{"title":"Factors affecting clinical outcomes of continuous and intermittent plasmapheresis in patients with severe hypertriglyceridemia","authors":"Eiman A. Hussein","doi":"10.1111/1744-9987.14134","DOIUrl":"https://doi.org/10.1111/1744-9987.14134","url":null,"abstract":"IntroductionAcute hypertriglyceridemia is considered a category III indication for plasmapheresis. The use of plasma as replacement fluid (RF) has been suggested to replace the consumed lipoprotein lipase. Heparin when used as an anticoagulant could possibly release lipoprotein lipase, thereby increasing triglyceride clearance.MethodsThe impact of RF (albumin vs fresh frozen plasma (FFP) and anticoagulant (ACD‐A vs. heparin) on triglycerides following plasmapheresis in 27 patients with severe hypertriglyceridemia (SHTG) was investigated. A paired study of four patients with recurrent SHTG was conducted, evaluating continuous (Optia) versus intermittent flow plasmapheresis (Haemonetics).ResultsShorter procedures positively impacted triglycerides (TG) drop post‐sessions <jats:italic>p</jats:italic> < 0.05. In albumin sessions, patients who used heparin demonstrated significantly greater drop in TG and required less sessions than did those with citrate <jats:italic>p</jats:italic> < 0.05. In heparin sessions, patients who used albumin demonstrated significantly greater drop in triglycerides and required less sessions than did those with FFP <jats:italic>p</jats:italic> < 0.05. Three of six patients who used FFP and heparin showed a triglyceride drop of 11.7% following three sessions and a 50% drop with one albumin session. Compared with Haemonetics, Optia removed comparable volumes of plasma in less time, processing smaller blood volumes and using less citrate <jats:italic>p</jats:italic> < 0.05. Patients demonstrated significantly lower drop in TG and required more sessions with Haemonetics than they did with Optia <jats:italic>p</jats:italic> < 0.05.ConclusionShorter procedure was the main predictor for effective TG clearance. This can be achieved by continuous apheresis technology, particularly when using albumin as RF. TG removal via Optia seems to be optimized by using heparin.","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":"41 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140812593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cansu Kosar Sahin, Hatice Ceylan, Canan Demir Barutcu
{"title":"A scale development study: Primary Caregiver Burden Scale Individuals Receiving Hemodialysis Treatment","authors":"Cansu Kosar Sahin, Hatice Ceylan, Canan Demir Barutcu","doi":"10.1111/1744-9987.14129","DOIUrl":"https://doi.org/10.1111/1744-9987.14129","url":null,"abstract":"IntroductionAs hemodialysis is a long‐term treatment method requiring significant self‐management skills, it affects both the patient and the caregiver in many ways. It is inevitable that changes in the burden perceived by the caregiver over time will not affect the patient's health care outcomes. The aim of this study was to develop an up‐to‐date scale by examining the psychometric properties of items created specifically for the care burden perceived by individuals who provide care for patients receiving hemodialysis treatment.MethodsThis study is a methodological study with the use of the COSMIN Checklist. The sample of the study included 404 individuals who were the primary caregivers of patients receiving hemodialysis treatment. Data were collected using descriptive characteristics form and the draft form of the Primary Caregiver Burden Scale Individuals Receiving Hemodialysis Treatment. Exploratory and confirmatory factor analysis and predictive validity were used to evaluate validity. The Cronbach's alpha reliability coefficient, item analysis, and test–retest method were employed to evaluate reliability.ResultsAccording to exploratory factor analysis, a scale structure with four subdimensions was determined, and goodness of fit was achieved using confirmatory factor analysis. The Cronbach's