Translational Metabolic Syndrome Research最新文献

{"title":"Review of the methods to measure non-adherence with a focus on chemical adherence testing","authors":"Hanad Osman ,&nbsp;Randah Alghamdi ,&nbsp;Pankaj Gupta","doi":"10.1016/j.tmsr.2021.12.001","DOIUrl":"10.1016/j.tmsr.2021.12.001","url":null,"abstract":"<div><p>A substantial number of patients with cardiovascular disease do not take their medications as prescribed. This can lead to an increased risk of disease complications, hospitalisations and death. Therefore, it is necessary to determine methods to detect non-adherence in patients accurately to ensure that patients can be identified and engaged with. This will allow adequate support to be provided to these patients to improve adherence rates and thus lead to better disease outcomes.</p><p>This review looks at a wide range of methods to establish medication non-adherence. There is a particular focus on chemical adherence testing as this method has gained acceptance in use in many hypertension clinics and has been recommended by European guidelines for use in patients with suspected resistant hypertension.</p><p>This review goes onto discuss the use of chemical adherence testing in hypertension clinics currently and also discusses some of the reasons behind non-adherence and provides solutions that can be discussed with the patients to overcome these challenges. The discussion between the clinician and the patient regarding the chemical adherence test result needs to be held in a no-blame environment to ensure that the patient can engage in an open and honest discussion with the clinician. More training is required for clinicians and healthcare professionals to ensure they feel confident to discuss adherence with their patients.</p><p>Even though chemical adherence testing is being used increasingly as the first-choice method to determine non-adherence, more research is required to increase uptake of chemical adherence testing in a wider range of settings.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"5 ","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588930321000098/pdfft?md5=0367e0db1a153e773e20055d75a0201e&pid=1-s2.0-S2588930321000098-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73126912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semaglutide is precipitating a revolution in obesity care","authors":"Khaled Alabduljabbar,&nbsp;Carel W. le Roux,&nbsp;Royce P. Vincent","doi":"10.1016/j.tmsr.2022.05.001","DOIUrl":"10.1016/j.tmsr.2022.05.001","url":null,"abstract":"","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"5 ","pages":"Pages 24-26"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2588930322000032/pdfft?md5=9112cb63e4043b19b46aa9c350dd16a5&pid=1-s2.0-S2588930322000032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86352087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC–MS and HPLC analysis of antiglycogenolytic and glycogenic compounds in kaempferol 3–O–gentiobioside containing Senna alata L leaves in experimental rats","authors":"S. Mohanasundaram ,&nbsp;N. Rangarajan ,&nbsp;V. Sampath ,&nbsp;K. Porkodi ,&nbsp;M. Pennarasi","doi":"10.1016/j.tmsr.2021.07.001","DOIUrl":"10.1016/j.tmsr.2021.07.001","url":null,"abstract":"<div><h3>Background</h3><p>Medicinal herbs have received attention as an alternative to prescription medications. Diabetes mellitus is a chronic disease that affects the normal metabolic pathways in several organs. The purpose of this study was to determine the metabolites responsible for the antiglycogenolytic and glycogenic effects of a hydroethanolic extract of <em>Senna alata</em> L in an experimental model of diabetes mellitus; the male albino Wister rat treated with streptozotocin.</p></div><div><h3>Results</h3><p>The therapeutic effects of Glibenclamide (0.6 mg/kg body weight) and <em>S. alata</em> L (400 mg/kg body weight) extracts were compared. The oral administration of this extract to diabetic rats resulted in a significant decrease in the levels of glycogenolytic factors that included: glycogen phosphorylase, glucose 6 phosphatase, glycosylated haemoglobin, and lactate dehydrogenase, and a significant increase in the levels of glycogenic factors such as plasma insulin, glycogen synthase, liver glycogen, hexokinase, pyruvate kinase After administration of the plant extract, the observed changes in the activities of these factors were found to be statistically significant and returned to near-normal levels. Additionally, the <em>S. alata</em> extract increased muscle and liver glycogen levels, demonstrating <em>S. alata</em> L's anti-diabetic properties. HPLC analysis identified Kaempferol 3–O–gentiobioside, while GCMS analysis showed the presence of phytol, stigmasterol, sitosterol, dimethyl derivatives, methyl esters, and octanoic acid derivatives.