The Lancet Regional Health: Western Pacific最新文献

{"title":"Secular trends in physical fitness and cardiovascular risks among Chinese college students: an analysis of five successive national surveys between 2000 and 2019","authors":"Shan Cai ,&nbsp;Yihang Zhang ,&nbsp;Ziyue Chen ,&nbsp;Yunfei Liu ,&nbsp;Jiajia Dang ,&nbsp;Jiaxin Li ,&nbsp;Tianyu Huang ,&nbsp;Ziyue Sun ,&nbsp;Yanhui Dong ,&nbsp;Jun Ma ,&nbsp;Yi Song","doi":"10.1016/j.lanwpc.2025.101560","DOIUrl":"10.1016/j.lanwpc.2025.101560","url":null,"abstract":"<div><h3>Background</h3><div>With increasing concerns about early-onset cardiovascular diseases, it is essential to understand the distribution of cardiovascular health among young adults. This study aimed to characterize trends in physical fitness and the prevalence of overweight/obesity (OWOB), elevated blood pressure (EBP), and their comorbidity among Chinese college students from 2000 to 2019 and to analyze the changes in their associations and subgroup differences.</div></div><div><h3>Methods</h3><div>Data were extracted from five cycles of the Chinese National Survey on Students' Constitution and Health (2000–2019), including 241,710 college students aged 19–22. Physical fitness indicator (PFI) was computed using standardized z-scores of forced vital capacity, sit-and-reach, 50-m dash, standing long jump, muscle strength, and endurance running. OWOB was defined as a body mass index ≥25 kg/m², and EBP as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg. Comorbidity was defined as the co-occurrence of OWOB and EBP. Mixed-effects logistic regression was used to analyze associations, and generalized linear mixed-effects models were applied to examine dose-response relationships.</div></div><div><h3>Findings</h3><div>The median of college students' PFI deteriorated continuously from −0.16 in 2000 to −1.99 in 2019, with boys experiencing a faster decline than girls. The prevalence of OWOB, EBP, and comorbidity increased significantly from 3.7%, 2.2%, and 0.3% in 2000 to 14.0%, 5.2%, and 1.8% in 2019, respectively, with boys exhibiting higher prevalence than girls. Decreasing PFI levels were significantly associated with the increasing prevalence of OWOB, EBP, and comorbidity, and such associations were strongest in 2019. L-shaped curves were observed for the relationships between PFI and the prevalence of OWOB, EBP, and comorbidity, with stronger associations in boys. Provincial population attributable fraction showed that when improving the PFI levels from low to middle-low or above, college students in Guizhou, Sichuan, and Yunnan provinces exhibited the most reductions in OWOB, EBP, and comorbidity.</div></div><div><h3>Interpretation</h3><div>Physical fitness among Chinese college students has significantly declined over the past two decades, accompanied by marked increases in the burden of cardiovascular risks. There is an urgent need to increase the focus on college students’ health and establish a college-based physical examination system to assess their long-term cardiovascular function.</div></div><div><h3>Funding</h3><div>The present study was funded by National Key R&amp;D Program of China (Grant No. 2024YFC2707901 to Yi Song), <span>National Natural Science Foundation of China</span> (Grant No. <span><span>82273654</span></span> to Yi Song), and <span>Beijing Office for Education Sciences Planning</span> (Grant No. <span><span>BBAA22027</span></span> to Yi Song).</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"58 ","pages":"Article 101560"},"PeriodicalIF":7.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The prevalence and associated disability burden of mental disorders in children and adolescents in China: a systematic analysis of data from the Global Burden of Disease Study” [The Lancet Regional Health–Western Pacific Volume 55, February 2025, 101486]","authors":"Wanyue Dong ,&nbsp;Yunning Liu ,&nbsp;Ruhai Bai ,&nbsp;Lei Zhang ,&nbsp;Maigeng Zhou","doi":"10.1016/j.lanwpc.2025.101556","DOIUrl":"10.1016/j.lanwpc.2025.101556","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"58 ","pages":"Article 101556"},"PeriodicalIF":7.