Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health最新文献_第2页

Study on LMP1 and lipid rafts by quantitative fluorescence resonance transfer method 定量荧光共振转移法研究LMP1与脂筏

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673642

Zhiwei Wu, Qing Ye, Xiaoyan Wang, Xian-zeng Zhang, S. Xie

引用次数: 0

Comparison of the performance of pulsed and continuous UVC-LED irradiation in the inactivation of several typical bacteria in drinking water 脉冲与连续UVC-LED照射对饮用水中几种典型细菌灭活效果的比较

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673713

Yanping Chen, Qihui Cheng

引用次数: 0

Signals are required by HSV-1 infected neurons to increase the amount of Aβ protein in the brain of Alzheimer’s disease patients 1型单纯疱疹病毒感染的神经元需要信号来增加阿尔茨海默病患者大脑中Aβ蛋白的含量

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673607

Haohan Sun

{"title":"Signals are required by HSV-1 infected neurons to increase the amount of Aβ protein in the brain of Alzheimer’s disease patients","authors":"Haohan Sun","doi":"10.1117/12.2673607","DOIUrl":"https://doi.org/10.1117/12.2673607","url":null,"abstract":"There are many studies on the relation between the HSV-1 virus and the Alzheimer’s disease. The HSV-1 virus is one of the most common type of virus found in the human brain. There are currently many hypothesis about the spreading of HSV-1 virus and formation of Aβ proteins in the brain, but none of the theories can completely explain the spreading of HSV-1 virus, formation of Aβ proteins. This paper is trying to find out whether signals are required by HSV-1 infected neurons to increase the amount of Aβ proteins that might cause Alzheimer’s disease (AD). Colon technology, Real-scale sponge human scale model, and human stem cell organoids are used in the experiments. The experiment is not actually conducted in this study, but based on various theories and experiments on signal transmissions, Aβ protein formations, development of Alzheimer’s disease and prediction in various paper and articles, signals send by the HSV-1 infected neurons could increase the amount of Aβ protein. Doing such study and experiment on how signals from HSV-1 virus infected neurons might cause the increase in amount of Aβ proteins might have great contributions on medicine development on Alzheimer’s disease.","PeriodicalId":231020,"journal":{"name":"Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health","volume":"336 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125719821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Numerical simulation of thermal damage in atherosclerotic plaque using microwave 微波对动脉粥样硬化斑块热损伤的数值模拟

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673574

Yong Liu, Ji-wen Hu, Yang Xie

{"title":"Numerical simulation of thermal damage in atherosclerotic plaque using microwave","authors":"Yong Liu, Ji-wen Hu, Yang Xie","doi":"10.1117/12.2673574","DOIUrl":"https://doi.org/10.1117/12.2673574","url":null,"abstract":"The purpose of this study is to explore the thermal damage of microwave to atherosclerotic plaques in order to achieve the purpose of treating atherosclerosis. In this paper, a fluid-solid-heat coupling model of thermal ablation of atherosclerotic plaque is established (The coupling model of blood-plaque-electromagnetic wave is studied in this paper, in which the thermal ablation of atherosclerotic plaque means that the electromagnetic wave is used to generate heat, and the temperature of atherosclerotic plaque tissue rises. If the cells in it reach the threshold of death temperature, they will be killed, so as to achieve the purpose of thermal ablation.). The electromagnetic field and bio-thermal equation are solved and analyzed by finite element method. By calculating the temperature and thermal damage distribution of microwave on atherosclerotic plaque, the effect of microwave on thermal ablation of atherosclerotic plaque was evaluated. The results show that the thermal damage degree of atherosclerotic plaque is positively correlated with electromagnetic wave frequency, electromagnetic wave power and heating time. The model shows that electromagnetic wave hyperthermia may provide a new therapeutic mode for thermal ablation of atherosclerotic plaques.","PeriodicalId":231020,"journal":{"name":"Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health","volume":"105 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121394783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrophotometric determination of sulfite in food by silicon molybdenum heteropoly acid 硅钼杂多酸分光光度法测定食品中的亚硫酸盐

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673903

Xin-rong Wen, C. Tu

引用次数: 0

Insights into the outward K+ currents-based gating mechanism of GIRK2 channel GIRK2通道外向K+电流门控机制的研究

