Toxicology communications最新文献_第6页

Treatment of acute aluminum toxicity due to alum bladder irrigation in a hemodialysis patient: a case report 明矾膀胱灌洗对血液透析患者急性铝中毒的治疗1例

Toxicology communications Pub Date : 2022-02-27 DOI: 10.1080/24734306.2022.2040148

David Loughran, D. Calello, Lewis Nelson

引用次数: 2

Lipid emulsion mitigates intravenous amiodarone toxicity in a rat model 脂质乳剂减轻大鼠静脉注射胺碘酮毒性

Toxicology communications Pub Date : 2022-02-02 DOI: 10.1080/24734306.2022.2031565

R. Stewart, Verity Newman, M. Harvey, Mingtan Tang, Zimei Wu, G. Cave

{"title":"Lipid emulsion mitigates intravenous amiodarone toxicity in a rat model","authors":"R. Stewart, Verity Newman, M. Harvey, Mingtan Tang, Zimei Wu, G. Cave","doi":"10.1080/24734306.2022.2031565","DOIUrl":"https://doi.org/10.1080/24734306.2022.2031565","url":null,"abstract":"Abstract Introduction Our study investigated whether lipid emulsion therapy could act as an antidote for intravenous amiodarone toxicity in a rat model. Methods 20 rats were randomised to receive lipid emulsion (ILE) or saline. Rats were infused with amiodarone at 1 mg/kg/min for 20 min. ILE rats then received 6 mL/kg of IV 20% ILE, with controls receiving saline. Amiodarone infusion then recommenced at 0.25 mg/kg/minute for 15 min. Heart rate and mean arterial pressure (MAP) were recorded at the commencement and end of the first amiodarone infusion, and every 5 min during the second amiodarone infusion until experiment termination. Blood was sampled for amiodarone concentration at the conclusion of each infusion. Results At experiment termination MAP was greater for the ILE group (85 vs 60 mmHg, p = 0.01), with no difference in heart rate between groups (224 vs 232 bpm, p = 0.19). Amiodarone concentration decreased after saline treatment and was stable after ILE (change −6.4 micromol/L saline, 0.11 micromol/L lipid p < 0.001) Conclusions ILE therapy mitigated intravenous amiodarone-induced hypotension in this rat model. While amiodarone was retained in lipid treated blood the quantum of this increase did not support the “lipid sink” hypothesis. Further research is required to evaluate the clinical relevance of these findings.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"6 1","pages":"30 - 34"},"PeriodicalIF":0.0,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81842049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series 环孢素作为一种治疗含阿曲霉毒素蘑菇中毒的新方法:一个病例系列

Toxicology communications Pub Date : 2022-01-05 DOI: 10.1080/24734306.2021.2006957

Constance A. Mackenzie, Emily Austin, M. Thompson, R. Tirona

{"title":"Cyclosporine as a novel treatment for amatoxin-containing mushroom poisoning: a case series","authors":"Constance A. Mackenzie, Emily Austin, M. Thompson, R. Tirona","doi":"10.1080/24734306.2021.2006957","DOIUrl":"https://doi.org/10.1080/24734306.2021.2006957","url":null,"abstract":"Abstract Ingestion of amatoxin-containing mushrooms can lead to fulminant hepatotoxicity and death. Despite recent interest in therapeutic options for amatoxin-exposed patients, there is no single, recommended treatment for amatoxin poisoning. Alpha-amanitin, the principal toxin in amatoxin-containing mushrooms, requires entry into hepatocytes via organic anion transporting polypeptide (OATP) 1B3 before the cascade of cellular events occurs leading to hepatocyte necrosis, liver failure, and in severe cases liver transplantation or death. Three patients managed through a single poison centre with confirmed amatoxin-containing mushrooms ingestions were treated with intravenous cyclosporine, a known potent OATP1B3 inhibitor, along with supportive care. All patients presented with classic delayed symptoms of nausea, vomiting and diarrhea. No patient progressed to fulminant hepatic failure, although two patients developed a transient rise in liver transaminases. All recovered and were discharged from hospital. No patient had an adverse effect from cyclosporine. In addition, we performed an in-vitro study of the role of cyclosporine in cultured HEK293T cells and human hepatoma Huh7 cells. Cyclosporine effectively inhibited OATP1B3-mediated uptake of alpha-amanitin, and improved cell viability of alpha-amanitin exposed cultured Huh7 cells. We conclude that IV cyclosporine, a drug readily available in most hospitals, may be useful to reduce hepatotoxicity from amatoxin poisoning.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"25 1","pages":"23 - 27"},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86069015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Homicide with intramuscular cyanide injection: a case report 肌肉注射氰化物杀人:一例报告

