THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL最新文献

{"title":"ENVIRONMENTAL CONTAMINATION BY PATHOGENS OF GEOHELMINTHIASIS IN THE SOUTH-EAST OF THE KURSK REGION","authors":"N. A. Samofalova, N. S. Malysheva, N. A. Vagin","doi":"10.31016/978-5-6048555-6-0.2023.24.396-401","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.396-401","url":null,"abstract":"Geohelminth infections are a complex and multifaceted problem that attracts the \u0000attention of both medical doctors and veterinarians, as well as scientists. They \u0000are the most common parasitic diseases. The annual number of recorded cases \u0000of geohelminthiasis in humans in the Kursk Region and conditions conducive \u0000to their spread have determined the timeliness of studies on contamination of \u0000environmental objects with geohelminth eggs. Analysis of the study results showed \u0000that the contamination of environmental objects with parasitic agents was 8.4%. \u0000Ascaris and Toxocara eggs were recorded in the samples. 7.9% of the examined soil \u0000samples, 13.7% of the manure and 3.7% of the runoff samples from the territories \u0000were positive for pathogens of geohelminthiasis. Depending on the season of the \u0000year, the indicators of environmental objects contaminated with geohelminth eggs \u0000were not the same. There was an increase in contamination of the soil and runoff from territories almost twice in the autumn period (prevalence, 12.6%) as compared \u0000with the summer period (EO 6.5%). Thus, environmental objects contaminated \u0000by parasitic agents indicate the circulation of geohelminthiasis pathogens among \u0000domestic animals in the study territories and a risk of infection with larval toxocariasis \u0000and ascariasis for the population.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82294292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STUDYING THE CHEMICAL STABILITY OF TRICLABENDAZOLE-BASED PREPARATIONS","authors":"M. Khalikov","doi":"10.31016/978-5-6048555-6-0.2023.24.493-497","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.493-497","url":null,"abstract":"The purpose of the research is to study the chemical stability of triclabendazole (TCB) \u0000in preparations obtained by its mechanochemical modification with polymeric \u0000substances and succinic acid (SA), as well as samples of Triclafascid obtained in \u00002015–2022 and left for storage at a temperature of 18–25 0C and a relative \u0000humidity of 55–60%. To achieve this goal, we selected samples of preparations \u0000obtained earlier and in freshly prepared solid dispersions (SD) based on TCB, SA, \u0000polyvinylpyrrolidone (PVP) and arabinogalactan (AG). Modification of TCB by \u0000polymeric substances was carried out at a weight ratio of components 1:9 in an LE101 ball mill at a rotation speed of 65–70 rpm with sampling for stability (integrity) \u0000analysis of TCB by high performance liquid chromatography (HPLC). The integrity \u0000analysis of TCB in its SDs obtained in 2015–2022 showed that there was no chemical \u0000destruction of TCB in them. The TCB substance is a stable chemical molecule \u0000that is not affected by destruction either during machining or during succinic acid \u0000treatment. The obtained SDs remain stable for TCB during storage for more than \u00007 years.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82719546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MELATONIN STIMULATES PHOTORECEPTOR DIFFERENTIATION IN REGENERATION OF PLANARIAN SCHMIDTEA MEDITERRANEA","authors":"N. Kreshchenko, D. E. Mitkovskii","doi":"10.31016/978-5-6048555-6-0.2023.24.229-234","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.229-234","url":null,"abstract":"The planarian Schmidtea mediterranea (Turbellaria, Platyhelminthes) has a \u0000pair of eyes on the anterior part of the body consisting of pigment cells and \u0000photoreceptor neurons capable of regeneration. The research represents a study \u0000of the effects of melatonin on photoreceptor differentiation after decapitation of \u0000the planarian. During the experiment, the worms were decapitated, and the eye \u0000regeneration was observed at days 3 and 4 of the regeneration. Different stages of \u0000the photoreceptor regeneration were observed such as both eyes in the regenerating \u0000planarians, planarians with one eye, and planarians with no eyes. In most of the \u0000animals, the photoreceptors were already visible at day 4 after the decapitation. In \u0000the experimental planarians exposed to melatonin at concentrations of 1 and 0.1 \u0000µM, the accelerated photoreceptor differentiation was observed. The stimulating \u0000effects of melatonin were detected in three animal groups on day 3 and 4 after the \u0000decapitation. The study will be continued to evaluate mechanisms of the melatonin \u0000action on planarian regeneration.