The Journal of Phytopharmacology最新文献_第6页

Phytosome: An Emerging Technique for Improving Herbal Drug Delivery 植物体:一种改善草药给药的新兴技术

The Journal of Phytopharmacology Pub Date : 2023-02-28 DOI: 10.31254/phyto.2023.12108

Pavan M Patel, C. Modi, H. Patel, U. Patel, Divya M. Ramchandani, H. Patel, Bhulesh V. Paida

{"title":"Phytosome: An Emerging Technique for Improving Herbal Drug Delivery","authors":"Pavan M Patel, C. Modi, H. Patel, U. Patel, Divya M. Ramchandani, H. Patel, Bhulesh V. Paida","doi":"10.31254/phyto.2023.12108","DOIUrl":"https://doi.org/10.31254/phyto.2023.12108","url":null,"abstract":"Because conventional medicine has a number of adverse side effects on the human body after continuous usage, there has been a new tendency to return to \"nature\" for the treatment of body disorders. Though their oral bioavailability is poor, flavonoids and other phytoactive components have a variety of nutritional, therapeutic, and preservation effects. Phytosomes are a revolutionary formulation method that addresses the issue of polar phytoconstituents' poor bioavailability while also delivering medications to targeted locations. Other advantages include reduced adverse effects, reduced dosage, improved absorption, and increased drug efficacy. To deliver the medicine to a specific site of action, novel drug delivery uses unique drug carriers such as solid-lipid nanoparticles, nano-structured lipid carriers, lipid vesicles, liposomes, phytosomes, and ethosomes. The physicochemical and pharmacological features of phytosomes, as well as their structure, are discussed in this article. The mechanism of phytosome production is also examined, as well as a variety of traditional and novel formulation approaches were also studied. The methods used to characterise and assess phytosomes provide insight into a number of methodologies that can be utilised to screen certain phytosome features. The pharmacological potential of phytosomes is compared to that of conventional and liposomal drug delivery systems. The scientific significance of a list of important phytosomes patented technologies of various commercially available herbal extracts is also examined.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76747446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Memory-Enhancing and Antioxidant Activities of the Hydroethanolic Leave Extract of Piliostigma reticulatum (Fabaceae) in the Monosodium Glutamate-Induced Alzheimer's Disease Model 谷氨酸钠诱导的阿尔茨海默病模型中毛茛叶氢乙醇提取物的记忆增强和抗氧化活性

The Journal of Phytopharmacology Pub Date : 2023-02-28 DOI: 10.31254/phyto.2023.12101

G. J. Beppe, B. P. Barga, Donatien Albert Atsamo, Christ-Roi Fedaski, A. I. Folefack, N. G. Allah-Doum, Franklin Gamo Zemo, A. Dongmo