</p></div><div><h3>Conclusion</h3><p>This work provides experimental evidence for the anti-diabetic potential of <em>S. alata</em> extract, which may result from the existence of beneficial bioactive chemicals. The aberrant metabolic enzymes in streptozotocin-induced diabetic rats' livers were restored following regular treatment with <em>S. alata</em> extract. As a result, <em>S. alata</em> leaves can affect blood glucose levels.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"4 ","pages":"Pages 10-17"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2021.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90543517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of dairy products fortified with nano-encapsulated vitamin D3 on physical and mental aspects of the health in obese subjects; the protocol of the SUVINA trial","authors":"Payam Sharifan ,&nbsp;Mohammad Bagherniya ,&nbsp;Maryam Mohammadi Bajgiran ,&nbsp;Mohammad Safarian ,&nbsp;Hassan Vatanparast ,&nbsp;Saeid Eslami ,&nbsp;Maryam Tayefi ,&nbsp;Majid Khadem-Rezaiyan ,&nbsp;Ali Baygan ,&nbsp;Mahdieh Khoshakhlagh ,&nbsp;Hamideh Ghazizadeh ,&nbsp;Gordon A. Ferns ,&nbsp;Mohammad Rashidmayvan ,&nbsp;Hanieh Palahang ,&nbsp;Mitra Rezaie ,&nbsp;Majid Ghayour-Mobarhan","doi":"10.1016/j.tmsr.2021.01.001","DOIUrl":"10.1016/j.tmsr.2021.01.001","url":null,"abstract":"<div><h3>Background</h3><p>Vitamin D deficiency is now very common globally. Although ultraviolet B (UVB) light dermal exposure is an important endogenous source of vitamin D, dietary supplementation and routine food fortification are of benefit for increasing serum 25-hydroxyvitamin D [25(OH)D]. However, there remains a high prevalence of vitamin D deficiency (~40 in Europe and 62% in Iran). We have designed a two-phase study including the production of nano-encapsulated vitamin D3, an assessment of its stability after fortifying dairy products, and a human trial evaluating the effects of fortified dairy products on the physical and mental health of participants.</p></div><div><h3>Methods</h3><p>and design: We established the optimal nanocapsule structure for vitamin D fortification of the various dairy products. The second phase of the study was performed as a ten-week, quadruple-blind randomized controlled trial, where milk and yogurt were fortified with vitamin D-containing nano-capsules, with active and control products being distributed to adult participants living in the City of Mashhad.</p></div><div><h3>Preliminary results</h3><p>Among 346 subjects who intended to participate in our study, 306 participants were selected according to inclusion criteria. At the end of the trial, seventeen subjects were excluded (with a dropout rate of 5.5%). The mean age of the eligible participants was 41.82 ± 7.81 (51.8% being women). Waist circumferences were 102.59 ± 7.74 and 89.39 ± 7.0 for men and women, respectively. There were no significant differences for weight, waist circumference, BMI, energy intake, and physical activity between the four groups at baseline assessments.</p></div><div><h3>Discussion</h3><p>This study will be the first RCT determining the efficacy of vitamin D fortification in dairy products using nano encapsulation technology on several aspects of physical and mental health. The sample size and high quality of methodology of this study demonstrate the feasibility and benefits of nanotechnology in the food fortification industry and general health in the population.</p></div><div><h3>The trial registration details</h3><p>registry name: The National Institute for Medical Research Development (NIMAD), registration number: IRCT20101130005280N27, date of registration: 3.9.2018 and the trial was prospectively registered.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"4 ","pages":"Pages 1-9"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2021.01.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86437397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"β-Cell Glucose Sensitivity determines hyperglycaemia in Polycystic Ovary Syndrome","authors":"Julie Tomlinson ,&nbsp;Andrea Mari ,&nbsp;Andrea Tura ,&nbsp;Kirsty Bond ,&nbsp;Elizabeth Stenhouse ,&nbsp;Tracy Dew ,&nbsp;Royce P. Vincent ,&nbsp;Jonathan Pinkney","doi":"10.1016/j.tmsr.2020.09.001","DOIUrl":"10.1016/j.tmsr.2020.09.001","url":null,"abstract":"<div><h3>Aims</h3><p>To investigate the mechanism of hyperglycaemia in women with Polycystic Ovary Syndrome (PCOS) by modelling physiological insulin secretion.</p></div><div><h3>Methods</h3><p>45 non-diabetic women with PCOS (defined by Rotterdam criteria) and 47 controls were studied. Insulin secretion was modelled from glucose and C-peptide concentrations during a 6-point oral glucose tolerance test (OGTT) and insulin resistance (IR) was determined by the Matsuda Insulin Sensitivity Index (ISI).