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88721856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFECTION OF LIVESTOCK ANIMALS WITH PARASITES IN THE CONDITIONS OF PEASANT FARMING IN THE MOSCOW REGION","authors":"I. I. Tsepilova, B. K. Laipanov, I. S. Shcherbakova","doi":"10.31016/978-5-6048555-6-0.2023.24.508-512","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.508-512","url":null,"abstract":"The socio-economic role in the development of peasant farming in the current \u0000conditions of import substitution will certainly increase, especially in filling local \u0000and regional markets with agricultural products. The limiting factor of farms of \u0000any form of ownership are parasitic diseases. Studies on the infection of livestock \u0000animals were carried out at a peasant farm enterprise of the Dmitrov City District \u0000of the Moscow Region. Feces were taken individually from each animal: cattle (70 \u0000lactating cows, and 32 young bulls on fattening), goats (15 milk goats, and 12 baby \u0000goats kept together), 10 Vietnamese pot–bellied pigs, 2 horses and ponies. Based \u0000on the conducted studies, it was found that the cattle, namely the lactating cows \u0000and bulls on fattening were infected by pathogens of gastrointestinal strongylatosis \u0000by 14.3 and 50%, and the milk and young goats, by 100%, which indicates a high \u0000infection rate of these pathogens in ruminants. Also, the nematode Strongyloides \u0000papillosus (IP=80%) and protozoa from the genus Eimeria (IP=53%) were identified \u0000in the mature goats. In the Vietnamese pot-bellied pigs, horses and ponies, the most common helminth infections were identified, namely: Oesophagostomum (IP=50%) \u0000and Ascaris suum (IP=80%) and pathogens from the Strongylata suborder, respectively.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87337323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARGULOSIS OF THE PERCH FROM LAKE KENON (ZABAIKALSKY KRAI)","authors":"T. Burdukovskaya, Z. Dugarov","doi":"10.31016/978-5-6048555-6-0.2023.24.112-116","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.112-116","url":null,"abstract":"Crustaceans of the subclass Branchiura Argulus foliaceus cause argulosis, an invasive \u0000disease in fish. Arguluses are temporary ectoparasites. Moving along the surface of \u0000the host's body, the crustaceans look for places accessible to blood vessels. After they \u0000have sucked blood, they leave the fish. Hemorrhages, wounds and ulcers appear in \u0000the affected areas. For free-swimming arguluses, behavioral adaptations are aimed \u0000at making the most of meetings with hosts and moving from one host to another. \u0000Our study presents data on crustaceans A. foliaceus from the perch from Lake Kenon \u0000(Amur River basin). The material was obtained from net catches in the first decade \u0000of June 2010. Individuals of the perch of the same size and age groups 2+–4+ were \u0000caught at the mouth of the Kadalinka River and in the warm water discharge zone of \u0000the Chita CHP-1. According to the results of our research, the relative abundance of \u0000argulus in the perch is significantly higher in the area of the mouth of the Kadalinka \u0000River than in the warm water discharge zone of the Chita CHP-1. In the springsummer period, the number of crustaceans increases during the spawning of adult \u0000fish and the feeding of juveniles in the area of the mouth of the Kadalinka River.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75087802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE DISTRIBUTION OF THE NEMATODE PARASCARIS EQUORUM (GOEZE, 1782) IN THE NORTH-WESTERN AND EASTERN AREAS OF UZBEKISTAN","authors":"S. Turgunov, A. J. Kaniyazov, E. Shakarboev","doi":"10.31016/978-5-6048555-6-0.2023.24.475-479","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.475-479","url":null,"abstract":"One of the common helminth infections of horses in Uzbekistan and other countries \u0000is parascaridosis. Infection of horses with the nematode Parascaris equorum (Goeze, \u00001782) in some regions of our country ranges from 27 to 38%. The purpose of \u0000this work is to study the distribution of the nematode Parascaris equorum in the \u0000northwestern and eastern regions of Uzbekistan, and the seasonal and age dynamics \u0000of infection of horses with this nematode. The studies were carried out in the regions \u0000of the Republic of Karakalpakstan and