{"title":"Memory-Enhancing and Antioxidant Activities of the Hydroethanolic Leave Extract of Piliostigma reticulatum (Fabaceae) in the Monosodium Glutamate-Induced Alzheimer's Disease Model","authors":"G. J. Beppe, B. P. Barga, Donatien Albert Atsamo, Christ-Roi Fedaski, A. I. Folefack, N. G. Allah-Doum, Franklin Gamo Zemo, A. Dongmo","doi":"10.31254/phyto.2023.12101","DOIUrl":"https://doi.org/10.31254/phyto.2023.12101","url":null,"abstract":"Background: Piliostigma reticulatum (Fabaceae) is a plant used in Cameroon for the treatment of madness and migraine. Aims and Objectives: This study aims to evaluate the memory-enhancing and antioxidant activities of the hydroethanolic leaves extract of PR in the monosodium glutamate-induced Alzheimer's disease model. Materials and Methods: The Y-maze, Radial-arm maze and Novel object recognition tests were used to assess short, and long-term memory. At the end of the experiments, the brains of mice were scavenged for biochemical and histological analysis. Results: It was observed that the hydroalcoholic extract of PR leaf significantly reversed the percentage of spontaneous alternation compared to the negative control group at the different doses tested (p<0.01; p<0.001) in the Y-maze test. In the radial arm maze test, the extract significantly (p<0.001) reduced the time spent consuming the bait, the number of reference memory and working memory errors at all doses. The treatment of animals with hydroethanolic extract of PR resulted in a significant increase in the discrimination index (p<0.001) in the unfamiliar object recognition test. In addition, the extract significantly (p < 0.01); p < 0.001) decreased acetylcholinesterase activity,and MDA levels at all tested doses; and significantly (p < 0.05; p < 0.001) increased SOD level and Catalase activity in comparison to the negative control group. The histological analysis showed that the extract of Piliostigma reticulatum protected the different structures of the hippocampus against damage caused by monosodium glutamate. Conclusion : The memoryenhancing induced by the hydroethanolic leaves extract of Piliostigma reticulatum could be due to his antioxidant and anticholinesterase properties. These effects could justify the use of this plant to manage nervous system affections.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75923162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of Spirulina platensis extract on aflatoxin B1 immunotoxicities in mice 螺旋藻提取物对小鼠黄曲霉毒素B1免疫毒性的保护作用

The Journal of Phytopharmacology Pub Date : 2023-02-28 DOI: 10.31254/phyto.2023.12104

Masese Johnson, Kipkoech Gilbert, Kimoloi Sammy, M. Peter, Nguka Gordon, M. Charles

{"title":"Protective effect of Spirulina platensis extract on aflatoxin B1 immunotoxicities in mice","authors":"Masese Johnson, Kipkoech Gilbert, Kimoloi Sammy, M. Peter, Nguka Gordon, M. Charles","doi":"10.31254/phyto.2023.12104","DOIUrl":"https://doi.org/10.31254/phyto.2023.12104","url":null,"abstract":"Aspergillus flavus and Aspergillus parasiticus are the main Aspergillums species that form aflatoxins. Aflatoxins are hepatotoxic, teratogenic, carcinogenic and immunosuppressive. This study aimed to assess Spirulina platensis (S. platensis) extract inhibitory effect against aflatoxin B1 (AFB1) induced immunotoxicity in male Swiss albino mice. Twenty-five inbred weaned mice were randomly divided into five groups. Group I (Control group), were given routine diet. Treatments administered were: Group II (S. platensis extract 100 mg/kg/day), Group III (AFB1 200 µg/kg/day), Group IV (S. platensis extract 100 mg/kg/day and AFB1 200 µg/kg/day) and Group V (S. platensis extract 200 mg/kg/day and AFB1 200 µg/kg/day) for 28 consecutive days. Blood was aseptically collected and centrifuged to obtain serum. Quantitative determination of IgG, IgM and IgA in blood serum was done using ELIZA kits. One-way ANOVA data analysis was done. Post-hoc analysis was done using Tukey’s Honestly Significantly Differenced (HSD). P<0.05 statistical significance level was considered significant. Compared to group I (control), treatment with AFB1 200 µg/Kg/day (group III) led to reduced IgA (0.7147±0.001 vs. 0.7075±0.010); reduced IgM (0.0916±0.003 vs. 0.0866±0.019) and elevated IgG (0.1746±0.001 vs. 0.2808±0.243) mean levels. Supplementation of S. platensis extract 200 mg/Kg/day (group V) reversed the AFB1 (200 µg/kg/day)-induced depression of IgA levels (0.7124±0.005 vs. 0.7075±0.010; P=0.05437); IgM (0.1005±0.004 vs. 0.0866±0.019; P=0.0178); as well as the induced elevation of IgG levels (0.1749±0.001 vs. 0.2808±0.243; P=0.0155). In conclusion, immune changes in IgG and IgM caused by AFB1 could be reversed by supplementation of S. platensis extract.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79137789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of in vitro antibacterial activity of Carum copticum extract against drug resistant Staphylococcus aureus from clinical and food sources 黄连提取物对临床和食物来源的耐药金黄色葡萄球菌的体外抗菌活性评价

