Thrita Pub Date : 2022-12-05 DOI: 10.5812/thrita-131959

Karim Javidaneh, Atousa Moradzadegan

{"title":"Effective Parameters for the Stimulation of Trehalose Synthesis in Saccharomyces cerevisiae","authors":"Karim Javidaneh, Atousa Moradzadegan","doi":"10.5812/thrita-131959","DOIUrl":"https://doi.org/10.5812/thrita-131959","url":null,"abstract":"Background: The ability of anhydrobiotic to survive long periods of stress conditions is associated with high trehalose levels found in these organisms as a responsive mechanism against stress and adverse conditions. Many methods and factors function as determinant agents of trehalose production and preservation in yeasts. Objectives: This study aimed to investigate the effect of three parameters on trehalose synthesis, including temperature, rate of feed, and time of aeration. Methods: To induce trehalose production in baker's yeast, we used an experimental design method in an industrial fermenter at the Khuzestan Yeast Company. The investigation of temperature, rate of feed, and time of aeration parameters in our recipe design were also performed after the cessation of feeding molasses. Results: The findings showed that temperature had the greatest effect on the synthesis of trehalose. Moreover, the interaction of three parameters was significantly effective for the stimulation of trehalose synthesis. We could also make a gas production surge in the dough by increasing the level of trehalose. Conclusions: We conclude that controlling the temperature and taking advantage of the interaction between temperature, rate of feed, and aeration time can help achieve the most effective trehalose synthesis and ensuing gas production in the dough.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86977063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of miR-4772-3pand miR-3173-3p Expression in Tissue Compared to Normal Tissue by Real-time PCR Real-time PCR检测mir -4772-3p和miR-3173-3p在组织中与正常组织的表达变化

Thrita Pub Date : 2022-11-01 DOI: 10.5812/thrita-129435

Roghayeh Roshani, F. Ashrafi, E. Moslemi, Hamid Khaledi

{"title":"Alterations of miR-4772-3pand miR-3173-3p Expression in Tissue Compared to Normal Tissue by Real-time PCR","authors":"Roghayeh Roshani, F. Ashrafi, E. Moslemi, Hamid Khaledi","doi":"10.5812/thrita-129435","DOIUrl":"https://doi.org/10.5812/thrita-129435","url":null,"abstract":"Background: In recent years, many studies have focused on the dysregulation of miRNA expression in cancer. These structures act as oncogenes and suppressors. In the present study, the expression levels of miR-3173-3p and miR-4772-3p were investigated in the tissue of glioblastoma multiforme (GBM) patients and healthy individuals. Methods: The present study was performed on 50 patients with GBM and 50 healthy individuals as the control group. Real-time PCR technique was used to determine the tissue levels of miR-3173-3p and miR-4772-3p. The biomarker evaluation of miR-3173-3p and miR-4772-3p was assessed using ROC curve analysis. Results: The expression level of miR-4772-3p was higher in women with GBM (P-value = 0.03). Increased concentration of miR-3173-3p in tissue of GBM patients showed a significant correlation with a final grade of disease progression (grades III and IV) (P-value = 0.007). ROC curve analysis and cut-off of 0.6939 showed that miR-4772-3p could detect the presence of malignant GBM with 88.89 sensitivity and 100.0 specificity. Conclusions: The present study reveals the potential oncogenic role of miR-4772-3p. Moreover, the progression of glioblastoma cancer in the final stages can be assessed by measuring the level of miR-4772-3p in patients’ tissue.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87212565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Effect of Creatine and Ginseng Supplementations on the Aerobic Power, Anaerobic Power, and Muscle Strength of the Male Players of the Iran National Epee Team 补充肌酸和人参对伊朗国家重剑男子运动员有氧、无氧力量和肌肉力量的影响比较

