SPIE Medical Imaging最新文献_第8页

3D ultrasound computer tomography: update from a clinical study 三维超声计算机断层扫描:来自临床研究的最新进展

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216686

T. Hopp, M. Zapf, E. Kretzek, J. Henrich, A. Tukalo, H. Gemmeke, C. Kaiser, J. Knaudt, N. Ruiter

{"title":"3D ultrasound computer tomography: update from a clinical study","authors":"T. Hopp, M. Zapf, E. Kretzek, J. Henrich, A. Tukalo, H. Gemmeke, C. Kaiser, J. Knaudt, N. Ruiter","doi":"10.1117/12.2216686","DOIUrl":"https://doi.org/10.1117/12.2216686","url":null,"abstract":"Ultrasound Computer Tomography (USCT) is a promising new imaging method for breast cancer diagnosis. We developed a 3D USCT system and tested it in a pilot study with encouraging results: 3D USCT was able to depict two carcinomas, which were present in contrast enhanced MRI volumes serving as ground truth. To overcome severe differences in the breast shape, an image registration was applied. We analyzed the correlation between average sound speed in the breast and the breast density estimated from segmented MRIs and found a positive correlation with R=0.70. Based on the results of the pilot study we now carry out a successive clinical study with 200 patients. For this we integrated our reconstruction methods and image post-processing into a comprehensive workflow. It includes a dedicated DICOM viewer for interactive assessment of fused USCT images. A new preview mode now allows intuitive and faster patient positioning. We updated the USCT system to decrease the data acquisition time by approximately factor two and to increase the penetration depth of the breast into the USCT aperture by 1 cm. Furthermore the compute-intensive reflectivity reconstruction was considerably accelerated, now allowing a sub-millimeter volume reconstruction in approximately 16 minutes. The updates made it possible to successfully image first patients in our ongoing clinical study.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128989606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

Rotation elastogram: a novel method to visualize local rigid body rotation under quasi-static compression 旋转弹性图:一种显示准静态压缩下局部刚体旋转的新方法

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216828

S. C., AliArshad Kothawala, A. Thittai

{"title":"Rotation elastogram: a novel method to visualize local rigid body rotation under quasi-static compression","authors":"S. C., AliArshad Kothawala, A. Thittai","doi":"10.1117/12.2216828","DOIUrl":"https://doi.org/10.1117/12.2216828","url":null,"abstract":"During manual palpation of breast masses, the perception of its stiffness and slipperiness are the two commonly used information by the physician. In order to reliably and quantitatively obtain this information several non-invasive elastography techniques have been developed that seek to provide an image of the underlying mechanical properties, mostly stiffness-related. Very few approaches have visualized the \"slip\" at the lesion-background boundary that only occurs for a loosely-bonded benign lesion. It has been shown that axial-shear strain distribution provides information about underlying slip. One such feature, referred to as \"fill-in\" was interpreted as a surrogate of the rotation undergone by an asymmetrically-oriented-loosely bonded-benign-lesion under quasi-static compression. However, imaging and direct visualization of the rotation itself has not been addressed yet. In order to accomplish this, the quality of lateral displacement estimation needs to be improved. In this simulation study, we utilize spatial compounding approach and assess the feasibility to obtain good quality rotation elastogram. The angular axial and lateral displacement estimates were obtained at different insonification angles from a phantom containing an elliptical inclusion oriented at 45°, subjected to 1% compression from the top. A multilevel 2D-block matching algorithm was used for displacement tracking and 2D-least square compounding of angular axial and lateral displacement estimates was employed. By varying the maximum steering angle and incremental angle, the improvement in the lateral motion tracking accuracy and its effects on the quality of rotational elastogram were evaluated. Results demonstrate significantly-improved rotation elastogram using this technique.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127890213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Monte Carlo investigation of the dosimetric effect of the Autoscan ultrasound probe for guidance in radiotherapy Autoscan超声探针在放射治疗中的剂量效应的蒙特卡罗研究

