The Korean Journal of Helicobacter and Upper Gastrointestinal Research最新文献_第2页

Gastric Cancer Genetics and Its Implications for Diagnosis, Prognosis, and Treatment of the Disease 胃癌遗传学及其对疾病诊断、预后和治疗的影响

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-06-10 DOI: 10.7704/kjhugr.2024.0018

José Pedro Santos, J. Figueiredo, J. Machado

{"title":"Gastric Cancer Genetics and Its Implications for Diagnosis, Prognosis, and Treatment of the Disease","authors":"José Pedro Santos, J. Figueiredo, J. Machado","doi":"10.7704/kjhugr.2024.0018","DOIUrl":"https://doi.org/10.7704/kjhugr.2024.0018","url":null,"abstract":"Gastric cancer (GC) is an aggressive disease and the fifth most common cancer worldwide with a variable geographical distribution. GC has a very low survival rate, mainly because of its heterogeneous presentation, multifactorial etiology, and late diagnosis. It is well established that various risk factors contribute to the development of the disease, including salty diet, smoking, and excessive alcohol consumption. Importantly, interactions between genetic and environmental traits trigger the activation of key signaling pathways, influencing gastric cell behavior towards neoplastic transformation and progression. Despite important advances in our understanding of GC, it remains a major health burden owing to epidemiological and therapeutic limitations. This study aimed to provide a comprehensive overview of the genetic landscape of GC phenotypes and molecular biomarkers for diagnosis and prognosis. In particular, we discuss the advances in genomic knowledge and technology that have yielded comprehensive information on the genetics of GC and classified it from a histological to a molecular perspective. Therefore, targeted and immune-based therapies have been developed, highlighting the challenges associated with intratumoral and interpatient heterogeneity. Finally, we explored potential research avenues on the intricacies of GC and identified accurate biomarkers for improved cancer screening and stratification. The development of innovative approaches to tackle relevant molecules is needed for GC management.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141366295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Male Patients Visited the Hospital With Diarrhea and Weight Loss 男性患者因腹泻和体重减轻到医院就诊

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-06-10 DOI: 10.7704/kjhugr.2024.0021

Ju Seok Kim

引用次数: 0

Viral Infection in Upper Gastrointestinal Tract 上消化道病毒感染

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-06-10 DOI: 10.7704/kjhugr.2024.0027

Hee Jin Kim, Hyun Jin Kim

{"title":"Viral Infection in Upper Gastrointestinal Tract","authors":"Hee Jin Kim, Hyun Jin Kim","doi":"10.7704/kjhugr.2024.0027","DOIUrl":"https://doi.org/10.7704/kjhugr.2024.0027","url":null,"abstract":"Viral infections of the upper gastrointestinal (GI) tract are not uncommon in clinical practice; however, these are frequently observed in immunocompromised patients and rarely in immunocompetent hosts. Compared with esophagitis, which may be associated with clinically significant outcomes, the stomach is a relatively rare site for opportunistic infections in immunocompetent patients. The most common clinically relevant upper GI tract viral infections include cytomegalovirus (CMV), Epstein-Barr virus (EBV), and herpes simplex virus infections. CMV esophagitis and gastritis, which primarily occur in immunocompromised patients, necessitate antiviral treatment, whereas immunocompetent patients typically respond to proton pump inhibitor administration. Most EBV-induced gastric infections are asymptomatic. However, EBV infection is a known etiological contributor to stomach cancer. EBV-associated gastric cancer shows distinctive clinical, pathological, genetic, and post-genetic mutation features and is therefore a clinically significant entity. Herpetic esophagitis usually affects immunocompromised patients and is uncommon in immunocompetent individuals. In this review, we discuss the general aspects and recent studies that have reported esophageal and gastric infections in immunocompromised patients.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":"121 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141361788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Analysis of Factors Associated With Helicobacter pylori Eradication Therapy 幽门螺杆菌根除疗法相关因素的综合分析

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-06-10 DOI: 10.7704/kjhugr.2023.0063

