Toxicology communications最新文献_第5页

Paracetamol-induced acute kidney injury in the absence of acute liver injury: a retrospective cohort study 在没有急性肝损伤的情况下，扑热息痛引起急性肾损伤:一项回顾性队列研究

Toxicology communications Pub Date : 2022-09-05 DOI: 10.1080/24734306.2022.2117941

Al-Badriyeh Daoud, K. Dalhoff, T. Petersen

引用次数: 1

Trends in drug use among young adult females: a 22-year retrospective analysis 年轻成年女性药物使用趋势:22年回顾性分析

Toxicology communications Pub Date : 2022-08-14 DOI: 10.1080/24734306.2022.2110201

Eric Clifford, P. Kilgore, U. Cvek, M. Trutschl, Stephen Baker, S. Conrad, Thomas Arnold, N. Korneeva

{"title":"Trends in drug use among young adult females: a 22-year retrospective analysis","authors":"Eric Clifford, P. Kilgore, U. Cvek, M. Trutschl, Stephen Baker, S. Conrad, Thomas Arnold, N. Korneeva","doi":"10.1080/24734306.2022.2110201","DOIUrl":"https://doi.org/10.1080/24734306.2022.2110201","url":null,"abstract":"Abstract Louisiana State University Health Sciences Center at Shreveport (LSUHSC-S) serves a largely minority-based, urban population. This study aims to identify trends in urine drug screen (UDS) results among females aged 18–35 visiting State University during 1998–2011 and 2012–2019. Using two databases extracted from the electronic medical record system, we performed statistical analysis of demographics and UDS results. Young females aged 18–35 mostly tested positive for cannabinoids and opiates during both periods, 1998–2011 and 2012–2019. African-American females had a higher percentage of positive UDS for illicit drugs, such as cannabinoids and cocaine, while Caucasian females had a higher rate for prescription drugs such as opiates, benzodiazepines, and amphetamine. Between 1998–2011 and 2012–2019, trends in drug screen results changed in both populations, with Caucasian females showing a drastic increase in amphetamines and African-American females showing increase in opiates and cannabinoids during 2012–2019. GatewayNet analysis (sequential-rule mining for inducing causation) for 2012–2019 indicated that a positive screen for amphetamines is likely preceded by a positive screen for cannabinoids, and benzodiazepines may be preceded by opiates. Our results emphasize the importance of drug use monitoring among young females of childbearing age. GatewayNet analysis implies a sequential nature to drug positivity on urine drug screening in this population.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"1 1","pages":"85 - 96"},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78839731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A cross-sectional assessment of package labels aimed at children of edible and leaf cannabis discarded in New York City 对纽约市丢弃的食用大麻和叶子大麻的儿童包装标签的横断面评估

Toxicology communications Pub Date : 2022-08-03 DOI: 10.1080/24734306.2022.2106397

Adam Blumenberg

{"title":"A cross-sectional assessment of package labels aimed at children of edible and leaf cannabis discarded in New York City","authors":"Adam Blumenberg","doi":"10.1080/24734306.2022.2106397","DOIUrl":"https://doi.org/10.1080/24734306.2022.2106397","url":null,"abstract":"Abstract Background Cannabis is a schedule 1 substance that cannot be possessed within the United States according to federal law. On March 31 2021, New York State legalized cannabis for sale and consumption. This study assesses the safety labeling and packaging aimed at children of cannabis containers during the peri-legalization period in New York City. Methods This is a cross-sectional and descriptive comparative study in which sidewalks in New York City were inspected for labeled cannabis containers during the four months prior and four months post legalization, i.e. from December 2020 until July 2021. Packages were systematically analyzed using a scoring system based on advertising techniques that may appeal to children and the American College of Medical Toxicology’s (ACMT) recommendations on cannabis safety labeling. Results and DiscussionOf the 114 packages, none met ACMT’s recommended safety labeling guidelines. Only 52% of containers indicated their contents, 40% referenced food, and 85% included elements that may appeal to children. Conclusion Precautionary measures such as child-resistant packaging, warning labels, and avoiding marketing to children are uncommon. Policy makers should consider regulating the safety labeling and advertising which appeals to children on cannabis packaging.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"50 1","pages":"78 - 84"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90945697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Brain MRI abnormalities in acute ethylene glycol poisoning: a case report 急性乙二醇中毒的脑MRI异常1例

Toxicology communications Pub Date : 2022-06-14 DOI: 10.1080/24734306.2022.2087019

