The Lancet Regional Health: Western Pacific最新文献

{"title":"From symptom relief to household control: baloxavir redefines antiviral strategies for influenza","authors":"Jin-Fu Xu , Yang Liu , Panpan Zhang , Bin Cao","doi":"10.1016/j.lanwpc.2025.101651","DOIUrl":"10.1016/j.lanwpc.2025.101651","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101651"},"PeriodicalIF":8.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the vaccine gap: overcoming barriers for special healthcare needs children in China","authors":"Yuming Liu , Yuan Dang , Lin Wang , Yangmu Huang","doi":"10.1016/j.lanwpc.2025.101644","DOIUrl":"10.1016/j.lanwpc.2025.101644","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101644"},"PeriodicalIF":8.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘A new framework for Australian specialty colleges and other healthcare leaders to address bullying, discrimination, and harassment that involves doctors’ [The Lancet Regional Health—Western Pacific 2024; 48:101118]","authors":"Thomas Lawson Haskell , Jim Stankovich , Nancy Louisa Merridew","doi":"10.1016/j.lanwpc.2025.101643","DOIUrl":"10.1016/j.lanwpc.2025.101643","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101643"},"PeriodicalIF":8.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imbalance between muscle strength development and weight gain in children and young adults in China: serial cross-sectional evidence from 1.33 million students from five successive national surveys between 2000 and 2019","authors":"Xijie Wang ,&nbsp;Huan Wang ,&nbsp;Xin Yuan ,&nbsp;Shan Cai ,&nbsp;Yangmu Huang ,&nbsp;Yi Song ,&nbsp;Zhiyong Zou ,&nbsp;Randall S. Stafford","doi":"10.1016/j.lanwpc.2025.101640","DOIUrl":"10.1016/j.lanwpc.2025.101640","url":null,"abstract":"<div><h3>Background</h3><div>Over the past decades, Chinese school-aged children and adolescents have experienced a rapid increase in overweight and obesity, but corresponding changes in muscle strength remain unclear. We aimed to elucidate trends in muscle strength development at both national and subnational level, and to investigate whether it has increased proportionally with weight gain.</div></div><div><h3>Methods</h3><div>Muscle strength (handgrip strength [kg] for upper body and standing broad jump [cm] for lower body) and weight measurements for 1.33 million children and adolescents aged 7 to 22 were obtained from five waves of the Chinese National Surveys on Students Constitution and Health (2000, 2005, 2010, 2014, and 2019). Trends in muscle strength indicators were investigated using t-test, with post-hoc pairwise comparisons performed using Bonferroni correction. Associations between muscle indicators with weight change were assessed with the Pearson correlation analysis.</div></div><div><h3>Findings</h3><div>Despite some increase during the first waves of survey, both handgrip strength and standing broad jump declined significantly between 2010 and 2019. The median handgrip strength decreased from 43.9 kg (95% CI 43.7 to 44.1) in 2010 to 42.5 kg (42.3 to 42.8) in 2019 among young males, and from 26.6 kg (26.5 to 26.7) in 2010 and to 26.0 kg (25.8 to 26.1) in 2019 among young females. From 2010 to 2019, median standing broad jump decreased from 234.3 cm (233.8–234.8) to 219.4 cm (218.8–220.1) among males, and from 172.8 cm (172.3–173.3) to 162.5 cm (162.0–163.1) among females. Over the last decade, both measures of muscle strength showed significant declines within each age- and sex-specific quantiles, with the most pronounced decreases observed at the lower quantiles and older ages. The most notable declines were observed in North China, Northeast China, and Middle-West China. As age and weight increased, the initially positive association between body weight and handgrip strength shifted to a progressive weakening, while the association between body weight and standing broad jump changed from non-significant to negative, at −0.51 (95% CI: −0.62 to −0.38) for males and −0.39 (95% CI: −0.52 to −0.24) for females.</div></div><div><h3>Interpretation</h3><div>This nationally representative study highlights a significant decline in muscle strength among Chinese students over the last decade. The imbalance between increasing body weight and declining muscle strength underscores the urgent need for targeted public health interventions to decrease obesity in Chinese students, to maximize their life-long health expectancy.