The American journal of pediatric hematology/oncology最新文献_第2页

Use of caudal block for pain control following bone marrow harvest in children. 儿童骨髓采集后使用尾侧阻滞控制疼痛。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

B Tesno, M B Jones, L Yu, D A Wall

引用次数: 0

Prevalence of antibodies to hepatitis C virus in transfused children with cancer. 癌症输血儿童丙型肝炎病毒抗体的流行

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

P M Monteleone, C Andrzejewski, J F Kelleher

{"title":"Prevalence of antibodies to hepatitis C virus in transfused children with cancer.","authors":"P M Monteleone, C Andrzejewski, J F Kelleher","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Hepatitis C virus (HCV) transmission is a well-documented complication of blood transfusions, although data on transfused children with cancer is sparse. Using a newer assay for anti-HCV antibodies, the prevalence of HCV infection was determined in a population of children with cancer in the United States.Patients and methods: Forty-five transfused children with cancer were studied for evidence of HCV infection. Patients had not received chemotherapy for a mean of 2.3 years or transfusions for a mean of 3.1 years before being evaluated. Levels of serum aminotransferases [aspartate aminotransferase and alanine aminotransferase (ALT)], hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), and hepatitis B core antibody (HBcAb) were assessed. A second-generation enzyme immunoassay (EIA) was used to screen for anti-HCV antibodies. Positive EIAs were supplemented by a radioimmunoblot assay (RIBA-2).Results: No patient tested positively for HBsAg, HBsAb, or HBcAb; four of 45 (8.9%) were positive for HCV antibodies by EIA. Three of the four (6.7% of the total) were also positive by RIBA-2 testing. The mean number of donor exposures was not significantly different between HCV-negative versus RIBA-2-positive patients (23.1 vs. 61.7, p = 0.16). ALT levels off therapy and peak ALT levels during therapy were significantly higher in the RIBA-2-positive group versus the HCV-negative group, although 36% of all patients (16 of 45) had at least one elevation in ALT greater than twice the upper limit of normal. All three RIBA-2-positive patients were transfused before institution of universal screening of blood donors for HCV in 1990 and had hepatomegaly noted at least once.Conclusions: We have identified a small group of children who may be at high risk for developing chronic active hepatitis and cirrhosis. Testing for HCV should be a routine part of long-term follow-up in children treated for cancer.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 4","pages":"309-13"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient erythroblastopenia of childhood. Prospective study of fifty patients. 儿童期短暂性红细胞减少症。对50例患者进行前瞻性研究。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

I Cherrick, G Karayalcin, P Lanzkowsky

{"title":"Transient erythroblastopenia of childhood. Prospective study of fifty patients.","authors":"I Cherrick, G Karayalcin, P Lanzkowsky","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To prospectively evaluate 50 patients with transient erythroblastopenia of childhood (TEC) at a single institution in order to compare those patients presenting with reticulocytopenia (group I) with those presenting in the recovery phase with reticulocytosis (group II); to further describe the clinical course of this common pediatric hematological disorder in a large number of patients, particularly the effect on the neutrophils; and to review the available literature regarding this disorder.Patients and methods: Fifty patients presenting to the Children's Hospital from September 1983 to September 1991 were prospectively evaluated. Those patients with a reticulocytosis and in recovery at the time of diagnosis were included and compared with those with reticulocytopenia. All patients were followed through complete recovery.Results: Thirty-six patients were reticulocytopenic (group I) and 14 had a reticulocytosis (group II). There was a high incidence of neutropenia (64%) in both groups and the resolution of this neutropenia was variable in relation to the resolution of the anemia, with 44% having the lowest ANC before, 9% simultaneous with, and 47% after the peak reticulocyte count.Conclusions: Our experience with a large group of patients with TEC suggests that neutropenia is an integral part of this disorder, and its recovery has no relation to the recovery of the anemia. A significant number of patients are described in the recovery phase for the first time, and this clarifies this group of patients in order to aid in their diagnosis, particularly in the differentiation from a hemolytic process. Some previously described associations of TEC are not supported in this study of a large number of patients.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 4","pages":"320-4"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secondary acute promyelocytic leukemia in a child treated with epipodophyllotoxins. 儿童继发性急性早幼粒细胞白血病1例。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

J A Lopez-Andrew, J Ferrís, A Verdeguer, C Esquembre, M L Senent, V Castel

引用次数: 0

Typhlitis in a patient with acute lymphoblastic leukemia prior to the administration of chemotherapy. 急性淋巴细胞白血病患者化疗前的斑疹伤寒。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

A F Paulino, R Kenney, E N Forman, L J Medeiros

引用次数: 0

Transient erythroblastopenia of the newborn caused by human parvovirus. 由人细小病毒引起的新生儿短暂性红细胞减少症。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