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-pandemic excess mortality of COVID-19 in Hong Kong: a retrospective study","authors":"Kehang Li ,&nbsp;Yuchen Wei ,&nbsp;Chi Tim Hung ,&nbsp;Carlos King Ho Wong ,&nbsp;Xi Xiong ,&nbsp;Paul Kay Sheung Chan ,&nbsp;Shi Zhao ,&nbsp;Zihao Guo ,&nbsp;Guozhang Lin ,&nbsp;Qiaoge Chi ,&nbsp;Carrie Ho Kwan Yam ,&nbsp;Tsz Yu Chow ,&nbsp;Conglu Li ,&nbsp;Xiaoting Jiang ,&nbsp;Shuk Yu Leung ,&nbsp;Ka Li Kwok ,&nbsp;Eng Kiong Yeoh ,&nbsp;Ka Chun Chong","doi":"10.1016/j.lanwpc.2025.101554","DOIUrl":"10.1016/j.lanwpc.2025.101554","url":null,"abstract":"<div><h3>Background</h3><div>As the COVID-19 pandemic shifted into the post-pandemic period in early 2023, following the COVID-19 normalization with relaxation of stringent control measures and high vaccination coverage in Hong Kong, its long-term impact on mortality remains challenging with necessary needs of data-driven insights. This study examined the pattern of post-pandemic excess mortality in Hong Kong.</div></div><div><h3>Methods</h3><div>We analyzed weekly inpatient death data from public hospitals from January 1, 2013, to June 1, 2024, using a mixed model with over-dispersed Poisson regression. Expected mortality was estimated as the difference between observed mortality and baseline derived from pre-pandemic data. Age-stratified analyses of overall and cause-specific mortality were conducted across the pre-Omicron pandemic, Omicron, and post-pandemic periods.</div></div><div><h3>Findings</h3><div>In the post-pandemic period, the excess mortality declined but remained six-fold higher (37.66 [95% CI: 32.72–42.60] per 100,000) than pre-Omicron level, maintaining significance after adjusting for age (32.79 [95% CI: 28.13–37.46] per 100,000). The older population experienced sustained excess mortality, with crude estimates of 100.51 and 586.74 per 100,000 among those aged 65–79 years and ≥80 years, respectively, primarily due to respiratory diseases. Younger population showed near-zero overall excess mortality, whereas increased excess mortality among them occurred in heart disease, cerebrovascular disease, and injuries.</div></div><div><h3>Interpretation</h3><div>Our findings highlight the lasting mortality impact of pandemic among vulnerable populations, specifically the older population, possibly due to the post-COVID conditions and circulating COVID-19, suggesting the need for targeted interventions for this group.</div></div><div><h3>Funding</h3><div><span>Health and Medical Research Fund</span>.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"58 ","pages":"Article 101554"},"PeriodicalIF":7.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143864083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in breast cancer screening and treatment in the Western Pacific: challenges and opportunities","authors":"Jia-Wern Pan,&nbsp;Mei-Chee Tai","doi":"10.1016/j.lanwpc.2025.101538","DOIUrl":"10.1016/j.lanwpc.2025.101538","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101538"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Universal health coverage for immigrants in Japan","authors":"Soichiro Saeki","doi":"10.1016/j.lanwpc.2025.101539","DOIUrl":"10.1016/j.lanwpc.2025.101539","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101539"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and visualising temporal trajectories of hospitalisations for traditional and non-traditional complications in people with type 2 diabetes: a population-based study","authors":"Hongjiang Wu ,&nbsp;Haobin Zhou ,&nbsp;Chuiguo Huang ,&nbsp;Aimin Yang ,&nbsp;Eric S.H. Lau ,&nbsp;Xinge Zhang ,&nbsp;Juliana N.M. Lui ,&nbsp;Baoqi Fan ,&nbsp;Mai Shi ,&nbsp;Ronald C.W. Ma ,&nbsp;Alice P.S. Kong ,&nbsp;Elaine Chow ,&nbsp;Wing-Yee So ,&nbsp;Juliana C.N. Chan ,&nbsp;Andrea O.Y. Luk","doi":"10.1016/j.lanwpc.2025.101532","DOIUrl":"10.1016/j.lanwpc.2025.101532","url":null,"abstract":"<div><h3>Background</h3><div>People with type 2 diabetes are increasingly susceptible to complications that are not specific to diabetes. We aimed to examine the temporal trajectories of hospitalisations for traditional and non-traditional complications in people with type 2 diabetes.</div></div><div><h3>Methods</h3><div>We included 758,254 people with incident type 2 diabetes between 2002 and 2018 in Hong Kong, followed up until 2019. We included hospitalisations for 72 selected diseases and all-cause deaths. We derived the temporal trajectories of hospitalisations based on pairs of disease associations and identified trajectory clusters using Markov Cluster Algorithm.