2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB)最新文献_第3页

Age-related changes in inhibition after cognitive training 认知训练后抑制的年龄相关变化

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544916

O. Razumnikova, A. Yashanina

{"title":"Age-related changes in inhibition after cognitive training","authors":"O. Razumnikova, A. Yashanina","doi":"10.1109/CSGB.2018.8544916","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544916","url":null,"abstract":"Cognitive intervention research focused on enhancing brain plasticity in healthy or mildly impaired older adults using training of different functions, such as mental speed, working memory or attention. As the age-related impairment of memory and executive functions is associated with decrease in inhibitory control, we investigated age-related inhibition effect after computer-based measuring and free self-determined program of these functions training in groups of younger and older adults. The findings demonstrate training-induced more slowly improvement of both memory and mental speed as well as reduced the inhibition-deficit in older than younger adults. Independently from age, different implicitly created strategies of remembering by retrieval-induced forgetting or forward effect of testing was revealed. Cognitive training induced the increased memory retrieval in younger with dominated forward effect of testing but in the seniors with pronounced inhibition function. So, computerized memory training differently stimulates cognitive reserves due to learning effect in younger and restored inhibition in older adults.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134532478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet-rich plasma in treatment of non-healing ulcers 富血小板血浆治疗不愈合溃疡

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544810

M. Smagin, A. Demura, O. Shumkov, M. Soluyanov, O. Poveshenko, V. Nimaev

引用次数: 0

Phenotypes of peripheral dendritic cells in patients with early rheumatoid arthritis 早期类风湿关节炎患者外周血树突状细胞的表型

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544807

M. Korolev, N. E. Banshchikova, E. Letyagina, V. Omelchenko, O. Poveshchenko, A. Lykov, M. Surovtseva

{"title":"Phenotypes of peripheral dendritic cells in patients with early rheumatoid arthritis","authors":"M. Korolev, N. E. Banshchikova, E. Letyagina, V. Omelchenko, O. Poveshchenko, A. Lykov, M. Surovtseva","doi":"10.1109/CSGB.2018.8544807","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544807","url":null,"abstract":"The search for new biomarkers that will allow the diagnosis of arthritis in the early, pre-destructive phase of the disease is still underway. Twenty two patients with early rheumatoid arthritis (RA), duration of the disease up to 12 months) were included in the study. Fifteen patient patients comprised a group of late rheumatoid arthritis. Eighteen patients with OA and without inflammatory arthropathy had formed the control group. Analysis of the B-lymphocytes, myeloid, and plasmacytoid DCs count was carried out using a flow cytofluorimeter (BD FACSCantoII, USA) and FacsDiva software. The percent of plasmacytoid DCs was statistically significant predominated in the group of patients with early and late RA in comparison with the control group - 3.8 * 10% and 9.0 * 10% vs 1.0 * 10%, respectively (p = 0.0042). Furthermore, the difference was found in the percent of cells with the phenotype B-lymphocytes: 7.95 * 10% and 7.7 * 10% vs 3.3* 10%, respectively (p = 0.014). The dynamics was detected due to a decrease in the percent of plasmacytoid dendritic cells and B-lymphocytes in patients in the group with early rheumatoid arthritis: respectively 3.5 * 10% vs 0.6 * 10% (statistically not significant, p> 0.05), and 6.9 * 106 / l vs 4.9 * 10% (p= 0.045). These data demonstrate the difference in the peripheral blood DCs subtypes ratio in group with early and late RA compared with OA- patients. These cellular markers can be used for early diagnosis, evaluation the activity and treatment effectiveness in patient with RA.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117331349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Serum Levels of Adipokines in Type 2 Diabetic Subjects: the Relationships with Adipose Tissue Distribution and Microvasculature 2型糖尿病患者血清脂肪因子水平:与脂肪组织分布和微血管的关系

