Thrombosis and haemostasis最新文献

{"title":"Clinical Outcomes of Venous Thromboembolism in Patients with Ankylosing Spondylitis vs. Other Immune-mediated Inflammatory Diseases: Insights from the RIETE Registry.","authors":"Romain Chopard, Gregory Piazza, Laurent Bertoletti, Nicolas Meneveau, Leticia Guirado, José Antonio Porras, Francisco Rivera-Cívico, José Felipe Varona Arche, Manuel Monreal, Clément Prati","doi":"10.1055/a-2722-7327","DOIUrl":"10.1055/a-2722-7327","url":null,"abstract":"<p><strong>Background and objectives: </strong>Ankylosing spondylitis (AnkS) has been associated with an increased risk of venous thromboembolism (VTE). Data comparing VTE events in AnkS with other immune-mediated inflammatory diseases and non-inflammatory patients are lacking. This study aimed to compare clinical outcomes between VTE patients with AnkS, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and patients without inflammatory disease.</p><p><strong>Methods: </strong>We analyzed 112,539 VTE patients enrolled in the RIETE registry. A Greedy Nearest Neighbor Matching approach was used to select a comparable non-inflammatory VTE cohort. Outcomes included recurrent VTE, mortality, and major bleeding at 1 year, and were compared using Cox regression or sub-hazard models.</p><p><strong>Results: </strong>Among the inflammatory-disease cohort of 2,427 VTE patients (mean age ± standard deviation, 64.1 ± 16 years, 41.4% males), 6.4% had AnkS, 50.6% had RA, 10.8% had SLE, and 32.2% had IBD. The matched population without inflammatory disease comprised 7,800 VTE patients. The rate of recurrent VTE was 11.5%, all-cause mortality 5.1%, and major bleeding 1.9% in AnkS patients. Similar rates were observed in patients with RA, SLE, or IBD. Recurrent VTE was significantly higher in AnkS patients than in the non-inflammatory group (HR, 7.43, 95% CI, 2.28-24.23). AnkS patients who discontinued anticoagulation earlier than 1 year experienced higher adverse outcomes (a composite of mortality, major bleeding, recurrent VTE) compared with those who pursued extended therapy.</p><p><strong>Conclusion: </strong>VTE patients with AnkS have clinical outcomes comparable to other inflammatory diseases but a significantly increased risk of recurrent VTE compared with non-inflammatory patients, suggesting that extended anticoagulation strategies may be warranted.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1061-1070"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approach to Optimizing Tranexamic Acid Use in Trauma: Potential Utilization of Trauma Phenotypes.","authors":"Jotaro Tachino, Shunichiro Nakao, Hisatake Matsumoto, Yusuke Katayama, Tetsuhisa Kitamura, Shigeto Seno, Jun Oda","doi":"10.1055/a-2806-3484","DOIUrl":"10.1055/a-2806-3484","url":null,"abstract":"<p><strong>Background: </strong>Tranexamic acid (TXA) reduces mortality in patients with trauma; however, optimal patient selection remains unclear. This study aimed to identify trauma subgroups most likely to benefit from TXA administration by integrating systematic evidence mapping with trauma phenotype analysis derived from the Japan Trauma Data Bank.</p><p><strong>Methods: </strong>We conducted a two-phase study: first, a systematic search of MEDLINE, Web of Science, and the Cochrane Library databases (inception to June 28, 2024) and identified randomized controlled trials (RCTs) evaluating TXA in trauma; second, we assessed TXA's association with mortality across phenotypes derived through machine learning-based clustering using 14 variables available during initial trauma care. Among eligible studies, control group mortality and number needed to treat (NNT) were calculated and visualized via bubble plots (size = sample size).</p><p><strong>Results: </strong>Five RCTs (<i>n</i> = 894-20,127; published 2010-2023) and one phenotype study (<i>n</i> = 24,058; four phenotypes) were included, all reporting mortality as an outcome. At approximately 1 month post-injury, control group mortality in RCTs ranged from 10 to 21.8%, whereas in-hospital mortality across phenotypes ranged from 3.9 to 51.4%. NNT varied from 22 to 68 (RCTs) and from 10 to 98 (phenotype study), with an inverse relationship between baseline mortality and NNT, indicating greater TXA benefit in higher-risk groups.</p><p><strong>Conclusion: </strong>This study suggests that TXA is more effective in trauma subgroups with higher baseline mortality. Phenotype-driven stratification using initial clinical data may support more targeted TXA administration and improve patient outcomes. Further research is needed to validate these phenotypes for clinical implementation.