alpha coefficient of the final form of the scale consisting of 34 items was found to be 0.95 for the total scale, 0.93 for the self‐management support subscale, 0.91 for the psychological support subscale, 0.91 for the caregiver symptom subscale, and 0.93 for the caregiver individual coping subscale.ConclusionThe Primary Caregiver Burden Scale Individuals Receiving Hemodialysis Treatment, which was found to meet the validity and reliability criteria, has a four‐point Likert‐type scoring structure, 34 items, and four subdimensions. It is thought that the scale can make significant contributions to the international literature if its validity and reliability are established with nursing practices and research.","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":"23 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140812591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rehab AlSayed Shaban, Ahmed E. Abdulgalil, Ahmed Bahie
{"title":"Post‐COVID anxiety, depression, and quality of life among Egyptian hemodialysis patients","authors":"Rehab AlSayed Shaban, Ahmed E. Abdulgalil, Ahmed Bahie","doi":"10.1111/1744-9987.14128","DOIUrl":"https://doi.org/10.1111/1744-9987.14128","url":null,"abstract":"IntroductionThis study examined the impact of Coronavirus disease 2019 on anxiety, depression, and health‐related quality of life (HRQOL) among Egyptian hemodialysis (HD) patients.MethodsThis multicenter cross‐sectional study was carried out in Egypt in the years 2021–2022, where 300 HD patients from four HD centers were allocated into two groups: post‐COVID and non‐COVID. The Hospital Anxiety and Depression Scale (HADS) and the Kidney Disease QOL‐36 questionnaire were used to assess anxiety, depression, and QOL of the included patients.ResultsIn the post‐COVID group, abnormal and borderline cases of anxiety and depression were detected in 38.6% and 62.5% of patients, respectively, with no statistically significant difference between both groups. The post‐COVID group showed higher work status and lower sexual and physical functioning, which correlated negatively with anxiety and depression scores.ConclusionPast‐COVID infection did not influence depression and anxiety symptoms in HD patients. Sexual and physical functioning were more affected among COVID‐survivors.","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":"27 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140614315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of medium cut‐off membranes on Pentosidine and N‐(carboxymethyl) lysine levels in uncontrolled diabetic hemodialysis patients","authors":"Neriman Sıla Koç, Hasan Yeter, Tolga Yıldırım, Yunus Erdem, Rahmi Yılmaz","doi":"10.1111/1744-9987.14126","DOIUrl":"https://doi.org/10.1111/1744-9987.14126","url":null,"abstract":"IntroductionPatients on hemodialysis, especially with diabetes, face elevated cardiovascular events. A major contributor to complications associated with diabetes is advanced glycation end products (AGEs). Removing these compounds is challenging in traditional hemodialysis. Medium‐cut‐off (MCO) membranes potentially remove toxins without significant albumin loss. This study explored how MCO membranes impact AGEs levels in uncontrolled diabetic patients undergoing hemodialysis.MethodsSixteen patients received MCO membrane dialysis, while others used high‐flux (HF) membranes. After 12 sessions, the dialyzers were switched, totaling 24 sessions. Blood samples at trial initiation (T0), session 12 (T1) and session 24 (T2) tested for CML, Pentosidine, laboratory parameters.ResultsSwitching dialyzers showed increased albumin with MCO‐to‐HF and decreased with HF‐to‐MCO, albeit nonsignificant (<jats:italic>p</jats:italic> = 0.5/<jats:italic>p</jats:italic> = 0.1). Patients on MCO had lower albumin levels than HF (<jats:italic>p</jats:italic> = 0.03/<jats:italic>p</jats:italic> = 0.6, respectively). Hemodialysis with MCO demonstrated lower levels of CML/Pentosidine compared to HF (<jats:italic>p</jats:italic> = 