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The Japanese journal of antibiotics最新文献

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[Carumonam].
The Japanese journal of antibiotics Pub Date : 2020-02-07 DOI: 10.32388/55zue3
A. Saito
{"title":"[Carumonam].","authors":"A. Saito","doi":"10.32388/55zue3","DOIUrl":"https://doi.org/10.32388/55zue3","url":null,"abstract":"An N-sulfo monocyclic beta-lactam antibiotic derived from sulfazecin. Carumonam has high resistance to beta-lactamases and activity against aerobic gram-negative bacteria. It reaches high urinary concentrations and may be used in the treatment of urinary tract infections.","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81201580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cefroxadine].
The Japanese journal of antibiotics Pub Date : 2020-02-07 DOI: 10.32388/lszpim
K. Mashimo
{"title":"[Cefroxadine].","authors":"K. Mashimo","doi":"10.32388/lszpim","DOIUrl":"https://doi.org/10.32388/lszpim","url":null,"abstract":"The antibacterial spectrum of cefroxadine was as wide as that of CEX, and its antibacterial effect was as strong as that of CEX or even 2-fold stronger against E. coli and Klebsiella. Cefroxadine was also proved to have stronger bactericidal or bacteriolytic effect than CEX and have better affinity with penicillin binding proteins. In clinical trials, an efficacy rate of 82.7% was achieved in a total of 2,009 cases of various infections analyzed. Cefroxadine displayed particularly good clinical and bacteriological effects for the infections of skin, soft tissues, respiratory tract and urinary tract. The rate of bacteria eradication in a total of 1,410 cases was 81.6%, showing good results against the bacteria such as S. aureus (83.9%, 167/199), E. coli (89.0%, 528/593), Klebsiella (78.0%, 78/100) and P. mirabilis (80.0%, 36/45). As for side effects, their incidence was a low of only 2.3%, the main ones being eruption and gastrointestinal symptoms just as recognized in conventional cephalosporins, and none of them was serious. Abnormal laboratory test values were only increases in eosinophil, S-GOT, S-GPT and Al-P values, and their incidence was low. From these findings, we may say that the drug is an effective, safe, and useful antibiotic among all other orally administered cephalosporins.","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86834119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The change of susceptibility of Streptococcus pneumoniae strains isolated from pediatric patients at Asahikawa Kosei Hospital between 2011 and 2015. 2011 - 2015年旭川Kosei医院儿科患者分离肺炎链球菌菌株的药敏变化
The Japanese journal of antibiotics Pub Date : 2016-12-01
Hiroshi Sakata
{"title":"The change of susceptibility of Streptococcus pneumoniae strains isolated from pediatric patients at Asahikawa Kosei Hospital between 2011 and 2015.","authors":"Hiroshi Sakata","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The susceptibility of 1578 Streptococcus pneumoniae strains isolated from pediatric patients at Asahikawa Kosei Hospital between 2011 and 2015 was tested to penicillin G (PCG), cefotaxime (CTX), ceftriaxone (CTRX), cefditoren (CDTR), meropenem (MEPM), erythromycin (EM) and levofloxacin (LVFX). Although no significant differences were observed, the percentage of strains with a minimal inhibitory concentration (MIC) of PCG of <0.1pg/mL increased from 55.5% (2011) to 64.0% (2015), whereas that of strains with MIC of ≥2μg/mL decreased from 14.8% to 9.5%. From 2011 to 2015, the percentage of strains with MIC ≤0.12ug/mL increased from 18.9% to 28.9% for CTX, from 20.5% to 30.2% for CTRX, from 29.2% to 40.9% for CDTR, and from 69.6% to 80.6% for MEPM. EM-resistant strains with MIC ≥22μg/mL accounted for as much as approximately 90% each year. One LVFX-resistant strain with MIC 8pg/mL has been detected each year since 2013.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36499005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of prevention in pneumonia in elderly -Attempted use of macrolide therapy. 预防老年人肺炎的重要性-尝试使用大环内酯类药物治疗。
The Japanese journal of antibiotics Pub Date : 2016-12-01
Naoyuki Miyashita, Miki Kato, Yasuhiro Kawai, Jiro Okimoto
{"title":"Importance of prevention in pneumonia in elderly -Attempted use of macrolide therapy.","authors":"Naoyuki Miyashita,&nbsp;Miki Kato,&nbsp;Yasuhiro Kawai,&nbsp;Jiro Okimoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pneumonia ranks as the third leading cause of death in Japan. About 97% of patients who die because of pneumonia are elderly, with aspiration generally thought to be involved in the majority of cases of pneumonia in elderly. Once an elderly individual contracts pneumonia, their physical function often declines and their activities of daily living diminish with hospital admission, even in individuals with no underlying disorders. Prolonged confinement to a bed and immobility leads to weakening of the legs and back, making it difficult for elderly patients to attend daily outpatient clinics, often leading to admission to nursing facilities for the aged instead of returning to their own home, even after curative treatment for pneumonia. Most such patients repeatedly develop pneumonia and repeated antibiotic treatment enhances the risk of the emergence of resistant organisms. It is beyond doubt, therefore, that prevention of pneumonia is of vital importance in the elderly.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36499003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High efficiency method of detection and isolation of neuraminidase inhibitor resistant influenza viruses by fluorescence sialidase imaging. 荧光唾液酸酶显像法高效检测和分离神经氨酸酶抑制剂耐药流感病毒。