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1006-1013"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13600770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition on Platelet Reactivity in Patients with Atherosclerotic Cardiovascular Disease: A Pooled Analysis of Two Randomized Double-blind Placebo-controlled Studies.","authors":"Luis Ortega-Paz, Yasushi Ueki, Claudio Laudani, Sylvain Losdat, Francesco Franchi, Ryota Kakizaki, Fabiana Rollini, Jonas Häner, Lorenz Räber, Dominick J Angiolillo","doi":"10.1055/a-2717-5994","DOIUrl":"10.1055/a-2717-5994","url":null,"abstract":"","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1071-1074"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of NOACS versus VKAS on Absolute and Relative Cognitive Function Decline Over Time: A Machine Learning Approach.","authors":"Sergio Ferrantelli, Mario Daidone, Giuseppe Armentaro, Gaetano Pacinella, Stefania Scaglione, Anna M Ciaccio, Edoardo Pirera, Carlo D Maida, Giuseppe Miceli, Giuliana Rizzo, Vittoriano Della Corte, Domenico Di Raimondo, Daniele Pastori, Angela Sciacqua, Antonino Tuttolomondo","doi":"10.1055/a-2698-3739","DOIUrl":"10.1055/a-2698-3739","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is the most common arrhythmia in older adults and is associated with an increased risk of cognitive impairment and dementia, even in patients without prior stroke. Nonvitamin K antagonist oral anticoagulants (NOACs) offer a better safety profile than vitamin K antagonists (VKAs), but their cognitive benefit remains uncertain.</p><p><strong>Aim: </strong>To assess the impact of NOACs versus VKAs on cognitive decline in elderly AF patients using a machine learning approach.</p><p><strong>Methods: </strong>This multicenter prospective cohort study included 983 AF outpatients enrolled between 2008 and 2022 at the Geriatrics Department, University of Catanzaro, and the ProMISE Department, University of Palermo. Stroke and bleeding risks were assessed using CHA₂DS₂-VASc and HAS-BLED scores. Cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Cognitive decline was defined as a decrease in MMSE score between baseline and follow-up. Patients with prior anticoagulant therapy (OAT), severe dementia, or comorbidities affecting cognition were excluded. Multivariable logistic regression and a random forest classifier were used to assess whether anticoagulant type independently predicted cognitive decline. Class imbalance was addressed using both class-weighted learning and the synthetic minority over-sampling technique (SMOTE), with model performance evaluated through repeated stratified cross-validation and threshold optimization.</p><p><strong>Results: </strong>At baseline, cognitive performance was comparable between groups (<i>p</i> = 0.11). After a mean follow-up of 7.2 ± 3.4 years, MMSE scores declined significantly more in VKA-treated patients (-1.7 vs. -0.3 points, <i>p</i> < 0.001). In logistic regression, NOAC use was independently associated with a lower risk of cognitive decline (odds ratio: 0.322; 95% confidence interval: 0.221-0.469; <i>p</i> < 0.0001). The random forest classifier achieved a mean cross-validated AUC of 0.8719 (standard deviation: 0.0273) and a test-set AUC of 0.880. Threshold adjustment and SMOTE improved sensitivity (recall increased: 0.47-0.84), with a precision-recall AUC of 0.763. Permutation importance analysis identified \"OAT\" as the top predictor. Predicted probabilities of cognitive decline were significantly higher in VKA users (median = 0.70) than in NOAC users (median = 0.09), confirmed by a Kolmogorov-Smirnov test (KS = 0.385, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>NOAC use is associated with a lower predicted probability of cognitive decline, suggesting potential cognitive benefits over VKAs.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1017-1027"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown of tmem183a in Zebrafish Causes Thrombocytopenia and Reduces Coagulation Factors, Disrupting Hemostasis.","authors":"Afnan Deebani, Jabila Mary, Sanchi Dhinoja, Ayah Al Qaryoute, Ritu Adhikary, Weam Fallatah, Pudur Jagadeeswaran","doi":"10.1055/a-2713-0711","DOIUrl":"10.1055/a-2713-0711","url":null,"abstract":"<p><strong>Background: </strong>Transmembrane proteins are a class of membrane-embedded proteins with largely unexplored functions. Previous RNAseq analysis identified transmembrane protein 183a (tmem183a) expression in zebrafish thrombocytes, and its knockdown led to increased gill bleeding. This study aimed to investigate the mechanism behind <i>tmem183a</i> knockdown-induced gill bleeding and its role in thrombocyte function and hemostasis.