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544862

D. Bulumbaeva, V. Klimontov, N. Bgatova, Y. Taskaeva, O. Fazullina, N. B. Orlov, V. Konenkov, M. Soluyanov, S. Savchenko

{"title":"Serum Levels of Adipokines in Type 2 Diabetic Subjects: the Relationships with Adipose Tissue Distribution and Microvasculature","authors":"D. Bulumbaeva, V. Klimontov, N. Bgatova, Y. Taskaeva, O. Fazullina, N. B. Orlov, V. Konenkov, M. Soluyanov, S. Savchenko","doi":"10.1109/CSGB.2018.8544862","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544862","url":null,"abstract":"The aim: to determine the relationships between serum levels of adipokines, body fat distribution, and the density and ultrastructure of blood and lymphatic microvessels in subcutaneous adipose tissue (AT) in type 2 diabetic subjects. Materials and Methods: We observed 125 patients, including 82 ones with obesity, and 30 lean non-diabetic individuals. The concentrations of leptin, resistin, visfatin, adipsin, and adiponectin in the fasting serum were determined by Multiplex analysis. The fat mass and AT distribution was assessed by DEXA. The samples of subcutaneous abdominal AT were obtained with the knife biopsy in 25 patients and in 15 healthy subjects. Immunohistochemistry for biomarkers CD-34, podoplanin and LYVE-1 was applied to identify the blood and lymphatic microvessels. Results: Patients with diabetes, as compared to control, had significantly higher levels of leptin (p=0.004), resistin (p<0.0001), adipsin (p<0.0001) and visfatin (p=0.0003). The concentrations of leptin, resistin and adipsin were associated with total fat mass. The levels of resistin and adiponectin demonstrated relationships with truncal and central abdominal fat mass. The increase in leptin levels in patients with type 2 diabetes and obesity was associated with a decrease in the volume and numeral density of the blood and lymph microvessels in the subcutaneous fat (r=-0.63, p=0.02; r=-0.55, p=0.05). The level of resistin was negatively correlated with the numeral density of lymphatic vessels (r=-0.59, p=0.03). Conclusion: The levels of circulating adipokines in patients with type 2 diabetes are related differently with body fat distribution and AT microvessel density.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115824842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG Alpha Asymmetry and Lateral Characteristics of Verbal Memory as a Useful Tool to Investigate Creative Capacity of the Aging Brain 脑电α -不对称和言语记忆的横向特征作为研究衰老大脑创造能力的有用工具

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544874

E. Privodnova

{"title":"EEG Alpha Asymmetry and Lateral Characteristics of Verbal Memory as a Useful Tool to Investigate Creative Capacity of the Aging Brain","authors":"E. Privodnova","doi":"10.1109/CSGB.2018.8544874","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544874","url":null,"abstract":"Cognitive training and rich environment are thought to contribute to high creativity in the elderly. Yet, the neural mechanisms underlying association between cognitive training and creativity is poorly understood. It has been reasoned that in young adults right cortex is more engaged in creative ideation. At the same time, right hemisphere is shown to be more affected by aging than left one. There are some reasons, that mental stimulation is effective in maintaining of functional productivity of the aging left hemisphere. We tested if index of EEG alpha asymmetry during divergent thinking and lateral characteristics of verbal memory may be considered as indicator of creative productivity in the elderly. 84 elderly mentally healthy adults participated in the study (43 were engaged in professional scientific activity). Laterality of verbal memory was assessed by dichotic test. EEG data were recorded while subjects were engaged in verbal divergent thinking test. ANOVA, regression and correlation analysis were used. Interhemispheric asymmetry in task-related alpha desynchronization with larger values in the right hemisphere was associated with the strength of right hemispheric strategies of verbal memory. This effect was related to low creative originality in elderly engaged in professional scientific activity. The results suggest that life-long mental stimulation could be responsible for additional involvement of the left-hemispheric strategies to enhance creative efficiency in the elderly. The study showed that the combination of psychometric and EEG methods of interhemispheric asymmetry assessment is a functional approach for objective investigation of creative capacity of the aging brain.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133938632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative Pharmacokinetic Analysis of а Novel Prolonged Release Dosage Form of Lithium Citrate in Mice 柠檬酸锂新型缓释剂型在小鼠体内的比较药动学分析