O Tugal, B Pallant, N Shebarek, S Jayabose

引用次数: 0

Refining therapeutic strategies for patients with resistant Wilm's tumor. 改进耐药Wilm肿瘤患者的治疗策略。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

N M Marina, J A Wilimas, W H Meyer, D P Jones, E C Douglass, C B Pratt

{"title":"Refining therapeutic strategies for patients with resistant Wilm's tumor.","authors":"N M Marina, J A Wilimas, W H Meyer, D P Jones, E C Douglass, C B Pratt","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: Despite the excellent prognosis for 90% of patients with Wilms' tumor, survival remains poor among those with recurrent or advanced disease or tumors of unfavorable histology. We sought to identify a chemotherapy regimen for this subset of patients that offers potential efficacy with minimal nephrotoxicity.Patients and methods: Through a review of patients' medical records, we compared the efficacy and nephrotoxicity of ifosfamide, cisplatin, cisplatin/etoposide, and ifosfamide/carboplatin/etoposide (ICE) regimens in 32 patients with recurrent (n = 23), refractory (n = 1), or metastatic (n = 8) Wilms' tumor, including six with tumors having unfavorable histologic features.Results: Single-agent ifosfamide was minimally nephrotoxic and induced responses in three of 11 patients, but none have survived. Cisplatin with or without etoposide induced responses in six of 18 patients with recurrent Wilms' tumor (there is one long-term survivor). Seven of eight patients with newly diagnosed extensive metastatic disease responded to cisplatin/etoposide plus vincristine, dactinomycin, adriamycin, and radiotherapy. This regimen produced three long-term survivors, but was associated with significant nephrotoxicity. The ifosfamide, carboplatin, and etoposide regimen induced responses in four of five patients treated, and had minimal nephrotoxicity. Two remain free of disease progression 22 months after recurrence.Conclusions: Although long-term survival remains to be determined, the ICE combination appears to be effective against recurrent Wilms' tumor without endangering the patients' single remaining kidney. Myelotoxicity can be ameliorated by administering growth factors. We suggest that ICE chemotherapy be considered for the primary treatment of high-risk patients with Wilms' tumor.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 4","pages":"296-300"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18973432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal malignancy involving the products of conception: a report of malignant melanoma and medulloblastoma. 母体恶性肿瘤涉及的产品受孕:恶性黑色素瘤和髓母细胞瘤的报告。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

J Brossard, S Abish, M L Bernstein, S Baruchel, L Kovacs, R Pollack

引用次数: 0

Transient abnormal myelopoiesis in Down's syndrome neonates. 唐氏综合征新生儿短暂性异常骨髓生成。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

Y L Kwong

引用次数: 0

Chronic parvovirus infection mimicking myelodysplastic syndrome in a child with subclinical immunodeficiency. 慢性细小病毒感染模拟骨髓增生异常综合征的儿童亚临床免疫缺陷。

The American journal of pediatric hematology/oncology Pub Date : 1994-11-01

H Hasle, G Kerndrup, B B Jacobsen, E D Heegaard, A Hornsleth, S T Lillevang

{"title":"Chronic parvovirus infection mimicking myelodysplastic syndrome in a child with subclinical immunodeficiency.","authors":"H Hasle, G Kerndrup, B B Jacobsen, E D Heegaard, A Hornsleth, S T Lillevang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: We present a report of a child with subclinical immunodeficiency who became chronically infected with parvovirus resulting in pancytopenia and morphologic abnormalities in the bone marrow mimicking myelodysplastic syndrome (MDS).Patients: An 8-year-old boy presented with severe anemia, moderate thrombocytopenia and granulocytopenia. The patient showed hyper-immunoglobulin M (IgM) immunodeficiency but no increased susceptibility to infections. The bone marrow was hypercellular with dysplastic granulocytopoiesis and erythroblastopenia.Results: Treatment with cyclosporine and i.v. Ig resulted in temporary normalization of the hemoglobin level. For several years it was assumed that the patient had MDS. A diagnosis of parvovirus infection was initially rejected due to the lack of specific antibodies and the absence of giant pronormoblasts in the bone marrow. When the polymerase chain reaction technique became available, parvovirus DNA was detected from the entire disease course.Conclusions: This case report expands our conception of the clinical spectrum of parvovirus infection and emphasizes that parvovirus must be considered as a differential diagnosis in MDS. We recommend performing a parvovirus DNA test despite negative serologic findings in patients with MDS, especially when associated with immunologic abnormalities.","PeriodicalId":22558,"journal":{"name":"The American journal of pediatric hematology/oncology","volume":"16 4","pages":"329-33"},"PeriodicalIF":0.0,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18975384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0