</div></div><div><h3>Funding</h3><div>This study was supported by the <span>National Natural Science Foundation of China</span> (<span><span>82073573</span></span> to ZZ; <span><span>82204067</span></span> to XW; <span><span>82273654</span></span> to YS).</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101640"},"PeriodicalIF":7.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisystem burden in cirrhosis: lessons from a marginalised population","authors":"Pojsakorn Danpanichkul ,&nbsp;Jeffrey V. Lazarus ,&nbsp;Ju Dong Yang ,&nbsp;Amit G. Singal","doi":"10.1016/j.lanwpc.2025.101645","DOIUrl":"10.1016/j.lanwpc.2025.101645","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101645"},"PeriodicalIF":7.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The psychological impact of conflict in the Middle East from 2023 to 2025 on Australian communities: a prospective cohort study","authors":"Susan J. Rees ,&nbsp;Tyson Whitten ,&nbsp;Alvin Kuowei Tay ,&nbsp;Aino Suomi ,&nbsp;Batool Moussa ,&nbsp;Fatima Hassoun ,&nbsp;Nawal Nadar ,&nbsp;Derrick Silove","doi":"10.1016/j.lanwpc.2025.101639","DOIUrl":"10.1016/j.lanwpc.2025.101639","url":null,"abstract":"<div><h3>Background</h3><div>There is a lack of empirical research on the mental health risks faced by populations living in high-income multicultural countries during a war in their country of origin. We examined mental health and psychosocial outcomes associated with a period during the 2023–2025 Middle East conflict (primarily involving Israel, Palestine and Lebanon) on Australian resident women including those who arrived from Lebanon, Gaza and other Palestinian Territories.</div></div><div><h3>Methods</h3><div>The mental health study assessed 410 Australian resident women at two points: one 12–18 months prior, and one period during the current Middle Eastern conflict extending from October 7, 2023, to December 2024. The three groups included those directly connected by birth or family to the conflict-affected regions: Lebanon, Gaza and other Palestinian territories (Middle East—LGP), Other Migrants not from the region, and Australian Born (AB) women with no connection to the region. Measures included the Mini-International Neuropsychiatric Interview to assess symptoms of panic disorder (PD), mood disorder (MDD), post-traumatic stress disorder (PTSD), separation anxiety disorder (SEPAD), Quality of Life, Worry about Family and Separation from Family overseas. Generalised linear mixed models and cumulative link mixed models were used to examine the trajectory of mental disorder symptoms over time for each group compared with the AB group. The analysis adjusted for age, marital status, financial difficulties, and COVID-19 stress.</div></div><div><h3>Findings</h3><div>Generalised linear and cumulative link mixed models revealed significant interaction effects, indicating that Middle East–LGP women experienced a significantly greater increase in PD symptoms (β = 1.26, SE = 0.54, <em>p</em> = 0.02) and poorer quality of life (β = 0.10, SE = 0.04, <em>p</em> = 0.009) from Time 1 to Time 2 compared to AB women. The Middle East—LGP women reported significantly greater increases in concerns about family overseas (log odds = 4.04, SE = 1.25, <em>p</em> = 0.001) and the ability to return home in an emergency (log odds = 3.41, SE = 1.20, <em>p</em> = 0.005).</div></div><div><h3>Interpretation</h3><div>This is a unique study of women’s mental health in a multicultural, high-income country, undertaken during conflict occurring in another region of the world. Panic Disorder symptoms, poorer quality of life and other psychosocial stress increased only in the group connected by migration to the conflict-affected region.</div></div><div><h3>Funding</h3><div><span>National Health and Medical Research Council</span>, Australia (<span><span>2018/GNT1164736</span></span>).</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101639"},"PeriodicalIF":7.