The Japanese journal of antibiotics Pub Date : 2016-12-01
Yuuki Kurebayashi
{"title":"High efficiency method of detection and isolation of neuraminidase inhibitor resistant influenza viruses by fluorescence sialidase imaging.","authors":"Yuuki Kurebayashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Influenza A and B viruses possess an enzyme \"sialidase\" that cleavages terminal sialic acid from glycochains. These viral sialidase proteins are highly expressed on the virus infected cells. We developed sialidase imaging probe \"BTP3-Neu5Ac\" that enables histochemical fluorescence staining of sialidase activity. BTP3-Neu5Ac was able to perform speedy and easy fluorescence imaging of these virus infected cells, with no needs of specific antibody and cell fixation. In addition, combination use of anti-influenza drugs (sialidase inhibitors) and BTP3-Neu5Ac resulted in selective fluorescence imaging for detection and high-efficiency isolation of drug-resistant virus. Fluorescence imaging of drug-resistant virus will be a powerful method for study of the drug-resistance mechanism, for monitoring of drug-resistant viruses. A novel tool for fluorescence imaging of viral sialidase activity is described in this review.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36499004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical experience with colistin in 9 Japanese patients with infection due to multi-drug resistance pathogens. 9例日本多药耐药病原菌感染患者应用粘菌素的临床体会。
The Japanese journal of antibiotics Pub Date : 2016-10-01
Yukihiro Hamada, Jun Hirai, Hiroyuki Suematsu, Yuka Yamagishi, David P Nicolau, Hiroshige Mikamo
{"title":"Clinical experience with colistin in 9 Japanese patients with infection due to multi-drug resistance pathogens.","authors":"Yukihiro Hamada,&nbsp;Jun Hirai,&nbsp;Hiroyuki Suematsu,&nbsp;Yuka Yamagishi,&nbsp;David P Nicolau,&nbsp;Hiroshige Mikamo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Colistin is a polypeptide antibiotic of the polymyxin family (polymyxin E) which has been reported to be active against many multidrug-resistant (MDR) Gram-negative aerobic bacteria collected across the globe. While this agent was not currently licensed in Japan, the emergence of MDR organisms has necessitated its off-label used in the country. However, colistin was approved in March, 2015. This retrospective observational report includes nine patients with MDR Gram-negative infections due to Pseudomonas aeruginosa (n=6) and Klebsiella spp. (n=3) who received intravenous colistin therapy as part of their antimicrobial regimen. The median age and duration of administration were 40 years (range 7-90) and 8 days (range 1-19). Clinical success was observed in all eight patients for whom efficacy could be evaluated. Two patients encountered colistin related adverse effects 22.2% (2/9). In both cases the nephrotoxicity and dysgeusia resolved after discontinuation of colistin therapy. In vitro studies conducted with these clinical isolates of P aeruginosa displayed synergy with the combination of colistin plus ceftazidime, rifampicin, meropenem or aztreonam. This report provides early evidence that colistin is generally safe, effective and demonstrates in vitro synergy when used in combination for the management of MDR Gram-negative pathogens derived from Japanese patients.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36502014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bactericidal effect of tosufloxacin on Haemophilus influenzae internalized in cultured human cells. 托舒沙星对人培养细胞内化流感嗜血杆菌的杀菌作用。
The Japanese journal of antibiotics Pub Date : 2016-10-01
Noboru Yamanaka, Nuneki Hotomi
{"title":"Bactericidal effect of tosufloxacin on Haemophilus influenzae internalized in cultured human cells.","authors":"Noboru Yamanaka,&nbsp;Nuneki Hotomi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Nontypeable Haemophilus influenzae, one of the major causative bacteria for acute otitis media (AOM), is also considered to cause intractable otitis media including prolonged AOM and recurrent AOM in children by the mechanism of internalization of the bacteria into epithelial cells of middle ear mucosa. In this study, we visualized the dynamics of H. infiuenzae internalization in cultured human cells. We also examined the effects of antimicrobials, including a novel quinolone, tosufloxacin, and a cephem antibacterial agent, cefditoren, on H. influenzae internalized in cultured human cells. The results indicated that (1) H. infiuenzae were internalized into human cells, (2) cefditoren has no effect on internalized H. influenzae, and (3) tosufloxacin has a bactericidal action on H. infiuenzae invading human cells. These data strongly support high clinical efficacy of tosuffoxacin on intractable otitis media in children.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36502013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensitivity surveillance of Pseudomonas aeruginosa isolates for several antibacterial agents in Chubu area (2013-2014). 中部地区2013-2014年铜绿假单胞菌对几种抗菌药物的敏感性监测