The Journal of Phytopharmacology Pub Date : 2023-02-28 DOI: 10.31254/phyto.2023.12106

J. Khan, R. Rathore, Iqbal Ahmad, Rubina Gill, F. Husain, Javeed Akhtar, L. D. Tolesa, Misbahu Abdu Ayanso, Mekonnen Begna

引用次数: 0

Modulatory potential of Tamarindus indica on steroidogenesis by targeting in vitro expression of CYP 19 and StAR genes in MCF-7 cell lines 以MCF-7细胞系体外表达cyp19和StAR基因为靶点的柽柳对类固醇生成的调控潜力

The Journal of Phytopharmacology Pub Date : 2022-12-20 DOI: 10.31254/phyto.2022.11606

A. Sandeshkrishna, Bimitha Benny, S. Samraj, P. John, U. Radhakrishnan

{"title":"Modulatory potential of Tamarindus indica on steroidogenesis by targeting in vitro expression of CYP 19 and StAR genes in MCF-7 cell lines","authors":"A. Sandeshkrishna, Bimitha Benny, S. Samraj, P. John, U. Radhakrishnan","doi":"10.31254/phyto.2022.11606","DOIUrl":"https://doi.org/10.31254/phyto.2022.11606","url":null,"abstract":"The use of medicinal plants for treating different ailments dates back to thousands of years through Ayurveda. They increased the efficacy of current chemotherapy while lowering the risk and side effects in cancer patients. The current study was carried out to identify the effect of methanolic extract of Tamarindus indica seed coat on the expression of CYP 19 and StAR gene in MCF -7 cell lines. The phytochemical analysis of T. indica seed coat extract was done through Gas chromatography- mass spectrometry and Fourier transform infrared spectroscopy. The half maximal inhibitory concentration (IC50) of the extract was discovered in a previous study using MTT assay and was found to be 32 µg/mL. The cells after treatment with extract at concentrations of 8, 16 and 32µg/mL produced a differential expression of CYP 19. There was a fold increase at IC50 concentration of the extract mean while the gene expression was decreased at higher and lower doses of IC50. On the other hand, a dose dependent fold increase was observed in the expression of StAR gene after treatment with the extract. The presence of Phyto steroids, fatty acid analogues and terpenoids were identified by gas chromatography mass spectrometry analysis. Fourier transform infrared spectroscopy analysis results supports the finding from GC-MS analysis. Even though there was an increase in the expression of StAR gene, there was a biphasic response with CYP19, which indicated a downregulation in the synthesis of oestrogen.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"14 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91504680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of Toddalia asiatica is associated with microcephaly and hypochondroplasia in mice 虎牙的毒性与小鼠小头畸形和软骨发育不良有关

The Journal of Phytopharmacology Pub Date : 2022-12-20 DOI: 10.31254/phyto.2022.11602