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A population-based study of cause-specific mortality in First Nations Australians with cirrhosis: impact of cardiometabolic comorbidities and liver disease risk factors","authors":"Vikas Bhasker ,&nbsp;Catherine Brown ,&nbsp;Jessica R. Fong ,&nbsp;Paul J. Clark ,&nbsp;Gunter Hartel ,&nbsp;Richard Skoien ,&nbsp;James O'Beirne ,&nbsp;Kai Wheeler ,&nbsp;Shelley E. Keating ,&nbsp;Elizabeth E. Powell ,&nbsp;Patricia C. Valery","doi":"10.1016/j.lanwpc.2025.101641","DOIUrl":"10.1016/j.lanwpc.2025.101641","url":null,"abstract":"<div><h3>Background</h3><div>Liver disease is an important contributor to high mortality in First Nations Australians. We describe cause-specific mortality by First Nations status in people with cirrhosis.</div></div><div><h3>Methods</h3><div>Population-based retrospective cohort analysis of all adults with cirrhosis admitted to hospitals in the state of Queensland (2007–2022). Patients (1909 First Nations and 20,584 non-First Nations) were followed from the first admission with cirrhosis until date of death, liver transplant, or 31 December 2022, whichever came first. Multivariable Cox regression and Fine and Gray proportional subhazard models were used to assess differences in mortality according to First Nations status.</div></div><div><h3>Findings</h3><div>During a median follow-up of 6.9 years (IQR 3.5–11.1), 995 (52.1%) First Nations and 11,367 (55.2%) non-First Nations patients died. First Nations people died on average 9.4 years younger than non-First Nations Australians (57.0 years (SD = 12.1) vs 66.4 years (SD = 12.2), respectively). Approximately half of First Nations (48.9%) and non-First Nations (50.4%) deaths had liver disease as their underlying cause, and the 10-year liver-related mortality did not differ according to First Nations status (adjusted-sHR = 0.92, 95% CI 0.83–1.01). First Nations patients had a 1.6-fold increased risk of 10-year mortality due to cardiovascular disease (adjusted-sHR = 1.59, 95% CI 1.29–1.96), diabetes (adjusted-sHR = 1.60, 95% CI 1.07–1.52), and infections/parasitic diseases (adjusted-sHR = 1.61, 95% CI 1.12–2.23) vs non-First Nations patients.</div></div><div><h3>Interpretation</h3><div>Mortality due to cardiovascular disease, diabetes, and infections/parasitic diseases are 60% higher in First Nations Australians with cirrhosis. The higher non-liver disease mortality in First Nations Australians reinforces the need for a holistic approach to management of metabolic comorbidities in patients with cirrhosis.</div></div><div><h3>Funding</h3><div>This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"61 ","pages":"Article 101641"},"PeriodicalIF":7.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying the contributions of cardiovascular risk factors to cardiovascular disease trends in 21st century Japan: a microsimulation study","authors":"Soshiro Ogata ,&nbsp;Eri Kiyoshige ,&nbsp;Yusuke Yoshikawa ,&nbsp;Koji Iihara ,&nbsp;Hitoshi Fukuda ,&nbsp;Masanobu Ishii ,&nbsp;Kenichi Tsujita ,&nbsp;Anna Head ,&nbsp;Brendan Collins ,&nbsp;Martin O'Flaherty ,&nbsp;Kunihiro Nishimura ,&nbsp;Chris Kypridemos","doi":"10.1016/j.lanwpc.2025.101623","DOIUrl":"10.1016/j.lanwpc.2025.101623","url":null,"abstract":"<div><h3>Background</h3><div>Recent stagnation or worsening trends in cardiovascular disease (CVD) risk factors, including low-density lipoprotein cholesterol (LDL-c) and obesity, might slow the decline in Japan's CVD burden. We aimed to quantify the impact of national changes in CVD risk factor distributions on Japan's CVD burden from 2001 to 2019.</div></div><div><h3>Methods</h3><div>We conducted a microsimulation study with counterfactual analysis using IMPACT_NCD-JPN, a validated model based on real-world data. It simulated a synthetic Japanese population (ages 30–99) from 2001 to 2019 using life-course data on seven CVD risk factors, estimating CVD incidence, mortality, and healthcare economics for synthetic individuals. The base-case reflected observed trends; counterfactual scenarios assumed 2001 levels persisted. Primary outcome was national CVD incidence (stroke and coronary heart disease).