The Lancet Regional Health: Western Pacific最新文献

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Factors influencing the implementation of best clinical practices for hip fracture management in resource-constrained hospitals in China and co-design of quality improvement interventions: a qualitative study 中国资源受限医院实施髋部骨折最佳临床实践的影响因素及质量改善干预措施的共同设计:一项定性研究
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-02 DOI: 10.1016/j.lanwpc.2026.101847
Tingzhuo Liu , Gang Liu , Ning Tang , Boya Nan , Chenguang Hao , Xuecheng Sun , Baorui Xing , Dongsheng Wu , Shuyuan Wang , Liming Li , Kangquan Shou , Yang Li , Lei Yang , Zhigang Zhong , Wei Tian , Qiang Li , Lei Si , Ronald Man Yeung Wong , Xinyi Zhang , Jing Zhang , Maoyi Tian
{"title":"Factors influencing the implementation of best clinical practices for hip fracture management in resource-constrained hospitals in China and co-design of quality improvement interventions: a qualitative study","authors":"Tingzhuo Liu , Gang Liu , Ning Tang , Boya Nan , Chenguang Hao , Xuecheng Sun , Baorui Xing , Dongsheng Wu , Shuyuan Wang , Liming Li , Kangquan Shou , Yang Li , Lei Yang , Zhigang Zhong , Wei Tian , Qiang Li , Lei Si , Ronald Man Yeung Wong , Xinyi Zhang , Jing Zhang , Maoyi Tian","doi":"10.1016/j.lanwpc.2026.101847","DOIUrl":"10.1016/j.lanwpc.2026.101847","url":null,"abstract":"<div><h3>Background</h3><div>Hip fractures are a significant health issue for ageing populations, with high mortality and severe long-term effects, placing a substantial burden on healthcare systems worldwide, including in China. Although a multidisciplinary co-management model is regarded as best practice for hip fracture management, it typically involves shared care between orthopaedic teams and perioperative medical specialists such as geriatrics or internal medicine, working closely with nursing and rehabilitation staff. Its success depends on well-established medical and human resources, making implementation challenging in many settings. This study investigates the current management practices for hip fractures in county-level hospitals in China to inform development of targeted quality improvement interventions aimed at improving care.</div></div><div><h3>Methods</h3><div>This qualitative study was conducted in three sequential steps. In the first step, focus group interviews were conducted with multidisciplinary healthcare providers and hospital administrators from ten county-level hospitals across China. Guided by national clinical guidelines, these interviews aimed to identify barriers and facilitators influencing the quality of hip fracture management in older adults. The second step employed patient journey mapping to systematically analyze the treatment and management processes for hip fractures within these hospitals. In the third step, two rounds of clinician- and manager-led, evidence-informed co-design workshops were held, bringing together clinical staff including orthopaedics, internist and general practitioners, public health professionals and health management professionals to collaboratively identify areas to be intervened and develop specific interventions.</div></div><div><h3>Findings</h3><div>A total of ten focus group discussions were conducted, one in each province, involving 137 participants. These discussions identified ten key barriers and ten facilitators influencing the quality of hip fracture care. The patient journey mapping documented the treatment process for hip fractures in older adults across ten county-level hospitals, highlighting issues such as surgical delays and inadequate multidisciplinary collaboration. The co-design workshops led to the development of three interventions: (1) optimization of in-hospital management processes, (2) empowerment of surgeons and physicians, and (3) enhancement of awareness among patients and their families.</div></div><div><h3>Interpretation</h3><div>This study provides a comprehensive understanding of the challenges related to the management of hip fracture in resource-constrained county-level hospitals in China. The proposed interventions are expected to improve care quality and outcomes for patients with hip fractures in resource-constrained settings. Future efforts will focus on conducting randomized controlled trials to evaluate the effectiveness of these intervention","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101847"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147603636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syndemic analysis of stroke in Indonesia 印度尼西亚中风的综合分析