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216653

M. Martyn, Tuathan P. O’Shea, E. Harris, J. Bamber, S. Gilroy, M. Foley

{"title":"Monte Carlo investigation of the dosimetric effect of the Autoscan ultrasound probe for guidance in radiotherapy","authors":"M. Martyn, Tuathan P. O’Shea, E. Harris, J. Bamber, S. Gilroy, M. Foley","doi":"10.1117/12.2216653","DOIUrl":"https://doi.org/10.1117/12.2216653","url":null,"abstract":"The aim of this study was to quantify the dosimetric effect of the Autoscan™ ultrasound probe, which is a 3D transperineal probe used for real-time tissue tracking during the delivery of radiotherapy. CT images of an anthropomorphic phantom, with and without the probe placed in contact with its surface, were obtained (0.75 mm slice width, 140 kVp). CT datasets were used for relative dose calculation in Monte Carlo simulations of a 7-field plan delivered to the phantom. The Monte Carlo software packages BEAMnrc and DOSXYZnrc were used for this purpose. A number of simulations, which varied the distance of the radiation field edge from the probe face (0 mm to 5 mm), were performed. Perineal surface doses as a function of distance from the radiation field edge, with and without the probe in place, were compared. The presence of the probe was found to result in an increase in perineal surface dose, relative to the maximum dose. The maximum increase in surface dose was 18.15%, at a probe face to field edge distance of 0 mm. However increases in surface dose fall-off rapidly as this distance increases, agreeing within Monte Carlo simulation uncertainty at distances ≥ 5 mm. Using data from three patient volunteers, a typical probe face to field edge distance was calculated to be ≈20 mm. Our results therefore indicate that the presence of the probe is unlikely to adversely affect a typical patient treatment, since the dosimetric effect of the probe is minimal at these distances.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121050879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A new post-phase rotation based dynamic receive beamforming architecture for smartphone-based wireless ultrasound imaging 一种基于后相位旋转的智能手机无线超声成像动态接收波束形成新架构

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216705

Minsuk Park, Jeeun Kang, Gunho Lee, Min Kim, T. Song

{"title":"A new post-phase rotation based dynamic receive beamforming architecture for smartphone-based wireless ultrasound imaging","authors":"Minsuk Park, Jeeun Kang, Gunho Lee, Min Kim, T. Song","doi":"10.1117/12.2216705","DOIUrl":"https://doi.org/10.1117/12.2216705","url":null,"abstract":"Recently, a portable US imaging system using smart devices is highlighted for enhancing the portability of diagnosis. Especially, the system combination can enhance the user experience during whole US diagnostic procedures by employing the advanced wireless communication technology integrated in a smart device, e.g., WiFi, Bluetooth, etc. In this paper, an effective post-phase rotation-based dynamic receive beamforming (PRBF-POST) method is presented for wireless US imaging device integrating US probe system and commercial smart device. In conventional, the frame rate of conventional PRBF (PRBF-CON) method suffers from the large amount of calculations for the bifurcated processing paths of in-phase and quadrature signal components as the number of channel increase. Otherwise, the proposed PRBF-POST method can preserve the frame rate regardless of the number of channels by firstly aggregating the baseband IQ data along the channels whose phase quantization levels are identical ahead of phase rotation and summation procedures on a smart device. To evaluate the performance of the proposed PRBF-POST method, the pointspread functions of PRBF-CON and PRBF-POST methods were compared each other. Also, the frame rate of each PRBF method was measured 20-times to calculate the average frame rate and its standard deviation. As a result, the PRBFCON and PRBF-POST methods indicates identical beamforming performance in the Field-II simulation (correlation coefficient = 1). Also, the proposed PRBF-POST method indicates the consistent frame rate for varying number of channels (i.e., 44.25, 44.32, and 44.35 fps for 16, 64, and 128 channels, respectively), while the PRBF-CON method shows the decrease of frame rate as the number of channel increase (39.73, 13.19, and 3.8 fps). These results indicate that the proposed PRBF-POST method can be more advantageous for implementing the wireless US imaging system than the PRBF-CON method.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132129368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A new approach to ultrasonic elasticity imaging 超声弹性成像的一种新方法

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216549

Cameron Hoerig, J. Ghaboussi, M. Fatemi, M. Insana

{"title":"A new approach to ultrasonic elasticity imaging","authors":"Cameron Hoerig, J. Ghaboussi, M. Fatemi, M. Insana","doi":"10.1117/12.2216549","DOIUrl":"https://doi.org/10.1117/12.2216549","url":null,"abstract":"Biomechanical properties of soft tissues can provide information regarding the local health status. Often the cells in pathological tissues can be found to form a stiff extracellular environment, which is a sensitive, early diagnostic indicator of disease. Quasi-static ultrasonic elasticity imaging provides a way to image the mechanical properties of tissues. Strain images provide a map of the relative tissue stiffness, but ambiguities and artifacts limit its diagnostic value. Accurately mapping intrinsic mechanical parameters of a region may increase diagnostic specificity. However, the inverse problem, whereby force and displacement estimates are used to estimate a constitutive matrix, is ill conditioned. Our method avoids many of the issues involved with solving the inverse problem, such as unknown boundary conditions and incomplete information about the stress field, by building an empirical model directly from measured data. Surface force and volumetric displacement data gathered during imaging are used in conjunction with the AutoProgressive method to teach artificial neural networks the stress-strain relationship of tissues. The Autoprogressive algorithm has been successfully used in many civil engineering applications and to estimate ocular pressure and corneal stiffness; here, we are expanding its use to any tissues imaged ultrasonically. We show that force-displacement data recorded with an ultrasound probe and displacements estimated at a few points in the imaged region can be used to estimate the full stress and strain vectors throughout an entire model while only assuming conservation laws. We will also demonstrate methods to parameterize the mechanical properties based on the stress-strain response of trained neural networks. This method is a fundamentally new approach to medical elasticity imaging that for the first time provides full stress and strain vectors from one set of observation data.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130494839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Spatial smoothing coherence factor for ultrasound computed tomography 超声计算机断层扫描的空间平滑相干系数