</div></div><div><h3>Findings</h3><div>From 2001 to 2019, systolic blood pressure (SBP) and smoking declined markedly (men/women) by 6·8/7·2 mmHg and 18·4/6·8%, respectively, while LDL-c, HbA1c, body mass index (BMI), physical activity (PA), and fruit/vegetable (FV) consumption showed smaller or adverse trends. Under the base-case and counterfactual scenarios, IMPACT_NCD-JPN estimated CVD incidence and quantified the differences between the scenarios. The changes in the CVD risk factors prevented or postponed 840,000 (95% uncertainty interval: 540,000–1,300,000) national CVD cases, cumulative from 2001 to 2019. Individual contributions were: SBP 540,000; smoking 280,000; LDL-c 27,000; HbA1c 7900; BMI −15,000; PA −16,000; and FV consumption −11,000.</div></div><div><h3>Interpretation</h3><div>SBP and smoking reductions drove most CVD burden declines in Japan (2001–2019). Modest benefits came from LDL-c and HbA1c, while rising BMI, and low PA and FV intake partly offset these benefits.</div></div><div><h3>Funding</h3><div><span>JSPS KAKENHI</span> <span><span>JP22K17821</span></span>, <span><span>JP25K02863</span></span>; the <span>Ministry of Health, Labour and Welfare</span> Comprehensive Research on Life-Style Related <span><span>22FA1015</span></span>, <span><span>24FA1015</span></span>.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"60 ","pages":"Article 101623"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of community acquired sepsis in children in Australia and New Zealand: a multicentre prospective cohort study","authors":"Elliot Long ,&nbsp;Meredith L. Borland ,&nbsp;Shane George ,&nbsp;Shefali Jani ,&nbsp;Eunicia Tan ,&nbsp;Natalie Phillips ,&nbsp;Amit Kochar ,&nbsp;Simon Craig ,&nbsp;Anna Lithgow ,&nbsp;Arjun Rao ,&nbsp;Emma Whyte ,&nbsp;Stuart Dalziel ,&nbsp;Stephen Hearps ,&nbsp;Ben Gelbart ,&nbsp;Sarah McNab ,&nbsp;Fran Balamuth ,&nbsp;Scott L. Weiss ,&nbsp;Nathan Kuppermann ,&nbsp;Amanda Williams ,&nbsp;Franz E. Babl ,&nbsp;Celine Lee","doi":"10.1016/j.lanwpc.2025.101608","DOIUrl":"10.1016/j.lanwpc.2025.101608","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric sepsis epidemiology is unclear due to variability in case ascertainment. We describe the epidemiology of community acquired sepsis in Australian and New Zealand children using the Phoenix sepsis criteria.</div></div><div><h3>Methods</h3><div>Prospective observational study conducted in 11 hospitals through the Paediatric Research in Emergency Departments International Collaborative (PREDICT) Network from April 2021 to December 2023. Children aged 0–&lt;18 years with suspected sepsis were included. Demographic information, therapies administered, and outcomes were collected, and the Phoenix sepsis criteria were applied.</div></div><div><h3>Findings</h3><div>Of 822,072 children assessed, 6232 (0.8%) children had suspected sepsis and 306 (&lt;0.1%) met the Phoenix sepsis criteria. Children who met the Phoenix sepsis criteria had higher rates of intensive care unit admission (245/306; 80.1% vs 1080/6232; 17.3%), vasoactive infusion (144/306; 47.1% vs 179/6232; 2.9%) mechanical ventilation (146/306; 47.7% vs 251/6232; 4.0%), and extracorporeal life support (12/306; 3.9% vs 13/6232; 0.2%) compared to the overall cohort. Intensive care unit and hospital length of stay were longer for those meeting Phoenix sepsis criteria than for the overall cohort (median 48.4 h vs 79.8 h and 69.7 h vs 189.8 h, respectively). Overall, 87/6232 (1.4%) patients died within 90 days, 42/306 (13.7%) of whom met Phoenix sepsis criteria.</div></div><div><h3>Interpretation</h3><div>Hospitalisation for suspected sepsis was relatively infrequent. The Phoenix sepsis criteria identified children with more severe illness and worse outcomes, but underestimated the overall burden of sepsis.</div></div><div><h3>Funding</h3><div>The <span>National Health and Medical Research Council</span>, the <span>Medical Research Futures Fund</span>, The <span>Royal Children's Hospital Foundation</span>, and the <span>Victorian Government</span>.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"60 ","pages":"Article 101608"},"PeriodicalIF":8.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming barriers in tuberculosis control: a case study from a remote community of South Australia","authors":"Joseph Inauen ,&nbsp;Adrienne Storken ,&nbsp;Carolyn Gill ,&nbsp;Michelle Brigham ,&nbsp;Martin Kelly ,&nbsp;Simone Barry","doi":"10.1016/j.lanwpc.2025.101604","DOIUrl":"10.1016/j.lanwpc.2025.101604","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"60 ","pages":"Article 101604"},"PeriodicalIF":7.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}