management","authors":"Smita Mahapatra ,&nbsp;Kaushik Patra ,&nbsp;Swarupa Panda ,&nbsp;Sasmita Behuria ,&nbsp;Pratima Kumari Sahu ,&nbsp;Madan Mohan Majhi","doi":"10.1016/j.tracli.2025.01.004","DOIUrl":"10.1016/j.tracli.2025.01.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Neonatal hyperbilirubinemia, or newborn jaundice, is a common condition caused by high bilirubin levels. Blood group incompatibility between mother and baby is a major cause. This study examined the link between different blood group incompatibilities and their management in newborns with jaundice.</div></div><div><h3>Material &amp; Methods</h3><div>This prospective observational study included 190 neonates with hyperbilirubinemia requiring phototherapy. They were divided into two groups: control (blood group compatible) and case (blood group incompatible). Data on demographics, investigations, and management were collected.</div></div><div><h3>Results</h3><div>Blood group incompatibility was present in 36.3% of cases, primarily ABO (28.9%). Rh incompatibility and ABO + Rh incompatibility accounted for 5.3% and 1.6%, respectively. DAT was positive in 32.7% of ABO incompatible cases, with anti-B more prevalent. Neonates with ABO incompatibility had the highest mean total serum bilirubin (TSB) level (13.04 mg/dL) and the largest overall decrease in TSB (–33.77%).The mean phototherapy duration was significantly longer in cases (44.1 h) compared to controls (35.5 h). ABO incompatible neonates had a longer average phototherapy duration (42.32 h) compared to controls. However, ABO+Rh and pure Rh incompatible cases had highest phototherapy duration among cases. Moreover, within ABO cases, the mean phototherapy duration was higher in DAT-positive cases (46 h) compared to DAT-negative cases (40.2 h). Delivery mode, parity, and gender did not significantly influence phototherapy duration, but gestational age might play a role.</div></div><div><h3>Conclusion</h3><div>Various blood group incompatibilities, beyond RhD, are significantly associated with hyperbilirubinemia requiring phototherapy. ABO incompatibility was the most common cause. Neonatal jaundice is linked to blood group mismatch, with ABO+Rh and pure Rh incompatibility requiring longer phototherapy. However, ABO incompatible cases had longer phototherapy in comparison to controls. Gestational age might influence phototherapy duration.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 82-86"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A false alarm of hemolytic transfusion reaction","authors":"Priyadarsini Jayachandran Arcot,&nbsp;Karan Kumar,&nbsp;Amin Mir","doi":"10.1016/j.tracli.2025.01.001","DOIUrl":"10.1016/j.tracli.2025.01.001","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 121-123"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of machine learning classifiers for predicting intraoperative blood transfusion in non-cardiac surgery","authors":"Insun Park ,&nbsp;Jae Hyon Park ,&nbsp;Jongjin Yoon ,&nbsp;Chang-Hoon Koo ,&nbsp;Ah-Young Oh ,&nbsp;Jin-Hee Kim ,&nbsp;Jung-Hee Ryu","doi":"10.1016/j.tracli.2024.10.006","DOIUrl":"10.1016/j.tracli.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to develop a machine learning classifier for predicting intraoperative blood transfusion in non-cardiac surgeries.</div></div><div><h3>Methods</h3><div>Preoperative data from 6255 patients were extracted from the VitalDB database, an open-source registry. The primary outcome was the area under the receiver operating characteristic (AUROC) curve of ML classifiers in predicting intraoperative blood transfusion, defined as the receipt of at least one unit of packed red blood cells. Five different machine learning algorithms including logistic regression, random forest, adaptive boosting, gradient boosting, and the extremely gradient boosting classifiers were used to construct a binary classifier for intraoperative blood transfusion, and their predictive abilities were compared.