The Italian journal of gastroenterology最新文献_第2页

Histopathological aspects of mucosal injury related to non-steroidal anti-inflammatory drugs. 与非甾体抗炎药相关的粘膜损伤的组织病理学方面。

The Italian journal of gastroenterology Pub Date : 1996-12-01

A S Taha

{"title":"Histopathological aspects of mucosal injury related to non-steroidal anti-inflammatory drugs.","authors":"A S Taha","doi":"","DOIUrl":"","url":null,"abstract":"As the majority of patients with chronic arthritis are treated, for many years, with non-steroidal anti-inflammatory drugs (NSAID), it is only natural to expect the long-term use of these agents to be associated with a range of oesophago-gastro-duodenal histopathological changes. We have demonstrated that oesophagitis (defined as basis of papillary length, basal cell hyperplasia and inflammatory cell infiltration) is less prevalent in patients taking NSAID. This phenomenon can be utilised in the treatment of certain conditions such as post-irradiation oesophagitis and Barrett's oesophagitis. It also implies that NSAID-related oesophageal ulceration is due to lodging of tablets in the oesophagus and is, in turn, preventable by swallowing of some fluids or solids after taking NSAID. In the stomach, long-term use of NSAID is associated with a specific entity known as chemical or reactive gastritis in about 25% of cases. This is frequently associated with ulceration. Chronic active superficial gastritis, in the presence of Helicobacter pylori, can be found in about 70% of cases. Not unlike oesophagitis, the prevalence of active duodenitis is low in chronic NSAID users. Local ulceration still takes place. This implies that duodenitis is not required in at least some cases of NSAID-related duodenal ulcers, and demonstrates the multi-factorial nature of the pathogenesis of mucosal damage in long-term users of a NSAID.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 Suppl 4 ","pages":"12-5"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19991054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrastructural damage of gastric epithelium in patients taking NSAIDs. 服用非甾体抗炎药患者胃上皮的超微结构损伤。

The Italian journal of gastroenterology Pub Date : 1996-12-01

M Caselli, M Ruina, R La Corte, L Trevisani, S Sartori, A Dentale, P Gaudenzi, F Trotta, V Alvisi

引用次数: 0

Gastroduodenal tolerability of highly specific cyclo-oxygenase-2 inhibitor. 高特异性环氧化酶-2抑制剂的胃十二指肠耐受性。

The Italian journal of gastroenterology Pub Date : 1996-12-01

J Hayllar, I Bjarnason

{"title":"Gastroduodenal tolerability of highly specific cyclo-oxygenase-2 inhibitor.","authors":"J Hayllar, I Bjarnason","doi":"","DOIUrl":"","url":null,"abstract":"Inhibition of constitutively expressed cyclo-oxygenase (COX-1) by NSAIDs is thought to play an important role is the gastrointestinal toxicity of NSAIDs. To minimise the intestinal toxicity of NSAIDS, highly selective COX-2 (induced at inflammatory sites) inhibitors have been developed. One such is flosulide. We assessed the gastroduodenal tolerability of flosulide (20 mg twice a day) in man and compared it with that of naproxen (500 mg twice a day) in a randomised, double blind crossover fashion in 19 patients with osteoarthrosis. Treatment period was 2 weeks with a 2-week washout period with endoscopy before and after each treatment. Gastroduodenal damage was assessed as by Lanza (Grades 0-4) and by the Gastroscopic Rating Scale (Grades 0-9). Flosulide was significantly better tolerated (p < 0.005, analyses of deviance) than naproxen. No stomach damage was seen in 13 (68%) patients following flosulide and 5 (37%) following naproxen (p < 0.001). Lanza scores following flosulide (0.58) were significantly better than that of naproxen (1.47) (p < 0.001). The duodenal damage was mild with both treatments. The selective COX-2 inhibitor, flosulide, is significantly better tolerated and causes less gastric mucosal damage than naproxen when given for two weeks.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 Suppl 4 ","pages":"30-2"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19991059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori infection in families of Helicobacter pylori-positive children. 幽门螺杆菌阳性儿童家庭幽门螺杆菌感染。

