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Efficacy and safety of Phillyrin (KD-1) capsule in the treatment of moderate COVID-19: protocol for a randomized controlled trial 菲连林(KD-1)胶囊治疗中度COVID-19的疗效和安全性:一项随机对照试验方案
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2021p1204001
Yang-qing Zhan, Ruifeng Chen, Q. Ma, Jinping Zheng, Xilong Deng, Wei Yang, L. Fu, Nanshan Zhong, Zifeng Yang
{"title":"Efficacy and safety of Phillyrin (KD-1) capsule in the treatment of moderate COVID-19: protocol for a randomized controlled trial","authors":"Yang-qing Zhan, Ruifeng Chen, Q. Ma, Jinping Zheng, Xilong Deng, Wei Yang, L. Fu, Nanshan Zhong, Zifeng Yang","doi":"10.53388/mhm2021p1204001","DOIUrl":"https://doi.org/10.53388/mhm2021p1204001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"91 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80513603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Development status and trend of traditional Chinese medicine database 中药数据库的发展现状与趋势
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022b0825001
Tao Xue, Shuai Gong, Tian-Hao Xie, Wenjuan Li, Jianyin Huang
{"title":"Development status and trend of traditional Chinese medicine database","authors":"Tao Xue, Shuai Gong, Tian-Hao Xie, Wenjuan Li, Jianyin Huang","doi":"10.53388/mhm2022b0825001","DOIUrl":"https://doi.org/10.53388/mhm2022b0825001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86962837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Euphorbiasteroid on gene expression in lung cancer cells based on gene chip 大戟星对肺癌细胞基因表达的影响
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022a0623001
Ziye Yang, Mingrui Jiang, Xiaotong Wei, Zhicheng Wang, Zhu-Zhu Yue, Jingqiu Zhang, Meng-Yu Chen, Huinan Wang, Menglin Wang, Shuanghui Shi, Ying-Zi Wang
{"title":"Effects of Euphorbiasteroid on gene expression in lung cancer cells based on gene chip","authors":"Ziye Yang, Mingrui Jiang, Xiaotong Wei, Zhicheng Wang, Zhu-Zhu Yue, Jingqiu Zhang, Meng-Yu Chen, Huinan Wang, Menglin Wang, Shuanghui Shi, Ying-Zi Wang","doi":"10.53388/mhm2022a0623001","DOIUrl":"https://doi.org/10.53388/mhm2022a0623001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75453580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention and treatment of traditional Chinese medicine against angiogenesis related cardiovascular diseases based on translational medicine 基于转化医学的中医药对血管生成相关心血管疾病的防治
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022b0507001
Herong Cui, Jiaxin Zheng, Xiaoyu Zhang, H. Shang
{"title":"Prevention and treatment of traditional Chinese medicine against angiogenesis related cardiovascular diseases based on translational medicine","authors":"Herong Cui, Jiaxin Zheng, Xiaoyu Zhang, H. Shang","doi":"10.53388/mhm2022b0507001","DOIUrl":"https://doi.org/10.53388/mhm2022b0507001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78549631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guizhi Fuling capsule can induce apoptosis of myeloma cells through the mitochondrial apoptosis pathway 桂枝茯苓胶囊可通过线粒体凋亡途径诱导骨髓瘤细胞凋亡
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022a0108001
R. Sun, Jie Xu, Yanyu Zhang, Xiaoqi Sun, X. Cui
{"title":"Guizhi Fuling capsule can induce apoptosis of myeloma cells through the mitochondrial apoptosis pathway","authors":"R. Sun, Jie Xu, Yanyu Zhang, Xiaoqi Sun, X. Cui","doi":"10.53388/mhm2022a0108001","DOIUrl":"https://doi.org/10.53388/mhm2022a0108001","url":null,"abstract":"Objective To observe the effects of Guizhi Fuling capsule (GZFLC) on RPMI 8226 cells and explore the mechanisms. Methods Cell Counting Kit-8 (CCK-8) assays and flow cytometry were used to detect the viability and apoptosis levels of RPMI 8226 cells. The effects on mitochondria were examined by ROS and JC-1 assays. Western blotting was used to detect the expression of B cell lymphoma-2 (Bcl-2), Bax, cleaved caspase-3, and Apoptotic protease-activating factor 1 (Apaf-1). Results GZFLC drug serum decreased the viability and increased the apoptosis of RPMI 8226 cells. In addition, this drug increased ROS levels and decreased the mitochondrial membrane potential (MMP). Western blotting showed that the Bcl-2/Bax ratios were decreased in the GZFLC drug serum-treated groups, whereas the expression levels of cleaved caspase-3 and Apaf-1 were increased. Conclusion GZFLC promoted apoptosis of myeloma cells through the mitochondrial apoptosis pathway.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"116 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86800619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thinking and practice on clinical safety evaluation of combination of traditional Chinese medicine and western medicine 中西医结合临床安全性评价的思考与实践
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022a1018001