</div></div><div><h3>Results</h3><div>337 (5%) patients received intraoperative blood transfusion. In the test-set, the logistic regression classifier demonstrated the highest AUROC (0.836, 95% CI, 0.795–0.876), followed by the gradient boosting classifier (0.810, 95% CI, 0.750–0.868), AdaBoost classifier (0.776, 95% CI, 0.722–0.829), random forest classifier (0.735, 95% CI, 0.698–0.771), and XGBoost classifier (0.721, 95% CI, 0.695–0.747). The logistic regression classifier showed a higher AUROC compared to that of a multivariable logistic regression model (0.836 vs. 0.623, <em>P</em> &lt; 0.001). Among various parameters used to construct the logistic regression classifier, the top three most important features were operation time (0.999), preoperative serum hemoglobin level (0.785), and open surgery (0.530).</div></div><div><h3>Conclusion</h3><div>We successfully developed various ML classifiers using readily available preoperative data to predict intraoperative transfusion in patients undergoing non-cardiac surgeries. In particular, the logistic regression classifier demonstrated the best performance in predicting intraoperative transfusion.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommandations pour la réalisation des examens d’immuno-hématologie de première intention par les laboratoires médicaux","authors":"Patrick Joubaud ,&nbsp;Jean-Marc Giannoli","doi":"10.1016/j.tracli.2024.10.004","DOIUrl":"10.1016/j.tracli.2024.10.004","url":null,"abstract":"<div><div>The main objective of these recommendations for good practices is to supplement the regulatory provisions of the decree of May 15, 2018 which sets the conditions for performing erythrocyte immunohematology tests in medical biology, in order to clarify their application for medical laboratories which conduct first-line immunohematology tests: erythrocyte phenotyping and detection of anti-erythrocyte antibodies. These recommendations cover all phases of a biological examination (pre-analytical, analytical, and post-analytical) as defined in the Public Health Code (Article L6211-2).</div><div>Four levels of recommendations have been established:</div><div>● Recommended practices: complying with the requirements of the NF EN ISO 15189:2022 standard and ensuring optimal medical service delivery.</div><div>● Acceptable practices: situations which deviate from the best practices in immunohematology but still ensuring satisfactory patient management as well as transfusion and obstetrical safety.</div><div>● Non-recommended practices: not complying with the requirements of the NF EN ISO 15189:2022 standard and not allowing satisfactory patient management, but ensuring transfusion and obstetrical safety.</div><div>● Unacceptable practices: presenting a risk for transfusion or obstetrical complications.</div><div>Compliance with these recommendations optimizes patient medical care, particularly in transfusion or obstetrical contexts.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 87-111"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a veno-venous extracorporeal membrane oxygenation program during the COVID-19 pandemic: Don’t forget to notify the blood bank","authors":"Alexis Berger ,&nbsp;Christophe Lelubre ,&nbsp;Charles Chevalier ,&nbsp;Jacqueline Massart ,&nbsp;David Fagnoul ,&nbsp;Steeve Dangotte ,&nbsp;Sotirios Marinakis ,&nbsp;Karim Homsy ,&nbsp;Badih Elnakadi ,&nbsp;Patrick Biston ,&nbsp;Michael Piagnerelli","doi":"10.1016/j.tracli.2024.10.008","DOIUrl":"10.1016/j.tracli.2024.10.008","url":null,"abstract":"<div><h3>Objectives</h3><div>During the SARS-CoV-2 pandemic, there has been significant increased use of vvECMO as rescue therapy. Patients with COVID-19 as anticoagulation is needed for vvECMO support, may develop bleeding complications requiring an increased number of RBC transfusions. We would like to report the RBC transfusion needs following the implementation of an ECMO program. Data on blood usage in this population is important in view of the decline in donations due to the pandemic.</div></div><div><h3>Study Design and Methods</h3><div>We analyzed data on RBC transfusions in patients who required vvECMO for COVID-19 related ARDS in a Belgian ICU from March 2020 to March 2022. The primary end point was RBC transfusion <strong>requirements</strong>. and the relationship to outcome. We also analyzed the evolution of this <strong>requirement</strong> during the four waves.</div></div><div><h3>Results</h3><div>We admitted 538 patients for hypoxemic ARDS due to COVID-19. Sixty patients (11%) required vvECMO, of whom 27 (45%) died. Forty-seven (78%) of the vvECMO patients were transfused a total of 403 packed RBC units. Sites of hemorrhagic complications were ECMO cannulation sites and lungs. RBC transfusion per patient per day on vvECMO was 0.50 [0.30–0.67] units. There were no differences in hemorrhagic complications in vvECMO survivors and non-survivors.