The Italian journal of gastroenterology Pub Date : 1996-12-01

M Bonamico, S Monti, I Luzzi, F M Magliocca, E Cipolletta, L Calvani, A Marcheggiano, R Rossi, P Paoluzi

{"title":"Helicobacter pylori infection in families of Helicobacter pylori-positive children.","authors":"M Bonamico, S Monti, I Luzzi, F M Magliocca, E Cipolletta, L Calvani, A Marcheggiano, R Rossi, P Paoluzi","doi":"","DOIUrl":"","url":null,"abstract":"Relatives of Helicobacter pylori positive patients show a higher incidence of Helicobacter pylori infection than the general population, probably due to relapses and/or reinfections between members of the family. Aim of this study was to evaluate the prevalence of the infection in 121 relatives of 41 children with Helicobacter pylori positive gastritis. Specific IgG antibodies (ELISA) were evaluated, and bacteria on gastric biopsy specimens were investigated by urease-rapid test, culture test and GIEMSA or acridine orange staining. Of the eighty-two relatives, 68% were antibody positive. Thirty-five agreed to undergo endoscopy. With the exception of one brother, all subjects (97%) were found to be infected by Helicobacter pylori. Two symptomatic relatives, with normal antibody titres, were submitted to endoscopy and found to be colonized by Helicobacter pylori. The present data confirm the high prevalence of infection within families and appear to demonstrate the usefulness of endoscopy for all subjects showing positive antibody titres as well as for symptomatic relatives, even if serologically negative, to confirm the presence of any pathological conditions and reduce the risk of relapses within families.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 9","pages":"512-7"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20079442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early pathogenic events in NSAID-induced gastrointestinal damage. 非甾体抗炎药引起的胃肠道损伤的早期致病事件。

The Italian journal of gastroenterology Pub Date : 1996-12-01

I Bjarnason, J Hayllar

{"title":"Early pathogenic events in NSAID-induced gastrointestinal damage.","authors":"I Bjarnason, J Hayllar","doi":"","DOIUrl":"","url":null,"abstract":"A number of studies show that the idea that inhibition of cyclooxygenase is the sole mechanism of NSAID-induced gastrointestinal damage is no longer tenable. We re-examined various aspects of the mechanism of small intestinal damage due to NSAIDs in rat. Subcellular organelle marker enzyme studies show selective alterations in mitochondrial and brush border marker enzymes. Electron microscopy shows changes compatible with uncoupling of mitochondrial oxidative phosphorylation. In vitro, all common acidic-NSAIDs (n = 15) were found to uncouple oxidative phosphorylation at concentrations (microM) easily achievable within intestinal epithelium. Experiments in bile duct ligated animals show that intact indomethacin within the gastrointestinal lumen is required for uncoupling. Relative importance and pathophysiological consequences of uncoupling and inhibition of cyclooxygenase were assessed following administration of R and S flurbiprofen: the former selectively uncouples whilst the latter is also an effective cyclooxygenase inhibitor. R flurbiprofen uncoupled in vitro and in vivo, increased intestinal permeability and caused mild intestinal inflammation, but had not significant effect on prostanoid levels and produced no ulcers. S flurbiprofen uncoupled and increased intestinal permeability equally but was associated with significant decreases in intestinal prostanoid levels, more inflammation and numerous ulcers. Collectively these studies suggest that uncoupling may underlie the \"topical\" phase of NSAID damage which leads to increased intestinal permeability and inflammation, but concomitant inhibition of cyclooxygenase is essential to drive the inflammation to ulcers.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 Suppl 4 ","pages":"19-22"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19991056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed tomography of bowel wall in patients with Crohn's disease: relationship of inflammatory activity to biological indices. 克罗恩病患者肠壁的计算机断层扫描:炎症活动与生物学指标的关系

