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The genus Strobilanthes: phytochemistry and pharmacology 桔梗属:植物化学和药理学
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022b0701001
Xiaoling Zhu, Yang Xu, De-juan Sun, Hua Li, Lixia Chen
{"title":"The genus Strobilanthes: phytochemistry and pharmacology","authors":"Xiaoling Zhu, Yang Xu, De-juan Sun, Hua Li, Lixia Chen","doi":"10.53388/mhm2022b0701001","DOIUrl":"https://doi.org/10.53388/mhm2022b0701001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"24 23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82820772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Indirubin suppresses 4T1 murine breast cancer in vitro and in vivo by induction of ferroptosis and up-regulation of Ptgs2 靛玉红在体外和体内通过诱导铁下垂和上调Ptgs2抑制4T1小鼠乳腺癌
TMR Modern Herbal Medicine Pub Date : 2021-04-09 DOI: 10.21203/RS.3.RS-390546/V1
Xiuping Kuang, Yingnan Jiang, Jiwei Huang, Yongzhi Guo, weixi Li
{"title":"Indirubin suppresses 4T1 murine breast cancer in vitro and in vivo by induction of ferroptosis and up-regulation of Ptgs2","authors":"Xiuping Kuang, Yingnan Jiang, Jiwei Huang, Yongzhi Guo, weixi Li","doi":"10.21203/RS.3.RS-390546/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-390546/V1","url":null,"abstract":"\u0000 Background\u0000\u0000Indirubin, isolated from Indigo Naturals, is reported to have the inhibitory activity of MCF-7 human breast cancer cells in vitro. However, studies on its anti-breast cancer activity in vivo and underlying mechanism are insufficient. We explored whether indirubin could trigger ferroptosis of breast cancer cells to exert anti-tumor activity.\u0000Methods\u0000\u0000Bioinformatical analysis was performed to detected the expression of prostaglandin-endoperoxide synthase 2 (Ptgs2) in breast cancer tissues Ptgs2-related prognosis for patients with breast cancer. Growth of 4T1 cells was assessed using wound healing assay and MTT assay. The levels of 4-HNE, GPX4, PTGS2 and GSK-3β proteins were detected by Western blot, and the mRNA of Ptgs2 was tested by qPCR. The GSH and MDA were determined by commercial kits. Molecular docking was employed to study interaction between indirubin and GSK-3β. An 4T1 murine breast cancer was adopted to evaluate the in vivo antitumor activity of indirubin.\u0000Results\u0000\u0000Indirubin promoted ferroptosis of 4T1 breast cancer cells with deplete of GSH, increased MDA and 4-HNE level, as well as decreased GPX4 expression. Indirubin suppressed the growth of 4T1 breast tumor in vivo. Mechanism study showed indirubin up regulated Ptgs2 expression by promoting phosphorylation (Ser 9) of GSK-3β.\u0000Conclusions\u0000\u0000Indirubin suppresses 4T1 murine breast cancer in vitro and in vivo by induction of ferroptosis and up-regulation of Ptgs2.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83551022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A brief overview of traditional Chinese medicine prescription powered by artificial intelligence 人工智能驱动的中药处方简介
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021b0412001
Hongyun Bao, R. Wen, Xuanya Li, Chen Zhao, Zhineng Chen
{"title":"A brief overview of traditional Chinese medicine prescription powered by artificial intelligence","authors":"Hongyun Bao, R. Wen, Xuanya Li, Chen Zhao, Zhineng Chen","doi":"10.53388/mhm2021b0412001","DOIUrl":"https://doi.org/10.53388/mhm2021b0412001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78072234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering the multi-target pharmacological mechanism of Xuebijing injection against sepsis by a systems pharmacology approach 用系统药理学方法揭示血必净注射液抗脓毒症的多靶点药理机制
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021a0110001
Ping Wang, Jingjing Zhu, J. Zhai, Xiaorui Li, H. Shang, Jianxun Wang
{"title":"Uncovering the multi-target pharmacological mechanism of Xuebijing injection against sepsis by a systems pharmacology approach","authors":"Ping Wang, Jingjing Zhu, J. Zhai, Xiaorui Li, H. Shang, Jianxun Wang","doi":"10.53388/mhm2021a0110001","DOIUrl":"https://doi.org/10.53388/mhm2021a0110001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90434217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guizhi-Fuling formula inhibits ovarian cancer progression by targeting STAT3 signaling network Guizhi-Fuling公式抑制卵巢癌进展通过瞄准STAT3信号网络