</div><div>The percentage of vvECMO patients receiving a RBC transfusion increased slightly during the last COVID-19 wave, with 92 % of patients transfused.</div></div><div><h3>Conclusions</h3><div>vvECMO program is associated with a major need for RBC transfusions. These data are important when blood availability is decreased due to a pandemic and illustrates the need for studies on optimizing blood management including therapeutic anticoagulation target, threshold for RBC transfusion or alternatives to RBC transfusion.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 15-19"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledging our reviewers 2024","authors":"","doi":"10.1016/S1246-7820(25)00034-5","DOIUrl":"10.1016/S1246-7820(25)00034-5","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Page 129"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond royalty: Unraveling the mystery of bluish discolouration in the blood transfusion set","authors":"Manish Raturi ,&nbsp;Rolika Nautiyal ,&nbsp;Viney Kumar ,&nbsp;Yashaswi Dhiman ,&nbsp;Dushyant Singh Gaur ,&nbsp;Hem Chandra","doi":"10.1016/j.tracli.2024.10.005","DOIUrl":"10.1016/j.tracli.2024.10.005","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 126-127"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of platelet storage duration on platelet increment and clinical outcomes in critically ill patients – A randomised controlled trial","authors":"Vivek Muraleedharan ,&nbsp;Paramjit Kaur ,&nbsp;Kshitija Mittal ,&nbsp;Sanjeev Palta ,&nbsp;Ravneet Kaur ,&nbsp;Gagandeep Kaur","doi":"10.1016/j.tracli.2024.11.001","DOIUrl":"10.1016/j.tracli.2024.11.001","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Platelet storage duration may influence transfusion effectiveness and patient outcomes.The present study aimed to evaluate the effect of platelet storage duration on platelet increment and clinical outcomes in patients admitted to the intensive care unit (ICU).</div></div><div><h3>Material and methods</h3><div>This prospective, open-label, randomized controlled trial, conducted at a single centre, enrolled ICU patients requiring platelet transfusion. Patients were randomly assigned to receive platelet concentrates aged ≤ 3 days (Group 1) or 4–5 days (Group 2). Platelet increments were assessed by Absolute Platelet Count Increment (ACI), Corrected Count Increment (CCI), and Percentage Platelet Recovery (PPR). Clinical outcomes including bleeding, infection rates, ICU stay, red cell transfusion requirements, and mortality were also monitored.</div></div><div><h3>Results</h3><div>Patients transfused fresher platelets (Group 1) had higher median ACI, CCI and PPR at 1 h compared to those transfused older platelets (Group 2) though the difference was not statistically significant. At 24 h, Group 1 patients had a median ACI of 28,000/µl compared to 14,000/µl in Group 2(p = 0.001). The median CCI was 16,800 in Group 1 versus 8,200 in Group 2(p = 0.001). Group 1 also had a higher median PPR of 45.7% compared to 23.6% in Group 2(p = 0.011).There was no significant difference in clinical outcomes such as bleeding, infection rates, ICU stay, or mortality between the groups. Multivariate analysis indicated that co-morbidities and higher APACHE-III score were associated with increased mortality.</div></div><div><h3>Conclusion</h3><div>Transfusion of fresher platelets resulted in higher increments and transfusion effectiveness but did not affect clinical outcomes or mortality.</div></div><div><h3>Trial registration details</h3><div>Clinical Trials Registry of India (CTRI/2023/03/050676).</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 20-27"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of alloimmunization in multi-transfused pediatric patients: A cross-sectional study from a sub-Himalayan tertiary care hospital in Uttarakhand India","authors":"Rajat Maini ,&nbsp;Anil Kumar Rawat ,&nbsp;Rakesh Kumar ,&nbsp;Manish Raturi","doi":"10.1016/j.tracli.2024.10.007","DOIUrl":"10.1016/j.tracli.2024.10.007","url":null,"abstract":"<div><h3>Background</h3><div>Packed red blood cell (PRBC) transfusion is critical in managing pediatric patients with conditions requiring frequent transfusions, such as leukemia, thalassemia, and bone marrow disorders. Alloimmunization, the formation of antibodies against foreign antigens present in the donor's blood, is a significant complication of repeated transfusions. Further, auto/alloimmunization is influenced by multiple factors, including antigenic differences between donor and recipient and the recipient’s immune status.