0.09/<jats:italic>p</jats:italic> = 0.9 for CML; <jats:italic>p</jats:italic> = 0.04/<jats:italic>p</jats:italic> = 0.3 for Pentosidine). Transitioning to HF led to elevated levels (<jats:italic>p</jats:italic> = 0.4/<jats:italic>p</jats:italic> = 0.09 for CML; <jats:italic>p</jats:italic> = 0.3/<jats:italic>p</jats:italic> = 0.07 for Pentosidine).ConclusionMCO dialysis in diabetic individuals notably reduces AGE levels.","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":"18 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140577033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Active vitamin D analog and SARS-CoV-2 IgG after BNT162b2 vaccination in patients with hemodialysis","authors":"Akio Nakashima, Izumi Yamamoto, Arisa Kobayashi, Keita Kimura, Tatsuhiro Yaginuma, Shinichiro Nishio, Kazuhiko Kato, Rena Kawai, Tetsuya Horino, Ichiro Ohkido, Takashi Yokoo","doi":"10.1111/1744-9987.14121","DOIUrl":"https://doi.org/10.1111/1744-9987.14121","url":null,"abstract":"Vaccination is the effective strategy for coronavirus disease 2019 (COVID-19). However, few studies have investigated the association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin (Ig)G and vitamin D.","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":"47 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140171148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic Apheresis and Dialysis Forthcoming Events April 2024","authors":"","doi":"10.1111/1744-9987.14009","DOIUrl":"https://doi.org/10.1111/1744-9987.14009","url":null,"abstract":"","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":"1 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140025438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of dialysis patients with hepatitis C virus in the era of direct-acting antiviral therapy.","authors":"Michel Jadoul, Laura Labriola","doi":"10.1111/1744-9987.14060","DOIUrl":"10.1111/1744-9987.14060","url":null,"abstract":"","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":" ","pages":"158-159"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10587132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenbin Wan, Yuanmei Pan, Ying Chen, Shuwei Bai, Xiaoying Yao, Yan Lin, Jun Wu, Liping Ni, Yufang Mei, Huiying Qiu, Yan Zhou, Yong Hao, Yangtai Guan
{"title":"The effect of double filtration plasmapheresis and corticosteroids on patients with anti-dipeptidyl-peptidase-like protein 6 encephalitis.","authors":"Wenbin Wan, Yuanmei Pan, Ying Chen, Shuwei Bai, Xiaoying Yao, Yan Lin, Jun Wu, Liping Ni, Yufang Mei, Huiying Qiu, Yan Zhou, Yong Hao, Yangtai Guan","doi":"10.1111/1744-9987.14039","DOIUrl":"10.1111/1744-9987.14039","url":null,"abstract":"<p><strong>Introduction: </strong>Anti-dipeptidyl-peptidase-like protein 6 (DPPX) encephalitis is a rare condition with varied symptoms including gastrointestinal issues, weight loss, cognitive and mental dysfunction, and hyperexcitability of the central nervous system.</p><p><strong>Methods: </strong>We studied five patients with anti-DPPX encephalitis who received immunotherapy, specifically DFPP, at our hospital. We analyzed their clinical symptoms, lab results, electrophysiological and imaging findings, and outcomes with immunotherapy.</p><p><strong>Results: </strong>Patients presented with cognitive dysfunction, tremor, seizures, psychiatric disturbances, and cerebellar and brainstem dysfunction. Magnetic resonance imaging (MRI) showed brain abnormalities in one patient and elevated cerebrospinal fluid (CSF) protein levels in two patients. Antibodies against DPPX were detected in all patients and in CSF in two patients. One patient had antibodies against anti-CV2/contactin response mediator protein 5 (CRMP5). All patients responded well to DFPP and corticosteroids.</p><p><strong>Conclusion: </strong>DFPP may be an effective treatment for anti-DPPX encephalitis. Further research is needed to understand disease progression and evaluate immunotherapy efficacy.</p>","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":" ","pages":"141-151"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdullah K Al-Hwiesh, Ibrahiem Saeed Abdul-Rahman, Jose Carolino Divino-Filho, Mohamed A Nasreldin, Amani A Al-Hwiesh, Nadia Al-Audah, Hatem H Althubaini, Moaz Abdulgalil, Ghassan A Salah, Mohammad Z Al-Baggal, Bassam A Abu-Oun, Nehad Al-Audah, Habib S Al-Ramadan, Kaltham Alfalah, Zahra Almarri, Ayat A Al-Awal