Thrita Pub Date : 2022-09-16 DOI: 10.5812/thrita-128754

T. Bagherpour, Ahmad Yaghobi, N. Nemati

{"title":"Comparison of the Effect of Creatine and Ginseng Supplementations on the Aerobic Power, Anaerobic Power, and Muscle Strength of the Male Players of the Iran National Epee Team","authors":"T. Bagherpour, Ahmad Yaghobi, N. Nemati","doi":"10.5812/thrita-128754","DOIUrl":"https://doi.org/10.5812/thrita-128754","url":null,"abstract":"Background: Measuring physical fitness by studying aerobic metabolism, anaerobic metabolism, and muscular strength in most sports research is one of the important indicators of professional athletes. Objectives: The aim of the present study was to compare six weeks of creatine supplementation and ginseng on the aerobic and anaerobic strength and muscle strength of the male players of the Iran national epee fencing team. Methods: This quasi-experimental study with a pretest-posttest design was performed on two experimental groups of creatine and ginseng as a double-blind study. A total of 14 male players of the national epee fencing team were assigned to two groups’ creatine supplement and ginseng supplement. The statistical significant difference was determined at P ≥ 0.05, and ANCOVA test was used to assess the differences between groups. All data were analyzed by the SPSS software version 25. Results: The results showed that the mean aerobic power in the creatine supplement group was significantly different from the ginseng supplement group (P = 0.001). In addition, the mean anaerobic control within the creatine supplement group is significantly higher than the ginseng supplement group (P = 0.001). The mean muscle strength in the creatine supplement group is significantly different from the ginseng group (P = 0.001). Higher mean aerobic power, anaerobic power, and muscle strength in the creatine supplement group, compared to the ginseng group, showed the more significant role of this supplement in raising aerobic power. Conclusions: It can be concluded that the role of creatine supplements in improving aerobic and anaerobic power and muscle strength could be more remarkable than the ginseng supplement.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87433035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Review of Reactive and Non-reactive Agility Tests Concerning Neurologic Aspects 神经学方面反应性和非反应性敏捷性测试综述

Thrita Pub Date : 2022-08-16 DOI: 10.5812/thrita-129744

Mohammad Tajik, M. Azarbayjani, M. Peeri

{"title":"A Review of Reactive and Non-reactive Agility Tests Concerning Neurologic Aspects","authors":"Mohammad Tajik, M. Azarbayjani, M. Peeri","doi":"10.5812/thrita-129744","DOIUrl":"https://doi.org/10.5812/thrita-129744","url":null,"abstract":": Agility is an essential component of sport performance, especially in ball sports. It is also a significant indicator of sport skills under competitive conditions. Agility is one of the most critical factors in the sport performance of soccer players. Agility and coordination of the nervous-muscular system to produce maximum force, as an important factor of function and physical fitness, which is considered along with perception and decision making in unpredictable situations. Assessment tests for assessing agility are divided into two general areas called non-reactive agility as well as reactive agility test. Although non-reactive agility tests are superior to reactive agility tests in terms of reliability, reactive agility tests are more similar to the movement and skill pattern in soccer and can distinguish players from each other well. In reactive agility tests, the movement path of the experimenter is not predictable and not all changes in path are predetermined and exactly the movement pattern in the soccer game where the movement path of the player is not predictable and the movement path of the ball as well as the prevailing conditions in the game that determine and change of direction player at any moment. The results showed that non-reactive agility had a higher relative validity and reliability than reactive agility. This small difference was acknowledged by researchers related to the reactivity and complexity of reactive agility tests. finally a review of the above studies and findings confirms that the use of reactive agility tests is necessary to evaluate athletes","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73261012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Effects of Physical Activity (PA) on Bone Density: Relying on Iranian Studies 体育活动(PA)对骨密度影响的综述:基于伊朗研究

Thrita Pub Date : 2022-08-14 DOI: 10.5812/thrita-128483

Mahdieh Nazari, M. Azarbayjani, S. Rahmati-Ahmadabad, M. Guerra Balic, Bryanne N. Bellovary

引用次数: 4

The Effects of Chlorpyrifos on Hippocampal Caspase-3 Levels and Passive Avoidance Memory in Rats 毒死蜱对大鼠海马Caspase-3水平及被动回避记忆的影响

Thrita Pub Date : 2022-06-05 DOI: 10.5812/thrita-123356

Sina Nikbin, S. B. Jameie, M. Azarbayjani, Nasrin Hosseini

{"title":"The Effects of Chlorpyrifos on Hippocampal Caspase-3 Levels and Passive Avoidance Memory in Rats","authors":"Sina Nikbin, S. B. Jameie, M. Azarbayjani, Nasrin Hosseini","doi":"10.5812/thrita-123356","DOIUrl":"https://doi.org/10.5812/thrita-123356","url":null,"abstract":"Background: Chlorpyrifos is an organophosphate pesticide that is widely used in the world. Exposure to chlorpyrifos is associated with some problems in cognitive functions, such as learning and memory. Caspase-3 is a cysteine protease that is activated in response to several apoptotic stimuli and triggers some proteolytic events, cell death, and neurodegeneration. Objectives: The aim of the present study was to clear potential mechanisms related to chlorpyrifos neurotoxicity through caspase-3 alteration and passive avoidance memory function. Methods: Male adult rats were randomly divided into the control, sham, and chlorpyrifos groups (eight rats in each group). The chlorpyrifos group received an intraperitoneal injection of chlorpyrifos (3 mg/kg/5 days) dissolved in dimethyl sulfoxide for two consecutive weeks. The caspase-3 levels in the hippocampus were assessed by the western blot technique, and also the passive avoidance task was used for memory evaluation. Results: Our findings showed that chlorpyrifos treatment markedly increased caspase-3 levels in the hippocampus and also increased the time spent in the dark chamber 24 h and one week after receiving foot shock in the chlorpyrifos group. Conclusions: Organophosphate pesticides exposure can impair passive avoidance memory, and high levels of caspase-3 in the hippocampus are proposed as a possible reason for neuronal toxicity and memory impairment.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82927282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Aerobic Exercise Training and Eugenol Supplementation on the Wnt, TGF-β, and Beta-Catenin gene Expression in Myocardial Tissue of Poisoned Rats Induced by Chlorpyrifos 有氧运动训练和丁香酚补充对毒死蜱中毒大鼠心肌组织Wnt、TGF-β和β - catenin基因表达的影响