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021a1021001
Q. Ma, Shi-rong Dong, Yuanyuan Shi, Tiangong Lu
{"title":"Guizhi-Fuling formula inhibits ovarian cancer progression by targeting STAT3 signaling network","authors":"Q. Ma, Shi-rong Dong, Yuanyuan Shi, Tiangong Lu","doi":"10.53388/mhm2021a1021001","DOIUrl":"https://doi.org/10.53388/mhm2021a1021001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"215 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72669033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Clinical research of traditional Chinese medicine under the influence of ICD-11: a new bridge and a new balance ICD-11影响下的中医临床研究:新的桥梁与新的平衡
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021o0125001
H. Shang
{"title":"Clinical research of traditional Chinese medicine under the influence of ICD-11: a new bridge and a new balance","authors":"H. Shang","doi":"10.53388/mhm2021o0125001","DOIUrl":"https://doi.org/10.53388/mhm2021o0125001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82260808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experimental study on the effect of Huangqi and Danshen ultramicro gel on vascular healing of wound in rats based on network pharmacology 基于网络药理学的黄芪、丹参超微凝胶对大鼠创面血管愈合影响的实验研究
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021a0711001
Yikang Yu, Kai Yu, B. Liang, Dong-Peng Tu, Wen-Kai Zhang, Chao Xu, Zheng Liu, Yi Peng, Bin Zhang
{"title":"Experimental study on the effect of Huangqi and Danshen ultramicro gel on vascular healing of wound in rats based on network pharmacology","authors":"Yikang Yu, Kai Yu, B. Liang, Dong-Peng Tu, Wen-Kai Zhang, Chao Xu, Zheng Liu, Yi Peng, Bin Zhang","doi":"10.53388/mhm2021a0711001","DOIUrl":"https://doi.org/10.53388/mhm2021a0711001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"137 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79724586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network pharmacology-based analysis on bioactive compounds and mechanisms in Yiqifumai formula in the treatment of heart failure 基于网络药理学的益气复脉方治疗心力衰竭活性成分及作用机制分析
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021a1017001
Herong Cui, Kedian Chen, Xiaoyu Zhang, H. Shang
{"title":"Network pharmacology-based analysis on bioactive compounds and mechanisms in Yiqifumai formula in the treatment of heart failure","authors":"Herong Cui, Kedian Chen, Xiaoyu Zhang, H. Shang","doi":"10.53388/mhm2021a1017001","DOIUrl":"https://doi.org/10.53388/mhm2021a1017001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87840639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pathological tissue segmentation by using deep neural networks 基于深度神经网络的病理组织分割
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021a0127001
Bo Pang, Jianyong Wang, Wei Zhang, Zhang Yi
{"title":"Pathological tissue segmentation by using deep neural networks","authors":"Bo Pang, Jianyong Wang, Wei Zhang, Zhang Yi","doi":"10.53388/mhm2021a0127001","DOIUrl":"https://doi.org/10.53388/mhm2021a0127001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78982388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination of XianGui capsule and LCZ696 inhibits doxorubicin-induced heart failure in mice 仙桂胶囊联合LCZ696对阿霉素致小鼠心力衰竭的抑制作用
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021a0506001
Yuanyuan Wang, Rong Huang, Jihong Han, Xiaoxiao Yang, Yajun Duan
{"title":"Combination of XianGui capsule and LCZ696 inhibits doxorubicin-induced heart failure in mice","authors":"Yuanyuan Wang, Rong Huang, Jihong Han, Xiaoxiao Yang, Yajun Duan","doi":"10.53388/mhm2021a0506001","DOIUrl":"https://doi.org/10.53388/mhm2021a0506001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79659516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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