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the prevalence and risk factors of auto/alloimmunization among pediatric patients undergoingmultiple PRBC transfusions in a tertiary care hospital in the sub-Himalayan region of Uttarakhand, India.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted on 113 multi-transfused pediatric patients aged 4 months to 18 years who received more than one PRBC transfusion between September 2022 and August 2023. Antibody screening and identification were performed using column agglutination techniques. Statistical analysis was conducted to evaluate associations between demographic, clinical factors, and antibody detection.</div></div><div><h3>Results</h3><div>Alloimmunization was observed in 5.31% of patients, with the majority developing antibodies against the MNS blood group system. Autoantibodies were more common, detected in 17.7% of patients. Significant associations were found between the history of prior PRBC transfusions and the formation of alloantibodies (<em>p</em> = 0.005). Age, gender, and ethnicity did not show a statistically significant association with antibody detection.</div></div><div><h3>Conclusions</h3><div>The study reveals a relatively higher prevalence of autoimmunization among multi-transfused pediatric patients. The history of PRBC transfusions was a significant risk factor, indicating the need for extended RBC phenotyping and tailored transfusion strategies to reduce alloimmunization risks in these patients. Most patients and blood donors in this region belong to the local Garhwali community. This homogeneity may help explain the lower rate of alloimmunization observed, suggesting a degree of antigenic similarity among the blood donors and the recipients.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 9-14"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing deterrents to engage in plasmapheresis donation: Evaluation of an experimental flyer","authors":"Antoine Beurel-Tréhan ,&nbsp;Florence Terrade ,&nbsp;Jean-Pierre Lebaudy ,&nbsp;Bruno Danic","doi":"10.1016/j.tracli.2025.01.003","DOIUrl":"10.1016/j.tracli.2025.01.003","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to measure the psychometrics qualities of an extended model of the Theory of Planned Behavior (TPB) applied to plasma donation, and its relevance in the evaluation of interventions aiming at converting whole-blood donors (WBD) to plasma donation.</div></div><div><h3>Methods</h3><div>Two studies were conducted. The first (N = 433) compared the efficacy of two communication strategies (standard strategy centered on motivations to donate <em>vs.</em> experimental strategy centered on barriers to donate) for influencing specific determinants of the extended model of the TPB and for engaging WBD in plasma donation. The second study (N = 309) evaluated the gain of adding to the experimental strategy an implementation intentions protocol to facilitate the behavior.</div></div><div><h3>Results</h3><div>Study 1 showed the relevance of the extended model as a measurement tool of intention’s determinants, and the efficacy of the experimental strategy compared to the standard approach to bolster intention, F(2,430) = 7.03, p &lt; 0.001, partial η² = 0.032, and to increase the likelihood of commitments χ2(2, N = 433) = 11.904, p = 0.003, Cramer’s V = 0.17. Study 2 replicated these results but did not demonstrate any effect of the implementation intentions protocol to strengthen the intervention, χ²(1, N = 188) = 1.341, p = 0.25.</div></div><div><h3>Conclusions</h3><div>These studies showed that addressing barriers to donation is an efficient communication and recruitment strategy. We encourage blood collection agencies to develop communication campaigns in this direction rather than focusing on donors motivations.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 1","pages":"Pages 69-76"},"PeriodicalIF":1.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}