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216191

Cuijuan Lou, Mengling Xu, Mingyue Ding, M. Yuchi

引用次数: 6

Development and evaluation of a novel VEGFR2-targeted nanoscale ultrasound contrast agents 新型vegfr2靶向纳米级超声造影剂的研制与评价

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2214812

Houqiang Yu, Chunfang Li, Xiaoling He, Qibing Zhou, Mingyue Ding

{"title":"Development and evaluation of a novel VEGFR2-targeted nanoscale ultrasound contrast agents","authors":"Houqiang Yu, Chunfang Li, Xiaoling He, Qibing Zhou, Mingyue Ding","doi":"10.1117/12.2214812","DOIUrl":"https://doi.org/10.1117/12.2214812","url":null,"abstract":"Recent literatures have reported that the targeted nanoscale ultrasound contrast agents are becoming more and more important in medical application, like ultrasound imaging, detection of perfusion, drug delivery and molecular imaging and so on. In this study, we fabricated an uniform nanoscale bubbles (257 nm with the polydispersity index of 0.458) by incorporation of antibody targeted to vascular endothelial growth factor receptor 2 (VEGFR2) into the nanobubbles membrane by using avidin-biotin interaction. Some fundamental characterizations such as nanobubble suspension, surface morphology, particle size distribution and zeta potential were investigated. The concentration and time-intensity curves (TICs) were obtained with a self-made ultrasound experimental setup in vitro evaluation. In addition, in order to evaluate the contrast enhancement ability and the potential tumor-targeted ability in vivo, normal Wistar rats and nude female BALB/c mice were intravascular administration of the nanobubbles via tail vein injection, respectively. Significant contrast enhancement of ultrasound imaging within liver and tumor were visualized. These experiments demonstrated that the targeted nanobubbles is efficient in ultrasound molecular imaging by enhancement of the contrast effect and have potential capacity for targeted tumor diagnosis and therapy in the future.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128319485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A method for investigating system matrix properties in optimization-based CT reconstruction 基于优化的CT重建中系统矩阵性质的研究方法

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2217111

Sean D. Rose, E. Sidky, Xiaochuan Pan

{"title":"A method for investigating system matrix properties in optimization-based CT reconstruction","authors":"Sean D. Rose, E. Sidky, Xiaochuan Pan","doi":"10.1117/12.2217111","DOIUrl":"https://doi.org/10.1117/12.2217111","url":null,"abstract":"Optimization-based iterative reconstruction methods have shown much promise for a variety of applications in X-ray computed tomography (CT). In these reconstruction methods, the X-ray measurement is modeled as a linear mapping from a finite-dimensional image space to a finite dimensional data-space. This mapping is dependent on a number of factors including the basis functions used for image representation1 and the method by which the matrix representing this mapping is generated.2 Understanding the properties of this linear mapping and how it depends on our choice of parameters is fundamental to optimization-based reconstruction. In this work, we confine our attention to a pixel basis and propose a method to investigate the effect of pixel size in optimization-based reconstruction. The proposed method provides insight into the tradeoff between higher resolution image representation and matrix conditioning. We demonstrate this method for a particular breast CT system geometry. We find that the images obtained from accurate solution of a least squares reconstruction optimization problem have high sensitivity to pixel size within certain regimes. We propose two methods by which this sensitivity can be reduced and demonstrate their efficacy. Our results indicate that the choice of pixel size in optimization-based reconstruction can have great impact on the quality of the reconstructed image, and that understanding the properties of the linear mapping modeling the X-ray measurement can help guide us with this choice.","PeriodicalId":228011,"journal":{"name":"SPIE Medical Imaging","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117289050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of patient movement during 3D USCT data acquisition 三维USCT数据采集过程中患者运动分析

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2216680

N. Ruiter, T. Hopp, M. Zapf, E. Kretzek, H. Gemmeke

引用次数: 10

Quantitative evaluation of PET image using event information bootstrap 基于事件信息自举法的PET图像定量评价

SPIE Medical Imaging Pub Date : 2016-04-01 DOI: 10.1117/12.2217154

Hankyeol Song, Shin Kwak, KyeongMin Kim, J. Kang, Y. Chung, S. Woo

引用次数: 0