Traditional & Kampo Medicine最新文献

{"title":"Successful treatment of an older patient with COVID‐19 pneumonia using herbal medicine—especially saikanto","authors":"T. Utsunomiya, Den-ichiro Yamaoka, T. Asakawa, Yukio Mizumoto, Yasutsugu Takada","doi":"10.1002/tkm2.1379","DOIUrl":"https://doi.org/10.1002/tkm2.1379","url":null,"abstract":"New antiviral drugs for COVID-19 have been launched with special approval. However, as there may be a shortage of drugs in the future, it may be difficult to provide appropriate medical intervention. Herein, we describe our experience of successfully treating COVID-19 pneumonia in an older patient using a Japanese herbal medicine without new antiviral drugs. A 94-year-old woman was diagnosed with COVID-19 and received home care. However, dyspnea appeared on day 4 of home treatment, so she visited the emergency department of our hospital. Her SpO2 then increased to 97% after oxygen delivery at a rate of 7 L/min via a mask. On physical examination, the patient presented with tachypnea (24 breaths per minute) and stable hemodynamics. Her blood pressure, heart rate, and body temperature were 104/65 mm Hg, 68 beats/min, and 37.5 C respectively. She had clear consciousness. Her height and body weight were 146 cm and 47 kg respectively. Laboratory test results are presented in Table 1. Computed tomography (CT) scan revealed infiltrates in the bilateral lower lungs with ground-glass signs. The qSOFA was one point and sepsis was not actively suspected, but the A-DROP was three points and the patient was indicated for hospitalization for severe pneumonia. Given her history of hypertension and stroke, she usually spent most of her time lying in bed, except for eating and defecating. Aspiration was not confirmed during home care. CT imaging showed mainly a groundglass appearance rather than an infiltrating shadow, so aspiration pneumonia was not actively suspected. Based on the course and CT imaging, typical bacterial pneumonia was not actively suspected and the use of antibiotics was withheld. Her respiration was stabilized with oxygen therapy; however, she was frail and old, and neither she nor her family wanted active treatment. As she could drink water, a Japanese herbal treatment for pneumonia was initiated. Her Kampo medical findings indicated that she had a deficiency. She complained of bitterness in her mouth and chest pain when coughing. Her pulse was weak","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83012522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe adverse reactions caused by Kampo formulas from the viewpoint of cases relieved by the Adverse Drug Reaction Relief System in 2021","authors":"Kazuo Yamada, Kensuke Usui, E. Suzuki","doi":"10.1002/tkm2.1378","DOIUrl":"https://doi.org/10.1002/tkm2.1378","url":null,"abstract":"Although most adverse reactions to Kampo formulas are mild, there have been reports of serious adverse reactions, such as interstitial pneumonia caused by Shosaikoto [1] and mesenteric phlebosclerosis caused by Kampo preparations containing gardenia fruit (Gardeniae fructus) [2]. Although some previous reports [3, 4] on the incidence of adverse reactions to Kampo medicines are known, there are no reports on the actual number of patients with serious adverse reactions that resulted in hospitalization or death, excluding mild and moderate cases, in Japan. The ‘Adverse Drug Reaction Relief System’ aims to provide relief benefits for patients who experienced adverse drug reactions, required hospitalization, or died due to the adverse reaction [5]. Relief cases under the Adverse Drug Reaction Relief System are cases of severe adverse reactions to drugs. This study aimed to observe the recent trend of severe adverse reactions caused by Kampo formulas by examining the data on relief cases from the Adverse Drug Reaction Relief System, published on the website of the Pharmaceuticals andMedical Devices Agency (PMDA) in 2021 [6]. Data of 72 cases (24 males and 48 females), in which Kampo formulas were identified as the causative drug, out of the 1442 relief cases recorded in the 2021 Adverse Drug Reaction Relief System, available on the PMDA website, were examined [4]. The age range of the patients was from 20 to over 80 years old (20–29 years: 5 cases; 30–39 years: 5 cases; 40–49 years: 14 cases; 50–59 years: 14 cases; 60–69 years: 13 cases; 70–79 years: 15 cases; and ≥80 years: 6 cases). Adverse drug reactions caused by Kampo medicines included drug-induced liver injury (38 cases, 14 of which were in combination with modern medicines), interstitial pneumonia (32 cases, 9 of which were in combination with modern medicines), pseudo-aldosteronism or hypokalemia (four cases), generalized drug rash (three cases, all in combination with modern medicines), and one case of erythema multiforme type drug eruption (one case). In five cases, two Kampo prescriptions were combined. One case