The American journal of pediatric hematology/oncology最新文献_第10页

Acute lymphoid leukemia associated with Maffucci's syndrome. 急性淋巴性白血病与马氏综合征相关。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

J T Rector, C L Gray, R W Sharpe, F W Hall, W Thomas, W Jones

{"title":"Acute lymphoid leukemia associated with Maffucci's syndrome.","authors":"J T Rector, C L Gray, R W Sharpe, F W Hall, W Thomas, W Jones","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Maffucci's syndrome is a nonhereditary congenital disorder associated with multiple enchondromas, soft tissue hemangiomas, or lymphangiomas. It carries an associated high risk of the development of malignant neoplasms, particularly sarcomatous transformation of an enchondroma, as well as other malignant mesodermal and nonmesodermal neoplasms. Hematopoietic malignancies arising in Maffucci's syndrome are exceedingly rare. We report the case of a 14-year-old girl with Maffucci's syndrome who developed acute lymphoid leukemia.Patients and methods: The patient presented at 18 months of age with enchondromatosis. Maffucci's syndrome was established at 10 years of age after the appearance of multiple hemangiomas.Results: At 14 years of age the patient developed fatigue, frequent nosebleeds, easy bruising, and weight loss, with circulating blasts in the peripheral blood. Bone marrow examination showed replacement of marrow spaces with leukemic blasts. Immunohistochemical and flow cytometric findings were consistent with a diagnosis of acute lymphoblastic leukemia with myeloid antigen expression.Conclusions: The occurrence of acute leukemia in a patient with Maffucci's syndrome may represent predisposition to yet another malignancy and reflect further expression of a generalized mesodermal dysplasia in these patients. It also emphasizes the need for aggressive surveillance in patients with Maffucci's syndrome.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"15 4","pages":"427-9"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19204089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yersinia enterocolitica bacteremia in a chronically transfused patient with sickle cell anemia. Case report and review of the literature. 镰状细胞性贫血慢性输血患者的小肠结肠炎耶尔森菌血症。病例报告及文献复习。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

F Blei, D R Puder

{"title":"Yersinia enterocolitica bacteremia in a chronically transfused patient with sickle cell anemia. Case report and review of the literature.","authors":"F Blei, D R Puder","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Yersinia enterocolitica sepsis is rarely encountered in patients without an underlying susceptibility and is most frequently reported in iron-overloaded patients. This is thought to be related to the unusual utilization of iron by this microorganism. We report a case of Y. enterocolitica bacteremia in a chronically transfused adolescent with sickle cell anemia. This type of serious infection in sickle cell disease is previously unreported. A description of the case and the relationship between Y. enterocolitica and iron is discussed. A review of the literature is presented.Results: Y. enterocolitica can cause a severe septicemia, and increased virulence of this organism has been shown to correlate with increased iron burden and/or use of the chelator deferoxamine. It may also occur as a consequence of a contaminated blood transfusion.Conclusions: We believe our case demonstrates that Y. enterocolitica should be considered a possible pathogen in febrile chronically transfused patients with sickle cell disease. Broad antibiotic coverage should be initiated and deferoxamine discontinued pending results of cultures.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"15 4","pages":"430-4"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19204090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features of primary human herpesvirus-6 infection in an infant with acute lymphoblastic leukemia. 急性淋巴细胞白血病婴儿原发性人疱疹病毒-6感染的临床特征

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

T Yoshikawa, I Kobayashi, Y Asano, T Nakashima, T Yazaki, S Kojima, A Yamada

引用次数: 0

Thrombosis in children receiving L-asparaginase. Determining patients at risk. 服用l -天冬酰胺酶的儿童血栓形成。确定高危患者。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

A D Shapiro, S L Clarke, J M Christian, L F Odom, W E Hathaway

引用次数: 0

Tumor necrosis factor-alpha in malignant disease. 肿瘤坏死因子在恶性疾病中的作用。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

J Abrahamsson, B Carlsson, L Mellander

引用次数: 0

The role of tranexamic acid in the treatment of giant hemangiomas in newborns. 氨甲环酸在新生儿巨血管瘤治疗中的作用。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

A B Morad, K L McClain, A K Ogden

引用次数: 0

Transient abnormal myelopoiesis of infancy associated with trisomy 21. 与21三体相关的婴儿短暂性骨髓异常。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

