The professional medical journal最新文献_第5页

Role of fingolimod in acute respiratory distress syndrome. 芬戈莫德在急性呼吸窘迫综合征中的作用。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.7983

Sarwat Jahan, Manzoor Khan, Salman Zahir, Khansa Khan, Sarah Saleem

{"title":"Role of fingolimod in acute respiratory distress syndrome.","authors":"Sarwat Jahan, Manzoor Khan, Salman Zahir, Khansa Khan, Sarah Saleem","doi":"10.29309/tpmj/2024.31.05.7983","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.7983","url":null,"abstract":"Objective: Sphingosine 1 Phosphate (S1P) is a key regulator of inflammation, angiogenesis, vessel permeability, and immune processes, acting through S1P receptors. Fingolimod (FTY720), an S1P receptor analog Fingolimod, was initially approved for multiple sclerosis treatment and has shown potential for application in infectious and inflammatory disorders, including COVID-19. Study Design: Comprehensive Literature Review. Setting: Northwest School of Medicine. Period: 1st March 2023 to 3rd July 2023. Methods: Examining S1P pathways, S1P receptor analogs, and their potential in treating inflammatory and infectious disorders, particularly COVID-19, utilizing Fingolimod. Results: S1P analogs have demonstrated therapeutic benefits in autoimmune diseases. In COVID-19, these analogs modulate the inflammatory response, reduce tissue damage, and promote viral clearance. Fingolimod, in particular, affects S1PR1, S1PR4, and S1PR5, blunting the inflammatory response and mitigating lung tissue injury. Early administration may prevent excessive inflammation without interfering with viral clearance. Potential risks include disturbance of cytokine homeostasis and delayed administration. Limited human studies and concerns about off-target effects need addressing. Conclusion: Fingolimod shows promise in treating COVID-19 by reducing inflammation and lung damage. Further research is needed to address limitations and ensure safety for clinical application. Sphingosine 1 Phosphate (S1P) plays a key role in regulating inflammation and immune responses, with Fingolimod being a potential treatment option.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"54 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The predictive validity of serum biochemical markers in case of acute biliary pancreatitis. 急性胆源性胰腺炎病例中血清生化指标的预测有效性。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.8003

Adnan Riaz, Sumera Saghir, Roomana Anwar, Sabeen Khalid, Muhammad Shakil, Tabinda Fatima

{"title":"The predictive validity of serum biochemical markers in case of acute biliary pancreatitis.","authors":"Adnan Riaz, Sumera Saghir, Roomana Anwar, Sabeen Khalid, Muhammad Shakil, Tabinda Fatima","doi":"10.29309/tpmj/2024.31.05.8003","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8003","url":null,"abstract":"Objective: To analyze the detection validity of serum biochemical markers in the suspicion of acute biliary disease. Study Design: Retrospective study. Setting: Department of Biochemistry, Islam Teaching Hospital, Sialkot. Period: January 2023 till June 2023. Methods: In a retrospective analysis of 70 patients, there were 35 patients suffering from acute biliary pancreatitis and 35 patients were suffering from non-biliary pancreatitis in group A and B respectively. The patients were identified based on high serum amylase levels. Age, gender, and history were examined, and patients with persistent abdominal pain and abnormal amylase levels were included. Computed tomography detected gallstones, and patients with chronic liver issues were excluded. Results: Comparative analysis conducted using Chi-square and Mann-Whitney tests in SPSS 15.0. A significant result was defined as a P value under 0.005. The sample collection was done from Islam teaching hospital Sialkot and the study was conducted at biochemistry lab of Islam medical college Sialkot. Conclusion: The study, involving 70 patients, aimed to predict acute biliary pancreatitis using serum biochemical markers. The two groups, one with acute biliary pancreatitis and other non-biliary, showed significant differences in key markers (total bilirubin, ALT, direct bilirubin, ALP, AST and serum amylase). These findings suggest the potential diagnostic relevance of these markers.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"28 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric arterial ischemic stroke; Risk factors, clinical presentation and short-term outcome of patients presenting at a tertiary care hospital. 小儿动脉缺血性中风；一家三级医院就诊患者的风险因素、临床表现和短期疗效。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.8053