the Ferghana Valley during 2018-2023. \u0000One hundred forty-three horses of different age groups in Karakalpakstan and 57 \u0000horses in the Fergana Valley were examined by the method of complete and partial \u0000helminthological dissections per Skrjabin. Fecal samples from 264 horses were \u0000studied using helminthocoprological methods. Parascaris infection rate in the horses \u0000examined by the method of complete and partial helminthological dissections \u0000averaged 33.6% in the study areas. Helminthocoprological methods were used to \u0000study the seasonal and age dynamics of the Parascaris equorum infection in the \u0000horses. Seasonal Parascaris equorum infection in the horses was 19.7% in spring, 25.4% in summer, 33.7% in autumn, and 35.2% in winter. Age-related invasiveness \u0000of the horses with nematodes was registered at 40.4% in the animals under two years \u0000old, 31.4% in the animals from two to five years old, and 24.6% in the animals over \u0000five years old.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75094953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROPEPTIDES INVOLVING IN THE REGULATION OF LOCOMOTOR BEHAVIOR OF ROOT-KNOT PLANT-PARASITIC NEMATODES (REVIEW)","authors":"T. Malyutina","doi":"10.31016/978-5-6048555-6-0.2023.24.281-284","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.281-284","url":null,"abstract":"In the last few decades, the attention of researchers has been attracted by endogenous \u0000FMRFamide-like neuropeptides found in a number of invertebrates, including \u0000species of the Nematoda phylum. A foreign literature review was presented for \u0000the functional significance of endogenous FMRFamide-like neuropeptides in \u0000locomotor behaviour of root-knot phytonematodes, representatives of the genus \u0000Meloidogyne Goldi, 1982, namely, Meloidogyne incognita, M. minor, M. hapla and \u0000M. graminicola. In Russia, such studies are not carried out. The main characteristics \u0000of phytoparasitic neuropeptides were obtained from the study of genes (flp-genes) \u0000that encode these neuropeptides. M. incognita was found to have FMRFamidelike positive immunoreactivity in the central nervous system and 19 flp genes. The \u0000Mi-flp-12 and Mi-flp-14 genes encode neuropeptides that stimulate locomotor \u0000behaviour, while Mi-flp-32 encodes a neuropeptide that inhibits parasite locomotor \u0000behaviour. Nematodes M. incognita and M. hapla were found to have G-proteincoupled receptors (GPCRs) encoded by the flp-32 gene, and their similarity \u0000to receptor 1 (C26F1) of the free-living nematode Caenorhabditis elegans was \u0000detected. Similar data were presented in the literature for M. graminicola. The \u0000peptidergic signaling nervous system of root-knot phytonematodes is similar to the \u0000system of nematodes in vertebrates and free-living nematodes, which indicates the \u0000conservatism of the system in species of the entire Nematoda phylum.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75619610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODIFICATIONS OF THE ASCARIS IDENTIFICATION METHOD BASED ON MASS SPECTROMETRY","authors":"I. Berezinskaya, S. A. Nagorniy, А. V. Aleshukina, I. Martyusheva","doi":"10.31016/978-5-6048555-6-0.2023.24.78-84","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.78-84","url":null,"abstract":"Currently, the diagnosis of helminthic diseases is based on microscopic observation \u0000of various stages of parasites, but microscopy is subjective and directly related to the \u0000competence of the researcher. Against this backdrop, researchers have described \u0000laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) \u0000as a potential innovative proteomic analysis tool for helminth identification and \u0000differentiation. The purpose of the research is to search for alternative consumables \u0000(lysis buffers) in connection with import substitution. For the study, the head \u0000ends of Ascaris lumbricoides, male and female (5 specimens each) were taken. The \u0000comparative protein profile of the ascarids by mass/charge ratio in the Flex analysis \u0000program revealed similar graphs of the head parts of the askaris (male and female) \u0000processed with lysis buffer from the Sepsityper Kit 50 and with buffer from the PCR kit. The results of the study show the possibility of species differentiation of \u0000nematodes using the MALDI-TOF MS method. Coincidences of informational \u0000data were found, which makes it possible to subsequently replace the lysis buffers. \u0000New approaches have been studied for more thorough processing of spectra and their \u0000visualization using the MALDI Biotyper software. The probability of replacing the \u0000lysis buffer from the Sepsityper Kit 50 with the lysis buffer used in PCR was shown.