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-05 DOI: 10.1016/j.lanwpc.2026.101849
Andi Alfian Zainuddin , Rais Reskiawan A. Kadir , Nurul Qalby , Hedi Kuswanto , Andi Afdal Abdullah , Takuro Furusawa , Haerani Rasyid , Irawan Yusuf
{"title":"Syndemic analysis of stroke in Indonesia","authors":"Andi Alfian Zainuddin ,&nbsp;Rais Reskiawan A. Kadir ,&nbsp;Nurul Qalby ,&nbsp;Hedi Kuswanto ,&nbsp;Andi Afdal Abdullah ,&nbsp;Takuro Furusawa ,&nbsp;Haerani Rasyid ,&nbsp;Irawan Yusuf","doi":"10.1016/j.lanwpc.2026.101849","DOIUrl":"10.1016/j.lanwpc.2026.101849","url":null,"abstract":"<div><h3>Background</h3><div>Stroke is the first leading cause of mortality in Indonesia, yet no national study has applied a comprehensive syndemic approach that integrates co-occurring diseases and socio-economic conditions to assess the determinant of this cerebrovascular disease. To address this gap, we analyzed the ten most prevalent clinical conditions and major socio-economic indicators to identify the interacting factors that contribute to stroke incidence.</div></div><div><h3>Methods</h3><div>We analyzed national health insurance data from over 12 million patients, integrated with provincial socio-economic indicators. All variables were aggregated and analyzed at the provincial level from 2018 to 2023. Multiple advanced statistical approaches were leveraged to identify syndemic patterns.</div></div><div><h3>Findings</h3><div>Stroke, diabetes mellitus (DM), chronic kidney disease (CKD), and poverty showed consistent increases across Indonesian provinces. Correlation analysis identified strong associations between stroke and CKD, DM, and cirrhosis, with poverty demonstrating a moderate correlation. Bayesian Gaussian Network Analysis indicated that stroke was the most probable downstream outcome (51.85%) within this interconnected system. Path analysis showed that DM had strong direct associations with CKD (75.88%) and cirrhosis (61.27%), indicating a major upstream role of diabetes in the network. CKD in turn showed substantial direct associations with both poverty (48.67%) and stroke (19.18), while poverty and cirrhosis also demonstrated indirect associations with stroke. Geographically and Temporally Weighted Regression revealed marked spatial and temporal heterogeneity in the strength of these determinants across provinces. Principal Component Analysis consistently clustered several provinces in high-burden syndemic profiles.</div></div><div><h3>Interpretation</h3><div>Stroke in Indonesia emerges as the convergent outcome of interconnected metabolic, hepatic, and socio-economic factors, rather than isolated clinical conditions. These findings underscore the importance of a syndemic framework to effectively reduce the national stroke burden.</div></div><div><h3>Funding</h3><div>This study was funded by <span>Indonesian Ministry of Higher Education, Science and Technology's BIMA Research Program</span> under grant number <span>050/E5/PG.02.00.PL/2024</span> and <span>02035/UN4.22.2/PT.01.03/2024</span>.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101849"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147710648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Putting rural health first in the fuel crisis 在燃料危机中把农村卫生放在首位
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.1016/j.lanwpc.2026.101872
The Lancet Regional Health – Western Pacific
{"title":"Putting rural health first in the fuel crisis","authors":"The Lancet Regional Health – Western Pacific","doi":"10.1016/j.lanwpc.2026.101872","DOIUrl":"10.1016/j.lanwpc.2026.101872","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101872"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147803410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating the economic burden of lower respiratory infections in China from 2020 to 2040: a health-augmented macroeconomic modelling study 估计2020 - 2040年中国下呼吸道感染的经济负担:一项增强健康的宏观经济模型研究
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-17 DOI: 10.1016/j.lanwpc.2026.101855