J. M. Martinez Manzano, K. Elkholy, K. Lo

引用次数: 0

Poisoning during the COVID-19 pandemic and lockdown: retrospective analysis of exposures reported to the Poison Unit of the Mansoura Emergency Hospital COVID-19大流行和封锁期间的中毒:对向曼苏拉急救医院中毒科报告的暴露情况的回顾性分析

Toxicology communications Pub Date : 2022-05-15 DOI: 10.1080/24734306.2022.2075182

S. Motawei, O. Shabka, Huimei Liu

{"title":"Poisoning during the COVID-19 pandemic and lockdown: retrospective analysis of exposures reported to the Poison Unit of the Mansoura Emergency Hospital","authors":"S. Motawei, O. Shabka, Huimei Liu","doi":"10.1080/24734306.2022.2075182","DOIUrl":"https://doi.org/10.1080/24734306.2022.2075182","url":null,"abstract":"Abstract Introduction Coronavirus disease 2019 (COVID-19), originated in late December 2019, in Wuhan, China. The World Health Organization declared a pandemic on 11 March 2020, with the rapidly rising number of cases and fatalities over hours and days all around the world. Aim To assess the number and the trend of the poisoning consultations to the Poison Unit in the Mansoura Emergency Hospital during the era of the COVID-19 pandemic in 2020. Methods We collected data from the database of the Poison Unit and the Statistics Department of the Mansoura Emergency Hospital of the cases and the calls coming to the Poison Unit in the period from January 2018 through December 2020. We compared 2020 exposures to 2018–2019 exposures by using simple logistic models to provide effect size with odds ratios. Results The Mansoura Emergency Hospital Poison Unit treated 1752 cases in 2020, compared to 2210 cases in 2018 and 2539 cases in 2019. The Poison Unit treated 26% fewer patients in 2020 than either 2018 or 2019), while calls increased nearly 50% in 2020 than in 2018 and 2019. Calls came more frequently from the general public than health professionals and more frequently in afternoon and evening than in the morning. There was a significant increase in the cases of pharmaceuticals ingestion, food poisoning, corrosives and households exposures in 2020 compared to 2018 and 2019 (p-value 0.004, 0.024, and 0.0002, respectively; odds ratio 1.224, 1.691, and 1.692, respectively). Conclusion The COVID-19 pandemic changed the pattern of poisoning exposure and use of the Poison Control Center services.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"31 1","pages":"66 - 70"},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81098018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Propafenone and valsartan overdose with cardiovascular deterioration managed with lipid emulsion and high dose insulin: a case report 脂质乳剂和大剂量胰岛素治疗普罗帕酮和缬沙坦过量并发心血管恶化1例报告

Toxicology communications Pub Date : 2022-05-04 DOI: 10.1080/24734306.2022.2069967

Connie H. Yoon, Natalie I. Rine, Adam Smith, M. Casavant

{"title":"Propafenone and valsartan overdose with cardiovascular deterioration managed with lipid emulsion and high dose insulin: a case report","authors":"Connie H. Yoon, Natalie I. Rine, Adam Smith, M. Casavant","doi":"10.1080/24734306.2022.2069967","DOIUrl":"https://doi.org/10.1080/24734306.2022.2069967","url":null,"abstract":"Abstract This is a case of a 23-year-old female who presented to the emergency department (ED) comatose after ingesting 7.8 g of propafenone and 11.7 g of valsartan. Upon arrival to the ED, the patient had seizures and required intubation. Several boluses of sodium bicarbonate were given as well as a continuous infusion to normalize QRS intervals. Norepinephrine and intravenous lipid emulsion (ILE) therapy were initiated. In the intensive care unit (ICU), the patient experienced persistent seizures and a 5-minute period of pulseless ventricular tachycardia. Subsequently, hyperinsulinemic-euglycemic therapy (HIET) was initiated. The patient received a 1 unit/kg intravenous bolus of regular insulin followed by a continuous infusion starting at 1 unit/kg/hr. Norepinephrine infusion was weaned off after 27 h of HIET. Within 48 h of presentation, the patient was transferred out of the ICU. This case exhibits the successful management of a mixed overdose with propafenone and valsartan utilizing a multimodal approach. In addition to supportive care, the patient received sodium bicarbonate, HIET, ILE and vasopressors to manage the cardiovascular collapse associated with these toxicities.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"9 1","pages":"62 - 65"},"PeriodicalIF":0.0,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79669017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe chemical corneal injury from hexavalent chromium exposure: a case report 六价铬暴露致严重化学性角膜损伤1例