Myung Jin Song, Byung Wook Jung, Chan Hyuk Park

{"title":"Comprehensive Analysis of Factors Associated With Helicobacter pylori Eradication Therapy","authors":"Myung Jin Song, Byung Wook Jung, Chan Hyuk Park","doi":"10.7704/kjhugr.2023.0063","DOIUrl":"https://doi.org/10.7704/kjhugr.2023.0063","url":null,"abstract":"Objectives: Associated factors for the failure of Helicobacter pylori (HP) eradication have been evaluated in many studies; however, the different study population of previous studies prevents us from understanding the comparative risk between factors. We aimed to comprehensively investigate factors associated with successful HP eradication based on a single study population.Methods: We retrospectively reviewed the medical records of adults diagnosed with HP infection between March 2021 and October 2022 at Hanyang University Guri Hospital. The study categorized eradication treatment methods based on the type of acid blockers (proton pump inhibitor [PPI] or potassium-competitive acid blocker [P-CAB]), antibiotic combination, and treatment duration. Demographics and clarithromycin-resistance mutation status were also considered as potential factors of HP eradication.Results: A total of 554 patients who received first-line HP eradication therapy were included. In the full-analysis set, the eradication rates according to the regimen were as follows: 7-day tegoprazan-based triple, 61.6%; 14-day tegoprazan-based triple, 77.5%; 14-day rabeprazole-based triple, 71.1%; 10-day rabeprazole-based concomitant, 73.1%; 10-day tegoprazan-based concomitant, 80.5%. The 14-day triple and 10-day concomitant therapies showed a superior eradication rate to the 7-day triple therapy regardless of the type of acid blockers (PPI or P-CAB). Additionally, clarithromycin-resistance mutation was the strongest predictor for eradication failure (hazard ratio 9.86 [95% confidence interval, 2.07–46.97]).Conclusions: The 14-day triple and 10-day concomitant therapy was superior to the 7-day triple therapy regardless of PPI or P-CAB use. However, clarithromycin-resistance mutation status was a more powerful predictor for HP eradication than the type of antibiotics and treatment duration.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":" 65","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141365662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Treatments in Perforation or Fistula in Upper Gastrointestinal Tract 上消化道穿孔或瘘管的内窥镜治疗

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-03-10 DOI: 10.7704/kjhugr.2024.0010

Sun Gyo Lim

{"title":"Endoscopic Treatments in Perforation or Fistula in Upper Gastrointestinal Tract","authors":"Sun Gyo Lim","doi":"10.7704/kjhugr.2024.0010","DOIUrl":"https://doi.org/10.7704/kjhugr.2024.0010","url":null,"abstract":"Perforations or fistulas in the gastrointestinal tract constitute serious emergencies and are associated with high morbidity and mortality rates. Such lesions, occurring in the esophagus, stomach, and duodenum, may arise from noniatrogenic causes (e.g., peptic ulcers, corrosive insults, trauma, malignant tumors) and iatrogenic causes (e.g., endoscopic procedures and surgeries). A prompt diagnosis and an appropriate management strategy are crucial for early recovery before secondary complications occur that may be induced by infection and/or chemical damage from gastric acid or bile. Various endoscopy-based treatment modalities have been developed and play pivotal roles in the management of upper gastrointestinal perforations and fistulas. Through-the-scope clips, self-expanding metallic stents, over-the-scope clips, endoscopic suturing devices, and endoscopic vacuum therapy have significantly improved the success rates associated with treating these types of lesions. However, choosing the optimal modalities that lead to good patient prognoses depends on the lesion characteristics, such as its size, duration, location, and surrounding tissue condition. Thus, gastrointestinal endoscopists have to regularly master and incorporate new endoscopy-based treatment approaches for these complicated conditions.","PeriodicalId":22895,"journal":{"name":"The Korean Journal of Helicobacter and Upper Gastrointestinal Research","volume":"13 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140255340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategic Role of Immunohistochemical Staining in Detection of Helicobacter pylori 免疫组化染色在检测幽门螺旋杆菌中的战略作用

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-03-10 DOI: 10.7704/kjhugr.2024.0006

Hyun Ho Choi

引用次数: 0

Application of Endoscopic Mucosal Resection After Circumferential Precutting in the Treatment of Gastric Adenoma Less Than 15 mm 环形预切后内镜黏膜切除术在治疗小于 15 毫米胃腺瘤中的应用

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-03-10 DOI: 10.7704/kjhugr.2023.0050

Ju Seok Kim

引用次数: 0

Recent Trends in Antibiotic Resistance Rates of Helicobacter pylori Strains in the Asia-Pacific Region 亚太地区幽门螺杆菌菌株对抗生素耐药率的最新趋势

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2024-03-10 DOI: 10.7704/kjhugr.2024.0001

Yeon Ji Kim

引用次数: 0

Endoscopic Bariatric Therapy for Obesity and Metabolic Syndrome 内窥镜减肥疗法治疗肥胖症和代谢综合征

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-12-10 DOI: 10.7704/kjhugr.2023.0049

Sang Pyo Lee

引用次数: 0

Can Sequential Therapy Replace Standard Triple Therapy as Helicobacter pylori Eradication? 序贯疗法能否替代标准三联疗法根除幽门螺旋杆菌？

The Korean Journal of Helicobacter and Upper Gastrointestinal Research Pub Date : 2023-12-10 DOI: 10.7704/kjhugr.2023.0047

Sang Gyun Kim

引用次数: 0