Samrah Ibrahim, Misbah Anjum, Shazia Soomro

{"title":"Pediatric arterial ischemic stroke; Risk factors, clinical presentation and short-term outcome of patients presenting at a tertiary care hospital.","authors":"Samrah Ibrahim, Misbah Anjum, Shazia Soomro","doi":"10.29309/tpmj/2024.31.05.8053","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8053","url":null,"abstract":"Objective: To determine the risk factors, clinical presentation and short term outcome in children presenting with arterial ischemic stroke at a tertiary care hospital. Study Design: Prospective Observational study. Setting: Medical Units of National Institute of Child Health, Karachi, Pakistan. Period: November 2022 October 2023. Methods: Children of either gender aged between 1 month to 12 years and admitted with the diagnosis of pediatric arterial ischemic stroke during the study duration were analyzed. Detailed medical and neurological examinations were performed. Routine work up and laboratory investigations were done. Modified Rankin Scale (MRS) scores at the time of enrollment, discharge and after 3 month follow-up were recorded. Results: In a total of 35 children, 21 (60.0%) were boys the mean age was 6.89±3.63 years. The most frequent presenting clinical features were focal neurological deficits noted in 29 (82.9%) children whereas fever, and fits were reported in 26 (74.3%), and 22 (62.9%) children, respectively. Right hemiplegia was observed in 15 (42.9%) children. Stroke was secondary to moyamoya 8 (22.9%), infections in 6 (17.1%) children. Mortality was reported among 3 (8.6%) children while 3 others lost during the follow ups. Comparison of mean mRS scores at the time of admission, discharge and after 3 months showed significant reduction (p<0.001). Conclusion: Focal neurological deficits were the predominant clinical features, with a significant incidence of associated fever and seizures. Moyamoya and infections emerged as primary causative factors. Despite a mortality rate of 8.6%, there was an overall improvement in outcomes, as evidenced by a significant reduction in Modified Rankin Scale scores at admission, discharge, and after three months.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"85 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To determine the frequency of triple vessel coronary artery disease in patients admitted with acute coronary syndrome. 确定急性冠状动脉综合征入院患者中出现三血管冠状动脉疾病的频率。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.8055

Sohail Bashir Sulehria, Hina Wajid, Abdul Wasae, Aqeel Asghar, Mushtaq Ahmad Shahid, Mariam Tahir

{"title":"To determine the frequency of triple vessel coronary artery disease in patients admitted with acute coronary syndrome.","authors":"Sohail Bashir Sulehria, Hina Wajid, Abdul Wasae, Aqeel Asghar, Mushtaq Ahmad Shahid, Mariam Tahir","doi":"10.29309/tpmj/2024.31.05.8055","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8055","url":null,"abstract":"Objective: To determine the frequency of triple vessel coronary artery disease in patients less than 40 years of age undergone diagnostic coronary angiography and were admitted with acute coronary syndrome Study Design: Cross Sectional study. Setting: Department of Cardiology, Punjab Institute of Cardiology, Lahore. Period: 3rd Sep 2018 to 2nd March 2019. Methods: It was consisted of 90 patients Results: Total 90 cases were enrolled in the study. All presented with central or left sided chest pain clinically diagnosed to be having acute coronary syndrome. All patients undergo diagnostic coronary angiography for the first time. 36.7 % of the presenting cases included in the present study were females while 63.3 % were males who had acute coronary syndrome. Average age of patients included in present study was 30.1±5.9 Data was stratified according to age, gender, type of ACS present. Post stratification chi-square test was applied. It showed that 23.29 % patients had triple vessel coronary artery disease whereas 76.71% did not have triple vessel coronary artery disease. Conclusion: TVCAD was observed in 23.29% of patients presented with acute coronary syndrome in patients less than 40 years of age.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"75 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulation-based interprofessional education for teaching evidence-based medical practice. 基于循证医学实践教学的模拟跨专业教育。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.7963

Khadija Farrukh, Fareeha Shahid, Fatima Zehra, Samreen Iqbal, Samia Ghulam Mohammad, Muhammad Ahsan

