Transfusion Clinique et Biologique最新文献

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Cardiac serious adverse reactions in donors in France 2010–21 2010-21 年法国捐献者的心脏严重不良反应 Évènements indésirables graves donneurs de type cardiaque en France 2010-21.
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.02.002
Karim Boudjedir , Monique Carlier , Isabelle Hervé , Paul-Michel Mertes , Sophie Somme , Anne-Marine Lenzotti , Gilles Folléa
{"title":"Cardiac serious adverse reactions in donors in France 2010–21","authors":"Karim Boudjedir ,&nbsp;Monique Carlier ,&nbsp;Isabelle Hervé ,&nbsp;Paul-Michel Mertes ,&nbsp;Sophie Somme ,&nbsp;Anne-Marine Lenzotti ,&nbsp;Gilles Folléa","doi":"10.1016/j.tracli.2025.02.002","DOIUrl":"10.1016/j.tracli.2025.02.002","url":null,"abstract":"<div><h3>Aim</h3><div>To study cardiac serious adverse reactions in blood donors (CSARD) reported in the context of whole blood donation (WBD) or apheresis donation (AD) in France. Although potentially serious, they have been poorly studied so far.</div></div><div><h3>Methods</h3><div>Retrospective descriptive study of the 125 CSARD (myocardial infarction-MI, acute coronary syndrome-ACS, angina pectoris-AP, rhythm disorder-RD) reported between 2010 and 2021. The studied parameters were age, gender, type of donation, diagnosis, time to onset, imputability, severity (grade), cardiovascular risk factors (CVRF). They were reviewed within the reports by 5 experts, who independently recorded their opinions on each parameter (except age, gender, type of donation). The collegial analysis of the opinions then resulted in a consensus for all cases. The time between the occurrence of CSARD and donation has been extended and limited to 48 h. An additional criterion of imputability was added for the CSARD attributed to causes other than the donation (e.g., coronary atheroma) but Aggravated or Triggered by the donation: AT1 possibly (&gt;24–48 h post-donation), AT2 probably (&gt;12–24 h post-donation) or AT3 certainly (within 12 h or pre-donation start).</div></div><div><h3>Results</h3><div>Out of 125 reports, 50 were excluded: cardiac qualification of SARD invalidated (8), lack of data (2), absence donation (1), occurrence more than 48 h after the donation (39). The 75 included CSARD (including 5 deaths) comprised 58 coronary events (38 MI, 13 ACS, 7 AP) and 17 RD, and their complementary imputability criterion (AT) was classified respectively as follows 1 (20%), 2 (24%), 3 (56%). The estimated cumulative incidence of CSARD/106 donations is 2.1, significantly higher for AD (5.3) than for WBD (1.6; <em>p</em> &lt; 0.001). The male (M) and female (F) percentages are 81% vs 19%, significantly different from the ones of the standard donor population over 2010–21: 48% M vs 52% F. The median ages, 55 years (30–70) in men, and 47 years (23–68) in women, were significantly higher than the ones of standard donor population 2010–21, respectively 46 (<em>p</em> &lt; 0,001) and 41 (<em>p</em> = 0,04). In the 58 coronary accidents, at least 3 CVRF were noted in 38 cases (66%) and at least 4 CVRF in 20 cases (34%), including 5 with 5 CVRF. In 6/75 cases (8%) pre-existing signs not detected during the pre-donation interview (PDI) would have permanently contraindicated donation.</div></div><div><h3>Conclusions</h3><div>A complementary study should assess whether a more formalised consideration of CVRF in the PDI could reduce the frequency of CSARD of coronary type.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 199-204"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of clinical manifestations and etiologies of megaloblastic anemia in children 儿童巨幼细胞性贫血的临床表现及病因分析。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.01.006
Rim Belhaj , Ines Maaloul , Roeya Kolsi , Taicir Rekik , Imen Chabchoub , Hajer Aloulou , Thouraya Kamoun
{"title":"Study of clinical manifestations and etiologies of megaloblastic anemia in children","authors":"Rim Belhaj ,&nbsp;Ines Maaloul ,&nbsp;Roeya Kolsi ,&nbsp;Taicir Rekik ,&nbsp;Imen Chabchoub ,&nbsp;Hajer Aloulou ,&nbsp;Thouraya Kamoun","doi":"10.1016/j.tracli.2025.01.006","DOIUrl":"10.1016/j.tracli.2025.01.006","url":null,"abstract":"<div><h3>Background and aim</h3><div>Megaloblastic anemia (MA) is a rare pathology in childhood due, in the majority of cases, to a deficiency of folic acid and/or vitamin B12 (cobalamin). This study aims to determine the epidemiological, clinical, and paraclinical profiles of MA in children and to specify its etiologies, therapeutic modalities, and treatment responses.