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673594

Rui Wang, Yanjie Lu, Dailin Li

{"title":"Insights into the outward K+ currents-based gating mechanism of GIRK2 channel","authors":"Rui Wang, Yanjie Lu, Dailin Li","doi":"10.1117/12.2673594","DOIUrl":"https://doi.org/10.1117/12.2673594","url":null,"abstract":"GIRK channels have been involved in numerous physiological functions by regulating cellular excitability. Considering the characteristics of inward rectification, structure activity relationships of GIRK channels have been studied extensively based on the inward movements of ions. In contrast, the outward K+ currents based gating mechanism remains to be investigated in depth, although some drug molecules (dofetilide, cromakalim, and pinacidil etc.) exert medical effects by the current block or activation. In this study, the all-atom microsecond-scale molecular dynamics method was employed to explore the outward currents based gating mechanism of the GRK2 channels, which were modulated by different factors (Na+, Gβγ, and Na+-Gβγ). The results show that the Na+ and Gβγ subunits work together to activate the GIRK2 channel, in which Na+ predominantly regulates the G-loop gate, while Gβγ subunits mainly regulate the HBC gate. Our findings provide structural insights into the gating mechanism of GIRK channels and help to understand the pathology and pharmacodynamics mechanisms of drugs related to outflow currents.","PeriodicalId":231020,"journal":{"name":"Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131479540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of polysaccharide in Pseudostellaria heterophylla by ultraviolet-visible spectrophotometry combined with different processing methods 紫外可见分光光度法结合不同炮制方法检测太子参多糖

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673598

Ting Chen, Haiyu Chen, L. Zhang, Sheng-ji Zhu, Bin Huang

引用次数: 0

Study on the anti-tumor effects of the key component of traditional Chinese medicine nightshade in the treatment of human gastric cancer (SGC7901 cell line) 中药龙葵关键成分对人胃癌(SGC7901细胞系)的抗肿瘤作用研究

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673679

Yisha Tang

{"title":"Study on the anti-tumor effects of the key component of traditional Chinese medicine nightshade in the treatment of human gastric cancer (SGC7901 cell line)","authors":"Yisha Tang","doi":"10.1117/12.2673679","DOIUrl":"https://doi.org/10.1117/12.2673679","url":null,"abstract":"Gastric cancer is among the most prevalent malignancies with high mortality and morbidity, so some safe and effective treatment methods, such as medications, are required. A previous study has revealed that Quercetin, a key component of traditional Chinese medicine nightshade, has anti-tumour effects on treating colon cancer by mediating the PI3K/AKT-dependent signalling pathway. This study will investigate the effects of Quercetin treatment on gastric cancer through several experiments, including measuring apoptosis by FACS for annexin V/HOECHST, cell number by MTT assay, phosphorylation levels of PI3K and AKT and 3 cleavages by western blot, treating SGC7901 xenograft mice with Quercetin and measuring xenograft tumour size. Materials include human cancer cell line SGC7901, Xenograft mice, different concentrations of Quercetin solution, DDP as positive control and PBS/DMSO as negative control. There are four most possible results: (1) Quercetin promotes apoptosis both in vitro and in vivo cell lines; The phosphorylation levels of PI3K and AKT decrease significantly, and expression of caspase 3 increases; (2) The Quercetin promotes apoptosis in vitro cell cultures; The phosphorylation levels of PI3K and AKT decrease significantly, and expression of caspase 3 increases; (3) The Quercetin promotes apoptosis in vitro cell cultures; (4) The Quercetin doesn’t promote any apoptosis both in vivo and in vitro. The result of this research will be important information for future investigation, which should focus on extending the use of Quercetin in different cancer, the mechanism of Quercetin promoting apoptosis in cancer cells in detail, and the clinical trial of Quercetin.","PeriodicalId":231020,"journal":{"name":"Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132210751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on breeding of Bacillus subtilis natto by ultraviolet mutation 紫外诱变选育纳豆枯草芽孢杆菌的研究

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673915

Yongmei Yang

引用次数: 1

Meta-analysis of related factors of premature ovarian failure based on computer 基于计算机的卵巢早衰相关因素荟萃分析

Biophysical Society of Guang Dong Province Academic Forum - Precise Photons and Life Health Pub Date : 2023-04-04 DOI: 10.1117/12.2673646

F. Yu, Youguo Chen

引用次数: 1