The Japanese journal of antibiotics Pub Date : 2016-10-01
Ai Kakumoto, Hayato Okade, Junichi Misuyama, Kazukiyo Yamaoka, Yuko Asano, Yoko Matsukawa, Hiroyuki Suematsu, Haruki Sawamura, Shigenori Matsubara, Naohiro Shibata, Kunitomo Watanabe, Yoshihiro Yamamoto, Hiromichi Iwasaki, Yuka Yamagishi, Hiroshige Mikamo
{"title":"Sensitivity surveillance of Pseudomonas aeruginosa isolates for several antibacterial agents in Chubu area (2013-2014).","authors":"Ai Kakumoto,&nbsp;Hayato Okade,&nbsp;Junichi Misuyama,&nbsp;Kazukiyo Yamaoka,&nbsp;Yuko Asano,&nbsp;Yoko Matsukawa,&nbsp;Hiroyuki Suematsu,&nbsp;Haruki Sawamura,&nbsp;Shigenori Matsubara,&nbsp;Naohiro Shibata,&nbsp;Kunitomo Watanabe,&nbsp;Yoshihiro Yamamoto,&nbsp;Hiromichi Iwasaki,&nbsp;Yuka Yamagishi,&nbsp;Hiroshige Mikamo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We investigated the susceptibility to antibacterial agents of 186 clinical isolates of Pseudomonas aeruginosa isolated from medical facilities in Gifu, Aichi, Toyama, and Fukui prefectures from October 2013 to February 2014. MIC₅₀/₉₀ of piperacillin (PIPC), tazobactam/piperacillin (TAZ/PIPC), ceftazidime (CAZ), cefepime (CFPM), imipenem (IPM), meropenem (MEPM), doripenem (DRPM), aztreonam (AZT), ciprofloxacin (CPFX), levofloxacin (LVFX), amikacin (AMK) and colistin (CL) against P aeruginosa was 8/32, 4/32, 2/8, 2/16, 1/32, 0.5/8, 0.25/4, 8/32, 0.25/8, 0.5/16, 4/8 and 1/1pg/mLrespectively. Two strains of multidrug resistant P aeruginosa were isolated (1.1%). They were isolated from the respiratory tract, intra-abdominal, and urinary infection. The susceptible ratio against P aeruginosa derived from intra-abdominal infection for carbapenem was lower than those from respiratory tract and urinary infection. The susceptible ratio against P aeruginosa derived from urinary infection for penicillin, cephem, monobactam, and fluoroquinolone was lower than those from respiratory and intra-abdominal infection. It is meaningful to pay attention to the susceptibility to antibacterial agents in each clinical specimen from infected organ.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36502457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantage and issue of silkworm model for development of anti-infective agents. 家蚕模型在抗感染药物开发中的优势与问题。
The Japanese journal of antibiotics Pub Date : 2016-10-01
Hiroshi Hamamoto
{"title":"Advantage and issue of silkworm model for development of anti-infective agents.","authors":"Hiroshi Hamamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We established silkworm infection model for developing a novel antibiotic. Silkworm model has less ethical issues and is low cost compared to mammalian model, thus allow us to use a lot of individuals for screening assay. In addition, we can evaluate therapeutic activity and toxicity of candidate samples because silkworm has similar pharmacokinetics as mammals. Using this system, we identified a novel antibiotic named \"Lysocin E\". In this review article, we describe advantages of silkworm model for development of antimicrobial agents.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36502011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of pediatric patient with acute enteritis due to CTX-M-1 5 extended-spectrum β-lactamase-producing Salmonella Blockley. ctx - m - 15广谱产β-内酰胺酶沙门氏菌引起的小儿急性肠炎1例。
The Japanese journal of antibiotics Pub Date : 2016-10-01
Storu Kutsuna, Shota Yonetani, Koji Araki, Hidemasa Izumiya
{"title":"A case of pediatric patient with acute enteritis due to CTX-M-1 5 extended-spectrum β-lactamase-producing Salmonella Blockley.","authors":"Storu Kutsuna,&nbsp;Shota Yonetani,&nbsp;Koji Araki,&nbsp;Hidemasa Izumiya","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This clinical case report concerns a pediatric patient with acute enteritis caused by multi-drug resistant Salmonella enterica serovar Blockley (Salmonella Blockley). A 3-year-old boy presented to our emergency room with a 5-day history of fever, abdominal pain, and bloody diarrhea. Stool culture tested positive for a Salmonella species, while the blood culture was negative. The patient was successfully treated with an oral antibiotic regimen of fosfomycin. The stool isolate was found to be resistant to multiple drugs, including cefpodoxime, cefotaxime, ceftazidime, and aztreonam, and was confirmed to be a CTX-M-15 extended-spectrum β-lactamase (ESBL)-producing strain of Salmonella Blockley. This is the first report of a pediatric patient in Japan with acute enteritis caused by a CTX-M-15 ESBL- producing strain of Salmonella Blockley.</p>","PeriodicalId":22536,"journal":{"name":"The Japanese journal of antibiotics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36502460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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