</div></div><div><h3>Methods</h3><div>This is a retrospective descriptive study of MA cases in children carried out in the General Pediatrics Department of the Hedi Chaker University Hospital of Sfax over a period of 42 years, from January 1979 to December 2021. We included all the patients under 16 years old with a myelogram showing megaloblastosis. The selected patients’ demographic characteristics, physical signs, laboratory findings, and treatment responses were recorded.</div></div><div><h3>Results</h3><div>Twenty cases of MA were collected, including 11 boys and 9 girls. The incidence of MA in children was 0.014%. The median age at diagnosis was 3.37 years. The clinical presentation was anemic syndrome with pallor and asthenia in all the cases. Neurological manifestations were noted in 2 cases and digestive disorders in 10 cases. Seven infants had psychomotor delays. On admission, all our patients had anemia with an average value of 5.6 g/dl. It was macrocytic in 19 cases. The blood count also revealed leukopenia (7 cases), thrombocytopenia (10 cases), and pancytopenia (5 cases). The myelogram showed megaloblastosis in all the cases and sideroblasts in one. A brain MRI was performed on five patients, and it showed abnormalities in three cases. The etiological investigations revealed a vitamin B12 deficiency secondary to a maternal Biermer’s disease (6 cases), malnutrition (3 cases), Imerslund’s disease (3 cases), congenital deficiency in transcobalamin II (3 cases), Biermer’s disease (1 case), giardiasis (1 case), folic acid deficiency secondary to a poor dietary intake (1 case), mitochondrial cytopathy with vitamin B12-Folic acid deficiency (1 case), and Pearson syndrome (1 case). Our treatment included symptomatic measures, replacement therapy, and etiological treatment. Favorable evolution was noted in 11 cases. Five patients had neurological sequelae, and one patient died.</div></div><div><h3>Conclusion</h3><div>Our study highlights the rarity and heterogeneity of the etiological contexts of MA in children. Early diagnosis and therapeutic support can improve the long-term neurological prognosis.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 159-163"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple method to predict lymphocyte collection for chimeric antigen receptor T-cell engineering 嵌合抗原受体t细胞工程中淋巴细胞收集预测的简单方法。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.01.005
O. Hequet , V. Mialou , F. Cognasse , S. Mazet , Y. Chelghoum , D. Revesz , C. Candido , J.F. Nicolas , M. Vocanson , F. Bérard , A. Guironnet-Paquet , Q.H. Le , P. Sesques , E. Bachy , H. Ghesquieres
{"title":"Simple method to predict lymphocyte collection for chimeric antigen receptor T-cell engineering","authors":"O. Hequet ,&nbsp;V. Mialou ,&nbsp;F. Cognasse ,&nbsp;S. Mazet ,&nbsp;Y. Chelghoum ,&nbsp;D. Revesz ,&nbsp;C. Candido ,&nbsp;J.F. Nicolas ,&nbsp;M. Vocanson ,&nbsp;F. Bérard ,&nbsp;A. Guironnet-Paquet ,&nbsp;Q.H. Le ,&nbsp;P. Sesques ,&nbsp;E. Bachy ,&nbsp;H. Ghesquieres","doi":"10.1016/j.tracli.2025.01.005","DOIUrl":"10.1016/j.tracli.2025.01.005","url":null,"abstract":"<div><h3>Introduction</h3><div>T lymphocyte collection is essential for CAR T-cell engineering in refractory hematologic malignancies but needs to be optimised. No guidelines have been established for predicting the amount of T lymphocytes to be collected. The quantity of lymphocytes and especially T cells collected depends on the pre-cytapheresis lymphocyte blood level (pcLBL) and the number of blood volumes (BVs) processed. Our aim was to define and standardise a simple method for predicting the number of T lymphocytes collected, taking into account the number of BVs processed and the pcLBL regardless of the procedures defined by different companies.</div></div><div><h3>Methods</h3><div>We used data from our large retrospective series, which included 407 collection sessions using the same cytapheresis method in 400 patients mainly being followed up for non-Hodgkin’s lymphoma (NHL) or multiple myeloma (MM). We initially analysed the performance of lymphocyte collections using collection efficiencies (CE1 and CE2), which are indices that determine the ability to collect as many cells as possible, and also assessed the percentage of neutrophils collected. Finally, we evaluated whether the number of T cells collected could be easily predicted by multiplying the pcLBL and number of BVs by an average factor.</div></div><div><h3>Results</h3><div>In our series, CE1 and CE2 for total lymphocytes and T cells were between 76 ± 15% and 69 ± 15%, thus confirming adequate cell collection. A low percentage of neutrophils was collected (9 ± 12%). Confirmation of adequate cell collection led us to consider the relationship between pcLBL and T-cell collection. We then demonstrated that the amount of T cells collected correlated with pcLBL, and could be predicted by multiplying pcLBL by 2.5 for each BV processed.</div></div><div><h3>Conclusion</h3><div>Easy prediction of T-cell collection is an important tool that can help apheresis and haematology teams monitor collection sessions, regardless of the companies involved and CAR T-cell technology.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 164-170"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized controlled clinical trial to compare the clinical outcome of random-based versus formula-based blood transfusion in a tertiary care hospital setting 一项随机对照临床试验,比较三级护理医院中随机输血与配方输血的临床结果。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.02.004