Yue Lin , Hexi Sun , Zhong Cao , Klaus Prettner , Xiaohui Xu , Yuchang Zhou , Peng Yin , David E. Bloom , Michael Kuhn , Till Winfried Bärnighausen , Bin Cao , Maigeng Zhou , Simiao Chen
{"title":"Estimating the economic burden of lower respiratory infections in China from 2020 to 2040: a health-augmented macroeconomic modelling study","authors":"Yue Lin ,&nbsp;Hexi Sun ,&nbsp;Zhong Cao ,&nbsp;Klaus Prettner ,&nbsp;Xiaohui Xu ,&nbsp;Yuchang Zhou ,&nbsp;Peng Yin ,&nbsp;David E. Bloom ,&nbsp;Michael Kuhn ,&nbsp;Till Winfried Bärnighausen ,&nbsp;Bin Cao ,&nbsp;Maigeng Zhou ,&nbsp;Simiao Chen","doi":"10.1016/j.lanwpc.2026.101855","DOIUrl":"10.1016/j.lanwpc.2026.101855","url":null,"abstract":"<div><h3>Background</h3><div>Lower respiratory infections (LRI) are a major cause of mortality in China, yet there is a striking lack of nationally representative studies and comprehensive evaluations of their long-term economic impact. This study aimed to quantify the long-term economic burden of LRI across China’s 31 provinces and regions, and to assess the spatial distribution.</div></div><div><h3>Methods</h3><div>We used an improved health-augmented macroeconomic model (HMM) to estimate the economic burden of LRI in mainland China from 2020 to 2040. The model captures the burden via two channels: (1) the impact of LRI-related mortality and morbidity on labor supply, and (2) the effect of treatment costs on physical capital accumulation. Data were sourced from the China Provincial Burden of Disease Study 2023, the Global Burden of Antimicrobial Resistance Study, and other publicly available literature.</div></div><div><h3>Findings</h3><div>From 2020 to 2040, LRI are projected to impose a cumulative economic loss of CNY 363 billion (95% UI: 216–710). Marked regional disparities were observed: Guangdong incurred the highest absolute burden (CNY 35.6 billion); Guizhou reported the largest economic losses relative to 61‰ GDP; and per capita losses were greatest in Southwest China. Although East and Southwest China bore the largest overall losses, the disease burden was disproportionately concentrated in Southwest China, which accounted for 33.6% of DALYs but only 23.2% of the total economic loss. Middle-income regions experienced the highest total losses (CNY 174 billion), while per capita losses were most pronounced in low-income areas (CNY 426). Notably, the share of treatment-related costs increased with decreasing income levels, ranging from 21% in Northwest China to just 2% in East China.</div></div><div><h3>Interpretation</h3><div>The economic burden of LRI in China is substantial and regionally inequitable, underscoring the substantial economic returns to targeted LRI prevention and control—particularly in under-resourced regions. Far from being a fiscal liability, such investments offer meaningful long-term economic returns and are essential to advancing health and economic equity nationwide.</div></div><div><h3>Funding</h3><div>The study was supported by <span>Horizon Europe</span> (<span><span>HORIZON-MSCA-2021-SE-01</span></span>; project number <span><span>101086139-PoPMeD-SuSDeV</span></span>), and <span>Ministry of Science and Technology of the People's Republic of China</span> (project number <span><span>2023ZD0506000</span></span>).</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101855"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147711126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Country-specific modifiable dementia risk factors across the Western Pacific Region determined by population attributable fraction 西太平洋地区由人口归因分数确定的特定国家可改变的痴呆危险因素
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-17 DOI: 10.1016/j.lanwpc.2026.101857
Claire V. Burley , Hamid R. Sohrabi , Maha Alshahrani , Jennifer Dunne , Sharon L. Naismith , Kaarin J. Anstey , Tanya Buchanan , Mario Siervo , Blossom C.M. Stephan
