The Italian journal of gastroenterology最新文献_第3页

Hepatitis C virus infection: a possible promoting agent in porphyria cutanea tarda. 丙型肝炎病毒感染:迟发性皮肤卟啉症的可能促进剂。

The Italian journal of gastroenterology Pub Date : 1996-12-01

K Antonov, Z Krastev, P Teoharov, E Zaharieva, A Alexiev, A Ivanova, D Adjarov

{"title":"Hepatitis C virus infection: a possible promoting agent in porphyria cutanea tarda.","authors":"K Antonov, Z Krastev, P Teoharov, E Zaharieva, A Alexiev, A Ivanova, D Adjarov","doi":"","DOIUrl":"","url":null,"abstract":"The study aimed to differentiate the factors triggering porphyria cutanea tarda, paying special attention to the presumed role of hepatitis C virus infection. In a representative Bulgarian contingent, HCV-antibodies were identified using ELISA II and immunoblot. Seropositivity was significantly higher (p < 0.01) in the sporadic form (36 out of 57 patients; 63.2%) compared with the familiar form (4 out of 20 subjects; 20%). Alcohol abuse was the most common factor preceding the expression of open porphyria both in the sporadic and the familiar forms. In 10 sporadic cases, no precipitating factors were observed, except for the fact that they were anti-HCV positive. In another 2 anti-HCV positive patients, porphyria cutanea tarda was preceded by blood transfusions. Renewed consumption of alcohol after successful treatment was a common reason for relapse, but relapses were most frequent in anti-HCV positive patients (35 relapses in 12 patients), in whom other promoting factors were absent. Analysis of triggering factors shows that most probably hepatitis C virus infection could contribute to the expression of porphyria cutanea tarda and the association of both diseases is not coincidental.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 9","pages":"482-6"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20079565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NSAID gastropathy: state of the art. 非甾体抗炎药胃病:最先进的。

The Italian journal of gastroenterology Pub Date : 1996-12-01

C Cervini, W Grassi, R De Angelis

引用次数: 0

Therapy of NSAIDs-induced gastropathy. 非甾体抗炎药诱发胃病的治疗。

The Italian journal of gastroenterology Pub Date : 1996-12-01

R La Corte, M Caselli, M Ruina, G Bajocchi, V Alvisi, F Trotta

{"title":"Therapy of NSAIDs-induced gastropathy.","authors":"R La Corte, M Caselli, M Ruina, G Bajocchi, V Alvisi, F Trotta","doi":"","DOIUrl":"","url":null,"abstract":"NSAID-induced gastropathy is the most frequent side effect due to NSAID use. The resulting clinical event is usually of little significance and only in a small percentage of cases results in serious side effects. Nevertheless, the large worldwide use of NSAIDs makes, even a rare side effect, numerically consistent. The pathogenesis of NSAID-induced gastropathy is related to two main mechanisms: an initial topical effect which is pH dependent and a systemic effect which is, more slowly developing, and mainly correlated to the inhibition of prostaglandin synthesis. The therapy of NSAID-gastropathy is almost completely identified with the therapy of NSAID ulceration because of its frequent relation to the development of potentially serious complications. In the case of symptomatic ulcer development the first therapeutic step is NSAID suspension and, in such a case all \"antiulcer\" drugs are efficient. When the NSAID can not be discontinued, omeprazole seems to be the most efficient drug; H2 blockers can promote ulcer healing but at a slower rate; sucralfate shows an efficacy similar to H2 blockers; misoprostol is useful in the prevention of NSAID-gastropathy. However, it is not so efficient in the treatment of established lesions and shows poor efficacy in the reduction of dyspeptic symptoms. For each one of these drugs it is necessary to obtain further data.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 Suppl 4 ","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19990266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic aspects of gastroduodenal mucosa due to NSAIDs. 非甾体抗炎药对胃十二指肠黏膜的内镜检查。

The Italian journal of gastroenterology Pub Date : 1996-12-01

M Ruina, M Caselli, S Sartori, L Trevisani, R La Corte, F Trotta, V Alvisi

引用次数: 0

Immune mechanisms in the pathogenesis of inflammatory gastrointestinal disorders. 炎症性胃肠疾病发病机制中的免疫机制。

The Italian journal of gastroenterology Pub Date : 1996-11-01

S Romagnani, P Parronchi, M D'Elios, P Romagnani, F Annunziato, M Menghetti, E Maggi, G Del Prete

引用次数: 0

Digestive endoscopy and portal hypertension. North Italian Endoscopic Club. 消化内窥镜检查和门静脉高压症。北意大利内窥镜俱乐部。