Prashant Pandey , Supriya Kumari , Gyanendra Agarwal , Shalendra Goel , Divya Setya , Saikat Mandal , Arghyadeep Marik , Mukesh Kumar Singh
{"title":"A randomized controlled clinical trial to compare the clinical outcome of random-based versus formula-based blood transfusion in a tertiary care hospital setting","authors":"Prashant Pandey ,&nbsp;Supriya Kumari ,&nbsp;Gyanendra Agarwal ,&nbsp;Shalendra Goel ,&nbsp;Divya Setya ,&nbsp;Saikat Mandal ,&nbsp;Arghyadeep Marik ,&nbsp;Mukesh Kumar Singh","doi":"10.1016/j.tracli.2025.02.004","DOIUrl":"10.1016/j.tracli.2025.02.004","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Red cell transfusion is the mainstay of therapy for anemia and it is important to transfuse adequate dosage of red cells to maintain tissue oxygen demands. Additionally, it is also important to avoid overload of red cells to prevent adverse effects. Therefore, we compared the rise in hemoglobin and hematocrit for random-Based transfusion (RBT) and formula-based blood transfusion (FBBT) among patients to get a better understanding of differences in clinical outcome between the two methods.</div></div><div><h3>Materials and methods</h3><div>In this study 752 patients were included who were admitted in the hospital and required transfusion of a single unit of PRBC. Patients included in the study were randomized in two categories, RBT and FBBT, using stratified random sampling without any bias. In RBT category, patients received blood transfusion according to standard practice i.e. patient received the full red cell unit without any modifications in volume. All odd number request in cross-match register during the study period who fulfilled the eligibility were included in this group. In FBBT group, even numbered requests in the crossmatch register were randomized to receive FBBT. In this category, patients received transfusion according to the following formula:</div><div>Volume of PRBCs to be transfused = TBV × (Desired Hct − Current Hct of patient)/ Hct of donor unit (where the desired rise of Hct is 3%).</div></div><div><h3>Results</h3><div>In our study we found that the rise in hemoglobin and hematocrit levels were significantly higher for patients receiving FBBT as compared to the patients receiving RBT. Pre-transfusion hemoglobin and hematocrit did not have a significant difference whereas the post transfusion hemoglobin and hematocrit showed a higher rise in the FBBT group as compared to the RBT group. (Welch corrected <em>t</em> = 2.633, <em>p</em> value = 0.0086).</div></div><div><h3>Conclusion</h3><div>This study re-emphasizes the value of FBBT over the routinely used RBT. This study found that FBBT had an edge over RBT, providing significantly higher increase in post-transfusion Hb and Hct. The authors therefore are of the opinion that use of FBBT may be considered in routine clinical practice to optimize transfusions for the patients.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 171-177"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of oral iron supplementation on first-time whole blood donors deferred due to low haemoglobin 口服铁质补充剂对因血红蛋白低而延期的首次全血献血者的影响。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.03.002
Apalak Garg , Ravneet Kaur , Tanvi Sood , Anshu Palta , Kshitija Mittal , Paramjit Kaur , Gagandeep Kaur
{"title":"Impact of oral iron supplementation on first-time whole blood donors deferred due to low haemoglobin","authors":"Apalak Garg ,&nbsp;Ravneet Kaur ,&nbsp;Tanvi Sood ,&nbsp;Anshu Palta ,&nbsp;Kshitija Mittal ,&nbsp;Paramjit Kaur ,&nbsp;Gagandeep Kaur","doi":"10.1016/j.tracli.2025.03.002","DOIUrl":"10.1016/j.tracli.2025.03.002","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Low haemoglobin (Hb) in whole blood donors account for 15.5% to 55.8% deferrals which is easily treatable. The present study was planned to determine the number of blood donors deferred due to low Hb becoming eligible to donate whole blood after iron supplementation.