The American journal of pediatric hematology/oncology最新文献_第6页

Acute splenic sequestration in the absence of palpable splenomegaly. 未见明显脾肿大的急性脾隔离。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

J R Casey, T R Kinney, R E Ware

引用次数: 0

Treatment of refractory Evans syndrome with alternate-day cyclosporine and prednisone. 环孢素与强的松隔日联合治疗难治性埃文斯综合征。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

W R Rackoff, C S Manno

引用次数: 0

Erythroid progenitors in the peripheral blood of children with sickle cell disease. 镰状细胞病患儿外周血中的红系祖细胞。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

T B West, K Ohene-Frempong, C J Stoeckert, S Surrey

{"title":"Erythroid progenitors in the peripheral blood of children with sickle cell disease.","authors":"T B West, K Ohene-Frempong, C J Stoeckert, S Surrey","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The goals of this study were (a) to determine the number of peripheral blood burst forming units-erythroid (BFU-E); (b) to define the relationship between circulating BFU-E number and fetal hemoglobin (HbF) level; and (c) to define the relationship between BFU-E number and age in pediatric sickle cell disease (SCD) patients.Patients and methods: Fetal hemoglobin (HbF) level and peripheral blood BFU-E number were determined in children < 18 years of age with SCD in a steady state of their disease. These data were compared with those of normal children.Results: An increased number of BFU-E was observed in the peripheral blood of children with SCD compared with normals (30.7 vs. 15.7 per 10(5) mononuclear cells, respectively; p = 0.009). Overall there was the suggestion of a direct relationship between HbF level and peripheral blood BFU-E number (regression coefficient = 0.445; p = 0.06). Additionally, a strong inverse relationship between BFU-E number and age (regression coefficient = -0.671; p < 0.0001) was observed.Conclusions: In children with SCD (a) there are an increased number of peripheral blood BFU-E compared with normal children; (b) the inverse relationship between HbF level and BFU-E number observed in adult SCD patients is not seen in children; and (c) there is a strong inverse relationship between age and BFU-E number. This information may help to further clarify the relationship between peripheral blood BFU-E and erythropoietic stress.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 2","pages":"116-9"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18523101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence and possible progression of a pelvic neuroblastoma detected by mass screening during 19 months. 盆腔神经母细胞瘤在19个月的大规模筛查中发现的持续性和可能的进展。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

M L Bernstein, E M Azouz, W Woods, M Tuchman, L Renaud, B Lemieux

{"title":"Persistence and possible progression of a pelvic neuroblastoma detected by mass screening during 19 months.","authors":"M L Bernstein, E M Azouz, W Woods, M Tuchman, L Renaud, B Lemieux","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The preclinical detection of neuroblastoma by screening for elevated levels of urinary catecholamines often leads to the discovery of children with early-stage, biologically favorable disease. It is uncertain how vigorously therapy must be pursued in such cases. We report an infant whose pelvic mass was initially thought to be a fecaloma, and consequently was not treated for 19 months.Case report: A 2-month-old girl was referred for evaluation for the presence of a neuroblastoma because of elevated urinary catecholamines detected in a mass screening program. Although no mass was initially found, urinary catecholamines became increasingly elevated, and a pelvic mass was finally radiologically identified. It was resected. Histology showed it to be a neuroblastoma, POG stage C, International stage 3, with unfavorable Shimada features, although near triploid with an unamplified N-myc oncogene. Chemotherapy was given for five cycles, and the child remains well, with no evidence of disease.Conclusion: Although mass screening programs often detect early- stage, biologically favorable neuroblastomas that may spontaneously regress, our case had rising levels of urinary catecholamines and unfavorable histologic features at the time of resection. The unusual location of the tumor, and radiologic features of a fecaloma, contributed to the delay in definitive diagnosis, although persistence of elevated urinary catecholamines in the absence of a tumor is infrequent.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 2","pages":"164-6"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19156849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic resonance imaging visualization of hemorrhage into a suprapatellar pouch in a child with hemophilia. 血友病患儿髌上囊出血的磁共振成像显示。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

R Nuss, R Kilcoyne, S Geraghty, R Wilkins, J Wiedel, M Manco-Johnson

引用次数: 0

Multivariate evaluation of prognostic factors in localized neuroblastoma. 局部神经母细胞瘤预后因素的多因素评价。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