The Italian journal of gastroenterology Pub Date : 1996-11-01

R Cestari, L Minelli, A Lanzini, G Missale, P Ravelli, B Salerni

{"title":"Digestive endoscopy and portal hypertension. North Italian Endoscopic Club.","authors":"R Cestari, L Minelli, A Lanzini, G Missale, P Ravelli, B Salerni","doi":"","DOIUrl":"","url":null,"abstract":"Improved knowledge of pathophysiology of portal hypertension and technological progress have contributed to development of new endoscopic techniques and pharmacological approaches to treatment of this condition. To put the role of endoscopy in the right perspective, it is important to consider that liver transplantation has greatly modified prognosis of cirrhosis. Because of the increase of indications for transplantation, these complications are no longer regarded as the last, but rather as an intermediate stage before a possible transplantation. We have reviewed some pathophysiologic, diagnostic and therapeutic aspects on portal hypertension, especially the role of endoscopy in diagnosis, natural history and therapeutic options for complications of cirrhosis. In addition to sclerotherapy, new endoscopic methods have been developed, with a low complication rate and possibility of being applied for treatment of gastric varices, i.e. injection of tissue adhesives and rubber band ligation. Besides oesophageal varices, gastric varices and portal hypertensive gastropathy (and portal colopathy) are important findings in cirrhosis. Further information is needed on natural history and treatment of these conditions. Digestive haemorrhage is the most important consequence of portal hypertension, so treatment should be aimed at controlling acute bleeding, rebleeding and, more important, at preventing first haemorrhagic episode. Good results will probably be obtained using a combination of drugs, a combination of endoscopic methods or a combination of both. All will need evaluation in randomised, controlled trials. These considerations renew interest in strategies for diagnosis and treatment of portal hypertension and a multidisciplinary approach may be necessary, involving gastroenterologists, endoscopists, interventionist radiologists and surgeons, ideally in a departmental environment.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 Suppl 2 ","pages":"18-33"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40824547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duodenal tumours. 十二指肠肿瘤。

The Italian journal of gastroenterology Pub Date : 1996-11-01

R Cheli, G Testino

引用次数: 0

Is there a need for gastrointestinal pathologists? Gruppo Italiano di Patologi dell'Apparato Digerente. 需要胃肠病理学家吗?意大利病理性与病理学组织。

The Italian journal of gastroenterology Pub Date : 1996-11-01

M Rugge, R Fiocca, C Bordi

{"title":"Is there a need for gastrointestinal pathologists? Gruppo Italiano di Patologi dell'Apparato Digerente.","authors":"M Rugge, R Fiocca, C Bordi","doi":"","DOIUrl":"","url":null,"abstract":"The interdisciplinary approach to medical practice is a cultural and operational prerequisite for proper diagnostic and therapeutic activity. Its constant application contributes to the improvement of medical performances with beneficial effects on their costs. Anatomic pathology interacts with clinical and instrumental diagnostics and makes a fundamental contribution to the conclusive diagnosis of disease. Furthermore, morphological data are often crucial in the monitoring of therapeutic effects and a mandatory prerequisite for evaluating the efficacy of treatment in clinical trials both on neoplastic and non-neoplastic diseases. Such deep involvement in clinical practice and the need to keep diagnostic practice up to date with the explosive advances in scientific knowledge justify the demand for pathologists specializing in sub-specialties of their discipline. However, there is an inevitable need for these dedicated pathologists to remain within the cultural and physical environment of the Pathology Department where they have been introduced to and trained in the discipline. The present paper highlights the scientific and practical motives leading to the creation in Italy, and other European countries of a working group open to pathologists particularly dedicated to gastrointestinal disease. The group is called the Gruppo Italiano di Patologi dell'Apparato Digerente (GIPAD).--Italian Group of Digestive Tract Pathologists.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 Suppl 2 ","pages":"34-6"},"PeriodicalIF":0.0,"publicationDate":"1996-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40824548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary gastro-oesophageal reflux disease and irritable oesophagus syndrome as causes of recurrent abdominal pain in children. 原发性胃食管反流病和食管易激综合征是儿童反复腹痛的原因。

The Italian journal of gastroenterology Pub Date : 1996-10-01

G Corrado, M Cavaliere, G Frandina, P Rea, C Pacchiarotti, P Capocaccia, E Cardi

引用次数: 0

Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism. 儿童幽门螺杆菌胃炎与非溃疡性消化不良。一周三联抗菌素治疗根除细菌的效果。

The Italian journal of gastroenterology Pub Date : 1996-10-01

S Cucchiara, G Salvia, N Az-Zeqeh, F D D'Armiento, M R De Petra, S Rapagiolo, A Campanozzi, M Emiliano

{"title":"Helicobacter pylori gastritis and non-ulcer dyspepsia in childhood. Efficacy of one-week triple antimicrobial therapy in eradicating the organism.","authors":"S Cucchiara, G Salvia, N Az-Zeqeh, F D D'Armiento, M R De Petra, S Rapagiolo, A Campanozzi, M Emiliano","doi":"","DOIUrl":"","url":null,"abstract":"Efficacy of one-week triple antimicrobial therapy (bismuth, tinidazole, amoxicillin) as compared to the same drug combination given for 4 weeks was assessed in children with Helicobacter pylori (H. pylori) gastritis and non-ulcer dyspepsia. Twenty-six patients (group A) and 30 (group B) had one-week and four-week schedule, respectively. Eradication (absence of organism at endoscopy at least 1 month after ending treatment) was achieved in 84.6% of group A (22) and 83.3% of group B (25), with marked reduction of histological gastritis score in both groups. Among patients with eradicated H. pylori, symptoms improved significantly in 14 and 16 patients of group A and B, respectively, but were still present in 17 (8 group A, 9 group B). The latter showed gastroparesis and abnormal gastro-oesophageal reflux at a subsequent diagnostic work-up and improved with prokinetic therapy. In 3 patients of group A and 3 of group B, symptoms improved despite persistence of bacterium into the stomach. Finally, in 3 cases (1 group A, 2 group B) both symptoms and H. pylori infection were unchanged. At 6 month follow-up, symptoms were present in 7 patients (3 group A, 4 group B): 6 of them (3 group A, 3 group B) showed H. pylori gastritis at endoscopy. We conclude that in children with dyspepsia and H. pylori gastritis one-week triple antimicrobial schedule is effective in eradicating bacterium; however, detection of H. pylori gastritis in dyspeptic children does not invariably indicate a pathogenic role of the organism in these patients.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 8","pages":"430-5"},"PeriodicalIF":0.0,"publicationDate":"1996-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19990267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0