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544827

A. Kotlyarova, A. Letyagin, T. Tolstikova, L. N. Rachkovskaya, T. Popova

{"title":"Comparative Pharmacokinetic Analysis of а Novel Prolonged Release Dosage Form of Lithium Citrate in Mice","authors":"A. Kotlyarova, A. Letyagin, T. Tolstikova, L. N. Rachkovskaya, T. Popova","doi":"10.1109/CSGB.2018.8544827","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544827","url":null,"abstract":"This study assessed the comparative pharmacokinetics of a novel prolonged release dosage form of lithium citrate in white outbred mature mice – males after single intragastrically administration. In the experiment mice were divided into two groups (8-10 animals each group) which were received lithium citrate (LC) (75 mg/kg) or complex based on lithium citrate, aluminum oxide and organosilicone polymer (LCAS) (1120 mg/kg) once intragastrically. These doses were calculated based on lithium containing at the ratio 5,6 mg/kg. Pharmacokinetic parameters and relative bioavailability were calculated based on lithium ions concentration in serum and brain, which was measured by inductively-coupled plasma atomic emission spectrometry (ICP-AES). According to received pharmacological data of LCAS the Cmax of lithium ions in serum is lower by 4,3 times, than if administration of LC, relative bioavailability of LCAS is 44.41% of standard LC. Performed research has proven that combining aluminium oxide and organosilicone polymer as supportive components with lithium citrate helps to maintaining a stable lithium ions concentration in blood and brain which is important for achieving positive lithium therapy effect.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114744344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous Glucose Monitoring Data Analysis in Insulin-Treated Type 1 And Type 2 Diabetic Subjects with the Use of Original Software 应用Original软件分析胰岛素治疗的1型和2型糖尿病患者的连续血糖监测数据

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544878

N. Myakina, Igor A. Lots, V. Klimontov

{"title":"Continuous Glucose Monitoring Data Analysis in Insulin-Treated Type 1 And Type 2 Diabetic Subjects with the Use of Original Software","authors":"N. Myakina, Igor A. Lots, V. Klimontov","doi":"10.1109/CSGB.2018.8544878","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544878","url":null,"abstract":"The aim: to compare glucose variability (GV) parameters derived from continuous glucose monitoring (CGM) in daytime and nocturnal hours in insulin-treated subjects with type 1 and type 2 diabetes.Materials and Methods: The CGM data from 130 type 1 diabetic and 117 type 2 diabetic patients were analyzed. The original software Sakharok was applied for time in range analysis. The GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were calculated with EasyGV software.Results: Patients with type 1 diabetes, as compared to those with type 2 diabetes, had higher mean 24-hour GV parameters: MAGE (p=0.000002), LI (p<0.00001), LBGI (p<0.00001), HBGI (p=0.008) and MAG (p=0.0002). Nocturnal MAGE, LI, MAG, HBGI, CONGA and time in hyperglycemic range were also higher in patients with type 1 diabetes (all p<0.02). Nocturnal LBGI and the prevalence of hypoglycemia were similar in both groups. In day-time hours type 1 diabetic subjects, as compare to those with type 2 diabetes, demonstrate lower CONGA (p=0.04) and higher prevalence of hypoglycemic episodes (p=0.000004).Conclusion: Insulin-treated patients with type 1 diabetes, as compared to type 2 diabetic subjects, have greater 24- hour CGM-derived GV parameters with more pronounced glucose fluctuations in the hyperglycemic range at night and more prevalent episodes of hypoglycemia in the daytime.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121654672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

BGRSSB 2018 Acknowledgement of Support BGRSSB 2018感谢支持

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/csgb.2018.8544899

引用次数: 0

Time in Range Analysis and Glucose Variability in Type 1 Diabetic Patients with Different Stages of Chronic Kidney Disease 1型糖尿病合并不同阶段慢性肾病患者的时间范围分析和血糖变异性