{"title":"Country-specific modifiable dementia risk factors across the Western Pacific Region determined by population attributable fraction","authors":"Claire V. Burley ,&nbsp;Hamid R. Sohrabi ,&nbsp;Maha Alshahrani ,&nbsp;Jennifer Dunne ,&nbsp;Sharon L. Naismith ,&nbsp;Kaarin J. Anstey ,&nbsp;Tanya Buchanan ,&nbsp;Mario Siervo ,&nbsp;Blossom C.M. Stephan","doi":"10.1016/j.lanwpc.2026.101857","DOIUrl":"10.1016/j.lanwpc.2026.101857","url":null,"abstract":"<div><h3>Background</h3><div>One-third of global dementia cases occur in the Western Pacific Region (WPR), a region of marked socioeconomic and cultural diversity. Understanding how modifiable risk factors contribute to dementia burden across countries is essential for designing context-specific prevention strategies. This study quantified country-level variability in dementia cases attributable to modifiable risk factors across the WPR.</div></div><div><h3>Methods</h3><div>Weighted population attributable fractions (PAFs) for nine modifiable factors: low education, obesity, physical inactivity, hypertension, diabetes, smoking, hearing loss, depression, and alcohol misuse were calculated for 32 countries. For 13 countries with full datasets, combined weighted PAFs were also generated for seven of the nine factors (excluding hearing loss and alcohol misuse). PAF values were compared across high-, upper-middle-, and lower-middle-income countries to explore socioeconomic patterns.</div></div><div><h3>Findings</h3><div>Weighted PAFs showed substantial cross-country variability. The largest variation occurred for low education (0.0–7.3%; n = 16; vs global 4.5%) and obesity (0.2–5.9%; n = 28; vs global 1.4%). Hypertension (0.9–2.2%; n = 27; vs global 2.2%) and alcohol misuse (0.0–0.5%; n = 24; vs global 1.0%) showed the least variation. Combined weighted PAFs ranged from 20.1% (Singapore) to 34.7% (Papua New Guinea). Income-related patterns emerged: low education contributed most to dementia burden in lower-middle-income countries, while diabetes and depression contributed more in upper-middle- and high-income countries.</div></div><div><h3>Interpretation</h3><div>Eliminating seven modifiable risk factors could prevent 20–35% of dementia cases across the WPR. Region-wide gains may be achieved by focussing on diabetes and hearing loss, while effective prevention strategies require tailoring to country-specific socioeconomic conditions, health-system capacity, and education inequalities.</div></div><div><h3>Funding</h3><div>This work was made possible through Dementia Australia's support of their Chair of Dementia (author BCMS). KJA is funded by an Australian Laureate Fellowship - Grant ID: FL190100011.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101857"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147711183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining culturally responsive sleep health care through Australian First Nations leadership 通过澳大利亚第一民族的领导定义具有文化响应性的睡眠保健
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-04 DOI: 10.1016/j.lanwpc.2026.101854
Bushra Nasir , Roslyn Von Senden , Wayne Williams , Timothy C. Skinner , Romola S. Bucks , Yaqoot Fatima
{"title":"Defining culturally responsive sleep health care through Australian First Nations leadership","authors":"Bushra Nasir ,&nbsp;Roslyn Von Senden ,&nbsp;Wayne Williams ,&nbsp;Timothy C. Skinner ,&nbsp;Romola S. Bucks ,&nbsp;Yaqoot Fatima","doi":"10.1016/j.lanwpc.2026.101854","DOIUrl":"10.1016/j.lanwpc.2026.101854","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101854"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147603165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Demographic and socioeconomic inequalities in sleep quality among Chinese aged 15 years and above: a national population-based study 中国15岁及以上人群睡眠质量的人口统计学和社会经济不平等:一项基于全国人口的研究
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-09 DOI: 10.1016/j.lanwpc.2026.101853
Yingchen Sang , Zhiping Peng , Xinying Zeng , Ying Liu , Youjiao Wang , Xin Gao , Chi Zhang , Ding Zou , Zhili Huang , Fang Han , Shiwei Liu
{"title":"Demographic and socioeconomic inequalities in sleep quality among Chinese aged 15 years and above: a national population-based study","authors":"Yingchen Sang ,&nbsp;Zhiping Peng ,&nbsp;Xinying Zeng ,&nbsp;Ying Liu ,&nbsp;Youjiao Wang ,&nbsp;Xin Gao ,&nbsp;Chi Zhang ,&nbsp;Ding Zou ,&nbsp;Zhili Huang ,&nbsp;Fang Han ,&nbsp;Shiwei Liu","doi":"10.1016/j.lanwpc.2026.101853","DOIUrl":"10.1016/j.lanwpc.2026.101853","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;High-quality sleep is essential for health, yet sleep patterns and their prevalence within the Chinese population remain inadequately characterized. We aimed to estimate the prevalence of poor sleep quality and various sleep characteristics within China, and to explore the social gradients and inequalities in sleep quality to identify vulnerable populations.