Rui Zheng, Zhao Chen, Chen Zhao, Xiaoyu Zhang, Mingli Ma, Yang Sun, H. Shang
{"title":"Thinking and practice on clinical safety evaluation of combination of traditional Chinese medicine and western medicine","authors":"Rui Zheng, Zhao Chen, Chen Zhao, Xiaoyu Zhang, Mingli Ma, Yang Sun, H. Shang","doi":"10.53388/mhm2022a1018001","DOIUrl":"https://doi.org/10.53388/mhm2022a1018001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90577054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key Genes of Chronic Pain Identified Through Bioinformatics Analyses 通过生物信息学分析确定慢性疼痛的关键基因
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022a0213001
Zhicheng Wang, Mingrui Jiang, Zhu-Zhu Yue, Xiaotong Wei, Shuanghui Shi, Menglin Wang, Huinan Wang, Qianqian Liu, Jingqiu Zhang, Mengyu Chen, Ying-Zi Wang
{"title":"Key Genes of Chronic Pain Identified Through Bioinformatics Analyses","authors":"Zhicheng Wang, Mingrui Jiang, Zhu-Zhu Yue, Xiaotong Wei, Shuanghui Shi, Menglin Wang, Huinan Wang, Qianqian Liu, Jingqiu Zhang, Mengyu Chen, Ying-Zi Wang","doi":"10.53388/mhm2022a0213001","DOIUrl":"https://doi.org/10.53388/mhm2022a0213001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85401155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genus Strobilanthes: phytochemistry and pharmacology 桔梗属:植物化学和药理学
TMR Modern Herbal Medicine Pub Date : 2022-01-01 DOI: 10.53388/mhm2022b0701001
Xiaoling Zhu, Yang Xu, De-juan Sun, Hua Li, Lixia Chen
{"title":"The genus Strobilanthes: phytochemistry and pharmacology","authors":"Xiaoling Zhu, Yang Xu, De-juan Sun, Hua Li, Lixia Chen","doi":"10.53388/mhm2022b0701001","DOIUrl":"https://doi.org/10.53388/mhm2022b0701001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"24 23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82820772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Indirubin suppresses 4T1 murine breast cancer in vitro and in vivo by induction of ferroptosis and up-regulation of Ptgs2 靛玉红在体外和体内通过诱导铁下垂和上调Ptgs2抑制4T1小鼠乳腺癌
TMR Modern Herbal Medicine Pub Date : 2021-04-09 DOI: 10.21203/RS.3.RS-390546/V1
Xiuping Kuang, Yingnan Jiang, Jiwei Huang, Yongzhi Guo, weixi Li
{"title":"Indirubin suppresses 4T1 murine breast cancer in vitro and in vivo by induction of ferroptosis and up-regulation of Ptgs2","authors":"Xiuping Kuang, Yingnan Jiang, Jiwei Huang, Yongzhi Guo, weixi Li","doi":"10.21203/RS.3.RS-390546/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-390546/V1","url":null,"abstract":"\u0000 Background\u0000\u0000Indirubin, isolated from Indigo Naturals, is reported to have the inhibitory activity of MCF-7 human breast cancer cells in vitro. However, studies on its anti-breast cancer activity in vivo and underlying mechanism are insufficient. We explored whether indirubin could trigger ferroptosis of breast cancer cells to exert anti-tumor activity.\u0000Methods\u0000\u0000Bioinformatical analysis was performed to detected the expression of prostaglandin-endoperoxide synthase 2 (Ptgs2) in breast cancer tissues Ptgs2-related prognosis for patients with breast cancer. Growth of 4T1 cells was assessed using wound healing assay and MTT assay. The levels of 4-HNE, GPX4, PTGS2 and GSK-3β proteins were detected by Western blot, and the mRNA of Ptgs2 was tested by qPCR. The GSH and MDA were determined by commercial kits. Molecular docking was employed to study interaction between indirubin and GSK-3β. An 4T1 murine breast cancer was adopted to evaluate the in vivo antitumor activity of indirubin.\u0000Results\u0000\u0000Indirubin promoted ferroptosis of 4T1 breast cancer cells with deplete of GSH, increased MDA and 4-HNE level, as well as decreased GPX4 expression. Indirubin suppressed the growth of 4T1 breast tumor in vivo. Mechanism study showed indirubin up regulated Ptgs2 expression by promoting phosphorylation (Ser 9) of GSK-3β.\u0000Conclusions\u0000\u0000Indirubin suppresses 4T1 murine breast cancer in vitro and in vivo by induction of ferroptosis and up-regulation of Ptgs2.","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83551022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A brief overview of traditional Chinese medicine prescription powered by artificial intelligence 人工智能驱动的中药处方简介
TMR Modern Herbal Medicine Pub Date : 2021-01-01 DOI: 10.53388/mhm2021b0412001
Hongyun Bao, R. Wen, Xuanya Li, Chen Zhao, Zhineng Chen
{"title":"A brief overview of traditional Chinese medicine prescription powered by artificial intelligence","authors":"Hongyun Bao, R. Wen, Xuanya Li, Chen Zhao, Zhineng Chen","doi":"10.53388/mhm2021b0412001","DOIUrl":"https://doi.org/10.53388/mhm2021b0412001","url":null,"abstract":"","PeriodicalId":23141,"journal":{"name":"TMR Modern Herbal Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78072234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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