Madridge Journal of Novel Drug Research最新文献

{"title":"Medicinal properties of Carica papaya Linn: Review","authors":"P. Sagadevan, S. Selvakumar, M. Raghunath, R. Megala, P. Janarthanan, C. V. Ebziba, V. Kumar","doi":"10.18689/mjndr-1000118","DOIUrl":"https://doi.org/10.18689/mjndr-1000118","url":null,"abstract":"Medicinal properties of plants derivatives from natural products have wide range of pharmacological significance. The properties of papaya ( Carica papaya ) fruit and other plant parts are well known in traditional system of medicine and also known for food and nutritional values throughout the world. During the most recent decades significant advancement has been accomplished in regards to the biological activity and medicinal use of papaya, additionally, it is considered as profitable nutraceutical natural product plant. In this current review discussed with medicinal properties of C. papaya.","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128355435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regioselective C-H Borylation of C (sp2)-H Bond","authors":"Hua Jing, J. Antilla, Hong-liang Li","doi":"10.18689/mjndr-1000117","DOIUrl":"https://doi.org/10.18689/mjndr-1000117","url":null,"abstract":"C-H activation reactions have become a powerful method to direct functionalization of alkyl, alkenyl, and aryl C-H bonds over the past few decades. Among of them, Iridium catalyzed transformation of aryl C-H bonds to C-B bonds is one of the most useful method. However, a central challenge in these reactions is controlling their site selectivity. Over the past decade, some methods have been developed to accomplish regioselective C-H borylation by catalysts or substrates modification. In this paper, some methods developed in recent years to realize ortho-, meta-, and para-selective C-H borylation will be summarized and their strategy and mechanism of these methods will be discussed.","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117207177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Atenolol on QT Interval in Instrumented Beagle Dogs","authors":"C. Chiang, D. Moser","doi":"10.18689/mjndr-1000116","DOIUrl":"https://doi.org/10.18689/mjndr-1000116","url":null,"abstract":"In cardiology, the QT interval is a measurement of the heart’s electrical cycle between the start of the Q-wave and end of the T-wave in electrocardiogram (ECG). Assessment of the QT interval is of clinical importance because prolongation of repolarization may be associated with malignant ventricular arrhythmias and sudden cardiac death. Atenolol, a beta-blocker, is an effective anti-hypertensive agent that its protective effect may reduce the QT interval in some patients. However, the data of atenolol in animals or patients with long-QT syndrome are limited. The goal of this paper was to evaluate the effect of atenolol on QT interval in beagle dogs. Two experiments conducted by the Health and Environmental Sciences Institute were used for the evaluation. In two Latin-square studies, beagles were given varying levels of atenolol on separating dosing days and their ECGs were measured telemetrically. As QT interval is correlated with heart rate, we investigated the relationship between heart rate and QT interval using the vehicle control group animals. In addition to QTcF, QT interval corrected based on Fridericia’s formula, QTcP, which was based on the study population, and QTcI, which was derived from each individual animal, were evaluated. QTcF, QTcP, and QTcI were analyzed for each dose group at each time point compared to the vehicle. The analyses suggest that atenolol does not affect QT interval in beagle dogs.","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129604985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Extended Infusion Piperacillin-Tazobactam plus Vancomycin versus Standard Infusion Piperacillin-Tazobactam plus Vancomycin in General Medicine Patients with a diagnosis of Healthcare associated Pneumonia","authors":"Kati J Khouri, Joseph Levato, Rolla T. Sweis","doi":"10.18689/mjndr-1000115","DOIUrl":"https://doi.org/10.18689/mjndr-1000115","url":null,"abstract":"Objective: The primary safety objective is Acute Kidney Injury (AKI), \u0000 defined as an increase in serum creatinine of at least 0.5 mg/dL or \u0000 a 50% increase in serum creatinine from baseline at any time during \u0000 antibiotic therapy. \u0000The objective of this study is to assess safety of Extended Infusion \u0000 Piperacillin-tazobactam (EIPT) and vancomycin therapy versus Standard \u0000 Infusion Piperacillin-tazobactam (SIPT) and vancomycin in general \u0000 medicine patients, and to evaluate if one treatment modality predisposes \u0000 patients to a greater risk of nephrotoxicity. \u0000Setting: Data from a large academic medical center was analyzed \u0000 over a 3 month period pre and post implementation of extended infusion \u0000 piperacillin-tazobactam protocol. \u0000Design: A retrospective analysis was conducted comparing patients \u0000 admitted to the hospital with a diagnosis of Healthcare Associated \u0000 Pneumonia (HCAP) who received EIPT plus vancomycin versus SIPT \u0000 plus vancomycin. Patients: Adult hospitalized patients on combination \u0000 therapy with two or more Serum Creatinine (SCr) measurements were \u0000 included. Patients were excluded if they are less than 18 years of age, \u0000 are pregnant, or if they are on any form of dialysis including continuous \u0000 renal replacement therapy. \u0000Conclusion: A total of 241 patients were evaluated for AKI. \u0000 Safety outcomes were compared between the two treatment groups \u0000 and contributing factors for developing AKI were also assessed. The \u0000 incidence of AKI was significantly higher in the SIPT and vancomycin \u0000 group (20.0%) compared with the EIPT and vancomycin group (10.0%) \u0000 in the analysis (p=0.033). There were no significant differences in the \u0000 baseline characteristics between the groups with the exception of a \u0000 higher percentage of patients with a diagnosis of hypertension in the \u0000 EIPT and vancomycin group (p<0.05).","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124872309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and Optimization of Controlled Porosity Osmotic Pump Tablets of Lamivudine using Sodium Chloride as Osmogen for the Treatment of AIDS","authors":"C. Sahoo, N. Sahoo, S. R. M. Rao, M. Sudhakar","doi":"10.18689/mjndr-1000114","DOIUrl":"https://doi.org/10.18689/mjndr-1000114","url":null,"abstract":"Chinmaya Keshari Sahoo1, Nalini Kanta Sahoo2*, Surepalli Ram Mohan Rao3 and Muvvala Sudhakar4 1 Ph.D