Gichuru M Joseph, M. Maina, Mburu N David, Menza C Nelson

{"title":"Toxicity of Toddalia asiatica is associated with microcephaly and hypochondroplasia in mice","authors":"Gichuru M Joseph, M. Maina, Mburu N David, Menza C Nelson","doi":"10.31254/phyto.2022.11602","DOIUrl":"https://doi.org/10.31254/phyto.2022.11602","url":null,"abstract":"In Kenya various plant extracts are widely used as folklore remedies for various ailments including malaria etc. However, use of these traditional remedies poses a risk to the users due to the scarcity of data on their safety including their teratogenic potential. Hence this study evaluated the teratogenic and sub-acute toxic effects of methanol: dichloromethane extract of Toddalia asiatica in animal mice. In the study, young female mice aged between 6-7weeks were mated with mature males and conception confirmed using vaginal plug, maternal weight and breast enlargement. Administration of the dosed of the plant extract and controls was done from day 6 through 15 of gestation. The mice were euthanized on the 19th day of gestation. The weight of the gravid uterus, pups, number of pups and gross examination to identify any physical abnormalities was done. In the toxicity study male mice aged between 6-7 weeks received oral administration of high doses of plant extract and the control daily for 28days. On the 29th day animals were sacrificed, cardiac puncture conducted and collected blood for hematology and biochemistry analysis. The data obtained was analyzed using one way ANOVA followed by Tukey as the post hoc test. Statistical significance was set p < 0.05. The extracts caused significant reduction (p<0.001) in head size, birth weights and length of the limbs but no effects on hematology parameters. Hence the plant extract exhibited teratogenic effects and thus should be used with care during pregnancy.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88485764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trewia nudiflora: A potential source of new drugs 海地Trewia:新药的潜在来源

The Journal of Phytopharmacology Pub Date : 2022-12-20 DOI: 10.31254/phyto.2022.11608

Razia Sultana, Mohammad Mostafa Mohsin Milon, M. Kader, S. Parvin, G. Parvez

引用次数: 2

Differential expression of steroidogenic genes in MCF-7 cell lines by methanolic extract of Mallotus phillippensis 马来莲甲醇提取物在MCF-7细胞系中类固醇基因的差异表达

The Journal of Phytopharmacology Pub Date : 2022-12-20 DOI: 10.31254/phyto.2022.11601

Bimitha Benny, A. Sandeshkrishna, S. Samraj, P. John, U. Radhakrishnan

{"title":"Differential expression of steroidogenic genes in MCF-7 cell lines by methanolic extract of Mallotus phillippensis","authors":"Bimitha Benny, A. Sandeshkrishna, S. Samraj, P. John, U. Radhakrishnan","doi":"10.31254/phyto.2022.11601","DOIUrl":"https://doi.org/10.31254/phyto.2022.11601","url":null,"abstract":"The role of oestrogen in the development of breast cancer is well documented. The aberrant expression of genes involved in oestrogen hormone synthesis can be one of the causes of breast cancer. Suppression of these genes is considered a therapeutic option for the treatment of breast cancer. In the present study, we evaluated the effect of a methanolic extract of Mallotus phillippensis leaves on the expression of CYP19 and StAR genes in MCF-7 breast cancer cell lines. The half maximal inhibitory concentration (IC50) of the extract was found to be 190 µg/mL. MCF-7 cells treated with half IC50, IC50 and double IC50 of the extract that is 95, 190 and 380 µg/mL, was used for evaluating the effect on the gene. Methanolic extract of M. phillippensis at double IC50 doses, upregulated the expression of StAR and CYP 19 genes, whereas at half IC50 and IC50 doses downregulated StAR and CYP 19 gene expression. The gas chromatography mass spectrometry analysis revealed the presence of phytosterols, fatty acid analogues and terpenoids in the extract which contributed to differential expression of StAR and CYP 19 genes. The confirmation of detected compounds was carried out by Fourier transform infrared spectroscopy analysis. From this study, it is inferred that higher doses of methanolic extract of Mallotus phillippensis can be used for treatment of the oestrogen deficient conditions leading to infertility while at lower doses significantly reduces StAR and CYP 19 gene expression can be recommended for the treatment of breast cancer.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85652179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The oral subacute toxicological activity of hydroalcoholic extract of Moringa oleifera Lam. (Moringaceae) growing in South West of Burkina Faso in Wistar rats 辣木水醇提取物的口服亚急性毒理学活性。生长在布基纳法索西南部Wistar大鼠体内的辣木科植物

The Journal of Phytopharmacology Pub Date : 2022-12-20 DOI: 10.31254/phyto.2022.11604

Andouormwine Abel Somé, P. A. Dabiré, Filpkière Léonard Da, Stanislas Sawadogo, M. Ouédraogo, B. Bayala