</div></div><div><h3>Findings</h3><div>During a median follow-up of 7.8 (IQR: 4–12) years, 57.6% of people experienced a hospitalisation for any of the 72 selected diseases and 22.6% of people died. Among the 5184 directional disease pairs, 95 were identified as having a significant and directional association. The three most common disease pairs were hospitalisations for urinary tract infection followed by pneumonia, ischemic heart disease followed by heart failure, and ischemic stroke followed by pneumonia. Cardiovascular and kidney diseases were predominant in the hospitalisation trajectories. However, these traditional complications had complex associations both among themselves and with various non-traditional complications across multiple systems. Three distinct trajectory clusters were identified, with heart failure/chronic kidney disease, pneumonia, and urinary tract infection as central diseases.</div></div><div><h3>Interpretation</h3><div>Cardiovascular and kidney diseases interacted with a broad set of non-traditional complications to influence the overall patterns of hospitalisation progression in people with diabetes, highlighting the need to broaden diabetes care to consider complications beyond the traditional focus.</div></div><div><h3>Funding</h3><div>Direct Grant for Research from <span>The Chinese University of Hong Kong</span>.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101532"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunotherapy in nasopharyngeal carcinoma: current status and unanswered questions","authors":"Xu Liu ,&nbsp;Jun Ma","doi":"10.1016/j.lanwpc.2025.101547","DOIUrl":"10.1016/j.lanwpc.2025.101547","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101547"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk-adjusted breast screening: an Australian perspective and considerations for the Western Pacific","authors":"Carolyn Nickson ,&nbsp;Louiza S. Velentzis ,&nbsp;G. Bruce Mann ,&nbsp;Paul Grogan ,&nbsp;Deborah Bateson ,&nbsp;Karen Canfell","doi":"10.1016/j.lanwpc.2025.101520","DOIUrl":"10.1016/j.lanwpc.2025.101520","url":null,"abstract":"<div><div>Breast cancer is the most common cancer in females globally, and the leading cause of female cancer deaths. The 2023 World Health Organisation Global Breast Cancer Initiative Framework aims to prevent 2·5 million deaths from breast cancer by 2040. Early detection of breast cancer is central to this goal, and population-based breast screening is key to early detection. A more risk-adjusted approach to screening within current target age ranges, whether risk-stratified (tailoring population-wide screening protocols based on risk) or risk-targeted (prioritising available screening services to higher risk females) is likely to prevent further deaths. This article presents a review of the risk-adjusted screening initiative in Australia (the Roadmap to Optimising Screening in Australia (ROSA) Project) and explores a potential framework for advancing risk-adjusted strategies for breast screening throughout the Western Pacific region.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101520"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informing health system planning for biomarker-based treatment: statistical prevalence projections for solid cancers with key pan-tumour biomarkers (dMMR, MSI, high TMB) in Australia to 2042","authors":"Yoon-Jung Kang ,&nbsp;Qingwei Luo ,&nbsp;Joachim Worthington ,&nbsp;Anna Kelly ,&nbsp;Jeff Cuff ,&nbsp;John Zalcberg ,&nbsp;Karen Canfell ,&nbsp;Julia Steinberg","doi":"10.1016/j.lanwpc.2025.101537","DOIUrl":"10.1016/j.lanwpc.2025.101537","url":null,"abstract":"<div><h3>Background</h3><div>Targeted cancer treatment based on mismatch repair deficiency (dMMR), microsatellite instability (MSI), or high tumour mutational burden (TMB) holds promise for improving patient outcomes, but presents substantial healthcare costs.</div></div><div><h3>Methods</h3><div>Using validated statistical methods, we projected 1-year to 5-year prevalence of individuals diagnosed with solid tumours exhibiting these biomarkers in Australia to 2042, for all solid cancers combined and 23 individual cancer types/groups, and separately for all stages combined, advanced disease at diagnosis (here, distant metastasis/lymph node involvement), and advanced disease after progression post-diagnosis.</div></div><div><h3>Findings</h3><div>The 5-year prevalence of individuals diagnosed with any solid cancer regardless of biomarker status is estimated to increase by 54·2%, from 438,346 in 2018 to 675,722 in 2042 (advanced disease at diagnosis: by 37·6% from 109,855 to 151,199), primarily due to population growth and ageing. The 5-year prevalence of individuals whose tumours exhibit a biomarker is estimated to increase accordingly, e.g. for advanced disease at diagnosis, from 3983 to 5448 for dMMR, from 2484 to 3553 for MSI, and from 13,310 to 17,893 for high TMB (representing 3·6%, 2·3% and 11·8% of 5-year prevalence of individuals with advanced disease at diagnosis, respectively; noting considerable overlap in the presence of these biomarkers).