{"title":"Simulation-based interprofessional education for teaching evidence-based medical practice.","authors":"Khadija Farrukh, Fareeha Shahid, Fatima Zehra, Samreen Iqbal, Samia Ghulam Mohammad, Muhammad Ahsan","doi":"10.29309/tpmj/2024.31.05.7963","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.7963","url":null,"abstract":"Objective: To achieve consensus on opinions of expert medical educationist on utilization of simulation-based interprofessional education as teaching strategy for evidence based practice teaching in undergraduate medical education. Study Design: Qualitative Case study. Setting: Bahria University Health Sciences Campus. Period: March 2023 to August 2023. Methods: Research using modified Delphi technique was done under ERC 16/2023-BUMDC. Communities of practice and transformative learning theory were used for guiding research design. Non-probability, snow-ball sampling technique was used to select expert panel as participants. Inclusion criteria were medical educationist with masters in health professional education and ten year of experience in department of medical education. Content analysis was used for analyzing data and atlas ti-9 was used for organizing data collected through online email interviews. Results: Final consensus of participants was attained on, third year, Simulation-based interprofessional education/ Assignments/ Journal Clubs/Case-based discussions, Fourth year, Simulation-based interprofessional education/ Journal Clubs/Case-based discussions, Content: Final year, Simulation-based interprofessional education/ Clinical setting/ Journal Clubs. Conclusion: Expert showed ninety percent consensus that simulation-based interprofessional education is good teaching strategies for teaching evidence –based practice in undergraduate medical.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"199 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between silver nitrate and table salt in the treatment of umbilical granuloma. 硝酸银和食盐在治疗脐肉芽肿方面的比较。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.8113

Abdul Khaliq, Muhammad Kashif, Syed Mohsin, Ali Shah, Tabinda Shadab, Romisa Rehman, Faizan Sadiq

{"title":"Comparison between silver nitrate and table salt in the treatment of umbilical granuloma.","authors":"Abdul Khaliq, Muhammad Kashif, Syed Mohsin, Ali Shah, Tabinda Shadab, Romisa Rehman, Faizan Sadiq","doi":"10.29309/tpmj/2024.31.05.8113","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8113","url":null,"abstract":"Objective: To compare the efficacy of table salt with silver nitrate in the treatment of umbilical granuloma presenting to the neonatal unit/paediatric department KTH. Study Design: Randomized Controlled Trial Setting: Neonatal Unit of Khyber Teaching Hospital. Period: November 2019 to November 2022. Methods: A total of 120 patients who presented to the neonatal unit/paediatric department, aged 15-60 days were enrolled in this study via consecutive sampling. Seventy-five patients each, were allocated to two groups, Group A (common salt) and Group B (silver nitrate). Sixteen patients from Group A whereas, in Group B, 17 patients were lost to follow-up. Results: A total of 58 out of the remaining 117 patients were female whereas 59 patients were male. Treatment response was recorded for both groups. The cure rate was greater among Group B (93%) as compared to Group A (88%) but there was no statistically significant difference between Group A and B in treatment response (p= 0.35). Conclusion: Table salt is a cheaper, easily accessible, and safe alternative to topical silver nitrate in the treatment of umbilical granuloma.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"34 S5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical evaluation of 0.8% hyaluronic acid gel adjunctive to scaling and root planning in the treatment of chronic periodontitis in Hyderabad Sindh. 海得拉巴信德省 0.8%透明质酸凝胶辅助洗牙和牙根规划治疗慢性牙周炎的临床评估。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.7828

Shafquat Hussain Khuwaja, S. Soomro, Khurram Anwar, Naveed Irfan, Arsalan Ahmed, Kundan