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73592058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETECTION OF REPRESENTATIVES OF THE GENUS CRENOSOMA MOLIN, 1861 IN WILD AND SYNANTHROPIC VERTEBRATES","authors":"A. Plieva, R. I. Balayeva","doi":"10.31016/978-5-6048555-6-0.2023.24.370-375","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.370-375","url":null,"abstract":"Crenosomiasis is an invasive disease of carnivores caused by parasitizing in the \u0000bronchi and trachea of nematodes Crenosoma vulpis, C. taiga, C. petrowi from \u0000the genus Crenosoma Molin, 1861, family Crenosomatidae Schulz, 1951, and \u0000superfamily Metastrongyloidea Lane, 1917. We have studied vertebrates of wild \u0000fauna and synanthropic animals for parasitizing of helminths of the genus Crenosoma \u0000Molin, 1861 in the adult and larval stages. Wild vertebrates (jackals, foxes, wolves, \u0000wild boars) were delivered to us by hunters usually in autumn and winter. The \u0000studies were carried out using the method of complete and partial helminthological \u0000dissections per K. I. Skryabin. The obtained helminths were fixed as follows: \u0000trematodes in 70% alcohol, nematodes in Barbagallo fluid, and labeled. The total \u0000infection of animals with Crenosoma was 83.3%. Severe infection was detected in \u0000foxes (83.3%) and hedgehogs (100%). Among wild vertebrates, one specimen of \u0000Sus scrofa was examined by partial helminthological dissection, in whose lungs we \u0000identified nematode Crenosoma sp. for the first time in the Republic of Ingushetia. \u0000When analyzing the literature sources on the infection of wild boars with this type of \u0000helminth in Russia, no data were found. Crenosoma sp. has been recorded in the wild \u0000boar in Russia for the first time.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82161949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"145th ANNIVERSARY OF THE BIRTH OF KONSTANTIN IVANOVICH SKRYABIN (1878-1972)","authors":"A. Uspensky, M. Arisov, O. Panova","doi":"10.31016/978-5-6048555-6-0.2023.24.23-34","DOIUrl":"https://doi.org/10.31016/978-5-6048555-6-0.2023.24.23-34","url":null,"abstract":"Konstantin Ivanovich Skryabin is an outstanding Helminthologist, Academician \u0000of three Academies of Sciences (V. I. Lenin All-Union Academy of Agricultural \u0000Sciences, USSR Academy of Sciences, USSR Academy of Medical Sciences), Hero \u0000of Socialist Labor, Lenin and Stalin (twice) prize winner, and Recipient of six Orders \u0000of Lenin. In 2023, the 145th Anniversary of his birth will be celebrated on December \u00007, 1878. Konstantin Ivanovich received the degree of Doctor of Veterinary Medicine \u0000in 1905 at the Yuryev Veterinary Institute (now the University of Tartu, Estonia). \u0000After completing his studies until 1911, he worked as a local city veterinarian for the \u0000first 2 years in Chimkent, and then in Aulie-Ata (later Dzhambul, now Taraz) of \u0000Turkestan where he collected an extensive helminthological collection. From 1912 to 1914 he worked on probation in the field of helminthology abroad, namely, in \u0000Germany, Switzerland, and France. Upon returning to Russia, he remained to work \u0000at the Veterinary Laboratory of the Ministry of Internal Affairs in St. Petersburg. \u0000From 1917 to 1920, K. I. Skryabin became the first Professor of the first Department \u0000of Parasitology in Russia at the Don Veterinary Institute in Novocherkassk. He \u0000organized not only pedagogical, but also scientific work; the idea of organizing \u0000helminthological expeditions was born here. In 1920, upon his return to Moscow, \u0000he became the Head of the Helminthological Department of the State Institute of \u0000Experimental Veterinary Medicine (SIEVM). All subsequent vigorous scientific \u0000activity of Konstantin Ivanovich was aimed at strengthening the positions of \u0000helminthology as a science in Russia, and expanding the network of educational \u0000and scientific organizations. K. I. Skryabin and his students created a huge number \u0000of works: articles and monographs. His publications list includes about 700 titles \u0000including a number of fundamental multivolume papers. Konstantin Ivanovich \u0000Skryabin died on October 17, 1972. He was buried at the Novo-Dyevitchiye \u0000cemetery in Moscow.","PeriodicalId":22969,"journal":{"name":"THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80940817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}