experienced two adverse reactions (drug-induced liver injury and generalized drug rash). The most common Kampo formula was saireito (18 cases), followed by saikokaryukotsuboreito (10 cases); bofutsushosan (six cases); seishinrenshiin, saikokeishikankyoto, and shin’iseihaito (four cases); shosaikotokakikyosekko and kakkonto (three cases); and nyoshinsan, shakuyakukanzoto, saibokuto, and hangeshashinto (two cases) (Table 1). Of these, five experienced adverse reactions to over-the-counter drugs (two cases of bofutsushosan), while one experienced an adverse reaction to a decoction. Kampo formulas causing drug-induced liver injury included saireito (eight cases); bofutsushosan (five cases); saikokaryukotsuboreito (three cases); shosaikotokakikyosekko (three cases); kakkonto, saikokeishikankyoto, shakuyakukanzoto, seishinrenshiin, and nyoshinsan (two cases); and nine other Kampo prescrip","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85691361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Western medicine and Japanese Kampo medicine are in a complementary relationship — Stillness and movement are beautifully harmonized in Japanese Kampo medicine","authors":"K. Tatsumi","doi":"10.1002/tkm2.1372","DOIUrl":"https://doi.org/10.1002/tkm2.1372","url":null,"abstract":"This review is a general outline to have a proper understanding of Japanese Kampo medicine from my point of view.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79002412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress and treatment of “long COVID” in non‐hospitalized patients: A single‐center retrospective cohort study","authors":"Rie Ono, Ryutaro Arita, S. Takayama, Takeshi Kanno, Akiko Kikuchi, Satoko Suzuki, Minoru Ohsawa, Natsumi Saito, Michiaki Abe, Ko Onodera, T. Akaishi, Y. Tadano, T. Ishii","doi":"10.1002/tkm2.1370","DOIUrl":"https://doi.org/10.1002/tkm2.1370","url":null,"abstract":"“Long COVID” or “post‐COVID conditions” describes prolonged symptoms after the acute phase of coronavirus disease 2019 (COVID‐19). However, there is a paucity of published reports on its treatment.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89338334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptoms associated with hematoma caused by radial artery injury successfully treated with jidabokuippo","authors":"H. Nakae, Yasuhito Irie","doi":"10.1002/tkm2.1374","DOIUrl":"https://doi.org/10.1002/tkm2.1374","url":null,"abstract":"Dear Editor Jidabokuippo (JDI) is a herbal mixture used in Japan to alleviate contusion-induced swelling and pain caused by bruises and sprains. It has also been applied to various traumas and cellulitis [1]. There have been a few reports of JDI being applied for bleeding and pain after venipuncture; however, there are few reports on the symptoms after arterial puncture [2,3]. We encountered a case in which JDI was useful for subcutaneous hematoma, swelling, and pain due to catheterization-induced radial artery injury. A 59-yearold man with a history of hypertension, acute myocardial infarction, and chronic kidney disease, experienced chest tightness one week before admission. As the patient’s chest tightness increased, he was admitted for suspected exertional angina pectoris and underwent coronary angiography. A percutaneous coronary intervention (PCI) sheath was inserted through the left radial artery. The patient was administered 200 mg of oral aspirin and 12,000 units of intravenous heparin during the PCI procedure. Immediately after PCI sheath insertion, blunt pain in the forearm developed, and swelling was noted (The Numerical Rating Scale [NRS] was 3/10). After the PCI procedure, compression hemostasis was intensified because of increased swelling in the forearm. Ultrasonography did not reveal any obvious hemorrhagic areas. After the procedure, hemoglobin and hematocrit levels decreased from 15.2 g/dl to 11.9 g/dl and from 46.0% to 35.7%, respectively. Nonetheless, the patient’s vital signs were stable, and he was discharged one day after the procedure. The subcutaneous hemorrhage and swelling in the left upper limb increased, and the pain in the forearm worsened to 8/10 on the NRS. Dorsiflexion of the wrist joint and extension of the elbow joint were no longer possible because of pain and swelling. Therefore, 7.5 g/day of JDI (extract TJ-89, Tsumura & Co., Tokyo, Japan) was administered (Figure 1a). Four days after the procedure, JDI was discontinued because the swelling and pain were reduced (NRS 5/10) (Figure 1b). However, a","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74795452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulcer‐healing effects of jumihaidokuto extract in a mouse model of methicillin‐resistant Staphylococcus aureus causing skin infection","authors":"M. Minami, T. Konishi, Masayo Taira, T. Makino","doi":"10.1002/tkm2.1371","DOIUrl":"https://doi.org/10.1002/tkm2.1371","url":null,"abstract":"Methicillin‐resistant Staphylococcus aureus (MRSA) is a pathogenic bacterium that causes severe skin diseases with ulceration. Since MRSA are not susceptible to multiple antibiotics, novel therapeutic agents are desired. Jumihaidokuto, a combination of 10 crude drugs, is a Japanese traditional Kampo medicine that is used for the treatment of skin diseases. In this study, we investigated the effects of jumihaidokuto extract (JHT) on MRSA‐infected mice.