{"title":"The oral subacute toxicological activity of hydroalcoholic extract of Moringa oleifera Lam. (Moringaceae) growing in South West of Burkina Faso in Wistar rats","authors":"Andouormwine Abel Somé, P. A. Dabiré, Filpkière Léonard Da, Stanislas Sawadogo, M. Ouédraogo, B. Bayala","doi":"10.31254/phyto.2022.11604","DOIUrl":"https://doi.org/10.31254/phyto.2022.11604","url":null,"abstract":"Acute and Subacute toxicity investigations were carried out to evaluate the safety of M. oleifera leaf used in the treatment of various diseases and in nutrition. Five groups of 10 rats of both sex (5rats/sex) were constituted. The first group served as control and received distilled water 10mL/kg/ day while groups II, III, and IV respectively received orally and daily the ethanolic extract of Moringa oleifera at doses 200, 400 and 800mg/kg bw for 4 weeks. The last group (V) considered as satellite group received also received the EEM 800mg/kg daily and orally for 4 weeks. At the end of the test period (4 weeks), the animals of this last group were observed without any treatment for 2 weeks again before their sacrifice in order to study the persistence or the disappearance of possible toxic effects of the extract. The rat was segregated according to gender and housed in cages of 5 rats. In Subacute toxicity investigated with Wistar rats, no mortality was recorded during the experimentation period. Moreover, there was no significant change in weight gain, relative organ weight, or hematological and serum chemical parameters except in a group of female animals where we noticed a reversible decrease in serum ALAT level (at 400mg/kg), total cholesterol (at 400mg/kg) and LDL level (at 800mg/kg) compared to ED group. The histopathological examination had shown some differences between the treated group and the control group that cannot be considered treatment-related.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85186082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological effects of Opilia amentacea Roxb, a medicinal plant used in traditional African medicine 非洲传统医药中使用的药用植物蛇毛的毒理学效应

The Journal of Phytopharmacology Pub Date : 2022-12-20 DOI: 10.31254/phyto.2022.11603

Sacramento T Isabelle, G. Félix, Sangare Maxime Machioud, Atègbo Jean-Marc

{"title":"Toxicological effects of Opilia amentacea Roxb, a medicinal plant used in traditional African medicine","authors":"Sacramento T Isabelle, G. Félix, Sangare Maxime Machioud, Atègbo Jean-Marc","doi":"10.31254/phyto.2022.11603","DOIUrl":"https://doi.org/10.31254/phyto.2022.11603","url":null,"abstract":"Opilia amantacea Roxb, is a medicinal plant widely used in traditional African medicine. However, data on its safety remain limited in the scientific literature. The purpose of this study was to evaluate the toxicity of Opilia amentacea Roxb. The work was carried out in accordance with the Organization for Economic Co-operation and Development (OECD) guidelines for the testing of chemicals using Method 423 on Wistar rats. The ethanolic extract of the leaves of Opilia amantacea Roxb was administered at a single dose of 2000 mg/kg. The different clinical signs observed after administration and over 14 days were recorded. As results, no mortality was observed. Only a general state of sleep was observed in animals of the control batch and the batch treated with the ethanolic extract of the plant tested. The biochemical parameters transaminase (AST, ALT), bilirubin (free and conjugated), alkaline phosphatases, uricemia, urea, creatinine) and the hematological parameters studied showed a nonstatistical difference (p>0.05) between the test batch and the control batch. The same applies to the variation in the weight of animals. The ethanolic extract of the leaves of Opilia amantacea Roxb does not have significant toxic effects on liver, kidney and blood tissue at a dose of 2000 mg/kg. From these data, it can be concluded that the ethanolic extract of Opilia amantacea Roxb does not exhibit acute toxicity to human health at the doses tested. Its use in traditional medicine may be recommended if efficacy data are established.","PeriodicalId":22851,"journal":{"name":"The Journal of Phytopharmacology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82794518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0