</p><p><strong>Results: </strong>Using piggyback gene knockdown and flow cytometry analysis, we found that <i>tmem183a</i> knockdown in zebrafish reduced thrombocyte counts. qRT-PCR analysis revealed decreased mRNA levels of <i>thpo</i>, <i>fli1</i>, and <i>mpl1</i> that are involved in thrombocyte differentiation and development, suggesting that their reduced expression contributed to thrombocytopenia. Further investigation into the coagulation pathways showed reduced fibrin generation as indicated by kPTT and kPT measurements and prolonged <i>in vivo</i> clot formation by laser-induced thrombosis assay. Additionally, whole blood aggregation in <i>tmem183a</i> knockdown zebrafish was decreased when stimulated by a collagen agonist. qRT-PCR measurements of coagulation factors <i>f5, f7, f8, f9a, f9b, f9l, f10</i>, and <i>vwf</i> following <i>tmem183a</i> knockdown showed decreased mRNA levels for all factors except for an increase in <i>f10</i> and no significant change in <i>vwf</i> compared to controls.</p><p><strong>Conclusion: </strong>The above findings suggested that <i>tmem183a</i> knockdown causes increased bleeding due to reduced thrombocyte counts and lower expression of key coagulation factors, underscoring its role in regulating hemostasis.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1028-1036"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Deficiency and Excessive Condition of Thrombin Burst Using Laboratory Tests.","authors":"Hideo Wada, Katsuya Shiraki, Hideto Shimpo, Toshiyuki Miyata","doi":"10.1055/a-2703-4175","DOIUrl":"10.1055/a-2703-4175","url":null,"abstract":"<p><p>Thrombin burst is an important mechanism for hemostasis, which is enhancement and amplification of the coagulation cycle, especially activation of coagulation factors XI, VIII, and V by thrombin on the activated platelets. Thrombin burst monitoring has been performed using hemostatic molecular markers, thrombin generation test (TGT), thromboelastography (TEG), and clot waveform analysis (CWA). In particular, CWA is a routine laboratory test that is neither time consuming nor expensive. Arterial thromboses, such as acute myocardial thrombosis and acute cerebral thrombosis, are associated with excessive condition of thrombin burst, and clotting time using a small amount of thrombin in CWA can detect activated or procoagulant platelets. Thrombin burst deficiency is caused by abnormalities of platelets such as thrombocytopenia or clotting factors such as hemophilia and acquired clotting factor deficiency, showing different CWA patterns. Patients with clotting factor VIII inhibitors are treated with bypass therapy, such as recombinant activated clotting factor VII and activated prothrombin complex concentrate, which can be monitored by CWA, TEG, or TGT.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"983-990"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Structured and Unstructured Data for Pulmonary Embolism Identification: Implications for Natural Language Processing (NLP) and Large Language Models (LLMs) in Thrombosis Research.","authors":"Sandra Ortega-Martorell, Ivan Olier, Yanda Meng, Yalin Zheng","doi":"10.1055/a-2840-0271","DOIUrl":"10.1055/a-2840-0271","url":null,"abstract":"","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1057-1060"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147594796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphoblasts Express Hemostatic Factors: A Mechanism for Hypercoagulability in Pediatric Acute Lymphoblastic Leukemia.","authors":"Ghada A Aborkhees, Kevin Dietrich, Amy J Barr, Lesley G Mitchell","doi":"10.1055/a-2713-0764","DOIUrl":"10.1055/a-2713-0764","url":null,"abstract":"<p><strong>Background: </strong>Venous thromboembolism (VTE) is a serious complication of pediatric acute lymphoblastic leukemia (ALL), primarily occurring during induction therapy and associated with acquired hemostatic abnormalities. However, the contribution of leukemic lymphoblasts to hypercoagulability remains unexplored. This study aimed to determine whether leukemic lymphoblasts express hemostatic factors that promote a hypercoagulable state and to assess the functional impact of lysed lymphoblasts on thrombin and fibrin generation.</p><p><strong>Methods: </strong>We examined the expression of 28 hemostatic factors at both mRNA and protein levels in four pediatric leukemic cell lines (T-ALL and B-ALL) and normal lymphocytes using RT-PCR and immunoblotting. To evaluate the overall functional effect, we conducted thrombin and fibrin generation assays by adding cell lysates to platelet-poor plasma in the absence of exogenous tissue factor or phospholipids.</p><p><strong>Results: </strong>Leukemic lymphoblasts constitutively expressed the procoagulants tissue factor, factor VIII and factor XIIIa; the coagulation inhibitors antithrombin, ADAMTS13 and TFPI; and the pro-fibrinolytic and antifibrinolytic proteins uPA, TAFI, and α2-AP. Lysed, but not intact, leukemic lymphoblasts enhanced thrombin and fibrin generation, indicating a procoagulant state. Additionally, leukemic lysates exhibited a hypo-fibrinolytic state, as evidenced by prolonged fibrin clot lysis times.</p><p><strong>Conclusion: </strong>These findings suggest that leukemic lymphoblasts actively contribute to a hypercoagulable state in pediatric ALL by simultaneously increasing procoagulant activity and impairing fibrinolysis. This study provides novel insights into the mechanisms underlying VTE risk in pediatric ALL, highlighting the role of leukemic lymphoblasts in disrupting the hemostatic balance.