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;For this nationally representative cross-sectional study, we recruited 46,452 community-based Chinese individuals aged 15 years or older from 420 communities (villages) using a multistage, stratified, cluster-randomized sampling design that considered geographic region, sex and age distribution. Face-to-face questionnaire interviews were conducted to collect self-reported data on demographic characteristics, socioeconomic status, Pittsburgh Sleep Quality Index (PSQI) responses, lifestyle factors, and current chronic disease status. We calculated the prevalence of poor sleep quality (PSQI &gt; 5) and various sleep parameters, as well as analyzed their distribution across various demographic and socioeconomic characteristics. Multivariable logistic regression models were applied to identify factors associated with poor sleep quality in the national sample and by age stratum.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Among Chinese individuals aged 15 years and above, the weighted prevalence was 23.9% (95% CI 21.6–26.2) for poor sleep quality under the PSQI &gt; 5 cutoff threshold, along with prevalence of 53.7% (95% CI 49.8–57.6) for reported sleep disturbances and 1.6% (95% CI 1.3–1.9) for use of hypnotic medication. The weighted mean was 27.5 min (95% CI 26.4–28.5) for sleep latency and 7.2 h (95% CI 7.2–7.3) for sleep duration. Multivariable analysis revealed that the likelihood of poor sleep quality was significantly associated with female sex (odds ratio 1.58 [95% CI 1.37–1.82]), advanced age (45–54 years: 1.56 [1.10–2.23]; 55–64 years: 2.06 [1.43–2.96]; ≥65 years: 2.39 [1.68–3.40]), lower household income (50,000–100,000 Chinese yuan [CNY]: 1.25 [1.07–1.46]; 100,000–200,000 CNY: 1.33 [1.01–1.75]), lower education level (junior high school: 0.84 [0.76–0.92]; high school: 0.78 [0.67–0.91]; university: 0.65 [0.54–0.77]), and occupation (government institution employee: 1.89 [1.31–2.73]; unemployed: 1.22 [1.01–1.46]). Women demonstrated significantly higher weighted prevalence of poor sleep quality compared to men. Beginning at age 25, the sex gap of poor sleep quality prevalence progressively widened from 5.2% (95% CI 0.9–9.6) in the 25–34 years age group to 14.3% (95% CI 10.2–18.4) among those aged 65 and older, with escalating statistical significance (P = 0.02 to P &lt; 0.001). No statistically significant associations were found between residence location and the prevalence of poor sleep quality (P &gt; 0.05). The factors associated with poor sleep quality were largely similar across age groups, with several important differenc","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101853"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147710577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increased burden of invasive group A streptococcal disease among Australian children, 2023–2024: a prospective cohort study 2023-2024年澳大利亚儿童侵袭性A组链球菌疾病负担增加:一项前瞻性队列研究
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-09 DOI: 10.1016/j.lanwpc.2026.101850
Yara-Natalie Abo , Jane Oliver , Alissa McMinn , Joshua Osowicki , Julia E. Clark , Christopher C. Blyth , Joshua R. Francis , Philip N. Britton , Jeremy P. Carr , Pierre R. Smeesters , Nigel W. Crawford , Andrew C. Steer
{"title":"Increased burden of invasive group A streptococcal disease among Australian children, 2023–2024: a prospective cohort study","authors":"Yara-Natalie Abo ,&nbsp;Jane Oliver ,&nbsp;Alissa McMinn ,&nbsp;Joshua Osowicki ,&nbsp;Julia E. Clark ,&nbsp;Christopher C. Blyth ,&nbsp;Joshua R. Francis ,&nbsp;Philip N. Britton ,&nbsp;Jeremy P. Carr ,&nbsp;Pierre R. Smeesters ,&nbsp;Nigel W. Crawford ,&nbsp;Andrew C. Steer","doi":"10.1016/j.lanwpc.2026.101850","DOIUrl":"10.1016/j.lanwpc.2026.101850","url":null,"abstract":"<div><h3>Background</h3><div>Global rates of invasive Group A <em>Streptococcus</em> (iGAS) disease surged from September 2022, exceeding pre-COVID-19 pandemic levels, showing atypical seasonality and disproportionately affecting children. We previously described the epidemiology of iGAS among Australian children from mid-2018 to end 2022 using data from the Paediatric Active Enhanced Diseases network and here provide updated clinical epidemiology for 2023 and 2024 to help inform public health strategies.