{"title":"Clinical conferences at The Johns Hopkins Hospital: Kaposi's sarcoma.","authors":"A F Hood, E R Farmer, R A Weiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kaposi's sarcoma is a multifocal neoplasm of the reticuloendothelial system which has generated great interest recently because of its association with immunosuppressive therapy and its occurrence within a group of homosexual men. Our case demonstrates a relationship between the discontinuation of immunosuppressive therapy and tumor regression in a renal transplant recipient. The clustering of cases in geographic areas and within ethnic groups implies that both heriditary and environmental factors contribute to the pathogenesis of this tumor. Recently described cases have occurred in a setting of multiple infections and concurrent impairment of cell mediated immunity. This suggests that Kaposi's sarcoma may be a model of chronic antigen stimulation leading to decreased immune responsiveness and subsequent unchecked growth of transformed cells.</p>","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 5","pages":"222-30"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17807335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rectosigmoidal adenocarcinoma after successful pull-through for imperforate anus and rectourethral fistula: a footnote to Dr. Hugh Young's 1933 operation.","authors":"H C Polk, J P Welch, H S Nagaraj, M Amin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"151-4"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F R Brown, M A Van Duyn, A B Moser, J D Schulman, W B Rizzo, R D Snyder, J V Murphy, S Kamoshita, C J Migeon, H W Moser
{"title":"Adrenoleukodystrophy: effects of dietary restriction of very long chain fatty acids and of administration of carnitine and clofibrate on clinical status and plasma fatty acids.","authors":"F R Brown, M A Van Duyn, A B Moser, J D Schulman, W B Rizzo, R D Snyder, J V Murphy, S Kamoshita, C J Migeon, H W Moser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"164-72"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The patient as partner: ethics in clinical oncology research.","authors":"R M Veatch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"155-61"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Colitic arthritis.","authors":"M C Hochberg, R S Feinstein, R L Moser, M J Ryan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"173-80"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S J Peroutka, B H Sohmer, A J Kumar, M Folstein, R G Robinson
{"title":"Hallucinations and delusions following a right temporoparietooccipital infarction.","authors":"S J Peroutka, B H Sohmer, A J Kumar, M Folstein, R G Robinson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"181-5"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disability from aminoglycoside-induced vestibular paralysis.","authors":"L R Proctor","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"162-3"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mannosidosis in an adult.","authors":"T R Montgomery, G H Thomas, D L Valle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":" ","pages":"113-21"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40724617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pseudohypoparathyroidism.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The current understanding of the adenylate cyclase complex has permitted us to regard PHP has a heterogeneous group of disorders related to each other through the common feature of resistance to PTH. Patients may present with hormone resistance limited to PTH, or with a metabolic disorder attributable to the resistance of multiple tissues to hormones that activate adenylate cyclase. The majority of the latter patients show deficient G-unit activity. The clinical expression of multiple hormone resistance in patients with the G-unit defect appears to be rather variable, despite an identical quantitative defect; hormone resistance seems incomplete, and patients may be hypocalcemic despite the presence of hyperparathyroid bone disease. It is therefore likely that the detailed biochemical study of patients with PHP may ultimately reveal a multiplicity of abnormalities in the hormone-receptor adenylate cyclase system that will explain the variability of hormone resistance.</p>","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 3","pages":"137-46"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17349046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sperm nuclear packing and regulation during spermatogenesis and fertilization.","authors":"B R Zirkin, D A Soucek, T S Chang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 3","pages":"101-12"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17862607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}