</p><p><strong>Key points: </strong>· Leukemic lymphoblasts express hemostatic system factors at gene and protein levels.. · Leukemic lymphoblasts lysis directly contributes to hypercoagulability and hypofibrinolysis in thrombin and fibrin generation assays..</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":"1037-1048"},"PeriodicalIF":5.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145293745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Val325Met Mutation Affects N-glycosylation and Impairs the Function of Protein C.","authors":"Shijie Zhou, Junwei Yuan, Xi Wu, Guanqun Xu, Yu Liu, Qiulan Ding, Wenman Wu, Jing Dai, Xiaobo Hu, Xuefeng Wang, Yeling Lu","doi":"10.1055/a-2963-4595","DOIUrl":"10.1055/a-2963-4595","url":null,"abstract":"<p><strong>Background: </strong>Protein C (PC) is a key anticoagulant protein that regulates hemostatic balance. Hereditary PC deficiency increases the risk of thrombosis. We identified the same mutation, c.1099G > A:p.V325 M (V325 M), in the <i>PROC</i> gene in four unrelated patients with thrombotic events and one patient with recurrent pregnancy loss, prompting further investigation.</p><p><strong>Objective: </strong>The objective of this study was to decipher the molecular basis of the clotting defect in patients carrying the V325 M mutation.</p><p><strong>Methods: </strong>We expressed and purified both wild-type and mutant PC/activated protein C (APC) in mammalian cells and characterized their properties in established coagulation and cytoprotective assay systems.</p><p><strong>Results: </strong>Functional characterization of the recombinant mutant APC revealed multiple defects, including reduced catalytic efficiency toward chromogenic substrates, decreased affinity for Na⁺, impaired anticoagulant activity in both purified and plasma systems, and diminished barrier-protective function. In parallel, electrophoretic analysis showed that the mutant APC exhibited an altered isoform distribution compared with wild-type; this difference was eliminated upon treatment with PNGase F for deglycosylation.</p><p><strong>Conclusion: </strong>Our studies demonstrate that the V325 M mutation directly impairs the anticoagulant and cytoprotective functions of PC, together with altered Nglycosylation patterns, providing a molecular mechanism for the prothrombotic phenotype observed in the carriers with this mutation.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VLDL Subfractions and Risk of Future Venous Thromboembolism- The HUNT Study.","authors":"Inga Aalberg Røstvold, Ben Michael Brumpton, Kristian Hveem, Bjørn Olav Åsvold, Guro Fanneløb Giskeødegård, George Davey Smith, Nicholas J Timpson, Kaitlin H Wade, John-Bjarne Hansen, Sigrid Kufaas Brækkan","doi":"10.1055/a-2963-4851","DOIUrl":"10.1055/a-2963-4851","url":null,"abstract":"<p><strong>Background: </strong>In vitro studies have suggested prothrombotic properties of very low-density lipoproteins (VLDL). Whether differences in VLDL particle size and lipid composition are related to venous thromboembolism (VTE) risk has been scarcely investigated. We aimed to investigate the association between chylomicron and VLDL subfractions and the risk of incident VTE in a population-based cohort.</p><p><strong>Methods: </strong>Participants (<i>n</i> = 17,032) from the third survey of the Trøndelag Health Study (HUNT3, 2006-08) were followed through December 31, 2019, and all incident VTE events during follow-up were validated and recorded. Nuclear magnetic resonance (NMR) spectroscopy was used to measure chylomicron and VLDL subfractions (including particle size, concentration, and lipid composition) in serum collected at cohort baseline. Associations between VLDL subfractions and risk of VTE were assessed using Cox regression models, adjusted for age, sex, and body mass index.</p><p><strong>Results: </strong>In total, 342 incident VTE cases occurred during a median follow-up of 12.0 years. No associations were found between VLDL particle size, VLDL concentration, VLDL lipid composition, and total triglycerides and VTE risk. All hazard ratios (HRs) per 1 standard deviation increase in VLDL metrics were within the range 0.87 to 1.16 and all 95% confidence intervals (CIs) included 1. Increasing quartiles of total VLDL particles (Q4 vs. Q1 HR: 1.12, 95% CI: 0.80-1.56) and the proportion of larger VLDL particles (Q4 vs. Q1: HR: 1.09, 95% CI: 0.81-1.45) were not associated with VTE risk.</p><p><strong>Conclusion: </strong>Total triglycerides and VLDL subfractions, including particle size, concentration, and lipid composition, were not associated with risk of incident VTE.</p>","PeriodicalId":23036,"journal":{"name":"Thrombosis and haemostasis","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}