</div></div><div><h3>Methods</h3><div>Prospective surveillance of 0–17-year-olds with iGAS admitted to six tertiary hospitals in five Australian states/territories in 2023 and 2024. Confirmed cases had GAS detected from ≥1 sterile site specimen; probable cases had detection of GAS in ≥1 non-sterile site specimen and diagnosis of septic shock, streptococcal toxic shock syndrome or necrotising fasciitis.</div></div><div><h3>Findings</h3><div>In 2023, the annualised incidence was 5.10 per 100,000 (95% CI 4.50–5.75, n = 263 cases) and dropped significantly in 2024 (annualised incidence 2.13, 95% CI 1.75–2.57, n = 111 cases). Quarter three peaks were not as predominant across 2023 and 2024 compared to usual patterns. Intensive care unit admission occurred among 147/374 (39%) children with six deaths. At discharge, 137/374 (37%) had not returned to premorbid function. Respiratory virus co-infection was found among 133/267 (49.8%) patients tested and was associated with higher risk of severe disease, RR 1.6 (95% CI 1.26–2.07). Adjunctive clindamycin, linezolid or intravenous immunoglobulin was used in 201/374 (54%), including 126/147 (86%) of severe disease cases.</div></div><div><h3>Interpretation</h3><div>We have captured the end of post-COVID-19 pandemic iGAS surge in sentinel Australian paediatric hospitals. High iGAS incidence peaked in 2023, before reducing to similar pre-pandemic incidence in 2024. The dynamic epidemiology and persistent burden of disease highlight the need for continued vigilant public health efforts, surveillance, and vaccine development.</div></div><div><h3>Funding</h3><div>This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101850"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147711184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
China’s nationwide antimicrobial resistance surveillance networks: a systematic analysis from One Health perspective 中国全国抗菌素耐药性监测网络:“一个健康”视角下的系统分析
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-03-30 DOI: 10.1016/j.lanwpc.2026.101848
Weibin Li , Lianping Yang , Fenqi Du , Xiaodong Guan , Haishaerjiang Wushouer
{"title":"China’s nationwide antimicrobial resistance surveillance networks: a systematic analysis from One Health perspective","authors":"Weibin Li ,&nbsp;Lianping Yang ,&nbsp;Fenqi Du ,&nbsp;Xiaodong Guan ,&nbsp;Haishaerjiang Wushouer","doi":"10.1016/j.lanwpc.2026.101848","DOIUrl":"10.1016/j.lanwpc.2026.101848","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) poses a growing threat to human, animal, and environmental health, necessitating integrated surveillance systems to effectively address this challenge. Globally, many countries have committed to expanding AMR monitoring under their national action plans, yet the development and alignment of surveillance systems across different sectors remain insufficiently documented, likewise in China with rapid economic transformation and severe health challenges. Using the EPI-Net One Health reporting guideline, we reviewed 13 nationwide AMR surveillance networks in China. The findings demonstrate notable progress in sector-specific surveillance, particularly within human and animal sector. However, gaps persist in environmental monitoring, cross-sector integration, methodological standardization, and data sharing, which constrain the generation of high-quality, comprehensive AMR data. These findings highlight the urgent need for increased investment in advanced technologies like whole-genome sequencing (WGS), alongside broader stakeholder engagement and clearer consensus on data governance and data-sharing mechanisms to strengthen AMR surveillance from One Health perspective.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"69 ","pages":"Article 101848"},"PeriodicalIF":8.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147603589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Democratising stroke recovery: a global, multilingual digital public good 民主化中风康复:一个全球性的、多语言的数字公共产品
IF 8.1 1区 医学
The Lancet Regional Health: Western Pacific Pub Date : 2026-04-01 Epub Date: 2026-04-09 DOI: 10.1016/j.lanwpc.2026.101859
Valery L. Feigin
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引用次数: 0
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