</div></div><div><h3>Material and methods</h3><div>The prospective interventional study was conducted over 18 months. Blood donors presenting for whole blood donation but deferred for low Hb (&lt;125 g/L) were included. First-time whole blood donors showing a picture of iron deficiency based on complete blood counts (CBC) and peripheral blood film (PBF) on the sample collected before the initiation of oral iron supplementation (Day 0) were contacted and requested to visit the blood centre. They were counselled and provided ferrous sulphate tablets (325 mg containing 100 mg elemental iron) to be taken daily after meals for 60 days. Compliance with the intake of iron supplementation was ensured. After completing oral iron supplementation for 60 days, a repeat sample was collected.</div></div><div><h3>Results</h3><div>A total of 126 donors were provided with iron supplementation for 60 days. A significant increase in mean haemoglobin was observed in the blood donors who completed iron supplementation therapy for 60 days [109 (15) to 126 (15) g/L; p value &lt; 0.001]. Seventy-six (60%) donors became eligible to donate blood. Regression models indicated that Hb levels on Day 60 were independently predicted by gender in donors who became eligible to donate.</div></div><div><h3>Conclusion</h3><div>Iron supplementation has the potential to enhance donor eligibility and significantly expand the safe donor pool.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 141-146"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immediate reporting of delayed donor adverse reactions: Role of AI driven mobile application 延迟供体不良反应的即时报告:人工智能驱动的移动应用程序的作用。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.02.005
Radheshyam Meher
{"title":"Immediate reporting of delayed donor adverse reactions: Role of AI driven mobile application","authors":"Radheshyam Meher","doi":"10.1016/j.tracli.2025.02.005","DOIUrl":"10.1016/j.tracli.2025.02.005","url":null,"abstract":"","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 257-258"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient quality improvement through the monitoring of Key Performance Indicators in the Quality management Review of a Blood Establishment (BE) 通过监测血液机构(BE)质量管理评审中的关键绩效指标进行有效的质量改进。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.02.008
Dimitra Moschandreou, Elisavet Grouzi
{"title":"Efficient quality improvement through the monitoring of Key Performance Indicators in the Quality management Review of a Blood Establishment (BE)","authors":"Dimitra Moschandreou,&nbsp;Elisavet Grouzi","doi":"10.1016/j.tracli.2025.02.008","DOIUrl":"10.1016/j.tracli.2025.02.008","url":null,"abstract":"<div><div>Efficient quality improvement in Blood Establishments (BE) relies on monitoring Key Performance Indicators (KPIs) within the Quality Management Review (QMR). KPIs serve as objective measures to identify system weaknesses and promote continuous quality improvement. The QMR integrates KPI data with inputs from various sources like non-conformities and audit reports, facilitating informed decision-making for improvement initiatives.</div><div>This study was conducted at the Transfusion Medicine Department of a General Oncology Hospital with the aim of evaluating the quality improvement. Over a period of 6 years (2018–2023) some interventions were implemented to enhance blood sufficiency and blood stock management. The aim of the present study was to assess the impact of these interventions on the values of KPIs and, consequently, on the effectiveness of the system regarding the examined issues. The values of the KPIs before and after the interventions were compared to identify statistically significant differences. The years following the interventions the WAPI% index for expired red blood cell units was reduced, the acceptance limits of units collected per blood drive were met, the blood units collected in the BE increased and the deficit in red blood unit was reduced. The selected KPIs were significantly improved with minor exceptions.</div><div>In conclusion, the systematic monitoring of KPIs and strategic interventions underscored in this study illustrate how targeted quality management practices can enhance operational efficiency and ensure sustainable improvements in BEs. Ongoing efforts to refine these approaches aim to achieve broader quality enhancement goals across blood management practices.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 134-140"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conservative blood priming for extracorporeal photopheresis to reduce allogenic blood exposure in pediatric patients 保守血液注入用于体外光造血术以减少儿科患者的同种异体血液暴露。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.02.009
Andriana Pavlovich , Paxton Barco , Brian Cook , Ashley Peck , Faith Matthews , Yembur Ahmad , Craig Fletcher , Yamac Akgun