</p></div><div><h3>Results</h3><p>(1). β-Cell Glucose Sensitivity (βCGS) is not intrinsically impaired in PCOS, but IR is increased. (2) However, women with PCOS and 2-hour hyperglycaemia (glucose &gt;7.5 mmol/l]) were characterized by worse βCGS compared with women with 2-hour glucose &lt;7.5 mmol/l (mean [SD]) 43.5 [23.6] versus 109.0 [68.5] pmol/min/ml/mmol; p = 0.04), and had higher waist circumference (116.8 [15.8] vs 93.5 [15.9] cm; p &lt; 0.01) and 120 minute insulin concentrations (964.0 [579.2–1214.7] vs 328.2 [242.2–475.7] pmol/l; p = 0.01). (3). In contrast, lean, insulin sensitive women with PCOS were euglycemic, even in the presence of poor βCGS, and exhibited favourable cardiometabolic risk profiles.</p></div><div><h3>Conclusions</h3><p>βCGS is not intrinsically impaired in PCOS, but it is the critical determinant of hyperglycaemia. Women with low βCGS, who also have central adiposity and IR exhibit 2-hour hyperglycaemia, whereas women with high βCGS are able to maintain euglycaemia despite central adiposity and IR. These findings show that (i) waist circumference and 2-hour glucose identify women at higher risk of diabetes, and confirm that (ii) obesity and IR are the key reversible targets for diabetes prevention in women with PCOS.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"3 ","pages":"Pages 35-41"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2020.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74105330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the effects of fatigue on blood glucose levels – Implications for diabetes","authors":"Curtis Beehan-Quirk ,&nbsp;Luke Jarman ,&nbsp;Shamona Maharaj ,&nbsp;Ann Simpson ,&nbsp;Najah Nassif ,&nbsp;Sara Lal","doi":"10.1016/j.tmsr.2020.03.001","DOIUrl":"10.1016/j.tmsr.2020.03.001","url":null,"abstract":"<div><p>The purpose of the current study was to investigate the differences and correlations between fatigue levels and blood glucose in individuals with and without diabetes, using psychometric and metabolic assessment of participants. The findings of the present study were that individuals with diabetes are susceptible to fatigue as measured by the Fatigue Severity Scale and the Checklist Individual Scale. Additionally, individuals with fatigue were found to be more susceptible to sleepiness and had overall lower poor sleep quality than those without diabetes as measured by the Karolinska Sleepiness Scale, the Epworth Sleepiness Scale and the Pittsburgh Sleep Quality index (&lt;0.05).</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"3 ","pages":"Pages 17-20"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2020.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86165427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The renal expression of epigenetic biomarkers for diabetic nephropathy","authors":"Long T. Nguyen,&nbsp;Sonia Saad,&nbsp;Carol A. Pollock","doi":"10.1016/j.tmsr.2020.05.002","DOIUrl":"10.1016/j.tmsr.2020.05.002","url":null,"abstract":"<div><p>Chronic kidney disease (CKD) is one of the most common complications in patients with diabetes. Identification of diabetic patients with high risk for CKD progression has been challenging due to various limitations of traditional diagnostic methods. Epigenetic modifications, particularly DNA methylation, have recently emerged as alternative predicting factors for diabetic nephropathy. Despite strong evidence of correlation, the mechanisms that link epigenetic changes in blood/monocytes with renal physiology are yet to be investigated. As such, it is important to examine the renal expression of these differentially methylated genes in diabetic individuals with and without CKD. Using an animal model of Type 2 diabetes (T2D) and biopsy/nephrectomy samples from patients with T2D without and with CKD, we demonstrated that CUE domain containing 1 (<em>cuedc1</em>), microtubule-associated protein 7 (<em>map7</em>), LIM Homeobox 6 (<em>lhx6</em>) and Thioredoxin Interacting Protein (Txnip) were downregulated in the kidneys of T2D animals and patients without CKD. Strikingly, the regulation of <em>cuedc1</em>, <em>map7</em> and <em>txnip</em> were significantly reversed in the presence of kidney dysfunction and fibrosis. The expression of Protein Kinase C Epsilon (<em>prkce</em>) was also significantly higher in T2D patients with CKD compared to the control group. Both <em>txnip</em> and prkce have been shown previously to be involved in the induction of diabetic nephropathy. These data provide evidence to support the relevance of epigenetic biomarkers in blood with renal pathophysiology in T2D.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"3 ","pages":"Pages 21-24"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2020.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80613814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of body mass index and body fat percentage for predicting cardiovascular disease risk","authors":"Hosein Sheibani ,&nbsp;Maryam Saberi-Karimian ,&nbsp;Habibollah Esmaily ,&nbsp;Mohsen Mouhebati ,&nbsp;Mohmoud Reza Azarpazhooh ,&nbsp;Ghasemali Divbands ,&nbsp;Marzieh Kabirian ,&nbsp;Roshanak Ghaffarian ,&nbsp;Maryam Tayefi ,&nbsp;Gordon A. Ferns ,&nbsp;Mohammad Safarian ,&nbsp;Majid Ghayour-Mobarhan","doi":"10.1016/j.tmsr.2020.06.001","DOIUrl":"10.1016/j.tmsr.2020.06.001","url":null,"abstract":"<div><h3>Background</h3><p>Anthropometric indices such as body mass index (BMI) and percent body fat (PBF) are easily measurable and have been consistently reported to be associated with cardiovascular disease (CVD) and its risk factors.