{"title":"Clinical evaluation of 0.8% hyaluronic acid gel adjunctive to scaling and root planning in the treatment of chronic periodontitis in Hyderabad Sindh.","authors":"Shafquat Hussain Khuwaja, S. Soomro, Khurram Anwar, Naveed Irfan, Arsalan Ahmed, Kundan","doi":"10.29309/tpmj/2024.31.05.7828","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.7828","url":null,"abstract":"Objective: To determine the effect of hyaluronic acid as an adjuvant to root planning and scaling for the management of chronic periodontitis patients. Study Design: Prospective Randomized-controlled Clinical study. Setting: Department of Periodontology, Faculty of Dentistry Isra Dental College Hyderabad. Period: 1st July 2022 to 31st June 2023. Methods: A total of 50 diagnosed patients of chronic periodontitis and assigned into two groups according to the treatment given. Group A received Hyaluronic acid+Scaling and Root Planning whereas group B patients received Scaling and Root Planning alone. Patients were clinically evaluated before receiving treatment. Periodontal Depth (PD), Clinical Attachment level (CAL), Blood on Probe (BOP), and Plague Index (PI) were recorded at Baseline appointments, 3rd-month appointments, and 6th-month appointments after receiving treatment. The results were analyzed by SPSS version 21. Results: in both groups, significant improvement was observed in the mean value of PD, and CAL after receiving treatment, while comparing both groups, Group A patients found more significant results (<0.05) as compared to Group B. The study also found a significant reduction in BOP and PI of both groups of patients after receiving treatment but there was not any significant difference found in the mean value of BOP and PI in both groups. Conclusion: The study was conducted to determine the effectiveness of Hyaluronic acid as an adjuvant therapy that may affect chronic periodontitis along with SRP. The current study concluded hyaluronic acid gel is an effective adjuvant therapy with SRP.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"144 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HbA1c as an early diagnostic marker in gestational diabetes mellitus. 将 HbA1c 作为妊娠糖尿病的早期诊断指标。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.7993

Shabana Abbas, M. Khattak, Sanober Hameed, Fatima-tuz-Zahra, Sami Saeed, Rabiya Shabir

{"title":"HbA1c as an early diagnostic marker in gestational diabetes mellitus.","authors":"Shabana Abbas, M. Khattak, Sanober Hameed, Fatima-tuz-Zahra, Sami Saeed, Rabiya Shabir","doi":"10.29309/tpmj/2024.31.05.7993","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.7993","url":null,"abstract":"Objective: To assess the effectiveness of HbA1c as an indicator of Gestational Diabetes mellitus(GDM). Study Design: Prospective Cases Control study. Setting: Fauji Foundation Hospital Rawalpindi. Period: March 2022 to Oct 2022. Methods: All pregnant females older than 18 years of age having pregnancy confirmed by gynecologist in 1st trimester were included. A 5ml blood sample was obtained from each case to evelaute the HbA1c level. Oral glucose tolerance test (OGTT) was performed on both groups at conception to 12 weeks (1st trimester) as well as at 12 to 24 weeks of gestation (2nd trimester) to evaluate correlation between OGTT and HbA1c test. All the females suffering from GDM were taken in cases group and comparatively in equal number non GDM pregnant women were taken in control group. All the relevant information was collected via study proforma and SPSS version 26 was used for analysis. Results: The number of females suffering from GDM was 45 in number and we took 45 pregnant females as control group. Average level of HbA1c in women with GDM (test group) was higher than in women with Non-GDM (control group). Patients having age groups 35-39 showing greater prevalence of gestational diabetes with 73.2% sensitivity and 66.7% specificity at a cut-off value of 5.6% (31 mmol/mol) for GDM diagnosis. Conclusion: The findings reveal significantly elevated HbA1c levels during both the first and second trimesters in individuals diagnosed with GDM, with a test specificity of 95%. This underscores its ability to accurately pinpoint individuals who truly have GDM. However, HbA1c is observed as a valuable diagnostic tool for the early detection of GDM.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications associated with HCV-related liver cirrhosis and their relationship with diabetic control. A tertiary care center study in Peshawar, Pakistan. 与丙型肝炎病毒相关的肝硬化并发症及其与糖尿病控制的关系。巴基斯坦白沙瓦市一家三级医疗中心的研究。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.8060

Zahidullah Khan, Wisal Ahmad, Mamoona Zaman, Inamullah Khan, Mohammad Haroon, Hamza Ali Khan, Irfan Ullah, Wadana Zafar