{"title":"Conservative blood priming for extracorporeal photopheresis to reduce allogenic blood exposure in pediatric patients","authors":"Andriana Pavlovich ,&nbsp;Paxton Barco ,&nbsp;Brian Cook ,&nbsp;Ashley Peck ,&nbsp;Faith Matthews ,&nbsp;Yembur Ahmad ,&nbsp;Craig Fletcher ,&nbsp;Yamac Akgun","doi":"10.1016/j.tracli.2025.02.009","DOIUrl":"10.1016/j.tracli.2025.02.009","url":null,"abstract":"<div><div>Extracorporeal photopheresis (ECP) is a vital therapeutic option for pediatric patients with immune-mediated conditions. However, the high extracorporeal volume (ECV) involved in ECP poses a risk of hypovolemia, often necessitating red blood cell (RBC) priming to maintain hemodynamic stability. This study evaluates a conservative approach to ECP without RBC priming in pediatric patients, aiming to reduce allogenic blood exposure. A retrospective review of 16 ECP procedures across 3 pediatric patients with ECV exceeding 15% of total blood volume (TBV) found no significant adverse events or hemodynamic instability. The absence of RBC priming did not result in any documented complications. These findings suggest that conservative blood priming can safely reduce allogenic blood exposure in pediatric ECP, potentially minimizing transfusion-related risks. Further research is needed to establish guidelines for patient selection and monitoring during non-prime ECP in pediatric populations.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 250-252"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and risk factors of acute transfusion reactions in patients admitted in intensive care unit on active monitoring after transfusion 重症监护病房患者输血后主动监测急性输血反应的发生率及危险因素。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.02.007
Disha Sharma , Ravneet Kaur , Tanvi Sood , Sanjeev Palta , Kshitija Mittal , Paramjit Kaur , Gagandeep Kaur , Shivangi Sharma
{"title":"Incidence and risk factors of acute transfusion reactions in patients admitted in intensive care unit on active monitoring after transfusion","authors":"Disha Sharma ,&nbsp;Ravneet Kaur ,&nbsp;Tanvi Sood ,&nbsp;Sanjeev Palta ,&nbsp;Kshitija Mittal ,&nbsp;Paramjit Kaur ,&nbsp;Gagandeep Kaur ,&nbsp;Shivangi Sharma","doi":"10.1016/j.tracli.2025.02.007","DOIUrl":"10.1016/j.tracli.2025.02.007","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Transfusion reaction is often masked in critically ill patients because of underlying disease or certain pre-medications. The study was planned to know the incidence and determine risk factors associated with these acute transfusion reactions (ATRs) in intensive care (ICU) patients by actively monitoring the transfusion events.</div></div><div><h3>Material and methods</h3><div>In this prospective observational study, critically ill patients admitted to ICU and having an ICU stay of 24 h prior to transfusion were enrolled. Each enrolled patient was actively monitored after each transfusion of blood component at 15 min, 1 h, 6 h and 24 h. Transfusion reactions reported from ICU during the study period were considered as passively reported ATRs.</div></div><div><h3>Results</h3><div>Transfusion of 850 components translating to 430 transfusion episodes was actively monitored. Thirty-three ATRs were observed in 27 patients. Incidence of ATR on active monitoring (0.039) was higher than on passive reporting (0.006). On active monitoring, 06 cases of TACO, 2 cases of TAD, 1 case each of TRALI and TTBI, 3 cases of FNHTR were recorded. A significant association between positive fluid balance (<em>p</em> = 0.01) and generalised oedema (<em>p</em> = 0.01) was observed with TACO. Twelve cases were labelled as unclassifiable complication of transfusion. Rise in BP was the only symptom observed in all these cases. The mean post-transfusion systolic blood pressure and diastolic blood pressure at 1 h, 6 h and 24 h were significantly higher (<em>p</em> &lt; 0.05) than pre-transfusion values.</div></div><div><h3>Conclusion</h3><div>Active monitoring provides us with a true insight into the incidence of various ATRs.</div></div>","PeriodicalId":23262,"journal":{"name":"Transfusion Clinique et Biologique","volume":"32 2","pages":"Pages 147-152"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Turning the tide of viral hepatitis-induced acute liver failure: The role of standard volume plasma exchange in adults and children 扭转病毒性肝炎引起的急性肝衰竭的趋势:成人和儿童标准容量血浆交换的作用。
IF 1.4 4区 医学
Transfusion Clinique et Biologique Pub Date : 2025-05-01 DOI: 10.1016/j.tracli.2025.01.007
Yashaswi Dhiman , Rolika Nautiyal , Anant Kumar , Saurabh Singh , Nitika Sarvesh Agrawal , Ashish Kumar Simalti , Veena Boswal , Sourabh Kumar , Manish Raturi , Dushyant Singh Gaur
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