Scholar, Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India 2 Professor & HOD, Department of Pharmaceutical Analysis and Quality assurance, MLR Institute of Pharmacy, Dundigal, Medchal, Telangana, India 3Professor, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia 4 Professor and Principal, Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, India","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128481723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching the Academic Subject Area of Medical and Pharmaceutical Merchandising to Prospective Graduate Nurses using the Instruments of Distance Learning","authors":"S. Yastremska, Yulia Ravliv, T. Groshovyi","doi":"10.18689/MJNDR-1000113","DOIUrl":"https://doi.org/10.18689/MJNDR-1000113","url":null,"abstract":"This work presents using the instruments of distance learning in student training at the Research and Training Institute of Nursing of Ivan Horbachevsky Ternopil State Medical University in the academic subject area of Medical and Pharmaceutical Merchandising. As students not only learn their text-based subject material in a distance mode, but also view video lectures at their convenient time, this allows for improving the level of theoretical training of specialists with higher nursing education and also for reinforcing their knowledge base required to improve practical skills. However, the students’ training needs further comprehensive upgrades and additions. informational education environment.","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124919622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of the Dissolution Behavior of the Poorly Water Soluble Drug Diacerein by Solid Dispersion Technology and its Formulation into Tablet Dosage Form","authors":"Sourabh Jain, B. P. Nagori, S. Yadav","doi":"10.18689/MJNDR-1000112","DOIUrl":"https://doi.org/10.18689/MJNDR-1000112","url":null,"abstract":"Diacerein (DAC) is an antiarthritic drug that shows almost negligible water solubility in acidic conditions and gets degraded at alkaline pH which restricts its oral bioavailability. The degradation product also leads to soft stool effect. The aim of the present study was to enhance the dissolution rate of DAC by solid dispersion (SD) technology and to incorporate the best SD formula (the one which is able to promote the highest drug release in minimum period of time) into tablet dosage form. Various binary (containing DAC and polyethylene glycols i.e. PEGs) and ternary (containing DAC, PEG and a pH modulating agent) SD formulations were prepared employing different process and formulation parameters. SDs so prepared were investigated for the dissolution behavior of DAC. The best SD formulation was characterized by aqueous solubility studies, XRD, ATR, SEM and DCS studies. A series of tablet dosage forms containing the best SD formula as the drug matrix was prepared using different concentrations of disintegrating agent. The best tablet (the one that allows the maximum disintegration in minimum period of time) was compared with the marketed preparation according to compendial specifications. All binary and ternary formulations increased drug dissolution rate. Dissolution studies show that there is a trend of increasing dissolution rate of DAC with decreasing molecular weight of PEGs as well as decreasing percentage of DAC in the SDs. Ternary SDs show higher dissolution in comparison to binary SDs, reflecting synergism of PEG4000 with urea. DAC solubility increased 3.39 times by the best SD formula. Physical characterization revealed the changes in solid state (decreased crystallinity) of DAC during the formation of SD. The best SD formula loaded tablet gave significantly higher dissolution compared to commercial product, which indicates its potential for delivering poorly water soluble drug DAC with enhanced bioavailability and reduced soft stool effects.","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"196 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114360493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murrayanine-1, 3, 4-Thiadiazole-Uracil Hybrid as Emerging Anti-inflammatory Candidate","authors":"Kanhaiya M. Dadure Debarshi Kar Mahapatra, Ruchi Shivhare, D. Mahapatra","doi":"10.18689/MJNDR-1000111","DOIUrl":"https://doi.org/10.18689/MJNDR-1000111","url":null,"abstract":"","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115694199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple– Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of time under Synchrotron Radiation","authors":"A. Heidari","doi":"10.18689/mjndr-1000110","DOIUrl":"https://doi.org/10.18689/mjndr-1000110","url":null,"abstract":"In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues before and after irradiating of synchrotron radiation using Heteronuclear Single–Quantum Correlation Spectroscopy (HSQC) and Heteronuclear Multiple–Bond Correlation Spectroscopy (HMBC). It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1 and 2) [1-151].","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124686683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adamantane, Irene, Naftazone and Pyridine-Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) Nano Molecules","authors":"A. Heidari","doi":"10.18689/MJNDR-1000109","DOIUrl":"https://doi.org/10.18689/MJNDR-1000109","url":null,"abstract":"In the current editorial, we study Adamantane, Irene, Naftazone and Pyridine– enhanced precatalyst preparation stabilization and initiation (PEPPSI) Nano molecules (Figure 1) incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, Tissues and tumors treatment under synchrotron and synchrocyclotron radiations. In this regard, the development of Chemical Modified Electrodes (CEMs) is at present an area of great interest. CEMs can be divided broadly into two main categories; namely, Surface modified and bulk modified electrodes. Methods of surface modification include adsorption, Covalent bonding, attachment of polymer Nano films, etc. Polymer Nano film coated electrodes can be differentiated from other modification methods such as adsorption and covalent bonding in that they usually involve multilayer as opposed to monolayer frequently encountered for the latter methods. The thicker Nano films imply more active sites which lead to larger analytical signals. This advantage coupled with other, Their versatility and wide applicability, Makes polymer Nano film modified electrodes particularly suitable for analytical applications [1-27].","PeriodicalId":228275,"journal":{"name":"Madridge Journal of Novel Drug Research","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122498033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}