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77053852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the metabolomic effects of Kampo formulas using 1H‐NMR spectroscopy: A case study of goreisan","authors":"S. Awale, M. Jo, Shiro Watanabe, N. Shibahara, Kinzo Matsumoto","doi":"10.1002/tkm2.1369","DOIUrl":"https://doi.org/10.1002/tkm2.1369","url":null,"abstract":"The purpose of this study was to explore the effects of goreisan (GRS) on rats through the analysis of 1H‐NMR of urine samples, to assess the variations in metabolites affected by GRS, and to gain a new metabolomic understanding of the effects of Kampo medicine.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74147159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of goreisan, for gestational edema and amniotic fluid decrease","authors":"F. Makimoto","doi":"10.1002/tkm2.1366","DOIUrl":"https://doi.org/10.1002/tkm2.1366","url":null,"abstract":"Ordinarily, a diuretic uniformly performs diuresis of body water and decreases it. When a diuretic is used for gestational edema, blood vessel dehydration and amniotic fluid are expected to decrease. This may be rather harmful for the gestational prognosis. Goreisan's mechanism of efficacy is different from that of ordinary diuretics. The results of treating gestational edema and amniotic fluid reduction with goreisan were studied. Whether goreisan is helpful for improving gestational prognosis was studied.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82780294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conference report: Third annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine","authors":"Tetsuhiro Yoshino, T. Yokogawa, Kohsuke Nakamichi, Yoshiaki Manse, Hayato Yoshikawa, Hiroaki Sasaki, Hirokazu Ando, Souichi Nakashima","doi":"10.1002/tkm2.1362","DOIUrl":"https://doi.org/10.1002/tkm2.1362","url":null,"abstract":"Four young researchers presented their studies in the field of traditional Japanese herbal medicine (Wakan‐yaku) at the third annual young researcher forum entitled “Respecting and Breaking Traditions,” held 1 week before the 2022 annual meeting of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine. Dr. Yokogawa presented her research focusing on the mechanism of the Ayurveda drug‐eluting string, Kshara Sutra, in treating anal fistulas, reporting on its effects on the anal tissue in an anal fistula rat model and its antibacterial activity against Escherichia coli and Staphylococcus aureus, the causative organisms of anal fistulas. Mr. Nakamichi presented his research focusing on the relationship between the efficacy of Kampo medicines with anti‐obesity effects and intestinal microbiota composition. His results partially revealed that bofutsushosan and boiogito affect lipid metabolism in mice and correlate with the intestinal microbiota composition. Dr. Manse reported the anti‐inflammatory activity of diterpenoid components in Enmei‐so (Isodonis Herba), revealing its novel inhibitory activity on nitric oxide released from activated macrophages and on inflammatory cytokines, and identified active components contributing to the inhibition and the mechanism of action. Mr. Yoshikawa reported the anticancer activity of small molecular compounds isolated from the medicinal plants, Valeriana fauriei and Hypericum erectum. His results suggest that five compounds may increase the sensitivity of human cervical carcinoma cells to adriamycin via HSP105 expression suppression. The event was conducted online, and included 78 participants. We intend to hold and improve this forum in 2023 and the future.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87143236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suppressive effects of Bombycis Feces (bombyx feces) and Bombyx Batryticatus (stiff silkworm) extracts on blood glucose level elevation in disaccharides‐loaded rats","authors":"H. Matsuda, Akifumi Nagatomo, M. Hatakeyama, Yoshiaki Manse, M. Yoshikawa, T. Morikawa","doi":"10.1002/tkm2.1368","DOIUrl":"https://doi.org/10.1002/tkm2.1368","url":null,"abstract":"Bombycis Feces (BF) and Bombyx Batryticatus (BB) are traditional medicines derived from silkworm. We investigated the suppressive effects of BF and BB extracts on elevated blood glucose levels in disaccharide‐loaded rats.","PeriodicalId":23213,"journal":{"name":"Traditional & Kampo Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76519354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}