Thrita Pub Date : 2022-05-18 DOI: 10.5812/thrita-118263

Fatemeh Parsa-Lisar, Hasan Matinhomaei, M. Azarbayjani

{"title":"The Effect of Aerobic Exercise Training and Eugenol Supplementation on the Wnt, TGF-β, and Beta-Catenin gene Expression in Myocardial Tissue of Poisoned Rats Induced by Chlorpyrifos","authors":"Fatemeh Parsa-Lisar, Hasan Matinhomaei, M. Azarbayjani","doi":"10.5812/thrita-118263","DOIUrl":"https://doi.org/10.5812/thrita-118263","url":null,"abstract":": Chlorpyrifos is an organophosphate toxin used to control agricultural pests that cause oxidative stress, apoptosis, and cell destruction in various body tissues, including the heart. The expression of Wnt, TGFβ, and beta-catenin plays a crucial role in cardiac fibrosis development. No study has investigated changes in the function of these genes following physical activity and eugenol supplementation in chlorpyrifos intoxication. The present study investigated the independent and interactive effect of aerobic exercise and eugenol supplementation on the Wnt, TGFβ, and beta-catenin gene expression in the heart tissue of rats poisoned with chlorpyrifos. Forty-two male rats were divided into seven groups: healthy control, healthy receiving DMSO as chlorpyrifos toxin solvent, healthy receiving corn oil as eugenol solvent, poisoned control, aerobic exercise poisoning, eugenol poisoning, aerobic poisoning, and eugenol poisoning. The expression of the desired genes in the hearts of rats was measured after providing the intervention. Data were analyzed using the one-way analysis of variance and Tukey's post hoc tests. Statistical significance was considered when P ≤ 0.05. Poisoning significantly increased the Wnt, TGFβ, and beta-catenin gene expression in the heart tissue. The use of exercise and supplementation reduced the Wnt, TGFβ, and beta-catenin gene expression, each independently, in the hearts of poisoned rats. Exercise-eugenol interaction did not significantly reduce the gene expression than exercise or supplementation alone. Overall, the present study showed the positive role of exercise and eugenol in reducing chronic cardiac toxicity on Wnt, TGFβ, and beta-catenin gene expression.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90522638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlations Between Gonadotropin Hormones and the Manifestations of Polycystic Ovary Syndrome 促性腺激素与多囊卵巢综合征表现的相关性研究

Thrita Pub Date : 2022-04-17 DOI: 10.5812/thrita-117396

Davoud Fazli, Seyed Peyman Moghaddasi

{"title":"Correlations Between Gonadotropin Hormones and the Manifestations of Polycystic Ovary Syndrome","authors":"Davoud Fazli, Seyed Peyman Moghaddasi","doi":"10.5812/thrita-117396","DOIUrl":"https://doi.org/10.5812/thrita-117396","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is the most common disease associated with chronic anovulation that affects 4 - 6% of women of reproductive age. Objectives: This study aimed to assess the correlation of luteinizing hormone (LH)/follicle-stimulating hormone (FSH) ratio with body mass index (BMI), hirsutism, age, and main clinical symptoms of PCOS in women. Methods: We compared hirsutism, irregular menses, menstrual pain, LH, FSH, and LH/FSH between 400 women diagnosed with PCOS based on Rotterdam Criteria and 500 healthy controls. Moreover, the relationships between all these variables were investigated. The data were evaluated by the Mann-Whitney test, chi-square test, and correlation coefficient. Results: In this study, mean weight and BMI, as well as the percentage of clinical factors, namely hirsutism, irregular menstruation, and menstrual pain in the PCOS group, were significantly higher than in the control group (P ≤ 0.001). In addition, the mean of LH, FSH, and LH/FSH in women with PCOS was significantly higher than the control group (P≤0.001). Our results showed a significant negative relationship between age and LH/FSH in the PCOS group (r = -0.106, P = 0.034). Conclusions: According to the findings of this study, LH/FSH ratio had a significant negative correlation with age. However, no relationship was observed between LH/FSH ratio and BMI.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87674929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Effects of 6 Weeks of Traditional and Wrestling-Technique-Based Circuit Training on the Blood Levels of Lactate, Lactate Dehydrogenase, Glucose, and Insulin in Young Male Wrestlers 6周传统与摔角技术循环训练对年轻男性摔角运动员血液中乳酸、乳酸脱氢酶、葡萄糖和胰岛素水平的影响比较