F Berthold, R Kassenböhmer, J Zieschang

{"title":"Multivariate evaluation of prognostic factors in localized neuroblastoma.","authors":"F Berthold, R Kassenböhmer, J Zieschang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: A multitude of risk factors has been described for patients with neuroblastoma. Little is known about the mutual interrelationship of these factors and their impact on patients with localized disease only.Patients and methods: We investigated the possible influence of 37 variables univariately on event-free survival (EFS) in 308 consecutive patients with neuroblastoma stages I-III using Kaplan-Meier estimates. The chi 2 test was applied to detect nonrandom correlations, and the Cox's regression model was used for the multivate evaluation of identified factors.Results: Seventeen factors appeared to influence EFS in stage I-III patients (p < 0.05, log-rank > 3.84), whereas 10 factors were found in the subgroup of stage III patients with midline crossing tumors (= stage III*, n = 128). The majority of univariately identified risk factors showed a nonrandom correlation to several others (p < 0.05). The multivariate analysis according to Cox selected for the patients with stages I-III the factors lactate dehydrogenase (LDH) (p = 0.0011), resectability (p = 0.0167), weight loss (p = 0.0185), tumor extension beyond midline (p = 0.0207), and age (p = 0.0233). For stage III* patients the model identified the factors LDH (p = 0.0089), weight loss (p = 0.0135), resectability (p = 0.0408), and age (p = 0.0700). The identification of these independent risk factors permitted the description of risk groups with EFS ratios after > 6 years between 22% and 96%.Conclusions: Risk estimation of high discriminating power is possible for patients with localized neuroblastoma using simple, readily available clinical data.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 2","pages":"107-15"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19157702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of heparin anticoagulation for neonatal renal vein thrombosis. 肝素抗凝治疗新生儿肾静脉血栓的疗效和安全性。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

R Nuss, T Hays, M Manco-Johnson

{"title":"Efficacy and safety of heparin anticoagulation for neonatal renal vein thrombosis.","authors":"R Nuss, T Hays, M Manco-Johnson","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: We report on the safety and efficacy of heparin anticoagulation for the treatment of neonatal renal vein thrombosis.Patients and methods: Six consecutive, prospectively identified, critically ill neonates with renal vein thrombosis were studied. Diagnosis of renal vein thrombosis was based on history and examination and confirmed with renal ultrasound. All neonates were treated with continuous i.v. heparin titrated to achieve a therapeutic whole blood clotting time and/or APTT.Results: Renal vein thrombosis was bilateral for three of six neonates. Heparin infusion rates varied from 8 to 40 U/kg/h and were administered for 7-14 days. Two neonates developed hemorrhagic complications; one had disseminated intravascular coagulation but did not hemorrhage until heparin toxicity ensued, and another was well until an umbilical catheter was removed while he was therapeutically heparinized. Renal outcome at 3 months to 6 years showed hypertension in one neonate, atrophic kidneys in two, and both hypertension and an atrophic kidney in one.Conclusions: Bleeding was a significant complication of heparin therapy for neonatal renal vein thrombosis. Renal dysfunction was not prevented in four of six neonates treated with heparin. Alternative approaches to titrate heparin, alternative anticoagulants, or fibrinolytic therapy should be considered as therapy for neonatal renal vein thrombosis.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 2","pages":"127-31"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19157704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A cost comparison of laboratory charges in treating childhood leukemia. A children's cancer group analysis. 治疗儿童白血病实验室费用的成本比较。儿童癌症组分析。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

P V Baranko

引用次数: 0

Yersinia enterocolitica infection in a patient with sickle cell disease after exposure to chitterlings. 镰状细胞病患者接触猪肠后的小肠结肠炎耶尔森菌感染。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

J J Stoddard, D S Wechsler, J P Nataro, J F Casella

{"title":"Yersinia enterocolitica infection in a patient with sickle cell disease after exposure to chitterlings.","authors":"J J Stoddard, D S Wechsler, J P Nataro, J F Casella","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: We describe certain clinical, epidemiologic, and host-susceptibility features of Yersinia enterocolitica infection in the context of a patient with underlying risk factors.Patients and methods: A 10-year-old black girl with sickle cell disease receiving chelation therapy for iron overload resulting from chronic transfusion therapy was admitted with acute abdominal pain and fever.Results: Upon hospital admission, differential diagnoses included enterocolitis, appendicitis, and vasoocclusive crisis. On the 6th hospital day, the patient's stool culture became positive for Y. enterocolitica. Household exposure to raw pork intestines (chitterlings) was the presumed source of the infection. Deferoxamine therapy was withheld, and antibiotic therapy was administered with subsequent clinical improvement.Conclusions: Y. enterocolitica infection should be considered as a cause of abdominal pain mimicking appendicitis in patients with underlying risk factors (including certain sickle cell patients). History of exposure to raw or undercooked pork products and appropriate cultures should be obtained. Deferoxamine therapy should be withheld in iron-overloaded patients presenting with such symptoms because deferoxamine and iron overload constitute independent risk factors for Yersinia infection. Such patients should be advised to avoid potential exposures to this pathogen.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 2","pages":"153-5"},"PeriodicalIF":0.0,"publicationDate":"1994-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19157707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive response to granulocyte-colony-stimulating factor in dyskeratosis congenita before matched unrelated bone marrow transplantation. 配对非相关骨髓移植前先天性角化不良患者粒细胞集落刺激因子阳性反应。

The American journal of pediatric hematology/oncology Pub Date : 1994-05-01

S L Pritchard, A K Junker

引用次数: 0