Toxicology communications Pub Date : 2022-01-05 DOI: 10.1080/24734306.2021.2015550

Natasha Tobarran, Emily K. Kershner, K. Cumpston, S. R. Rose, B. Wills

引用次数: 1

Angel or devil? Medicinal history of poppy in traditional Chinese medicine 天使还是魔鬼?罂粟在中药中的药史

Toxicology communications Pub Date : 2022-01-01 DOI: 10.53388/20220202014

T. Communications

引用次数: 0

Exposure to sharp injuries among hospital medical waste handlers 医院医疗废物处理人员受到尖锐伤害

Toxicology communications Pub Date : 2022-01-01 DOI: 10.53388/20220202012

A. Lateef

引用次数: 1

Prediction of the mechanisms of liver injury of Epimedii Folium by network pharmacology and validation in HepaRG Cells 网络药理学预测淫羊藿肝损伤机制及HepaRG细胞验证

Toxicology communications Pub Date : 2022-01-01 DOI: 10.53388/2022020206

Xiaotong Duan, Shan-gao Li, Qiyi Wang, Jing-Xian Liu, Tianmu He, Liu Liu, Meichen Liu, Yun Liu, Rong Yan, Jianyong Zhang, Xiaofei Li

引用次数: 0

Overview about toxicology of cannabis smoking 大麻吸食毒理学综述

Toxicology communications Pub Date : 2022-01-01 DOI: 10.53388/20220202011

Omar Negm

引用次数: 0

Regulatory framework of cosmetic in the European Union 欧盟化妆品监管框架

Toxicology communications Pub Date : 2022-01-01 DOI: 10.53388/20220202013

Preeti Gautam, D. Ghanghas, P. Mittal, Vikas Gupta, Kanika Dhiman

引用次数: 1

Use of Phyllomedusa bicolour secretion during kambô ritual: observational responses, dosage, and risk of adverse events 在kambô仪式中使用双色Phyllomedusa分泌物:观察反应、剂量和不良事件的风险

Toxicology communications Pub Date : 2022-01-01 DOI: 10.1080/24734306.2021.2006524

Caitlin Thompson, B. Malcolm, J. Tegzes

{"title":"Use of Phyllomedusa bicolour secretion during kambô ritual: observational responses, dosage, and risk of adverse events","authors":"Caitlin Thompson, B. Malcolm, J. Tegzes","doi":"10.1080/24734306.2021.2006524","DOIUrl":"https://doi.org/10.1080/24734306.2021.2006524","url":null,"abstract":"Abstract The ‘kambô’ ritual involves application of Phyllomedusa Bicolor poison to superficial burns made on the user’s skin. Existing kambô literature describes case reports of severe harms. The objective of the current study was to better characterize typical observed responses to kambô administration. We performed a retrospective review of a kambô practitioner’s practice. Statistical analysis was descriptive, and characterized the number of kambô points or location of points administered as well as physical responses such as facial swelling, diaphoresis, immediate bowel movement, syncope, and occurrence of emesis. There were 147 unique participants that underwent 241 kambô rituals included. The mean number of points administered was 4.2 ± 2.2, while the median was 3 (range 1–11). Common physical responses included facial swelling (70.5%), diaphoresis (53.3%), bowel movement (45.2%), and syncope (10.4%). Higher number of points administered and receiving kambô at multiple locations appeared to increase facial swelling and diaphoresis. Responses to kambô are likely to be dose-dependent. No severe adverse effects were recorded in the sample, although some responses or components of the kambô ritual may promote risks of harm due to hyponatremia, asphyxiation from emesis, and injury due to syncope.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"27 1","pages":"6 - 12"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83176374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0