A C Homans, A M Verissimo, V Vlacha

{"title":"Transient abnormal myelopoiesis of infancy associated with trisomy 21.","authors":"A C Homans, A M Verissimo, V Vlacha","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: A unique myelodysplastic syndrome referred to as transient abnormal myelopoiesis (TAM) has been reported to occur primarily in infants with Down's syndrome (DS) or other abnormalities of chromosome 21. This disorder raises basic questions regarding the pathogenesis of leukemia, yet its natural history is poorly documented and derives from small series and isolated case reports.Patients and methods: To better characterize TAM, we accumulated data on 35 cases identified through a questionnaire mailed to pediatric oncologists in the United States. These cases, pooled with two that we recently encountered, and 58 comparable cases reported in the literature comprise a series of 95 cases of TAM in DS.Results: The patients in this series were notable for the high morbidity and mortality of this reportedly benign condition. Eleven percent of the patients died during the initial event, and the overall mortality for the entire series was 27%. Twenty-eight of the 85 patients (33%) who survived the initial event developed a subsequent hematologic disorder, most often acute nonlymphocytic leukemia, at a median age of 16 months.Conclusions: No initial clinical or hematologic features predicted the development of a subsequent hematologic disorder. However, those patients initially mosaic for the presence of trisomy 21 did not develop subsequent abnormalities. This series reviews questions regarding leukemogenesis in DS and underscores the importance of conducting future prospective studies of this unique hematologic disorder.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"15 4","pages":"392-9"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19204083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B19 parvovirus-induced anemia in a normal child. Initial bone marrow erythroid hyperplasia and response to intravenous immunoglobulin. 正常儿童B19细小病毒引起的贫血。初始骨髓红细胞增生和对静脉注射免疫球蛋白的反应。

The American journal of pediatric hematology/oncology Pub Date : 1993-11-01

J C Murray, M V Gresik, F Leger, K L McClain

引用次数: 0

Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients. 软组织周围神经上皮瘤。回顾性分析15例儿科患者。

The American journal of pediatric hematology/oncology Pub Date : 1993-08-01

C C Silliman, G W Mierau, J D Strain, Y White, L McNeely, H Wilson, L McGavran, J W Cullen

{"title":"Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients.","authors":"C C Silliman, G W Mierau, J D Strain, Y White, L McNeely, H Wilson, L McGavran, J W Cullen","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: The purpose of this study was to determine the clinical outcome for pediatric patients with peripheral neuroepithelioma treated with combined modality therapy and followed long enough to account for late relapses.Patients and methods: Fifteen patients, ages 3 3/12 to 19 10/12 years, with peripheral neuroepithelioma (median follow-up 91 months) were diagnosed at The Children's Hospital, Denver, Colorado over the period 1980-1989. All of these malignancies originated in the soft tissues. A critical review of these cases was performed with particular consideration given to the site and stage of the tumor and to the radiographic findings at presentation. Thirteen patients had bulk (> 5 cm in the greatest dimension) or metastatic disease. Four patients had primary tumors involving the chest wall. All patients received chemotherapy, which included at least doxorubicin, vincristine, and cyclophosphamide. Definitive surgical resections were performed on 13 of 15 patients.Results: Five patients relapsed. Three were late relapses 24-44 months after diagnosis. Three of the five patients who relapsed had chest wall primaries. There were three deaths in this series due to peripheral neuroepithelioma and one due to sepsis. The overall survival was 68.5%, and the recurrence-free, survival 55.2%. Two patients with pulmonary relapses were treated with surgery and intensive chemotherapy and remain free of disease > 51 months following recurrence.Conclusions: Combined treatment modalities appear to be important for optimal outcome. This series represents the first report of favorable outcome of peripheral neuroepithelioma using a series with follow-up that is long enough to account for late relapses.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"15 3","pages":"299-305"},"PeriodicalIF":0.0,"publicationDate":"1993-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19314978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Megakaryocytes and megakaryocyte progenitors in human cord blood. 人脐带血中的巨核细胞和巨核细胞祖细胞。

The American journal of pediatric hematology/oncology Pub Date : 1993-08-01

T A Olson

引用次数: 0