{"title":"Complications associated with HCV-related liver cirrhosis and their relationship with diabetic control. A tertiary care center study in Peshawar, Pakistan.","authors":"Zahidullah Khan, Wisal Ahmad, Mamoona Zaman, Inamullah Khan, Mohammad Haroon, Hamza Ali Khan, Irfan Ullah, Wadana Zafar","doi":"10.29309/tpmj/2024.31.05.8060","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8060","url":null,"abstract":"Objective: To determine the frequencies of liver cirrhosis-associated complications in patients with HCV+ diabetic patients and its association with HbA1C. Study Design: Observational Cross-sectional study. Setting: Medical Wards of Khyber Teaching Hospital. Period: October 2019 to November 2020. Methods: After approval from the hospital ethical committee, all HCV positive diabetic patients were enrolled in the study. Informed consent was obtained and relevant examination was performed. Hematemesis was diagnosed clinically, while venous blood was sent for all routine and relevant specialized investigations. Twenty-four-hour urinary output was calculated. Abdominal ultrasounds and Triphasic CT abdomen were done where required. Data were collected on structurally designed proforma. All data were entered into SPSS version 22. Results: A total of 62 patients were enrolled. The mean age was 49. 23 years ± 11.72 SD. Twenty-three patients (37.1%) were males, while 39 patients (62.9%) were females. Forty-nine patients (79%) were PCR-positive for HCV. Most patients (58.1%) had less than five years duration of HCV. Frequency of SBP was 16.1%, hepatic encephalopathy was 22.6%, ascites was 40.3%, hematemesis was 11.3%, portal vein hypertension was 45.2%, and HCC 3.2%. On post-stratification, significant associations emerged with age, where SBP (p <0.01), hepatic encephalopathy (p<0.001), and ascites (p<0.0001), increased with advancing age, while hematemesis (p<0.04) and portal vein hypertension (p<0.04) were more pronounced in younger patients. Conclusion: In conclusion, individuals with both chronic HCV and diabetes mellitus exhibit an increased risk of cirrhosis-related complications. The most common complication was portal vein hypertension followed by ascites and hepatic encephalopathy. The complications like SBP, Hepatic encephalopathy and ascites associated with increasing age.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"101 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum of respiratory distress and outcome in neonates admitted in National Institute of Child Health, Karachi, Pakistan. 巴基斯坦卡拉奇国立儿童健康研究所收治的新生儿呼吸窘迫频谱及结果。

The professional medical journal Pub Date : 2024-05-04 DOI: 10.29309/tpmj/2024.31.05.8043

Lachhman Singh, Mashal Khan, Dr. Lachhman Singh Rajput, Rajput Mashal Khan

{"title":"Spectrum of respiratory distress and outcome in neonates admitted in National Institute of Child Health, Karachi, Pakistan.","authors":"Lachhman Singh, Mashal Khan, Dr. Lachhman Singh Rajput, Rajput Mashal Khan","doi":"10.29309/tpmj/2024.31.05.8043","DOIUrl":"https://doi.org/10.29309/tpmj/2024.31.05.8043","url":null,"abstract":"Objective: To find out the spectrum of respiratory distress and outcome in neonates admitted to Neonatal Intensive care unit (NICU) of National Institute of Child Health (NICH), Karachi, Pakistan. Study Design: Cross-sectional study. Setting: NICU of NICH, Karachi, Pakistan. Period: June 2022 to May 2023. Methods: We analyzed 148 neonates of either gender presenting with respiratory distress. At the time of enrollment, demographic and clinical information was noted in all neonates along with detailed maternal history. Relevant laboratory and radiological studies were performed. Final outcomes were recorded in terms of discharged, expired or referred. Results: In a total of 148 neonates, 96 (64.9%) were boys. The mean age was 4.04±5.65 days. Tachypnea, nasal flaring, intercostal recession, subcostal recession, grunting, and cyanosis 148 (100%), 146 (98.6%), 138 (93.2%), 133 (89.9%), 97 (65.5%), and 83 (56.1%) were the most frequent clinical presentations among neonates with respiratory distress. The most frequent causes behind respiratory distress were noted to be respiratory distress syndrome, sepsis, and meconium staining of labour in 31 (20.9%), 25 (16.9%), and 24 (16.2%) neonates. Mortality was observed in 21 (14.2%) neonates. Significant association of neonates presenting with congenital pneumonia (p=0.048), or congenital anomalies (p<0.001) were found to with poor outcomes. Mechanical ventilation was found to have significant relationship with poor outcomes (p<0.001). Conclusion: Tachypnea, Nasal flaring, intercostal and subcostal recessions, grunting, and cyanosis were the primary clinical presentations among the neonates with respiratory distress. Congenital pneumonia, and congenital anomalies emerged as key predictors of poor outcomes.","PeriodicalId":22991,"journal":{"name":"The professional medical journal","volume":"144 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0