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544805

N. Myakina, Alla K. Vigel, Igor A. Lots

{"title":"Time in Range Analysis and Glucose Variability in Type 1 Diabetic Patients with Different Stages of Chronic Kidney Disease","authors":"N. Myakina, Alla K. Vigel, Igor A. Lots","doi":"10.1109/CSGB.2018.8544805","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544805","url":null,"abstract":"The aim: to assess the relationships between glucose variability (GV) parameters and renal function in patients with type 1 diabetes (T1D) at different stages of chronic kidney disease (CKD). Materials and Methods: We observed 127 patients with T1D, 48 M/79 F, from 18 to 72 years of age. Patients were divided into 5 groups: 1) no signs of CKD (CKD0), n=27; 2) CKD С1-C2, n=67; 3) CKD С3-C4, n=26; 5) CKD С5 (hemodialysis, n=7). Time in ranges and GV parameters: Mean Amplitude of Glucose Excursions (MAGE), Lability Index (LI), Low Blood Glucose Index (LBGI), High Blood Glucose Index (HBGI), 2-hour Continuous Overlapping Net Glycemic Action (CONGA), and Mean Absolute Glucose (MAG) were derived from 72-hour continuous glucose monitoring. Results: As compared to patients without CKD, the values of MAGE, LI, HBGI were increased significantly in patients with CKD C1-C2 (all p<0.05). No differences were found in all GV parameters between CKD C3-C4 and CKD0 groups. In patients on hemodialysis time in hyperglycemic range, MAGE, LI, CONGA and HBGI were significantly higher as compared to other groups (all p<0.05). In patients with CKD C3-C5 there were negative correlations between HBGI, CONGA and estimated glomerular filtration rate (eGFR). In patients with eGFR >60 ml/min/1.73m2 HbA1c levels correlated positively with mean monitored glucose, time in hyperglycemic range, HBGI, CONGA, MAGE, LI, and MAG. On the contrary, in patients with lower eGFR none of GV parameters correlated with HbA1c. Conclusions: The results demonstrate non-linear relationships between eGFR and GV parameters in patients with T1D.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127967849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Switching to insulin glargine 300 U/mL from other basal insulin analogues provides less 24-hour glucose variability in hospitalized patients with type 1 diabetes 从其他基础胰岛素类似物改用甘精胰岛素300 U/mL可降低住院1型糖尿病患者24小时血糖变异性

2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\Systems Biology (BGRS\SB) Pub Date : 2018-08-01 DOI: 10.1109/CSGB.2018.8544728

V. Klimontov, E. Koroleva, O. Fazullina

{"title":"Switching to insulin glargine 300 U/mL from other basal insulin analogues provides less 24-hour glucose variability in hospitalized patients with type 1 diabetes","authors":"V. Klimontov, E. Koroleva, O. Fazullina","doi":"10.1109/CSGB.2018.8544728","DOIUrl":"https://doi.org/10.1109/CSGB.2018.8544728","url":null,"abstract":"We aimed to assess the effect of transition to Gla-300 from other basal insulin analogues on glucose variability (GV) parameters in hospitalized patients with type 1 diabetes. Materials and Methods: Twenty six diabetic subjects, 10 M/16 F, from 19 to 67 years of age (median – 44 years), HbA1c from 6.9 to 13.2% (median –9.4%), were switched to Gla-300 from other basal analogues: Gla-100 (n=15), detemir (n=10), and degludec (n=1). Dose titration of Gla-300 was performed in accordance with current recommendations. The GV parameters: High Blood Glucose Index (HBGI), Low Blood Glucose Index (LBGI), Mean Amplitude of Glucose Excursions (MAGE), and Lability Index (LI) were derived from two 3-day 6-point glucose profiles. Results: At 6-12 day after transition to Gla-300 mean fasting and postprandial glucose decreased significantly (10.3, 8.1-12.2 vs. 7.8, 6.7-8.8 mmol/l, p=0.008 and 10.5, 7.9-14.2 vs. 7.9, 6.7-9.6 mmol/l, p=0.02 resp.). There was decrease in the values of HBGI (11.2, 6.3-18 vs. 6.9, 3.6-12.1, p=0.01) and LI (3.4, 2.1-6.1 vs. 2.2, 1.6-3.5, p=0.04), without significant LBGI increment (1.6, 0.5-4.0 vs. 2.7, 0.7-5.0 (mmol/l)2/h, р=0.16) and MAGE changes (5.7, 3.6-6.8 vs. 4.4, 3.3-6.0 mmol/l, p=0.32). The mean dose of basal insulin did not change significantly (25.5, 19-32 vs. 27, 18-38 U/day, p=0.97). Conclusion: Switching to insulin Gla-300 from other basal insulin analogues provided less 24-hour GV in hospitalized patients with type 1 diabetes.","PeriodicalId":230439,"journal":{"name":"2018 11th International Multiconference Bioinformatics of Genome Regulation and Structure\\Systems Biology (BGRS\\SB)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125134247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0