</div></div><div><h3>Interpretation</h3><div>We present the first long-term projections for cancer prevalence associated with key pan-tumour biomarkers in Australia, to inform health policy and healthcare planning for targeted therapies.</div></div><div><h3>Funding</h3><div>Medical Research Future Fund—Preventive and Public Health Research Initiative—2019 <span>Targeted Health System</span> and <span>Community Organization Research</span> Grant Opportunity (MRF1200535), <span>Cancer Institute NSW</span> Career Development Fellowship (2022/CDF1154), <span>National Health and Medical Research Council of Australia</span> Investigator Grant (APP1194679).</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101537"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area-level socioeconomic inequalities in hypertension care cascade in China: a nationwide population-based study based on the ChinaHEART project","authors":"Wenyao Peng ,&nbsp;Siqi Lin ,&nbsp;Xuan Liu ,&nbsp;Bowang Chen ,&nbsp;Xueke Bai ,&nbsp;Chaoqun Wu ,&nbsp;Xiaoyan Zhang ,&nbsp;Yang Yang ,&nbsp;Jianlan Cui ,&nbsp;Wei Xu ,&nbsp;Lijuan Song ,&nbsp;Hao Yang ,&nbsp;Wenyan He ,&nbsp;Yan Zhang ,&nbsp;Xi Li ,&nbsp;Jiapeng Lu","doi":"10.1016/j.lanwpc.2025.101544","DOIUrl":"10.1016/j.lanwpc.2025.101544","url":null,"abstract":"<div><h3>Background</h3><div>Socioeconomic status (SES) is one of key social determinants of health. Compared to individual-level SES, the association between area-level SES and hypertension management has been understudied and under-recognised. In this study, we aimed to assess the association between area-level SES and hypertension awareness, treatment, combination therapy and control, and the modification effect of individual characteristics on the associations.</div></div><div><h3>Methods</h3><div>During Dec 2015 and Dec 2022, 1,559,748 residents with hypertension aged 35–75 years from 31 provinces in the China Health Evaluation And risk Reduction through nationwide Teamwork (ChinaHEART) were included. The composite value of area-level SES was generated from national census data and categorized into tertiles. Multivariable mixed models with random effects to account for county-level administrative area were fitted to compute odds ratios (OR) and 95% confidence intervals (CIs) for the independent and interactive associations of both area- and individual-level SES with hypertension management (awareness, treatment, combination therapy and control) and their disparities across different population subgroups.</div></div><div><h3>Findings</h3><div>Among the included participants with hypertension aged 59·1 ± 9·1 years, 794,675 (50·95%), 650,485 (41·70%) and 206,103 (13·21%) were aware, treated, and controlled, respectively. Compared with the high area-level SES group, the low group was significantly associated with a lower odds of hypertension awareness (OR: 0·75, 95% CI: 0·65–0·86), treatment (0·69, 0·59–0·81), combination therapy (0·65, 0·51–0·84), and control (0·62, 0·51–0·75). Participants with low SES at both individual and area level had the lowest odds of hypertension management. Area-level SES had stronger influences on hypertension awareness, treatment and control, but a weaker influence on combination therapy, in the young and those with high individual-level SES.</div></div><div><h3>Interpretation</h3><div>Area-level SES on plays a key role in the awareness, treatment, combination therapy and control of hypertension, with different magnitude of associations. Integrated action to improve area-level circumstances and promote targeted interventions to hypertension care cascade are needed to reduce health inequalities in China.</div></div><div><h3>Funding</h3><div>The <span>CAMS Innovation Fund</span> for Medical Science; the <span>National High Level Hospital Clinical Research Funding</span>; the <span>National Natural Science Foundation of China</span> of China; the <span>Ministry of Finance</span> of China and <span>National Health Commission</span> of China; the 111 Project from the <span>Ministry of Education of China</span>.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"57 ","pages":"Article 101544"},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}