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Niaoduqing Granules Inhibits TGF-β1-induced Epithelial-Mesenchymal Transition in Human Renal Tubular Epithelial HK-2 Cells 尿毒清颗粒抑制TGF-β1诱导的人肾小管上皮HK-2细胞上皮间质转化
TMR Modern Herbal Medicine Pub Date : 2020-06-12 DOI: 10.21203/rs.3.rs-34640/v1
Chuying Huo, Huayi Yang, W. Ning, Lin-zhong Yu, Chunlin Fan, Jingyu Quan, L. Deng, Zhi-Ling Yu, Junshan Liu, Huihui Cao
{"title":"Niaoduqing Granules Inhibits TGF-β1-induced Epithelial-Mesenchymal Transition in Human Renal Tubular Epithelial HK-2 Cells","authors":"Chuying Huo, Huayi Yang, W. Ning, Lin-zhong Yu, Chunlin Fan, Jingyu Quan, L. Deng, Zhi-Ling Yu, Junshan Liu, Huihui Cao","doi":"10.21203/rs.3.rs-34640/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-34640/v1","url":null,"abstract":"\u0000 Background: Chronic renal failure (CRF) is a worldwide public health burden. Niaoduqing granules (NDQ) is widely used for CRF treatment in China. However, the underlying mechanism of NDQ is not fully studied. This study is aimed to investigate whether NDQ ameliorate CRF by inhibiting TGF-β1-induced EMT in human renal tubular epithelial HK-2 cells.Methods: MTT assay and colony formation assay were used to investigate the cytotoxicity of NDQ in HK-2 cells. Morphological changes of HK-2 cells after TGF-β1 or/and NDQ treatment were observed under a microscope. Wound-healing, migration and invasion assays were performed to determine the cell movement, migratory and invasive abilities, respectively. Western blot analysis was carried out to examine the protein levels of TGF-β type I receptor (TβRI) and EMT-associated factors. Fluorescence confocal microscopy was applied to observe the organization of F-actin.Results: NDQ suppressed TβRI expression dose-dependently. NDQ inhibited TGF-β1-stimulated EMT in HK-2 cells, supported by the evidences that NDQ prevented morphology change, attenuated cell migration and invasion, downregulated EMT factors and reorganized F-actin distribution in TGF-β1-stimulated HK-2 cells.Conclusions: NDQ attenuates chronic renal failure which may be associated with inhibition of TβRI expression and EMT process.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77748159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of theophylline/chitosan/β-cyclodextrin microspheres for oral drug delivery on an asthmatic rat model 茶碱/壳聚糖/β-环糊精微球口服给药对哮喘大鼠模型的影响
TMR Modern Herbal Medicine Pub Date : 2020-05-01 DOI: 10.12032/TMRMHM202003071
Saisai Wang, Haijing Zhang, Xiaoming Cui, Liping Zhao, Mingxia Jiang, Zhilu Xu, Dong-zhen Mu, Weifen Zhang
{"title":"Effects of theophylline/chitosan/β-cyclodextrin microspheres for oral drug delivery on an asthmatic rat model","authors":"Saisai Wang, Haijing Zhang, Xiaoming Cui, Liping Zhao, Mingxia Jiang, Zhilu Xu, Dong-zhen Mu, Weifen Zhang","doi":"10.12032/TMRMHM202003071","DOIUrl":"https://doi.org/10.12032/TMRMHM202003071","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75477742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The roles of traditional Chinese herbal medications in regulating mitochondrial activity to reverse cancer 中药在调节线粒体活性以逆转癌症中的作用
TMR Modern Herbal Medicine Pub Date : 2020-05-01 DOI: 10.12032/TMRMHM202003076
Lichao Sun, Guihua Tian, H. Shang
{"title":"The roles of traditional Chinese herbal medications in regulating mitochondrial activity to reverse cancer","authors":"Lichao Sun, Guihua Tian, H. Shang","doi":"10.12032/TMRMHM202003076","DOIUrl":"https://doi.org/10.12032/TMRMHM202003076","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88617943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dendrobium huoshanense improves doxorubicin-induced heart failure in C57BL/6 mice 霍山石斛改善阿霉素诱导的C57BL/6小鼠心力衰竭
TMR Modern Herbal Medicine Pub Date : 2020-05-01 DOI: 10.12032/TMRMHM202003064
Rong Huang, Yuanyuan Wang, Yingquan Liang, Maoyun Yu, Yuanli Chen, Jihong Han, Xiaoxiao Yang, Yajun Duan
{"title":"Dendrobium huoshanense improves doxorubicin-induced heart failure in C57BL/6 mice","authors":"Rong Huang, Yuanyuan Wang, Yingquan Liang, Maoyun Yu, Yuanli Chen, Jihong Han, Xiaoxiao Yang, Yajun Duan","doi":"10.12032/TMRMHM202003064","DOIUrl":"https://doi.org/10.12032/TMRMHM202003064","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90846352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research progress on chemical composition, pharmacological effects of Forsythia suspensa (Thunb.) Vahl and predictive analysis on Q-marker 连翘化学成分及药理作用的研究进展Q-marker的Vahl及预测分析