Thrita Pub Date : 2022-02-15 DOI: 10.5812/thrita.122183

Mohammad-Ali Zeratgar, A. Ghanbari-Niaki, S. Rahmati-Ahmadabad

{"title":"Comparison of the Effects of 6 Weeks of Traditional and Wrestling-Technique-Based Circuit Training on the Blood Levels of Lactate, Lactate Dehydrogenase, Glucose, and Insulin in Young Male Wrestlers","authors":"Mohammad-Ali Zeratgar, A. Ghanbari-Niaki, S. Rahmati-Ahmadabad","doi":"10.5812/thrita.122183","DOIUrl":"https://doi.org/10.5812/thrita.122183","url":null,"abstract":"Background: Nowadays, circular training has become more common than traditional training in wrestling. Objectives: This study aimed to compare the effects of 6 weeks of traditional and circular wrestling training on blood lactate, lactate dehydrogenase (LDH), glucose, and insulin concentrations in young male wrestlers. Methods: Twenty-seven young male wrestlers were randomly divided into 3 groups (ie, traditional wrestling training, circular wrestling training, and control groups) and performed interventions based on the group name for 6 weeks. Blood samples were taken from all subjects 48 hours before and 48 hours after the interventions and sent to a laboratory for analysis. Blood concentrations of lactate, LDH, glucose, and insulin were measured by enzyme-linked immunosorbent assay (ELISA). Data were analyzed using multivariate analysis of covariance (MANCOVA) and suitable post hoc test. Results: Traditional training significantly increased plasma lactate concentrations of wrestlers (P = 0.01) and had no significant effect on their serum LDH, insulin, and glucose concentrations (P > 0.05). Circular training significantly increased plasma lactate (P = 0.03) and serum insulin (P = 0.004) concentrations and had no significant effect on serum LDH and glucose concentrations (P > 0.05). Conclusions: These 2 types of training have a similar effect on the measured variables; however, it seems that circular training has a more significant effect on the measured variables than traditional training, which can probably be attributed to the use of more lactic energy resources and apparatus in circular training, which in turn can be used in preparation.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80096199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cognitive Impairment and Related Causes in Hemodialysis Patients 血液透析患者的认知障碍及其相关原因

Thrita Pub Date : 2022-02-13 DOI: 10.5812/thrita.115833

E. Shahraki, M. Shakiba, Melika Gholampour Yazdi, Narjes Sargolzaie

{"title":"Cognitive Impairment and Related Causes in Hemodialysis Patients","authors":"E. Shahraki, M. Shakiba, Melika Gholampour Yazdi, Narjes Sargolzaie","doi":"10.5812/thrita.115833","DOIUrl":"https://doi.org/10.5812/thrita.115833","url":null,"abstract":"Background: End-stage renal disease (ESRD) is the stage of renal failure that requires renal replacement therapy such as hemodialysis. Despite the beneficial effects of hemodialysis on patient survival and progress in the treatment of various disorders in these patients, patients still suffer from numerous complications, such as neurological and cognitive disorders, which do not improve with dialysis. Objectives: This study aimed to evaluate cognitive impairment in hemodialysis patients in Zahedan, Iran, and design a model to predict the risk. Methods: This cross-sectional study was performed on 114 hemodialysis patients in Zahedan. Due to the socioeconomic status of the people of this region and the lack of a similar study in this part of Iran, the mini-mental state examination (MMSE) was performed. An information checklist, including age, gender, lifetime frequency of hemodialysis, and duration of hemodialysis, was completed by the investigator. Results: The MMSE score showed that cognitive impairment was common in ESRD patients, and its prevalence was significantly higher in elderly patients. Patients' cognitive function was significantly related to the lifetime frequency and duration of dialysis. Based on these results, we designed a model to predict the likelihood of cognitive impairment. Conclusions: The results show that cognitive impairment is a common problem among ESRD patients. Dementia is associated with multiple risks such as death, withdrawal from dialysis, hospitalization, and exacerbation of disability in ESRD patients. Therefore, effective recognition and management of these disorders can improve clinical care.","PeriodicalId":23167,"journal":{"name":"Thrita","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84193972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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