The Johns Hopkins medical journal最新文献

{"title":"Lupus nephritis.","authors":"Annie Y. Suh, Robert M. Rosa","doi":"10.1142/9789812384768_0007","DOIUrl":"https://doi.org/10.1142/9789812384768_0007","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"53 1","pages":"101-6"},"PeriodicalIF":0.0,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79114253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tardive dyskinesia.","authors":"P. V. Rabins, L. E. Tune, P. McHugh","doi":"10.1891/9780826179340.0378","DOIUrl":"https://doi.org/10.1891/9780826179340.0378","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"7 1","pages":"206-11"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84724348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated intravascular coagulation.","authors":"Daniel Bell, Taha Khan","doi":"10.53347/rid-64952","DOIUrl":"https://doi.org/10.53347/rid-64952","url":null,"abstract":"Disseminated intravascular coagulation (DIC) is a clinico-pathological syndrome of variable expression, resulting from uncontrolled simultaneous activation of the coagulation and fibrinolytic systems. DIC can be initiated in a variety of different ways. Additional studies are needed to determine the importance of vascular endothelial damage, hemodynamic alterations and the role of naturally occurring inhibitors of hemostasis. Progressive increase in our understanding of the mechanisms involved in triggering DIC will improve our therapeutic measures in the rational management of these patients. Absolutely essential in the successful management of patients with DIC is identification and control of the underlying illness.","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"11 2","pages":"289-99"},"PeriodicalIF":0.0,"publicationDate":"2018-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72619680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-1-antitrypsin deficiency.","authors":"B. Fahy, S. Lareau, P. Meek, C. Strange","doi":"10.1164/RCCM.19812P23","DOIUrl":"https://doi.org/10.1164/RCCM.19812P23","url":null,"abstract":"People with alpha-1 antitrypsin deficiency usually develop the first signs and symptoms of lung disease between ages 20 and 50. The earliest symptoms are shortness of breath following mild activity, reduced ability to exercise, and wheezing. Other signs and symptoms can include unintentional weight loss, recurring respiratory infections, fatigue, and rapid heartbeat upon standing. Affected individuals often develop emphysema, which is a lung disease caused by damage to the small air sacs in the lungs (alveoli). Characteristic features of emphysema include difficulty breathing, a hacking cough, and a barrel-shaped chest. Smoking or exposure to tobacco smoke accelerates the appearance of emphysema symptoms and damage to the lungs.","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"38 1","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2018-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88315122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymyalgia rheumatica.","authors":"W. R. Bell, H. F. Klinefelter","doi":"10.1007/springerreference_61553","DOIUrl":"https://doi.org/10.1007/springerreference_61553","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"69 1","pages":"175-87"},"PeriodicalIF":0.0,"publicationDate":"2015-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88956496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rapid diagnosis of viral infections.","authors":"M. Loeffelholz","doi":"10.1309/E505-UL0Y-QX7A-JFMC","DOIUrl":"https://doi.org/10.1309/E505-UL0Y-QX7A-JFMC","url":null,"abstract":"283 © The laboratory diagnosis of viral infections traditionally has been considered a lengthy process, providing results that may have minimal clinical impact. Specimens inoculated into cell culture tubes typically require incubation for several days prior to development of cytopathic effect or detection by methods such as hemadsorption. Culture tubes are often observed for 2 weeks or longer before reporting negative results. However, significant advances during the past 10 to 15 years in the development of viral diagnostic tests provide rapid and more useful results. Cell culture incubation times have been shortened significantly with the use of centrifugation enhanced shell vials. Methodologies that detect viral antigens or nucleic acids directly in patient specimens can be completed in minutes or hours. Decreased sensitivity and speci-ficity may accompany improved time to detection. The costs required to perform newer, rapid tests versus traditional culture methods are additional considerations. Rapid tests may have unique specimen requirements. All of these issues must be weighed carefully when considering which tests to offer. Respiratory Viruses Rapid tests have had more impact on the detection of respiratory viruses than any other group of viruses. Indeed, studies have demonstrated a number of positive outcomes of rapid detection of respiratory viruses in hospitalized patients, including decreased length of hospitalization, patient isolation, costs, and better use of antibiotics. 1,2 Respiratory viruses that are frequently identified by both traditional and rapid methods include influenza virus, respiratory syncytial virus (RSV), adenovirus, and parainfluenza virus. All of these viruses will grow in commonly available cell lines in tube cultures and are usually detectable after several days of incubation. However, influenza and parainfluenza viruses may not produce discernible cytopathic effect (CPE), requiring blind hemadsorption or immuno-fluorescence staining of cells. Respiratory syncytial virus is more labile than other respiratory viruses. Titers decrease rapidly during specimen transport, even at 4°C. Culture is therefore a relatively insensitive test for RSV. Non-culture methods perform well in comparison. Rapid non-culture tests used routinely to detect respiratory viruses include direct immunofluorescence assay (DFA) and anti-gen/enzyme assays employing solid membrane surfaces. Centrifugation-enhanced shell vials provide rapid culture detection of respiratory viruses. The DFA procedure utilizes fluorochrome (usually fluorescein isothiocyanate)-labeled monoclonal anti-bodies for the staining of viral antigens within infected cells. Following excitation, fluorochromes emit light at specific wavelengths. Fluorescein isothiocyanate appears apple green when excited by ultraviolet light. The DFA procedure can be performed on a variety of respiratory specimens including swabs …","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"19 1","pages":"126-31"},"PeriodicalIF":0.0,"publicationDate":"2002-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78948528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulinoma.","authors":"장혁재, 한덕종, 박건춘, 이기업","doi":"10.1016/b978-1-4160-3969-3.00217-1","DOIUrl":"https://doi.org/10.1016/b978-1-4160-3969-3.00217-1","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"1969 1","pages":"118-23"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91378950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical therapy of complex partial epilepsy.","authors":"R S Fisher, S Uematsu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 6","pages":"332-43"},"PeriodicalIF":0.0,"publicationDate":"1982-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18192579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"True hermaphroditism.","authors":"G D Berkovitz,&nbsp;J A Rock,&nbsp;M D Urban,&nbsp;C J Migeon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Eleven cases of true hermaphroditism (eight previously reported) studied at The Johns Hopkins Hospital are presented. The two most recently observed patients had what is to be considered an appropriate endocrine evaluation. This includes karyotyping, and measurement of 24-hour urinary 17-ketosteroids, gonadotropins, plasma testosterone, dihydrotestosterone, and all their precursors before and following a human chorionic gonadotropin stimulation test, and a sexual skin biopsy for androgen receptor binding and 5 alpha-reductase activity. The differential diagnosis of true hermaphroditism is discussed and an approach to gender assignment is presented.</p>","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 6","pages":"290-7"},"PeriodicalIF":0.0,"publicationDate":"1982-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18192576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic epidermal necrolysis.","authors":"E J Seifter,&nbsp;T T Provost,&nbsp;E R Farmer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 6","pages":"326-31"},"PeriodicalIF":0.0,"publicationDate":"1982-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18192578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}