Toxicology communications Pub Date : 2022-04-13 DOI: 10.1080/24734306.2022.2058253

Daisuke Ueno, Yasukazu Shiino, Hisataka Fujimoto, Takahiro Okane, Sachiko Yamada, Jiro Takahashi, Takahiro Inoue

{"title":"Severe chemical corneal injury from hexavalent chromium exposure: a case report","authors":"Daisuke Ueno, Yasukazu Shiino, Hisataka Fujimoto, Takahiro Okane, Sachiko Yamada, Jiro Takahashi, Takahiro Inoue","doi":"10.1080/24734306.2022.2058253","DOIUrl":"https://doi.org/10.1080/24734306.2022.2058253","url":null,"abstract":"Abstract Eye exposure to hexavalent chromium (Cr(VI)) acid can cause blindness. A 42-year-old man working in a plating operation presented to the emergency department following a workplace incident. He had unintentionally fallen into a tank containing a mixture of 25% Cr(VI) and sulfuric acid (2.0 g/L) at a temperature of approximately 40 °C. The tank dimensions tank were 8 (depth) × 4 (width) × 3 (length) meters. A colleague rescued him from the tank, and he underwent a full body wash at the worksite. Emergency services adequately flushed both eyes with a 0.9% saline solution. He had significant corneal injury; however, no other significant injuries occurred. Upon presentation at the emergency department, the patient underwent a whole-body shower, and both eyes were flushed with 0.9% saline solution. As a treatment for acute chromium poisoning, he received dimercaprol and ascorbic acid. Additionally, he received eye drops for chemical corneal injury. The patient later underwent bilateral corneal transplants for chemical corneal injury but remained nearly blind. We describe a case of severe chemical corneal injury with limbal stem cell deficiency, leading to blindness due to Cr (VI) acid exposure.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"8 1","pages":"58 - 61"},"PeriodicalIF":0.0,"publicationDate":"2022-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91185060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wartime toxicology: the spectre of chemical and radiological warfare in Ukraine 战时毒理学:乌克兰化学和放射性战争的幽灵

Toxicology communications Pub Date : 2022-04-01 DOI: 10.1080/24734306.2022.2056374

P. Chai, Y. Berlyand, E. Goralnick, C. Goldfine, M. Vanrooyen, D. Hryhorczuk, T. Erickson

引用次数: 8

The poisoning of big data: using large data registries for research in toxicology 大数据的中毒:利用大数据登记进行毒理学研究

Toxicology communications Pub Date : 2022-03-02 DOI: 10.1080/24734306.2022.2045788

Anita Mudan, J. Lebin, C. Smollin

引用次数: 0

Unintentional ethylene glycol ingestions in children 儿童无意中摄入乙二醇

Toxicology communications Pub Date : 2022-02-28 DOI: 10.1080/24734306.2022.2045123

A. Nemanich, S. Bryant

{"title":"Unintentional ethylene glycol ingestions in children","authors":"A. Nemanich, S. Bryant","doi":"10.1080/24734306.2022.2045123","DOIUrl":"https://doi.org/10.1080/24734306.2022.2045123","url":null,"abstract":"ABSTRACT Background: Toxic alcohol poisoning may result in severe acidemia and death. Previous work from our regional poison center (RPC) revealed that most pediatric unintentional methanol exposures are benign and do not require alcohol dehydrogenase (ADH) blockade or hemodialysis. Methods: We retrospectively reviewed all ethylene glycol (EG) cases in patients less than 6 years of age reported to our RPC over a 19 year period. We included unintentional ingestions with measured EG concentrations. Results: Twenty-nine cases met inclusion criteria. EG concentrations were undetectable in 25 cases (86%). No patient became symptomatic or acidemic. No EG concentration warranted treatment with ADH inhibition or hemodialysis. However, 21 patients (72%) received fomepizole or ethanol. Fifteen patients (52%) transferred from a community hospital to a pediatric specialty hospital. All 27 children admitted to the hospital went to a pediatric intensive care unit (PICU) while awaiting EG results. Conclusions: No child during the 19-year period required either antidote or hemodialysis. Unintentional EG exposures in typical pediatric patients may warrant nothing more than repeat laboratory testing (electrolytes, pH) to exclude evolving toxicity. Timely availability of EG laboratory test results would likely reduce unnecessary and expensive use of antidote, transport, and PICU resources.","PeriodicalId":23139,"journal":{"name":"Toxicology communications","volume":"9 1","pages":"42 - 45"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87306587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2