{"title":"A nephrologist dream of peritoneal dialysis catheter with zero migration: A multicenter prospective study.","authors":"Abdullah K Al-Hwiesh, Ibrahiem Saeed Abdul-Rahman, Jose Carolino Divino-Filho, Mohamed A Nasreldin, Amani A Al-Hwiesh, Nadia Al-Audah, Hatem H Althubaini, Moaz Abdulgalil, Ghassan A Salah, Mohammad Z Al-Baggal, Bassam A Abu-Oun, Nehad Al-Audah, Habib S Al-Ramadan, Kaltham Alfalah, Zahra Almarri, Ayat A Al-Awal","doi":"10.1111/1744-9987.14045","DOIUrl":"10.1111/1744-9987.14045","url":null,"abstract":"<p><strong>Introduction: </strong>PD catheter tip migration is a common complication and a significant cause of catheter malfunction. In this perspective, we present our experience with a new catheter and a new technique that involves the use of a new triple cuff PD catheter and a low entry site in an attempt to prevent PD catheter migration.</p><p><strong>Methods: </strong>A total of 503 incident PD patients have been studied in more than one PD center over a period of 5 years.</p><p><strong>Results: </strong>During the 5-year follow up we recorded zero percent catheter migration. Other technical complications were poor drainage in 3.4%, omental wrap in 2.8%, early leakage in 3.4%, and catheter replacement in 2.4%. By the end of the study, the one-year PD catheter survival was 97.6%.</p><p><strong>Conclusion: </strong>Our new triple cuff PD catheter and our low-entry approach seem to be effective in preventing PD catheter migration and minimizing other mechanical complications.</p>","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":" ","pages":"89-95"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10381120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vasileios Terpos, Stefanos Roumeliotis, Panagiotis I Georgianos, Eleni Papa, Dimitrios G Tsalikakis, Evangelos Papachristou, Vassilios Liakopoulos
{"title":"Diuretics or ultrafiltration in the treatment of acute decompensated heart failure: An updated systematic review and meta-analysis.","authors":"Vasileios Terpos, Stefanos Roumeliotis, Panagiotis I Georgianos, Eleni Papa, Dimitrios G Tsalikakis, Evangelos Papachristou, Vassilios Liakopoulos","doi":"10.1111/1744-9987.14037","DOIUrl":"10.1111/1744-9987.14037","url":null,"abstract":"<p><strong>Introduction: </strong>Hospitalization for decompensated heart failure is a major public health issue.</p><p><strong>Methods: </strong>We performed a meta-analysis to summarize and analyze if there is a benefit in using ultrafiltration over diuretics in terms of reducing mortality or hospital readmissions, primarily and identified 10 randomized controlled trials (RCTs) including 941 patients.</p><p><strong>Results: </strong>Compared to diuretics, treatment with ultrafiltration was associated with a significant reduction in heart failure hospitalizations (risk ratio [RR]: 0.72; 95% confidence interval [CI]: 0.55-0.96, p = 0.02) and significant increase in weight and net fluid loss (mean difference [MD]: -1.55, CI: -2.36 to -0.74, p = 0.0002) and (MD: -2.10, CI: -3.32 to -0.89, p = 0.0007), respectively. There was no significant difference among treatments regarding the duration of hospitalization, the increase in serum creatinine levels, and mortality.</p><p><strong>Conclusion: </strong>Among patients with decompensated heart failure, compared to diuretics, ultrafiltration is associated with reduced rehospitalizations and increased weight/net fluid loss.</p>","PeriodicalId":23021,"journal":{"name":"Therapeutic Apheresis and Dialysis","volume":" ","pages":"9-22"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}