TMR Modern Herbal Medicine Pub Date : 2020-05-01 DOI: 10.12032/TMRMHM202003069
Hui Peng, Peng Lu, Yiting Liu, Chuanxin Liu, Yanquan Gao, E. Nwafor, Yuelin Zhang, Zhidong Liu
{"title":"Research progress on chemical composition, pharmacological effects of Forsythia suspensa (Thunb.) Vahl and predictive analysis on Q-marker","authors":"Hui Peng, Peng Lu, Yiting Liu, Chuanxin Liu, Yanquan Gao, E. Nwafor, Yuelin Zhang, Zhidong Liu","doi":"10.12032/TMRMHM202003069","DOIUrl":"https://doi.org/10.12032/TMRMHM202003069","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84705264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The research idea of Xuebijing injection in influencing severe pneumonia-pulmonary fibrosis with blood stasis syndrome evolution by inhibiting inflammation, endotoxin and dispersing blood stasis 血必净注射液抑制炎症、内毒素、散瘀对重症肺炎-肺纤维化血瘀证演变影响的研究思路
TMR Modern Herbal Medicine Pub Date : 2020-05-01 DOI: 10.12032/TMRMHM202003070
Rui Zheng, Chengyu Li, Ping Wang, Min Li, Pengqian Wang, Changming Zhong, Jian-xun Wang, H. Shang
{"title":"The research idea of Xuebijing injection in influencing severe pneumonia-pulmonary fibrosis with blood stasis syndrome evolution by inhibiting inflammation, endotoxin and dispersing blood stasis","authors":"Rui Zheng, Chengyu Li, Ping Wang, Min Li, Pengqian Wang, Changming Zhong, Jian-xun Wang, H. Shang","doi":"10.12032/TMRMHM202003070","DOIUrl":"https://doi.org/10.12032/TMRMHM202003070","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78335265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The functional components and mechanism of Linderae Radix in treating diabetic nephropathy based on the network pharmacology 基于网络药理学的林芝治疗糖尿病肾病的作用成分及机制研究
TMR Modern Herbal Medicine Pub Date : 2020-05-01 DOI: 10.12032/TMRMHM202003063
Su Wu, Yao Yujian, Mang Xiao, Meiling Yan, Xie Yiqiang, Ni Yali
{"title":"The functional components and mechanism of Linderae Radix in treating diabetic nephropathy based on the network pharmacology","authors":"Su Wu, Yao Yujian, Mang Xiao, Meiling Yan, Xie Yiqiang, Ni Yali","doi":"10.12032/TMRMHM202003063","DOIUrl":"https://doi.org/10.12032/TMRMHM202003063","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82923345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospects for the future of clinical efficacy evaluation of traditional Chinese medicine——Emphasis on original theory and clinical practice 展望中药临床疗效评价的未来——强调理论创新和临床实践
TMR Modern Herbal Medicine Pub Date : 2020-02-01 DOI: 10.12032/TMRMHM202003057
Chen Zhao, Wei-qiang Mu, H. Shang
{"title":"Prospects for the future of clinical efficacy evaluation of traditional Chinese medicine——Emphasis on original theory and clinical practice","authors":"Chen Zhao, Wei-qiang Mu, H. Shang","doi":"10.12032/TMRMHM202003057","DOIUrl":"https://doi.org/10.12032/TMRMHM202003057","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81327480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Angelica Polysaccharide on telomere length in mice with benzene-induced aplastic anemia 当归多糖对苯致再生障碍性贫血小鼠端粒长度的影响
TMR Modern Herbal Medicine Pub Date : 2020-02-01 DOI: 10.12032/TMRMHM202003059
R. Sun, X. Cui, Qingsong Wang, Yanyu Zhang, Xiaoqi Sun
{"title":"Effects of Angelica Polysaccharide on telomere length in mice with benzene-induced aplastic anemia","authors":"R. Sun, X. Cui, Qingsong Wang, Yanyu Zhang, Xiaoqi Sun","doi":"10.12032/TMRMHM202003059","DOIUrl":"https://doi.org/10.12032/TMRMHM202003059","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77346179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of Alpinia oxyphylla on oxidative stress and expression of p47phox in diabetic nephropathy rats 木质素对糖尿病肾病大鼠氧化应激及p47phox表达的影响
TMR Modern Herbal Medicine Pub Date : 2020-02-01 DOI: 10.12032/TMRMHM202003061
Xian Wang, Chang Liu, Mi Li, Yiqiang Xie, Kai Li
{"title":"Effects of Alpinia oxyphylla on oxidative stress and expression of p47phox in diabetic nephropathy rats","authors":"Xian Wang, Chang Liu, Mi Li, Yiqiang Xie, Kai Li","doi":"10.12032/TMRMHM202003061","DOIUrl":"https://doi.org/10.12032/TMRMHM202003061","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90793517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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