The Italian journal of gastroenterology Pub Date : 1996-12-01

E Tomei, D Diacinti, M Marini, M Boirivant, P Paoluzi

{"title":"Computed tomography of bowel wall in patients with Crohn's disease: relationship of inflammatory activity to biological indices.","authors":"E Tomei, D Diacinti, M Marini, M Boirivant, P Paoluzi","doi":"","DOIUrl":"","url":null,"abstract":"Bowel wall thickening in Crohn's disease can be demonstrated by Computed Tomography. The aim of this investigation was to correlate different patterns of bowel wall thickening, detected with Computed Tomography, with serological parameters of activity of Crohn's disease. Thirty-eight patients (24 males, 14 females, aged 21 to 62 years) were studied. Patients were divided into 3 groups according to Computed Tomography appearance of bowel wall: 1) homogeneous symmetrical thickening of wall; 2) bowel showing a layer of submucosal low attenuation; 3) scarred narrowing of wall producing stenosis. A patient was considered to have biochemically active disease if at least 2 of the following parameters were abnormal: ESR, C-reactive protein, seromucoids, serum albumin, serum alpha-2 globulin. The first group comprised 20 patients (16 active disease, 4 inactive) and the second group 13 (all inactive); the 2 groups showed a significant difference (Fisher exact test: p < 0.0005) in biological activity. Since only 5 patients belonged to the third group (3 active, 2 inactive disease), no definite conclusion can be drawn on the possible correlation between this Computed Tomography pattern and activity of disease. Results shows a correlation between Computed Tomography patterns of bowel wall disease and biochemical activity of Crohn's disease.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 9","pages":"487-92"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20079566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances on NSAID and NSAID Gastropathy, 1st annual meeting. Ferrara, Italy, 6-7 December 1996. Proceedings. 非甾体抗炎药和非甾体抗炎药胃病的最新进展，第一届年会。1996年12月6日至7日，意大利费拉拉。程序。

The Italian journal of gastroenterology Pub Date : 1996-12-01

引用次数: 0

Stimulatory effect of (R) alpha-methylhistamine on duodenal HCO3- secretion in anaesthetized rats. (R) α -甲基组胺对麻醉大鼠十二指肠HCO3分泌的刺激作用。

The Italian journal of gastroenterology Pub Date : 1996-12-01

G Coruzzi, E Gambarelli, G Bertaccini

引用次数: 0

Prevention of NSAID-gastropathy. 预防非甾体抗炎药-胃病。

The Italian journal of gastroenterology Pub Date : 1996-12-01

S Ardizzone, G Bianchi Porro

引用次数: 0

Pilot study of a short course of ribavirin and alpha interferon in the treatment of chronic active hepatitis C not responding to alpha-interferon alone. 短期利巴韦林和α干扰素治疗慢性活动性丙型肝炎的初步研究，单独α干扰素治疗无效。

The Italian journal of gastroenterology Pub Date : 1996-12-01

G Scotto, V Fazio, G Tantimonaco

{"title":"Pilot study of a short course of ribavirin and alpha interferon in the treatment of chronic active hepatitis C not responding to alpha-interferon alone.","authors":"G Scotto, V Fazio, G Tantimonaco","doi":"","DOIUrl":"","url":null,"abstract":"Chronic active hepatitis due to HCV represents a severe progressive disorder of the liver, At present, Interferon seems to be the most efficacious treatment available, however, only 20-25% of the patients treated achieve complete remission. The efficacy has, therefore, been evaluated of Ribavirin, a nucleoside analogue active both on DNA and RNA viruses, in the treatment of non responders to a previous course of interferon. Twenty patients were randomly assigned to two groups: A) received the association R (800 mg/day for 2 months)+interferon (9 Mu/week for 6 months); B) received IFN (9 Mu/week for 6 months). All patients completed the study without important side effects. Four patients in group A presented reduced ALT and loss of viraemia during treatment with Ribavirin. Only one patient in group B had reduced indices of cell lysis and was negative for HCV-RNA during the course of the study. However, viremia and an increase of ALT values were observed in all of these subjects once treatment was interrupted. The results emerging from this study indicate that Ribavirin therapy, at the dose and duration of treatment employed, is not sufficient to change the natural course of events of chronic active hepatitis from HCV.","PeriodicalId":22546,"journal":{"name":"The Italian journal of gastroenterology","volume":"28 9","pages":"505-11"},"PeriodicalIF":0.0,"publicationDate":"1996-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20079441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0