</p></div><div><h3>Aims</h3><p>We aimed to compare the association of several CVD risk factors with BMI and PBF to determine which of these adiposity indices had the greater predictive value.</p></div><div><h3>Methods and materials</h3><p>Data were derived from the MASHAD cohort study. The cohort was categorised into 4 groups: group 1 (low or normal BMI and PBF, N = 1670), group 2 (low or normal BMI but high PBF, N = 992), group 3 (high BMI and low or normal PBF, N = 837), and group 4 (high BMI and PBF, N = 6245). The best cut-off points were defined by ROC analysis.</p></div><div><h3>Results</h3><p>BMI was more strongly correlated with systolic and diastolic blood pressure, serum urate, serum hsCRP, fasting plasma glucose and TC/HDL-C ratio compared to PBF. But BMI was less strongly correlated with three lipid parameters (total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol), Logistic regression analysis showed that BMI was the best predictor for the majority of risk factors, apart from LDL-C in men and LDL-C, TC and non-HDL-C (NHC) in women. ROC analysis showed that BMI had a greater AUC for risk factors other than for SBP, HTN, DM, TC, LDL-C, impaired fasting glucose, non-HDL cholesterol in men and for TC, TG, TC, DBP, HTN, and non-HDL Cholesterol, among female subjects.</p></div><div><h3>Conclusions</h3><p>The results suggest that in our population from northeastern Iran, BMI may be a better predictor of several CVD risk factors compared to PBF.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"3 ","pages":"Pages 29-34"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2020.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78042621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The metabolic role of depression and burnout in nurses","authors":"Betina Ferreira ,&nbsp;Shamona Maharaj ,&nbsp;Ann Simpson ,&nbsp;Najah Nassif ,&nbsp;Sara Lal","doi":"10.1016/j.tmsr.2020.03.002","DOIUrl":"10.1016/j.tmsr.2020.03.002","url":null,"abstract":"<div><p>The present study aimed to assess the associations between depression and burnout, and blood glucose levels and haemoglobin A1c in nurses and non-nurses, using psychometric and metabolic assessment. Nurses experienced a significantly higher level of burnout than non-nurses (p &lt; 0.05), as measured by the Emotional Exhaustion scale of the Maslach Burnout Inventory, as well as a significantly lower level of burnout than non-nurses as measured by the Personal Accomplishment subscale of the Maslach Burnout Inventory (p &lt; 0.01).</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"3 ","pages":"Pages 9-11"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2020.03.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90759668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of heart failure with preserved ejection fraction in the presence of diabetes mellitus","authors":"Sargon Lazar ,&nbsp;Benjamin Rayner ,&nbsp;Guillermo Lopez Campos ,&nbsp;Kristine McGrath ,&nbsp;Lana McClements","doi":"10.1016/j.tmsr.2020.04.002","DOIUrl":"10.1016/j.tmsr.2020.04.002","url":null,"abstract":"<div><p>Cardiovascular disease (CVD) is the leading cause of death globally. People living with type 2 diabetes mellitus (T2DM) have up to three times higher risk of developing CVD, particularly heart failure with preserved ejection fraction (HFpEF), for which there is no effective treatment. The need for tangible interventions has led to investigations into a number of biomarkers associated with metabolic and vascular dysfunction that could be utilised for diagnostic and treatment purposes. This review discusses the importance and mechanisms of inflammatory and angiogenic biomarkers, which have shown the most potential in the pathogenesis and diagnosis of HFpEF, particularly in the presence of diabetes. In depth “in silico” analysis was also carried out to identify pathogenic pathways associated with HFpEF, both in the presence and absence of diabetes. The results identified mostly inflammatory pathways associated with HFpEF in the presence of diabetes, and a number of pathways related to angiogenesis, remodelling, metabolism as well as inflammation, in the absence of diabetes. The shared and unique pathways identified in HFpEF in the presence and absence of diabetes, should be explored further in order to improve management and outcomes of people living with HFpEF, taking into the account other underlying conditions.</p></div>","PeriodicalId":23223,"journal":{"name":"Translational Metabolic Syndrome Research","volume":"3 ","pages":"Pages 1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.tmsr.2020.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90863239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}